Drugs used in dyslipidemia

ยารักษาภาวะไขมันในเลือดผิดปกติ

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• Sarayut Lahnwong, M.D., Ph.D.

• Department of Pharmacology, Faculty of Medicine

• Khon Kaen University

Objectives

• Site of actions

• Mechanism of actions

• Clinical uses

• Important side effects

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References

• Goodman and Gilmans The Pharmacological Basis of Therapeutics 13e (2018)

• Katzung & Trevor's Pharmacology: Examination & Board Review, 12e (2019)

• เภสชัวทิยา ส าหรับนักศกึษาวทิยาศาสตรส์ขุภาพ เลม่ 1, ภาควชิาเภสชัวทิยา คณะแพทยศาสตร ์มหาวทิยาลยัขอนแกน่ (2562)

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Plasma lipoproteins

• Chylomicrons

• Very low-density lipoproteins (VLDL)

• Intermediate density lipoproteins (IDL)

• Low-density lipoproteins (LDL)

• High-density lipoproteins (HDL)

• Lp(a) lipoprotein

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Plasma lipoproteins

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Plasma lipoproteins

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Management

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Drugs used in dyslipidemia

• HMG-CoA reductase inhibitors: Statins

• Fibric acid derivatives: Fibrates

• Nicotinic acid: Niacin

• Bile acid binding resins

• Inhibitors of intestinal sterol absorption

• Omega-3 fatty acids (fish oil derivatives)

1. HMG-CoA reductase inhibitors

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Mechanism of action

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2. Fibric acid derivatives

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3. Nicotinic acid: Niacin

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4. Bile acid binding resins

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5. Inhibitors of intestinal sterol absorption

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6. Omega-3 fatty acids (fish oil derivatives)

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Q & A