api & intermediates catalogue - pharmacompass.com · 广东莱佛士制药技术有限公司...

广东莱佛士制药技术有限公司

Guangdong Raffles PharmaTech Co. Ltd

地址：中国广东省惠州市大亚湾石化大道中滨海十路北三号 516083

ADD.: No3, Binhai 10th Road North, Shihua Dadao Middle, DayaBay, Huizhou, Guangdong, China 516083

电话 Tel.：+86-752-5538396; +86-189-2733-0312 邮箱 Email：[email protected].

网址 Website：www.rafflespt.com

API & Intermediates Catalogue

API Name s/n Chemical Name Structure CAS No.

Pazopanib

帕唑帕尼

1. Pazopanib Hydrochloride (API)

635702-64-6

2. Pazopanib free base

444731-52-6

3.

N-(2-Chloropyrimidin-4-yl)-N-meth

yl-2,3-dimethyl-2H-indazol-6-amin

e

444731-75-3

4. 6-[N-(2-chloropyrimidin-4-yl)amin

o]-2,3-dimethyl-2H-indazole

444731-74-2

5. 2,3-dimethyl-2H-indazol-6-amine

hydrochloride

635702-60-2

6. 2,3-dimethyl-2H-indazol-6-amine

444731-72-0

7. 2,3-dimethyl-6-Nitro-2H-indazole

444731-73-1

8. 3-methyl-6-nitro-indazole

6494-19-5

Trametinib

曲美替尼

9. Trametinib DMSO (API)

1187431-43-1

10. Trametinib solvent free

871700-17-3

mailto:[email protected]









Trametinib

曲美替尼

Trametinib

曲美替尼

11.

N-(3-(3-cyclopropyl-1-(2-fluoro-4-i

odophenyl)-6,8-dimethyl-2,4,7-trio

xo-1,2,3,4,7,8-hexahydropyrido[2,

3-d]pyrimidin-5-ylamino)phenyl)ac

etamide

871700-25-3

12.

3-cyclopropyl-1-(2-fluoro-4-iodoph

enyl)-6,8-dimethyl-2,4,7-trioxo-1,

2,3,4,7,8-hexahydropyrido[2,3-d]p

yrimidin-5-yl 4-methylbenzenesulf

onate

871700-32-2

13.


enyl)-5-hydroxy-6,8-dimethylpyrid

o[2,3-d]pyrimidine-2,4,7(1H,3H,8

H)-trione

871700-24-2

14.


enyl)-6-(methylamino)pyrimidine-

2,4(1H,3H)-dione

871700-22-0

15.

(E)-N'-(1-cyclopropyl-3-(2-fluoro-4

-iodophenyl)-2,6-dioxo-1,2,3,6-tetr

ahydropyrimidin-4-yl)-N,N-dimeth

ylformimidamide

871700-30-0

16.

6-amino-3-cyclopropyl-1-(2-fluoro-

4-iodophenyl)pyrimidine-2,4(1H,3

H)-dione

871700-28-6

17. 1-cyclopropyl-3-(2-fluoro-4-iodoph

enyl)urea

871700-18-4










Axitinib

阿西替尼

18. Axitinib (API)

319460-85-0

19. 2-(1H-indazol-6-ylthio)-N-methyl-

Benzamide

944835-85-2

20.

6-Iodo-3(E)-2-pyridin-2-yl-vinyl)-1-

(tetrahydropyran-2-yl)-1H-indazol

e

886230-77-9

21. 6-Iodo-1H-indazole

261953-36-0

22. 3-Iodo-6-nitro-1H-indazole

70315-70-7

23. 2,2'-disulfanediylbis(N-methylben

zamide)

2527-58-4

24. 2-mercapto-N-methyl-Benzamide

20054-45-9

Dabrafenib

达拉非尼

25. Dabrafenib Mesylate (API)

1195768-06-9

26. Dabrafenib Base

1195765-45-7










Dabrafenib

达拉非尼

27.

N-{3-[5-(2-chloro-4-pyrimidinyl)-2-

(1,1-diethylethyl)-1,3-thiazol-4-yl]-

2-fluoraphenyl}-2,6-difluorobenze

nesulfonamide

1195768-23-0

28.

N-{3-[(2-chloro-4-pyrimidinyl)acety

l]-2-fluorophenyl}-2,6-difluorobenz

enesulfonamide

1195768-20-7

29. Methyl 3-((2,6-difluorophenyl)sulf

onamido)-2-fluorobenzoate

1195768-19-4

30. Methyl 3-amino-2-fluorobenzoate

1195768-18-3

31. 2,2,2-trimethylthioacetamide

630-22-8

Eltrombopag

Olamine

艾曲波帕

32. Eltrombopag Olamine (API)

496775-62-3

33. Eltrombopag Acid

496775-61-2


http://tools.wmflabs.org/magnustools/cas.php?language=en&cas=496775-62-3&title=

http://tools.wmflabs.org/magnustools/cas.php?language=en&cas=496775-62-3&title=









Eltrombopag

Olamine

艾曲波帕

34. 3'-amino-2'-hydroxybiphenyl-3-car

boxylic acid

376592-93-7

35. 2'-hydroxy-3'-nitro-[1,1'-biphenyl]-

3-carboxylic acid

376591-95-6

36. 3'-amino-2'-hydroxybiphenyl-3-car

boxylic acid HCl

376591-97-8

37. 5'-chloro-2'-hydroxy-3'-nitro-[1,1'-

Biphenyl]-3-carboxylic acid

376592-58-4

38. 5'-chloro-2'-hydroxy-[1,1'-Bipheny

l]-3-carboxylic acid,

376592-57-3

39.

3-methyl-1-(3,4-dimethylphenyl)-2

-pyrazolin-5-one

2-(3,4-Dimethyl-phenyl)-5-methyl-

1,2-dihydro-pyrazol-3-one

18048-64-1

277299-70-4

Etoricoxib

依托考昔

40. Etoricoxib (API)

202409-33-4

41. 1-(6-methyl-3-pyridyl)-2-(4-(methy

lsulfonyl)-phenyl)ethanone

221615-75-4

42. 1-(6-Methylpyridin-3-yl)-2-[4-(met

hylthio)phenyl]ethanone

221615-72-1


http://www.chemicalbook.com/Search.aspx?keyword=2-Hydroxy-3-nitro-%5b1,1-biphenyl%5d-3-carboxylic%20acid

http://www.chemicalbook.com/Search.aspx?keyword=2-Hydroxy-3-nitro-%5b1,1-biphenyl%5d-3-carboxylic%20acid









Etoricoxib

依托考昔

43. 4-methylsulphonylphenylacetic

acid

90536-66-6

44. 4-methylthiophenylacetic acid

16188-55-9

45. 2-chloro-1,3-bis(dimentylamino)tri

methinium hexafluorophosphate

249561-98-6

46. Methyl 6-methylnicotinate

5470-70-2

Celecoxib

塞来昔布 47. Celecoxib (API)

169590-42-5

Dolutegravir

度鲁特韦

48. Dolutegravir Sodium (API)

1051375-19-9

49. Dolutegravir free acid

1051375-16-6

50.

(4R,12aS)-N-(2,4-Difluorobenzyl)-

7-methoxy-4-methyl-6,8-dioxo-3,

4,6,8,12,12a-hexahydro-2H-[1,3]o

xazino[3,2-d]pyrido[1,2-a]pyrazine

-9-carboxamide

1335210-35-9

51.

(4R,12aS)-7-Methoxy-4-methyl-6,

8-dioxo-3,4,6,8,12,12a-hexahydro

-2H-[1,3]oxazino[3,2-d]pyrido[1,2-

a]pyrazine-9-carboxylic acid

1335210-34-8

52.

1-(2,2-dimethoxyethyl)-5-methoxy

-6-(methoxycarbonyl)-4-oxo-1,4-di

hydropyridine-3-carboxylic acid

1335210-23-5










Dolutegravir

度鲁特韦

53.

Dimethyl 3-(benzyloxy)-1-(2,2-di

methoxyethyl)-4-oxo-1,4-dihydrop

yridine-2,5-dicarboxylate

1357289-08-7

54. Dimethyl 3-(benzyloxy)-4-oxo-4H-

pyran-2,5-dicarboxylate

1246616-66-9

Cabotegravir

卡博特韦

55. Cabotegravir Sodium

1051375-13-3

56. Cabotegravir Free Acid

1051375-10-0

57.

(3S,11aR)-N-(2,4-difluorobenzyl)-6-methoxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-d]pyrido[1,2-a]pyrazine-8-carboxamide

1335210-25-7

58.

(3S,11aR)-6-methoxy-3-methyl-5,

7-dioxo-2,3,5,7,11,11a-hexahydro

oxazolo[3,2-d]pyrido[1,2-a]pyrazin

e-8-carboxylic acid

1335210-24-6

HCV Product

Intermediates

(Glecaprevir,

Grazoprevir,

Voxilaprevir,

Simeprevir，

Ruzasvir)

59. N-(tert-butyl)-3-chloropropane-1-sulfonamide

63132-85-4

60. N-tert-butylcyclopropanesulfonam

ide

630421-42-0

61. Cyclopropanesulfonamide

154350-29-5

62. 1-Methylcyclopropanesulfonamid

e

669008-26-8


http://baike.molbase.cn/cidian/1585352











HCV Product

Intermediates

(Glecaprevir,

Grazoprevir,

Voxilaprevir,

Simeprevir，

Ruzasvir)

63.

(1R,2R)-1-amino-2-(difluoromethy

l)-N-((1-methylcyclopropyl)-(methy

lene)sulfinyl)cyclopropane-1-carb

oxamide

1360997-58-5

64.

(1R,2R)-1-amino-2-(difluoromethy

l)-N-((1-methylcyclopropyl)sulfony

l)cyclopropane-1-carboxamide hy

drochloride

1360828-80-3

65. 3-(1,1-difluoroallyl)quinoxalin-2-ol

1294512-27-8

as

66. 2-chloro-3-(1,1-difluoroallyl)quino

xaline

1365970-41-7

67.

1-(tert-butyl) 2-methyl (2S,4R)-4-

((3-(1,1-difluoroallyl)quinoxalin-2-

yl)oxy)pyrrolidine-1,2-dicarboxylat

e

1365970-42-8

68. (1R,2R)-2-(allyloxy)cyclopentan-1

-ol

1365970-44-0

69.

(S)-2-{[(((1R,2R)-2-(allyloxy)cyclo

pentyl)oxy)carbonyl]amino}-3,3-di

methylbutanoic acid

1365970-45-1

70.

methyl (2S,4R)-1-((S)-2-(((((1R,2

R)-2-(allyloxy)cyclopentyl)oxy)car

bonyl)amino)-3,3-dimethylbutanoy

l)-4-[(3-(1,1-difluoroallyl)quinoxali

n-2-yl)oxy]pyrrolidine-2-carboxylat

e

1365970-46-2










HCV Product

Intermediates

(Glecaprevir,

Grazoprevir,

Voxilaprevir,

Simeprevir，

Ruzasvir)

71.

Methyl (33R,35S,91R,92R,5S,E)-

5-(tert-butyl)-14,14-difluoro-4,7-di

oxo-2,8,10-trioxa-6-aza-1(2,3)-qui

noxalina-3(3,1)-pyrrolidina-9(1,2)-

cyclopentanacyclotetradecaphan-

12-ene-35-carboxylate

1365970-47-3

72.

(33R,35S,91R,92R,5S,E)-5-(tert-b

utyl)-14,14-difluoro-4,7-dioxo-2,8,

10-trioxa-6-aza-1(2,3)-quinoxalina

-3(3,1)-pyrrolidina-9(1,2)-cyclopen

tanacyclotetradecaphan-12-ene-3

5-carboxylic acid

1365970-48-4

73.

(33R,35S,91R,92R,5S,E)-5-(tert-b

utyl)-N-((1R,2R)-2-(difluoromethy

l)-1-(((1-methylcyclopropyl)sulfony

l)carbamoyl)cyclopropyl)-14,14-dif

luoro-4,7-dioxo-2,8,10-trioxa-6-az

a-1(2,3)-quinoxalina-3(3,1)-pyrroli

dina-9(1,2)-cyclopentanacyclotetr

adecaphan-12-ene-35-carboxami

de

1365970-03-1

74. Cyclopropanecarbothioamide

20295-34-5

Vilanterol

维兰特罗

75. Vilanterol Trifenatate (API)

503070-58-4

76. Benzene, 2-[[2-[(6-broMohexyl)ox

y]ethoxy]Methyl]-1,3-dichloro

503070-57-3

77.

4H-1,3-Benzodioxin-6-Methanol,

2,2-diMethyl-a-[[(phenylMethyl)a

Mino]Methyl]-, (aR)-

452342-08-4

78. (R)-2-amino-1-(2,2-dimethyl-4H-b

enzo[d][1,3]dioxin-6-yl)ethanol

208925-08-0










79. (5R)-2-Oxazolidinone, 5-(2,2-diM

ethyl-4H-1,3-benzodioxin-6-yl)

452339-73-0

Umeclidinium

Bromide

芜地溴铵

80. Umeclidinium Bromide (API)

869113-09-7

81. ((2-Bromoethoxy)methyl)benzene

1462-37-9

82. Diphenyl(quinuclidin-4-yl)methano

l

461648-39-5

83. Ethyl quinuclidine-4-carboxylate

22766-68-3

84. Ethyl quinuclidine-4-carboxylate

Hydrochloride 22766-67-2

Indacaterol

茚达特罗

85. Indacaterol Maleate (API)

753498-25-8

86.

(R)-N-(2-(8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl)-2-hydroxyethyl)-5,6-diethyl-2,3-dihydro-1H-inden-2-aminium benzoate

753498-24-7










Indacaterol

茚达特罗

87. 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone

173140-90-4

88. (R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one

530084-79-8

89. 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline

100331-89-3

90. 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

312753-53-0

Bimatoprost

比马前列素

91. Bimatoprost (API)

155206-00-1

92.

(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2[(E)-(S)-3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid methyl ester

38315-47-8

93.

(5Z)-7-[(1R)-3α,5α-Dihydroxy-2β-[(1E,3S)-3-hydroxy-5-phenyl-1-pentenyl]cyclopentan-1α-yl]-5-heptenoic acid

38344-08-0


http://www.chemicalbook.com/Search.aspx?keyword=(Z)-7-%5b(1R,2R,3R,5S)-3,5-DIHYDROXY-2-((E)-(S)-3-HYDROXY-5-PHENYL-PENT-1-ENYL)-CYCLOPENTYL%5d-HEPT-5-ENOIC%20ACID%20METHYL%20ESTER











Bimatoprost

比马前列素

94.

2H-Cyclopenta[b]furan-2,5-diol, hexahydro-4-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]-, (3aR,4R,5R,6aS)-

856240-62-5

95.

(+)-(3aR,4R,5r,6aS)-Hexahydro-5-hydroxy-4-[(1E,3R)-3-hydroxy-5-phenyl-1-pentenyl]-2H-cyclopenta[b]furan-2-one

41639-74-1

96.

[(3aR,4R,5R,6aS)-4-[(3S)-3-hydroxy-5-phenylpent-1-enyl]-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] benzoate

55444-68-3

97. Dimethyl(2-oxo-4-phenylbutyl)phosphonate

41162-19-0

Tafluprost

他氟前列素

98. Tafluprost (API)

209860-87-7

99. 7-[2-(3,3-difluoro-4-phenoxybut-1-enyl)-3,5-dihydroxycyclopentyl]hept-5-enoic acid

209860-88-8

100.

2H-Cyclopenta[b]furan-2,5-diol, 4-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]hexahydro-, (3aR,4R,5R,6aS)-

209861-02-9

101.

(3aR,4R,5R,6aS)-4-[(1E)-3,3-Difluoro-4-phenoxy-1-butenyl]hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-one

209861-01-8


http://www.chemicalbook.com/Search.aspx?keyword=Dimethyl-(2-oxo-4-phenylbutyl)phosphonate,%2098%20%25

http://www.chemicalbook.com/Search.aspx?keyword=Dimethyl-(2-oxo-4-phenylbutyl)phosphonate,%2098%20%25









Tafluprost

他氟前列素

102.

(3aR,4R,5R,6aS)-5-(benzoyloxy)-4-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]hexahydro-2H-Cyclopenta[b]furan-2-on

209861-00-7

103.

(3aR,4R,5R,6aS)-2-oxo-4-((E)-3-oxo-4-phenoxybut-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl benzoate

51638-91-6

104. Dimethyl(2-oxo-3-phenoxypropyl)phosphonate

40665-68-7

Travoprost

曲沃前列素

105.

2H-Cyclopenta[b]furan-2,5-diol, hexahydro-4-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-, (3aR,4R,5R,6aS)-

1204185-88-5

106.

(3aR,4R,5R,6aS)-5-hydroxy-4-[(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one

53872-60-9

107.

[1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-hexahydro-4-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-2-oxo-2H-cyclopenta[b]furan-5-yl ester

114488-91-4

108.

[1,1'-Biphenyl]-4-carboxylic acid (3aR,4R,5R,6aS)-hexahydro-2-oxo-4-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-2H-cyclopenta[b]furan-5-yl ester

54142-64-2

109. Dimethyl[2-oxo-3-[3-(trifluoromethyl)phenoxy]propyl]phosphonate

54094-19-8

Lubiprostone

鲁比前列酮 110.

(3aR,4R,5R,6aS)-4-((E)-4,4-difluoro-3-oxooct-1-en-1-yl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one

136790-72-2










Latanoprost

拉坦前列素

111. Latanoprost Lactone Diol

145667-75-0

112.

(3aR,4R,5R,6aS)-4-((R)-3-hydroxy-5-phenylpentyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate

353522-93-7

Dinoprostone

地诺前列酮 113.

(2-oxoheptyl)-phosphonicacidimethylester

36969-89-8

Methoxamine

盐酸甲氧明 114.

1-(2,5-dimethoxyphenyl)propan-1-one

5803-30-5

115. 3,5-dimethoxyaniline

10272-07-8

116. 2,6-dichloro-3,5-dimethoxyaniline

872509-56-3

QL03 117. 6-fluoro-4-hydroxyquinoline

391-78-6

QL04 118. 4-chloro-6-fluoroquinoline

391-77-5

TSC 119. Dimethyl Trithiocarbonate

2314-48-9

TBD 120. 1,5,7-Triazabicyclo[4.4.0]dec-5-ene

5807-14-7


http://www.chemicalbook.com/Search.aspx?keyword=LATANOPROST%20LACTONE%20DIOL










MTBD 121. 7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene

84030-20-6

羟乙基淀粉 122. Hydroxyethylamyl

9005-27-0

Sertraline/

Dasotraline 123.

(4S)-(3',4'-Dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one

124379-29-9

SA04 124. N,N-dioctadecylaniline

72072-19-6

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