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a r c h s o c e s p o f t a l m o l . 2 0 1 1;8 6(1 0):314319
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Original article
Intravitreal triamcinolone acetonide use in diffusepersistent diabetic macular edema,
M. Garca Fernndez , A. Garca Alonso, M. Fonoll Gil, S. Rodrguez VillaSeccin de Retina, Servicio de Oftalmologa, Hospital Universitario Central de Asturias (H.U.C.A), Oviedo, Asturias, Spain
a r t i c l e i n f o
Article history:
Received 7 November 2010
Accepted 9 May 2011
Available online 3 March 2012
Keywords:
Diabetic macular oedema
Intravitreal triamcinolone acetonide
injection
Central macular thickness
Intraocular pressure
a b s t r a c t
Purpose: To determine the efficacy of intravitreal triamcinolone injections (iv TA) for
diffuse persistent diabetic macular oedema (DMO) based on the functional parameter
of modification in best corrected visual acuity (BCVA) and the anatomic parame-
ter of quantitative changes in central macular thickness, as determined by optical
coherence tomography (OCT). The secondary outcome is to analyse the safety of the
procedure.
Methods: In this retrospective study, 16 patients (22 eyes) were included over a period of six
months. Type and time of evolution of diabetes mellitus, previous treatments, BCVA, lens
status, intraocular pressure (IOP) and central macular thickness, were analysed. During the
follow-up period were collected: number of injections, changes in BCVA, IOP, central macular
thickness, and complications observed.
Results: Improvement in BCVA was recorded in 30.77%, 47.37% and 52.63%, at one,
three and six months, respectively (p < .05 at 3 months). The IOP increased in 57.69%
at one month, and 75 and 47.05%, at 3 and 6 months, respectively (p < .05 at
3 months). Progression of cataracts was found in 22.72%. No cases of endophthalmitis were
observed.
Conclusions: Intravitreal TA is a good therapeutic option for patients with persistent DMO,
increasing BCVA and decreasing central macular thickness in the short term, with a per-
centage of clinical resolution of more than 70%. However, due to the transient effect,
and potential adverse effects, it should be administered to selected refractory cases with
nloaded from http://www.elsevier.es, day 04/07/2017. This copy is for personal use. Any transmission of this document by any media or format is strictly prohibited.nloaded from http://www.elsevier.es, day 04/07/2017. This copy is for personal use. Any transmission of this document by any media or format is strictly prohibited.
caution. 2010 Sociedad Espaola de Oftalmologa. Published by Elsevier Espaa, S.L. All rights
reserved.
Please cite this article as: Garca Fernndez M, et al. Uso de triamcinolona intravtrea en el tratamiento del edema macular diabticodifuso persistente. Arch Soc Esp Oftalmol. 2011;86:3149. Partially presented as a free communication in the 86 Congreso of the Sociedad Espanola de Oftalmologa (September 2010).
Corresponding author.E-mail address: [email protected] (M. Garca Fernndez).
2173-5794/$ see front matter 2010 Sociedad Espaola de Oftalmologa. Published by Elsevier Espaa, S.L. All rights reserved.
dx.doi.org/10.1016/j.oftale.2012.02.005http://www.elsevier.es/oftalmologiamailto:[email protected]
a r c h s o c e s p o f t a l m o l . 2 0 1 1;8 6(1 0):314319 315
Uso de triamcinolona intravtrea en el tratamiento del edema maculardiabtico difuso persistente
Palabras clave:
Edema macular diabtico
Inyeccin de triamcinolona
acetnido intravtrea
Grosor macular central
Presin intraocular
r e s u m e n
Propsito: Explorar la eficacia de las inyecciones de triamcinolona intravtrea (TA iv) en el
edema macular diabtico (EMD) difuso persistente, segn el parmetro funcional de la
modificacin en la mejor agudeza visual corregida (MAVC) y el parmetro anatmico del
cambio cuantitativo en el espesor foveal central, determinado por tomografa de coherencia
ptica (OCT). El objetivo secundario es analizar la seguridad del procedimiento.
Mtodos: En este estudio retrospectivo se incluyeron 16 pacientes (22 ojos), en un periodo
de seis meses. Se analiz tipo y tiempo de evolucin de la diabetes mellitus, tratamientos
previos, MAVC, estado del cristalino, presin intraocular (PIO) y espesor macular central. A
lo largo del seguimiento se recogieron datos relativos al nmero de inyecciones, as como a
cambios en MAVC, PIO, grosor foveal, y complicaciones observadas.
Resultados: Se produjo mejora en la MAVC en el 30,77, 47,37 y 52,63%, al mes, 3 y 6 meses,
respectivamente (p < 0,05 a los 3 meses). Se observ incremento de la PIO en el 57,69% al mes,
y en el 75% y 47,05%, a los 3 y 6 meses (p < 0,05 a los 3meses). Se cuantific una disminucin
en el grosor foveal al mes, 3 y 6 meses (p < 0,05). Se observ progresin de catarata en 22,72%.
No se apreci ningn caso de endoftalmitis.
Conclusiones: La TA iv es una buena opcin terapetica para los pacientes con EMD persis-
tente, mejorando la MAVC y reduciendo el grosor macular a corto plazo, con porcentajes
de resolucin clnica de ms del 70%. Sin embargo, su efecto transitorio y sus potenciales
efectos adversos hacen que deba administrarse en casos refractarios con precaucin.
2010 Sociedad Espaola de Oftalmologa. Publicado por Elsevier Espaa, S.L. Todos los
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Document downloaded from http://www.elsevier.es, day 04/07/2017. This copy is for personal use. Any transmission of this document by any media or format is strictly prohibited.Document downloaded from http://www.elsevier.es, day 04/07/2017. This copy is for personal use. Any transmission of this document by any media or format is strictly prohibited.
ntroduction
ersistent diabetic macular edema (DME) is the most frequentause of visual acuity loss in patients with diabetic retinopa-hy. It affects 29% of patients having over 20 years of evolutionf the disease.1
Focal or grid laser photocoagulation is the accepted stan-ard treatment. However, the response of edemas in theseatients is not uniform because diffuse edemas, particularlyhose exhibiting cystic patterns, are resistant to conventionalaser treatment.
Triamcinolone acetonide (TA) is a corticosteroid with powerful and lasting anti-inflammatory, hormonal andetabolic action which is acquiring increasing importance
n the treatment of retinal, vascular and inflammatoryisorders.2 It has been experimentally determined that triam-inolone diminishes the vascular patency and stabilizes theematoretinal barrier (HRB).3
The intravitreal injection of triamcinolone has the advan-age of high bioavailability in its action area without the sideffects of systemic corticoids. However, its intraocular usenvolves potential risks and complications, some of whichre common to any substance administered through an inva-ive pathway (vitreous or retinal hemorrhage, retina detach-ent, iatrogenic cataracts, endophthalmitis) while others are
ependent on the nature of the drug such as ocular hyperten-ion, cataract development or pseudoendophthalmitis.2
The main objective of this study is to explore the efficacyf intravitreal TA injections in persisting diffuse DME, accord-
ng to the functional parameter of change in best correctedisual acuity (BCVA) and the anatomic parameter of changes in
derechos reservados.
the central foveal thickness determined with optic coherencetomography (OCT). A secondary aim is to determine the safetyof the procedure by assessing the applications encountered ina series of patients.
Subjects, material and methods
A retrospective, longitudinal study carried out in patientsdiagnosed with persistent diffuse macular edema in our hos-pital, secondary to diabetic retinopathy and treated with4 mg/0.05 ml injections of intravitreal TA (TA iv) (TrigonDepot Bristol-Myers Squibb, New York).
The design of the study was accepted by the Ethics Com-mittee of the hospital, and all the patients signed an informedconsent. The methodology of the study was designed in accor-dance with the guidelines of the Helsinki Declaration. Theinclusion criteria were: patients over 18 years of age withdiffuse diabetic ME with foveal center compromise (Fig. 1),absence of ocular hypertension or glaucoma, absence of ocu-lar surgical interventions or treatments in the past 6 monthsand having received single or multiple iv TA injections due totheir ME.
The injections were administered after being prepared inthe lab with centrifugation at 3000 rpm during 5 min, with-drawal of solvents and subsequent reconstitution with BSS.
All the patients underwent a complete ophthalmolog-ical exploration, including BCVA assessment with Snellen
optotypes, biomicroscopic exploration of the anterior andposterior segment, applanation tonometry, angiofluoresce-ingraph (AFG) (Imageet, Topcon, Tokio) and OCT. The OCTstudies were carried out under midriasis, either with the
316 a r c h s o c e s p o f t a l m o l . 2 0 1 1;8 6(1 0):314319
Fig. 1 (A) Funduscopic appearance. A slight macularedema with diffused retinal thickening and perifoveal hardexudation incomplete ring associated to dottedhemorrhages in the 4 quadrants. (B) Tomographyappearance: cystic macular edema. 1 indicates macular
Table 1 Baseline patient characteristics.
Mean age 69.75 (SD: 7.69) (range: 6186)Females 7/16 (43