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Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Fumito Endo, Okiru Komine, Noriko Fujimori-Tonou, Masahisa Katsuno, Shijie Jin, Seiji Watanabe, Gen Sobue, Mari Dezawa, Tony Wyss- Coray, Koji Yamanaka Cell Reports Volume 11, Issue 4, Pages 592-604 (April 2015) DOI: 10.1016/j.celrep.2015.03.053 Copyright © 2015 The Authors Terms and Conditions

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Page 1: Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Fumito

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells 

Fumito Endo, Okiru Komine, Noriko Fujimori-Tonou, Masahisa Katsuno, Shijie Jin, Seiji Watanabe, Gen Sobue, Mari Dezawa, Tony Wyss-Coray, Koji Yamanaka 

Cell Reports Volume 11, Issue 4, Pages 592-604 (April 2015)

DOI: 10.1016/j.celrep.2015.03.053

Copyright © 2015 The Authors Terms and Conditions

Page 2: Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Fumito

Figure 1

Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions

Page 3: Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Fumito

Figure 2

Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions

Page 4: Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Fumito

Figure 3

Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions

Page 5: Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Fumito

Figure 4

Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions

Page 6: Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Fumito

Figure 5

Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions

Page 7: Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Fumito

Figure 6

Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions

Page 8: Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Fumito

Figure 7

Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions

Page 9: Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Fumito

Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions