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TRANSCRIPT
![Page 1: B BcB B B B|B B. ÷B BN!¢Õ. %µ Ï(» · BkB¦BnB·BtB]B¤B B®BpB_BjB¦ BkB¦BnB·Bt B]B¤B B® B B¦B B®2D BkB¦BnB·Bt ( )3 6ý p%m- BkB¦BnB·Bt: :Ã:¸ BM1 BB B]B¤B B® B](https://reader043.vdocuments.pub/reader043/viewer/2022040201/5e56dacb8bea1f586a6980bb/html5/page/1.jpg)
20%
80%
Val Leu Ile
Leucine BCAA
12% 23%
10% 21%
8.5% 20%
8% 18%
8% 18%
7% 15%
Val Leu Ile
![Page 2: B BcB B B B|B B. ÷B BN!¢Õ. %µ Ï(» · BkB¦BnB·BtB]B¤B B®BpB_BjB¦ BkB¦BnB·Bt B]B¤B B® B B¦B B®2D BkB¦BnB·Bt ( )3 6ý p%m- BkB¦BnB·Bt: :Ã:¸ BM1 BB B]B¤B B® B](https://reader043.vdocuments.pub/reader043/viewer/2022040201/5e56dacb8bea1f586a6980bb/html5/page/2.jpg)
0
50
100
150
200ControlLeuIleVal
% c
on
tro
l
Skeletal muscle Liver
a
b
a a DNA mRNA
eIF2eIF4S6K1eIF4F
S6K1
BCAA
Leu
S6
eIF2
Met
mTOR
PKB
4E-BP1P
S6K1P
S6
Met
PS6
Met
P
?
eIF4F
5’-UTRmRNA
LL--LeuLeuD-Leu
-KICPDK1
PI3K
B,H, L
-
Leu
?
![Page 3: B BcB B B B|B B. ÷B BN!¢Õ. %µ Ï(» · BkB¦BnB·BtB]B¤B B®BpB_BjB¦ BkB¦BnB·Bt B]B¤B B® B B¦B B®2D BkB¦BnB·Bt ( )3 6ý p%m- BkB¦BnB·Bt: :Ã:¸ BM1 BB B]B¤B B® B](https://reader043.vdocuments.pub/reader043/viewer/2022040201/5e56dacb8bea1f586a6980bb/html5/page/3.jpg)
Whey peptide
> 10,000 0.010,000 - 5,000 0.35,000 - 3,000 0.63,000 - 1,000 13.21,000 - 500 26.6500 - 300 21.8
< 300 37.6
4240
50
100
150
200
250300
350
400
450
500
45 50 55 60 65 70 75 80Time(min)
A(2
10)
BCAABCAAs
Wistar 5 wk. old ~130g
HW-3
vs.BCAA mix
HW-3 BCAAs
LL
LL
L
LL
L
L
L
HW 3 > BCAAs HW 3 > BCAAs
![Page 4: B BcB B B B|B B. ÷B BN!¢Õ. %µ Ï(» · BkB¦BnB·BtB]B¤B B®BpB_BjB¦ BkB¦BnB·Bt B]B¤B B® B B¦B B®2D BkB¦BnB·Bt ( )3 6ý p%m- BkB¦BnB·Bt: :Ã:¸ BM1 BB B]B¤B B® B](https://reader043.vdocuments.pub/reader043/viewer/2022040201/5e56dacb8bea1f586a6980bb/html5/page/4.jpg)
HW 3BCAAs
AAmix
Wistar 5 wk. old ~130g Oral administration
HW-3
vs.Amino Acids mix
HW-3 AAmix
L
L
HW 3 > AAmix HW 3 > AAmix
Casein = WPC > HW 3HbA1c: Casein = WPC > HW 31,5 AG: Casein = WPC = HW 3