bioengineering with (only) dna
DESCRIPTION
Bioengineering with (only) DNA. Dave Zhang 2nd Annual Unither Nanomedical and Telemedical Technology Conference 26 Feb 2009. DNA vs. genetic engineering. Genetic engineering. DNA engineering. A. Z. Ansari, Nature Chemical Biology , 2007. Nanoengineer, by Nanorex - PowerPoint PPT PresentationTRANSCRIPT
Bioengineering with (only) DNA
Dave Zhang
2nd Annual Unither Nanomedical and Telemedical Technology Conference
26 Feb 2009
DNA vs. genetic engineering
Genetic engineering DNA engineering
A. Z. Ansari, Nature Chemical Biology,
2007Nanoengineer, by Nanorex
http://nanoengineer-1.com/content/index.php?option=com_content&task=view&id=37&Itemid=47
DNA abstraction
Michael Ströck,
http://en.wikipedia.org/wiki/File:DNA_Overview.png
Structures
CiliaCell wall Actin and myosin
C. Daghlian,http://refm.dartmouth.edu/images/mammalianLungSEM/source/9.html
Lacey Samuels,
https://www.biomedia.cellbiology.ubc.ca/cellbiol/user/scripts/qry_media_id.php?media_id=212
http://online-media.uni-marburg.de/histologie/introhis/HIS/txt/muscsem/musc01_sem.htm
E. Winfree, F. Liu, L.A. Wenzler, N.C. Seeman, Nature 1998Y. He, T. Ye, M. Su, C. Zhang, A.E. Ribbe,
W. Jiang, C. Mao, Nature 2008P. Rothemund, Nature 2006
Two-dimensional latticeThree-dimensional shapes
Aperiodic structures
2 um x 8 um500,000 tiles!
Structures
Logic and actuators
Amoeba
Micrographia,http://www.micrographia.com/specbiol/protis/homamoeb/amoe0100/amoeba21.htm
Algae
Yum! Granite
Boolean Logic
Logical processing
D. Y. Zhang, in preparation
Input 1 Input 2
Logical AND gate substrate
Output
Logical processing
D. Y. Zhang, in preparation
Logical processing
Logical processing
NAND gate is universal!
D. Y. Zhang, in preparation
Actuators and motors
B. Yurke, A.J. Turberfield, A.P. Mills, F. C. Simmel, J.L.
Neumann, Nature 2000
Amplification and reproduction
http://www.bunny-rabbits.com/http://www.kindplanet.org/thesanctuary.html
Jeff Hardin,http://worms.zoology.wisc.edu/dd2/echino/cleavage/intro.html
Amplification and reproduction
Spontaneous generationNot really alive:more like crystallization in a supersaturated solution
Cons:
Pro:If we know what we’re looking for, we can amplify its concentration dynamically.
Amplification and reproduction
D. Y. Zhang, A.J. Turberfield, B. Yurke, E. Winfree, Science
2007
Amplification and reproduction
Interaction with general chemistry
Adapted from David Liu’s website:http://evolve.harvard.edu/rschdts.htm#DTS
Z. J. Gartner, B. N. Tse, R. Grubina, J.B. Doyon, T.M. Snyder, D.R. Liu, Science 2004
Small organic group
Boom!Boom!
DNA engineering as a nanomedical tool
•Instrument-free disease detection
•Embedded control of apoptosis
•Control of developmental biology
Parting Thought
http://www.kurzweilai.net/articles/images/Carlson(PaceAndProliferation)figure1.gif
Thanks for listening!
(and thanks to the following for their money:)