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GGGNNNIIIPPPSSSTTT BBBUUULLLLLLEEETTTIIINNN 22200011144415th August, 2014 Volume No.: 36 Issue No.: 03

Vision

TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE FIELDOF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE BASED

LEARNING AND PRACTICE

Contents • Message from PRINCIPAL• Editorial board• Historical article• News Update• Knowledge based Article• Disease Related Breaking

News• Upcoming Events• Drugs Update• Campus News• Student’s Section• Editor’s Note• Archive

GNIPST Photo Gallery For your comments/contribution OR For Back-Issues, mailto:[email protected]

GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY

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MESSAGE FROM PRINCIPAL

"It can happen. It does happen. But it can't happen if you quit." Lauren Dane.

‘We are what we repeatedly do. Excellence then is not an act, but a habit.’ Aristotle

It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank the last year’s editors and congratulate the newly selected editors for the current year.

Our first consideration is always in the best interest of the students. Our goal is to promote academic excellence and continuous improvement.

I believe that excellence in education is aided by creating a learning environment in which all learners are supported in maximizing their potential and talents. Education needs to focus on personalized learning and instruction, while promoting an education system that is impartial, universally accessible, and meeting the needs of all students.

It is of paramount importance that our learners have sufficient motivation and encouragement in order to achieve their aims. We are all very proud of you, our students, and your accomplishments and look forward to watching as you put your mark on the profession in the years ahead.

The call of the time is to progress, not merely to move ahead. Our progressive Management is looking forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken in this direction and fruits of these efforts will be received by our students in the near future. Our Teachers are committed and dedicated for the development of the institution by imparting their knowledge and play the role of facilitator as well as role model to our students.

The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positive challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holistic needs of our students.

I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of the opportunities and meet the challenges with purpose and determination.

Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us on this path.

My best wishes to all.

Dr. A. Sengupta

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EDITORIAL BOARD

CHIEF EDITOR DR. ABHIJIT SENGUPTA EDITOR MS. JEENATARA BEGUM ASSOCIATE EDITOR MR. DIPANJAN MANDAL

HISTORICAL ARTICLE The Royal Toxicologist – Mithridates VI Mithridates VI, King of Pontus (about 100 B.C.), though he battled Rome for a lifetime, found time to make not only the art of poisoning, but also the art of preventing and counteracting poisoning, subjects of intensive study. Unhesitatingly, he used himself as well as his prisoners as "guinea pigs" on which to test poisons and antidotes. Behind him are rhizotomists, offering fresh, flowering aconite, ginger, and gentian. At lower right is a crater - a two-piece forerunner of the champagne bucket. His famed formula of alleged panantidotal powers, "Mithridatum," was popular for over a thousand years.

NEWS UPDATE Brain imaging shows brain differences in risk-

taking teens: (15th August, 2014) Brain differences associated with risk-taking teens have been investigated by researchers who found that connections between certain brain regions are amplified in teens more prone to risk. "Our brains have an emotional-regulation network that exists to govern emotions and influence decision-making," explained the study's lead author. "Antisocial or risk-seeking behavior may be associated with an imbalance in this network."


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Guidelines can predict early menopause in child cancer survivors, giving hope for fertility: (15th August, 2014) Girls with cancer who are most likely to become infertile after treatment can be identified using guidelines developed almost 20 years ago, new research shows. The criteria will help to select which girls should be offered the opportunity to freeze some tissue from their ovaries for use in the future.

New ways to treat solid tumors using protein: (15th August, 2014) An antibody against the protein EphA3, found in the micro-environment of solid cancers, has anti-tumor effects, an international team of scientists has shown. As EphA3 is present in normal organs only during embryonic development but is expressed in blood cancers and in solid tumors, this antibody-based approach may be a suitable candidate treatment for solid tumors.

Previous pulmonary disease linked to increased lung cancer risk in large study: (15th August, 2014) Links between a number of common respiratory diseases and an increased risk of developing lung cancer have been found in a large pooled analysis of seven studies involving more than 25,000 individuals. "The variations in the associations between lung cancer and different patterns of previous respiratory diseases that we observed in our study may indicate differences in the underlying etiological mechanisms," said the lead author. "Better understanding of these associations may help guide the type and


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frequency of clinical surveillance needed for patients with each of these diseases."

Low vitamin D levels linked to increased risks after noncardiac surgery: (15th August, 2014) Patients with low blood levels of vitamin D are at increased risk of death and serious complications after noncardiac surgery, suggests a study. The researchers analyzed the relationship between vitamin D level and surgical outcomes in approximately 3,500 patients who underwent operations other than heart surgery between 2005 and 2011. Only patients who had available data on vitamin D levels around the time of surgery -- from three months before to one month afterward -- were included in the study.

Single enzyme necessary for development of diabetes: (14th August, 2014) An enzyme called 12-LO promotes the obesity-induced oxidative stress in the pancreatic cells that leads to pre-diabetes, and diabetes. 12-LO's enzymatic action is the last step in the production of certain small molecules that harm the cell, according to researchers. The findings will enable the development of drugs that can interfere with this enzyme, preventing or even reversing diabetes.

Adults with autism at higher risk of sexual victimization, study shows: (14th August, 2014) Adults with autism are at a higher risk of sexual victimization than adults without, due to lack of sex education, but with improved interventions that focus on sexual knowledge and skill building, the risk could be reduced, according to a study. 'Adults with Autism Spectrum Disorder gain more of their sexual knowledge


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from external sources such as the internet and the television whereas social sources would include parents, teachers and peers,' says one author.

Cystic fibrosis mucus defect present at birth: (14th August, 2014) Mucus is key to keeping our lungs clean and clear of bacteria, viruses, and other foreign particles that can cause infection and inflammation. When we inhale microbes and dust, they are trapped in the mucus and then swept up and out of the lungs via a process called mucociliary transport. New research shows that cystic fibrosis causes a specific defect in this process, reducing the ability to clear particles and germs out of the airway. For detail mail to editor

KNOWLEDGE BASED ARTICLE

Rheumatoid Arthritis

RA is a chronic (long-term) disease that causes pain, stiffness, swelling and limited motion and function of many joints. While RA can affect any joint, the small joints in the hands and feet tend to be involved most often. Inflammation sometimes can affect organs as well, for instance, the eyes or lungs. The stiffness seen in active RA is most often worst in the morning. It may last one to two hours (or even the whole day). Stiffness for a long time in the morning is a clue that you may have RA, since few other arthritic diseases behave this way. For instance, osteoarthritis most often does not cause prolonged morning stiffness.

Other signs and symptoms that can occur in RA include:


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Loss of energy

Low fevers

Loss of appetite

Dry eyes and mouth from a related health problem, Sjogren's syndrome

Firm lumps, called rheumatoid nodules, which grow beneath the skin in places such as the elbow and hands Cause:

RA is an autoimmune disease. This means that certain cells of the immune system do not work properly and start attacking healthy tissues —the joints in RA. The cause of RA is not known. Yet, new research is giving us a better idea of what makes the immune system attack the body and create inflammation. In RA, the focus of the inflammation is in the synovium, the tissue that lines the joint.

RA is the most common form of autoimmune arthritis, affecting more than 1.3 million Americans. Of these, about 75% are women. In fact, 1–3% of women may get rheumatoid arthritis in their lifetime. The disease most often begins between the fourth and sixth decades of life. However, RA can start at any age.

Diagnosis:

RA can be hard to detect because it may begin with subtle symptoms, such as achy joints or a little stiffness in the morning. Also, many diseases behave like RA early on. For this reason, if you


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or your primary care physician thinks you have RA, you should see a rheumatologist. A rheumatologist is a

physician with the skill and knowledge to reach a correct diagnosis of RA and to make the most suitable treatment plan. Diagnosis of RA depends on the symptoms and results of a physical exam, such as warmth, swelling and pain in the joints. Some blood tests also can help confirm RA. Telltale signs include:

Anemia (a low red blood cell count)

Rheumatoid factor (an antibody, or blood protein, found in about 80% of patients with RA in time, but in as few as 30% at the start of arthritis)

Antibodies to cyclic citrullinated peptides (pieces of proteins), or anti-CCP for short (found in 60–70% of patients with RA)

Elevated erythrocyte sedimentation rate (a blood test that, in most patients with RA, confirms the amount of inflammation in the joints) Treatment:

Therapy for RA has improved greatly in the past 30 years. Current treatments give most patients good or excellent relief of symptoms and let them keep functioning at, or near, normal levels. With the right medications, many patients can achieve “remission” — that is, have no signs of active disease. There is no cure for RA. The goal of treatment is to lessen your symptoms and poor function. Doctors do this by starting proper medical therapy as soon as possible, before your joints have lasting damage. No single treatment works for all patients. Many people with RA must change their treatment at least once during their lifetime. Good


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control of RA requires early diagnosis and, at times, aggressive treatment. Thus, patients with a diagnosis of RA should begin their treatment with disease-modifying antirheumatic drugs — referred to as DMARDs. These drugs not only relieve symptoms but also slow progression of the disease. Often, doctors prescribe DMARDs along with nonsteroidal anti-inflammatory drugs or NSAIDs and/or low-dose corticosteroids, to lower swelling, pain and fever. DMARDs have greatly improved the symptoms, function and quality of life for nearly all patients with RA. Ask your rheumatologist about the need for DMARD therapy and the risks and benefits of these drugs. Common DMARDs include methotrexate (brand names include Rheumatrex® and Folex®), leflunomide (Arava), hydroxychloroquine (Plaquenil) and sulfasalazine (Azulfidine). Older DMARDs include gold, given as a pill — auranofin (Ridaura) — or more often as an injection into a muscle (such as Myochrysine). The antibiotic minocycline (e.g., Minocin, Dynacin and Vectrin) also is a DMARD, as are the immune suppressants azathioprine (Imuran) and cyclosporine (Sandimmune and Neoral). These three drugs and gold are rarely prescribed for RA these days because other drugs work better or have fewer side effects.

DISEASE RELATED BREAKING NEWS Ebola virus disease, West Africa (15th August,

2014)

Between 12 and 13 August 2014, a total of 152 new cases of Ebola virus disease (laboratory-confirmed, probable, and suspect cases) as well as 76 deaths were reported from Guinea, Liberia, Nigeria and Sierra Leone. Read more


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http://www.who.int/csr/don/2014_08_15_ebola/en/

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UPCOMING EVENTS 5th International Conference on Stem Cells and Cancer 2014, JNU Convention Centre, New Delhi, India from 8-10 November, 2014

DRUGS UPDATES FDA Approves Belsomra: (13th August, 2014) Belsomra is an orexin receptor antagonist and is the first approved drug of this type. Orexins are chemicals that are involved in regulating the sleep-wake cycle and play a role in keeping people awake. Belsomra alters the signaling (action) of orexin in the brain.. Read more

CAMPUS NEWS The Fresher’s welcome programme was held on 14th August, 2014. I

welcome the 1st year students. We congratulate the following M.Pharm. final year students who

have made their positions in different pharmaceutical companies. Anirban Banerjee (Emami Ltd.) Mahender Roy (Stadmed private Ltd.)

We congratulate the following B.Pharm. final year students for their success. Samadrita Mukherjee (Abbott India Ltd.) Suman Sarkar (Tata Medical Centre-Apollo Pharmacy) Shrewashee Mukherjee (Fresenius Kabi-Parenteral Nutrition) Avishek Naskar (Glaxo SmithKline-Marketing) Bappaditya Manik (USV Limited) Sarbani Das (Nutri Synapzz-Marketing) Ankita Roy (Nutri Synapzz-Marketing) Rahul Mitra (B M Pharmaceuticals-Production)

The following B.Pharm. final year students have qualified, GPAT-2014. We congratulate them all. Utsha Sinha


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http://www.drugs.com/newdrugs/fda-approves-belsomra-suvorexant-insomnia-4069.html

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Satarupa Bhattacharya Sandipan Sarkar Purbali Chakraborty

Reminiscence, 2014(GNIPST Reunion) was held in College campus on 2nd February,2014.

1st Annual Sports of GNIPST was held on 3rd February,2014 in College campus ground.

An industrial tour and biodiversity tour was conducted in Sikkim for B.Pharm and B.Sc. students under the supervision of Mr. Asis Bala, Ms. Jeentara Begum and Ms. Moumita Chowdhury.

B.Pharm 3rd year won the GNIPST Football Champions trophy, 2013. B.Pharm 3rd year won the final match 1-0 against B.Pharm 2nd year. Deep Chakraborty was the only scorer of the final.

STUDENTS’ SECTION WHO CAN ANSWER FIRST????

Which medal was first awarded to L. Ahlfors and J Doglous in 1936?

Ingrid Newkirk founded which organization?

Answer of Previous Issue’s Questions: A) Linkedln

B) Vitamin A (retinol)


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Identify the person

Answer of Previous Issue’s Image: Albert einstein

Send your thoughts/ Quiz/Puzzles/games/write-ups or any other contributions for Students’ Section& answers of this Section at [email protected]

EDITOR’S NOTE

It is a great pleasure for me to publish the 3rd issue of 36th Volume of GNIPST BULLETIN. All the followers of GNIPST BULLETIN are able to avail the bulletin through facebook account ‘GNIPST bulletin’ I am very much thankful to all the GNIPST members and readers who are giving their valuable comments, encouragements and supports. I am also thankful to Dr. Abhijit Sengupta, Director of GNIPST for his valuable advice and encouragement. Special thanks to Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidar and Mr. Soumya Bhattacharya for their kind co-operation and technical supports. Thank you Mr. Soumya Bhattacharya for the questionnaires of the student section. An important part of the improvement of the bulletin is the contribution of the readers. You are invited to send in your write ups, notes, critiques or any kind of contribution for the forthcoming special and regular issue.


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ARCHIVE

Students of GNIPST organized pre puja celebration programme, ‘Saaranya’ on 7th October, 2013 in college Auditorium.

GNIPST organized a garment distribution programme on 28th September, 2013 at Dakshineswar Kali Temple and Adyapith, Kolkata. On this remarkable event about hundred people have received garments. More than hundred students and most of the faculties participated on that day with lot of enthusiasm.

GNIPST celebrated World Heart Day (29th September) and Pharmacist’s Day (25th September) on 25th and 26th September, 2013 in GNIPST Auditorium. A seminar on ‘Violence against woman’ and ‘female foeticide’ was held on GNIPST Auditorium on 25th September organized by JABALA Action Research Organization. On 26th September an intra-college Oral and Poster presentation competition related to World Pharmacist’s day and Heart day was held in GNIPST. Ms. Purbali Chakraborty of B.Pharm 4th year won the first prize in Oral Presentation. The winner of Poster presentation was the group of Ms. Utsa Sinha, Mr. Koushik Saha and Mr. Niladri Banerjee (B.Pharm 4th year). A good number of students have participated in both the competition with their valuable views.

Teacher’s day was celebrated on 5th September, 2013 by the students of GNIPST in GNIPST Auditorium.


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Azalea (exotic flower ) , the fresher welcome programme for newcomers of GNIPST in the session 2013-14 was held on 8th August in GNIPST Auditorium.

One day seminar cum teachers’ development programme for school teachers on the theme of “Recent Trends of Life Sciences in Higher Education” organized by GNIPST held on 29th June, 2013 at GNIPST auditorium. The programme was inaugurated by Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy Director of JIS Group and Dr. Abhijit Sengupta, Director cum Principal of GNIPST with lamp lighting. The programme started with an opening song performed by the B.Pharm students of this institute. The seminar consists of a series of lectures, video presentations and poster session. On the pre lunch session 4 lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty respectively. On their presentation the speakers enlighten the recent development of Pharmacy, Genetics and Microbiology and their correlation with Life Sciences. On the post lunch session, Ms. Saini Setua and Ms. Sanchari Bhattacharjee explained the recent development and career opportunities in Biotechnology and Hospital Management. The programme was concluded with valedictory session and certificate distribution. About 50 Higher secondary school teachers from different schools of Kolkata and North& South 24 Parganas district of West Bengal participated in this programme. A good interactive session between participants and speakers was observed in the seminar. The seminar was a great success with the effort of faculties, staffs and students of our Institute. It was a unique discussion platform for school teachers and


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professional of the emerging and newer branches of Life Science.

The general body meeting of APTI, Bengal Branch has been conducted at GNIPST on 15th June, 2012. The program started with a nice presentation by Dr. Pulok Kr. Mukherjee, School of Natural Products, JU on the skill to write a good manuscript for publication in impact journals. It was followed by nearly two hour long discussion among more than thirty participants on different aspects of pharmacy education. Five nonmember participants applied for membership on that very day.

GNIPST is now approved by AICTE and affiliated to WBUT for conducting the two years’ post graduate course (M.Pharm) in PHARMACOLOGY. The approved number of seat is 18.

The number of seats in B.Pharm. has been increased from 60 to 120.

AICTE has sanctioned a release of grant under Research Promotion Scheme (RPS) during the financial year 2012-13to GNIPST as per the details below: a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical Science & Technology. b. Principal Investigator: Dr. LopamudraDutta.

c. Grant-in-aid sanctioned:Rs. 16,25000/- only d. Approved duration: 3 years

e. Title of the project: Screening and identification of potential medicinal plant of Purulia & Bankura districts of West Bengal with respect to diseases such as diabetes, rheumatism, Jaundice, hypertension and developing


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biotechnological tools for enhancing bioactive molecules in these plants.


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