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何山个人简历

Shan He — Curriculum Vitae

工作单位：宁波大学食品与药学学院

Affiliation: College of Food and Pharmaceutical Sciences at Ningbo University

职称/学位：教授/博士

Position/Degree: Professor/PhD

学科方向：海洋药物学

Discipline: Marine Pharmaceutical Science

邮箱 Email：heshan@nbu.edu.cn

教育与工作经历 Education and Professional Experience：

2000.09—2004.06 浙江大学 化学系 理学学士

Zhejiang University, Bachelor in Chemistry

2004.09—2009.06 浙江大学 化学系 理学博士（保送，硕博连读）

Zhejiang University, PhD in Chemistry

2009.07—2011.05 美国华盛顿州立大学生物化学研究所 博士后

Washington State University, Institute of Biological

Chemistry, PostDoc

2014.12—2015.06 美国东北大学生物系 访问学者（国家留学基金资助）

Northeastern University, Department of Biology, Visiting

Scholar (China Scholarship Council)

2011.06—2018.06 宁波大学 海洋学院 海洋药学系 副教授

Ningbo University, College of Marine Sciences,

Department of Marine Pharmacy, Associate Professor

2013.01—2018.06 宁波大学 海洋学院 海洋药学系 系主任

Ningbo University, College of Marine Sciences,

Department of Marine Pharmacy, Chair

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2016.12—Present 宁波大学李达三叶耀珍伉俪李本俊

海洋生物医药研究中心 常务副主任

Ningbo University, Li Dak Sum Marine

Biopharmaceutical Research Center, Executive Director

2018.06—Present 宁波大学 食品与药学学院 教授

Ningbo University, College of Food and Pharmaceutical

Sciences, Full Professor

研究方向 Research Interest：

1. 海洋“未培养”微生物资源挖掘与新天然产物发现

Marine Uncultured Microorganisms Resource Mining and New Natural

Products Discovery

2. 海洋中光层海洋生物资源挖掘与科学潜水

Marine Twilight Zone Bioresource Mining and Scientific Diving

3. 海洋微藻毒素的发现、制备与快速检测方法研究

Marine microalgal toxins: Discovery, purification and detection

4. 海洋天然产物高效制备新方法研究

New Method for Efficient Purification of Marine Natural Products

5. 海洋药物研发

Marine New Drugs Development

主持科研项目 Research Grants：

1. 国家自然科学基金(NSFC)面上项目，基于 iChip 技术的海洋“未培养”微生

物资源挖掘及新天然产物发现（41776168），2018.01-2021.12，77.2 万元

2. 国家自然科学基金(NSFC)青年项目，海洋 Uncultured 放线菌资源挖掘及

新天然产物发现（41306134），2014.01-2016.12，24 万元

3. 国家外专局/教育部 111 计划，海洋生物医药创新引智基地（D16013），

2016.08-2021.08，200 万元

4. 国家科技部(MOST)重点研发计划项目子课题，深海多孔动物门药物先导化

合物的高效筛选与发现（2018YFC0310902），2018.08-2021.12，30 万元

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5. 国家科技部(MOST)星火计划，褐藻多酚作为大黄鱼饲料添加剂的应用与推

广（2013GA701024），2013.01-2014.12，80 万元

6. 教育部(MOE)博士点基金，卡罗藻毒素高效制备及其在养殖水域中的快速

检测新方法研究（20133305120007），2014.01-2016.12，4 万元

7. 浙江省自然科学基金(Zhejiang NSF)，基于高速逆流色谱的卡罗藻毒素高效

制备及新天然产物发现（LQ13B020004），2013.01-2015.12，5 万元

8. 浙江省科技厅(Science Technology Department of Zhejiang Province)钱江

人才计划，通过氧化胁迫葡萄科植物产生新型抗脑卒中先导化合物的研究

（2012R10068），2012.08-2013.12，10 万元

9. 浙江省科技厅(Science Technology Department of Zhejiang Province)重点

科技创新团队子课题，海洋蓝细菌中新型抗肿瘤药物的开发（2012R10029-

2），2011.04-2014.06，15 万元

10. 宁波市科技局(Science Technology Department of Ningbo City)富民项目，

海洋抗 菌微 生物 产 业化研 究及 其在 大 黄鱼养 殖中 的应 用 示范

（2017C10016），2017.01-2019.12，40 万元

11. 宁波市自然科学基金(Ningbo NSF)，白藜芦醇低聚体生物合成诱导及聚合

度与神经保护的构效研究（2013A610278），2013.02-2015.01，3 万元

12. 宁波市海洋局(Marine Department of Ningbo City)海洋经济创新发展示范

项目，宁波海洋生物高值利用公共服务平台-宁波海洋微生物资源开发利用

子平台（NBHY-2017-P2），2018.03-2020.12，400 万元

13. 宁波市科技局(Science Technology Department of Ningbo City)，宁波市海

洋生物产业调研，2016.11-2017.06，10 万元

荣誉奖项 Awards：

1. 宁波市科技进步奖二等奖，2018 年（第一完成人）

Science and Technology Advance Award of Ningbo City Government,

Second Prize, 2018

2. 宁波大学阳光教授奖，2017年

Excellent “Sunshine” Professor Award by Ningbo University, 2017

3. 宁波市自然科学优秀论文奖三等奖，2015年

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Outstanding Paper Award in Natural Sciences by Ningbo City Government,

2015

4. 宁波市优秀博士后荣誉称号，2013 年

Outstanding PostDoc Award by Ningbo City Government, 2013

人才工程 Talent Programs：

1. 浙江高校中青年学科带头人，2017 年

Leading Young Investigator in Higher Education, Zhejiang Province, 2017

2. 宁波市领军拔尖人才，2015年

Leading and Outstanding Talent, Ningbo City, 2015

3. 宁波大学浙东青年学者，2015年

Zhedong Young Scholar Fellowship, Ningbo University, 2015

4. 浙江省钱江人才计划，2012年

Qianjiang Talent, Zhejiang Province, 2012

学术兼职 Academic Service and Committees：

1. 浙江省药学会海洋药物专业委员会委员，2015-至今

Zhejiang Pharmaceutical Association, Marine Drugs Committee, 2015-

Present

2. 中国药学会海洋药物专业委员会青年委员，2016-至今

Chinese Pharmaceutical Association, Marine Drugs Young Investigator

Committee, 2016-Present

3. 浙江省药学会生物制药专业委员会委员，2017-至今

Zhejiang Pharmaceutical Association, Biopharmaceutics Committee, 2017-

Present

4. 国家自然科学基金地学部海洋生物领域通讯评审专家，2017-至今

Reviewer of NSFC Marine Biology Section, 2017-Present

5. 宁波市“科技创新 2025”重大专项生物医药领域专家组，2019-至今

Experts Committee of Ningbo Sci&Tech Innovation 2025 Key Projects in

Biomedicine, 2019-Present

6. 中国药学会海洋药物专业委员会委员，2019-至今

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Chinese Pharmaceutical Association, Marine Drugs Committee, 2019-

Present

邀请报告 Invited Presentations：

1. “Marine Twilight Zone: A New Frontier for Bioprospecting”. Presented Oct

31, 2019 at 5th Sino-Italian Symposium on Bioactive Natural Products and

7th Yangtze River Delta International Symposium on Marine Drugs;

Hangzhou, China.

2. “海洋中光层生物资源挖掘”. 2019 年 9 月 4 日，海洋领域面向 2035 年中长

期科技规划战略研究 “未来海洋-青年研讨会”，北京

3. “Marine New Microbial Resource Mining and Natural Products Discovery”.

2019 年 4 月 26 日，中国科学院南海海洋研究所，广州

4. “Bioresource Mining of the Ocean Twilight Zone”. 2019 年 3 月 4 日，中国

科学院深圳先进技术研究院，深圳

5. “The Ocean Twilight Zone: Resource mining and Biomedical Potential”.

Presented Feb 8, 2019 at National Institute of Molecular Biology and

Biotechnology, University of Philippines, Diliman; Manila, Philippines.

6. “International Innovation in Marine Biomedicine”. Plenary Speaker.

Presented Oct 22, 2018 at 9th Annual and 2nd International Convention of

Philippine Society for Cell Biology; Manila, Philippines.

7. “新萃取技术在海洋天然产物高效分离中的应用”. 2018 年 11 月 7 日，第十

三届海洋药物学术年会暨 2017 国际海洋药物研讨会，山东青岛

8. “Application of New Extraction Technique in Efficient Separation of Marine

Natural Products”. Presented Oct 21, 2017 at Asian Federation for

Pharmaceutical Sciences Conference; Xiamen, China.

9. "From Terrestrial to Marine: Tracing the Ecologically Important Natural

Products for Drug Discovery". Presented June 22, 2017 at American

Council for Medicinally Active Plants 8th annual meeting; Clemson, SC,

USA.

10. “海洋天然产物高效制备新方法研究”. 2016 年 12 月 1 日，第四届长三角海

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洋生物医药产学研科技论坛暨第二届浙江省海洋药物学术会议，浙江舟山

11. “海洋天然产物高效制备新方法研究”. 2015 年 10 月 27 日，第十二届全国海

洋药物学术年会，浙江舟山

科学潜水资质 Scientific Diving Qualification

中国首位完成百米下潜的科学潜水员 (2019 年 7 月 26 日)

First Chinese Scientist Diving the Depth of 100m (July 26th, 2019)

科学潜水员 Scientific Diver (CMAS)

氮醉管理技术潜水员七级 Narcosis Management Level 7 (PSAI)

延伸深度技术潜水员 Extended Range Tech Diver (PSAI)

进阶高氧空气技术潜水员 Advance Nitrox Tech Diver (PSAI)

进阶开放水域潜水员 Advance Open Water Diver (PADI)

论文列表 Publications：

1. Weiyan Zhang, Can Chen, Ye Yuan, Dengquan Su, Lijian Ding, Slava S Epstein*, Shan

He*. Pararhodobacter marinus sp. nov., a bacterium isolated from marine sediment in

the East China Sea and emended description of the genus Pararhodobacter.

International Journal of Systematic and Evolutionary Microbiology 2018, 69, 3293–

3298.

2. Jianzhou Xu, Mengqi Yi, Lijian Ding*, Shan He*. A Review of Anti-Inflammatory

Compounds from Marine Fungi, 2000–2018. Marine Drugs 2019, 17, 636.

3. Ning Wang, Panpan Qiu, Wei Cui, Xiaojun Yan, Bin Zhang*, Shan He*. Recent

Advances in Multi-target Anti-Alzheimer Disease Compounds (2013 Up to the Present).

Current Medicinal Chemistry 2019, 26, accepted.

4. Te Li, Ning Wang, Ting Zhang, Bin Zhang*, Thavarool P. Sajeevan, Valsamma Joseph,

Lorene Armstrong, Shan He, Xiaojun Yan, C. Benjamin Naman*. A Systematic Review

of Recently Reported Marine Derived Natural Product Kinase Inhibitors. Marine Drugs

2019, 17, 493.

5. Lijian Ding, Lu Ren, Shuang Li, Jingjing Song, Zhiwen Han, Shan He*, Shihai Xu*.

Production of New Antibiotic 4-Hydroxy-α-Pyrones by a Marine Fungus Aspergillus

niger Cultivated in Solid Medium. Marine Drugs 2019, 17, 344.

6. Shao-Qiang Fan, Chun-Lan Xie, Jin-Mei Xia, Cui-Ping Xing, Zhu-Hua Luo, Zongze

Shao, Xiao-Jun Yan, Shan He, Xian-Wen Yang*. Sarocladione, a unique 5,10:8,9-

diseco-steroid from the deep-sea-derived fungus Sarocladium kiliense. Organic &

Biomolecular Chemistry 2019, 17, 5925-5928.

7. Xiaoping He, Lu Ren, Lijian Ding*, Jianzhou Xu, Bin Zhang, Weiyan Zhang, Shan He*.

Penichrypyrone A, a New γ-Pyrone Derivative from the Sponge-derived Fungus

Penicillium chrysogenum LS18. Natural Product Communications 2019, accepted.

8. Xiaoping He, Lijian Ding*, Mengqi Yi, Jianzhou Xu, Xuezhen Zhou, Weiyang Zhang,

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Shan He*. Separation of five diketopiperazines from the marine fungus Alternaria

alternate HK-25 by high-speed counter-current chromatography. Journal of Separation

Science 2019, 42, 2510–2516.

9. Liming Huang, Lijian Ding*, Xiaohui Li, Ning Wang, Yushan Yan, Mengxiang Yang, Wei

Cui, C. Benjamin Naman, Kejun Cheng, Weiyan Zhang, Bin Zhang, Haixiao Jin, Shan

He*. A new lateral root growth inhibitor from the sponge-derived fungus Aspergillus sp.

LS45. Bioorganic & Medicinal Chemistry Letters 2019, 29, 1593–1596.

10. Jiaxiao Yao, Yuanmei Shi, Yong Liu, Shan He, Lijian Ding*, Fan Yang. Highly Oxidized

Ergosterol Derivatives from the Fungus Nigrospora oryzae, Chemistry of Natural

Compounds 2019, 55, 390-392.

11. Wei Li, Lijian Ding*, Ning Wang, Jianzhou Xu, Weiyan Zhang, Bin Zhang, Shan He,

Bin Wu, Haixiao Jin*. Isolation and Characterization of Two New Metabolites from the

Sponge-Derived Fungus Aspergillus sp. LS34 by OSMAC Approach. Marine Drugs

2019, 17, 283.

12. Weiyan Zhang, Xuezhen Zhou, Ye Yuan, Biyin Liu, Slava S. Epstein*, Shan He*.

Complete Genome Sequence of Saccharospirillum mangrovi HK-33T Sheds Light on

the Ecological Role of a Bacterium in Mangrove Sediment Environment. Current

Microbiology 2019, 76, 231–236.

13. Lijian Ding*, Peng Xu, Te Li, Xiaojian Liao, Shan He*, Shihai Xu*. Asperfurandiones A

and B, two antifungal furandione analogs from a marine-derived fungus Aspergillus

versicolor. Natural Product Research 2019, 33, 3404-3408.

14. Qingmei Sun, Fufeng Liu, Jingcheng Sang, Miaoman Lin, Jiale Ma, Xiao Xiao, Sicheng

Yan, C. Benjamin Naman, Ning Wang, Shan He, Xiaojun Yan, Wei Cui*, Hongze Liang*.

9-Methylfascaplysin Is a More Potent Aβ Aggregation Inhibitor than the Marine-Derived

Alkaloid, Fascaplysin, and Produces Nanomolar Neuroprotective Effects in SH-SY5Y

Cells. Marine Drugs 2019, 17, 121.

15. Yong Liu, Lijian Ding*, Fang Fang, Shan He*. Penicillilactone A, a novel antibacterial

7-membered lactone derivative from the sponge-associated fungus Penicillium sp.

LS54. Natural Product Research 2019, 33, 2466-2470.

16. Xuezhen Zhou, Mengqi Yi, Lijian Ding*, Shan He, Xiaojun Yan*. Isolation and

Purification of a Neuroprotective Phlorotannin from the Marine Algae Ecklonia maxima

by Size Exclusion and High-Speed Counter-Current Chromatography. Marine Drugs

2019, 17, 212.

17. Jing Xuan Zhu, Lijian Ding*, Shan He*. Discovery of a new biphenyl derivative by

epigenetic manipulation of marine-derived fungus Aspergillus versicolor. Natural

Product Research 2019, 33, 1191-1195.

18. Dengquan Su, Lijian Ding*, Shan He*. Marine-derived Trichoderma Species as a

Promising Source of Bioactive Secondary Metabolites. Mini-Reviews in Medicinal

Chemistry 2018, 18, 1702-1713.

19. Lijian Ding*, Te Li, Xiaojian Liao, Shan He*, Shihai Xu*. Asperitaconic acids A–C,

antibacterial itaconic acid derivatives produced by a marine-derived fungus of the

genus Aspergillus. The Journal of Antibiotics 2018, 71, 902-904.

20. Panpan Qiu, Lijian Ding,* Dengquan Su, Shan He*. A new cyclopentenone derivative

from the sponge-associated fungus Hypocrea koningii. Chemistry of Natural

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Compounds, 2018, 54, 631-633.

21. Weiyan Zhang, Ye Yuan, Dengquan Su, Lijian Ding, Xiaojun Yan, Min Wu, Slava S.

Epstein*, Shan He*. Saccharospirillum mangrovi sp. nov., a bacterium isolated from

mangrove sediment. International Journal of Systematic and Evolutionary Microbiology

2018, 68, 2813-2818.

22. Wei-Yan Zhang, Ye Yuan,Deng-Quan Su, Xiao-Ping He, Shuai-Bo Han, Slava S.

Epstein*, Shan He*, Min Wu. Gallaecimonas mangrovi sp. nov., a novel bacterium

isolated from mangrove sediment. Antonie van Leeuwenhoek 2018, 111, 1855–1862.

23. Jialing Wang, Jiachen Zheng, Chunhui Huang, Jiaying Zhao, Jiajia Lin, Xuezhen Zhou,

C. Benjamin Naman, Ning Wang, William H. Gerwick, Qinwen Wang, Xiaojun Yan, Wei

Cui*, Shan He*. Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces

Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on

Glycogen Synthase Kinase 3β. ACS Chemical Neuroscience 2018, 9, 1349−1356.

24. Yong Liu, Xuezhen Zhou, C. Benjamin Naman, Yanbin Lu, Lijian Ding*, Shan He*.

Preparative Separation and Purification of Trichothecene Mycotoxins from the Marine

Fungus Fusarium sp. LS68 by High-Speed Countercurrent Chromatography in

Stepwise Elution Mode. Marine Drugs 2018, 16, 73.

25. Kang Wu, Lijian Ding*, Peng Zhu, Shuang Li, Shan He*. Application of the Response

Surface Methodology to Optimize the Fermentation Parameters for Enhanced

Docosahexaenoic Acid (DHA) Production by Thraustochytrium sp. ATCC 26185.

Molecules 2018, 23, 974.

26. Jiaying Zhao, Fufeng Liu, Chunhui Huang, Jieyi Shentu, Minjun Wang, Chenkai Sun,

Liping Chen, Sicheng Yan, Fang Fang, Yuanyuan Wang, Shujun Xu, C. Benjamin

Naman, Qinwen Wang, Shan He* and Wei Cui*. 5-Hydroxycyclopenicillone Inhibits β-

Amyloid Oligomerization and Produces Anti-β-Amyloid Neuroprotective Effects In Vitro.

Molecules 2017, 22, 1651.

27. Jiajia Lin, Jie Yu, Jiaying Zhao, Ke Zhang, Jiachen Zheng, Jialing Wang, Chunhui

Huang, Jingrong Zhang, Xiaojun Yan, William H. Gerwick, Qinwen Wang, Wei Cui*,

Shan He*. Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced

Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y

Cells. Oxidative Medicine and Cellular Longevity 2017, 2017, 6792543.

28. Fang Fang, Jiaying Zhao, Lijian Ding, Chunhui Huang, C. Benjamin Naman, Shan He*,

Bin Wu , Peng Zhu, Qijun Luo, William H. Gerwick, Xiaojun Yan, Qinwen Wang, Zaijun

Zhang, Wei Cui*. 5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor

from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34. Marine Drugs 2017, 15,

260.

29. Bibi N. Auckloo, Chengqian Pan, Najeeb Akhter, Bin Wu*, Xiaodan Wu, Shan He.

Stress-Driven Discovery of Novel Cryptic Antibiotics from a Marine Fungus Penicillium

sp. BB1122. Frontiers in Microbiology, 2017, 8, 1450.

30. Jie Yu, Jiajia Lin, Rui Yu, Shan He, Qinwen Wang, Wei Cui*, Jinrong Zhang*.

Fucoxanthin prevents H2O2-induced neuronal apoptosis via concurrently activating

the PI3-K/Akt cascade and inhibiting the ERK pathway. Food and Nutrition Research

2017, 61, 1304678.

31. Siying Xiang, Fufeng Liu, Jiajia Lin, Huixin Chen, Chunhui Huang, Liping Chen, Yiying

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Zhou, Luying Ye, Ke Zhang, Jiukai Jin, Jiacheng Zhen, Chuang Wang, Shan He,

Qinwen Wang, Wei Cui*, Jinrong Zhang*. Fucoxanthin Inhibits β‑Amyloid Assembly

and Attenuates β‑Amyloid Oligomer-Induced Cognitive Impairments. Journal of

Agricultural and Food Chemistry 2017, 65, 4092−4102.

32. Yue Mi, Jinrong Zhang*, Shan He, Xiaojun Yan. New Peptides Isolated from Marine

Cyanobacteria, an Overview over the Past Decade. Marine Drugs 2017, 15, 132.

33. Mengchuan Wang, Jinrong Zhang*, Shan He, Xiaojun Yan. A Review Study on

Macrolides Isolated from Cyanobacteria. Marine Drugs 2017, 15, 126.

34. Pengjie Cai, Shan He*, Chengxu Zhou, Allen R. Place, Saddef Haq, Lijian Ding, Haimin

Chen, Ying Jiang, Cheng Guo, Yaru Xu, Jinrong Zhang, Xiaojun Yan*. Two new

karlotoxins found in Karlodinium veneficum (strain GM2) from the East China Sea.

Harmful Algae 2016, 58, 66–73.

35. Lin Li, Shan He*, Lijian Ding, Ye Yuan, Peng Zhu, Slava Epstein, Jianzhong Fan,

Xiaokai Wu, Xiaojun Yan*. Efficient Preparation of Streptochlorin from Marine

Streptomyces sp. SYYLWHS-1-4 by Combination of Response Surface Methodology

and High-Speed Counter-Current Chromatography. Molecules 2016, 21, 693.

36. Jiajia Lin, Ling Huang, Jie Yu, Siying Xiang, Jialing Wang, Jinrong Zhang, Xiaojun Yan,

Wei Cui*, Shan He*, Qinwen Wang*. Fucoxanthin, a Marine Carotenoid, Reverses

Scopolamine-Induced Cognitive Impairments in Mice and Inhibits Acetylcholinesterase

in Vitro. Marine Drugs 2016, 14, 67.

37. Xiaokai Wu, Jinrong Zhang*, Binbin Gu, Shan He, Jiayin Zhang. A new Antioxidative

Resveratrol Trimer from the Roots and Stems of Vitis quinquangularis. Records of

Natural Products 2016, 10, 349-354.

38. Qijun Luo, Yue Song, Liyang Zheng, Juanjuan Chen*, Jilin Xu*, Shan He, Xiaojun Yan.

Characterization of Phytoplankton Communities in Response to Macronutrient

Treatments Determined by High-Performance Liquid Chromatography Mass

Spectrometry. Analytical Letters 2016, 49, 1758-1771.

39. Lijian Ding, Shan He*, Wei Wu, Haixiao Jin, Peng Zhu, Jinrong Zhang, Tingting Wang,

Ye Yuan, Xiaojun Yan*. Discovery and Structure-Based Optimization of 6-

Bromotryptamine Derivatives as Potential 5-HT2A Receptor Antagonists. Molecules

2015, 20, 17675-17683.

40. Peijuan Zhou, Qijun Luo*, Lijian Ding, Fang Fang, Ye Yuan, Juanjuan Chen, Jinrong

Zhang, Haixiao Jin, Shan He*. Preparative Isolation and Purification of Lignans from

Justicia procumbens Using High-Speed Counter-Current Chromatography in Stepwise

Elution Mode. Molecules 2015, 20, 7048-7058.

41. Binbin Gu, Yanying Zhang, Lijian Ding, Shan He*, Bin Wu, Junde Dong, Peng Zhu,

Juanjuan Chen, Jinrong Zhang, Xiaojun Yan*. Preparative Separation of Sulfur-

Containing Diketopiperazines from Marine Fungus Cladosporium sp. Using High-

Speed Counter-Current Chromatography in Stepwise Elution Mode. Marine Drugs

2015, 13, 354-365.

42. Hai-min Chen, Zhu-jun Zhu, Juan-Juan Chen, Rui Yang, Qi-jun Luo, Ji-lin Xu, Shan

He, Xiao-Jun Yan. A multifunctional lipoxygenase from Pyropia haitanensis-The cloned

and functioned complex eukaryotic algae oxylipin pathway enzyme. Algal Research

2015, 12, 316-327.

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43. Lijian Ding, Shan He*, Xiaojun Yan*. Efficient preparation of pseudoalteromone A from

marine Pseudoalteromonas rubra QD1-2 by combination of response surface

methodology and high-speed counter-current chromatography: a comparison with

high-performance liquid chromatography. Applied Microbiology and Biotechnology

2014, 98, 4369-4377.

44. Tingting Wang, Shan He*, Xiaojun Yan, Peng Zhu. Macrolactins: Antitumor Antibiotics

as Marine Drug Lead. Current Organic Chemistry 2014, 18, 804-811.

45. Juanjuan Chen, Dandan Song, Qijun Luo, Tong Mou, Rui Yang, Haimin Chen, Shan

He, Xiaojun Yan*. Determination of Floridoside and Isofloridoside in Red Algae by High-

Performance Liquid Chromatography–Tandem Mass Spectrometry. Analytical Letters

2014, 47, 2307-2316.

46. Wei Jiang, Panpan Ye, Chen-Tung Arthur Chen, Kuiwu Wang, Pengyuan Liu, Shan He,

Xiaodan Wu, Lishe Gan, Ying Ye, Bin Wu*. Two Novel Hepatocellular Carcinoma Cycle

Inhibitory Cyclodepsipeptides from a Hydrothermal Vent Crab-Associated Fungus

Aspergillus clavatus C2WU. Marine Drugs 2013, 11, 4761-4772.

47. Binbin Gu, Shan He*, Xiaojun Yan, Lixin Zhang*. Tentative biosynthetic pathways of

some microbial diketopiperazines. Applied Microbiology and Biotechnology 2013, 97,

8439–8453.

48. Binbin Gu, Yaru Xu, Shan He*. A New Resveratrol Trimer from the Roots and Stems

of Vitis wenchowensis. Molecules 2013, 18, 7486-7491.

49. Shan He*, Xiaojun Yan*. From Resveratrol to Its Derivatives: New Sources of Natural

Antioxidant. Current Medicinal Chemistry 2013, 20, 1005-1017.

50. Shan He, Hongqiang Wang, Peng Zhu, Juanjuan Chen, Rui Yang, Xiaojun Yan*.

Preparative Isolation and Purification of Macrolactin Antibiotics from Marine Bacterium

Bacillus amyloliquefaciens using High-Speed Counter-Current Chromatography in

Stepwise Elution Mode. Journal of Chromatography A 2013, 1272, 15-19.

51. Shan He, Hongqiang Wang, Bin Wu, Hui Zhou, Peng Zhu, Rui Yang, Xiaojun Yan*.

Response Surface Methodology Optimization of Fermentation Conditions for Rapid

and Efficient Accumulation of Macrolactin A by Marine Bacillus amyloliquefaciens ESB-

2. Molecules 2013, 18, 408-417.

52. Shan He, Tingting Wang, Rui Yang, Binbin Gu, Haixiao Jin, Xiaojun Yan*. Advances in

Marine Polyphenol Analysis. Current Analytical Chemistry 2013, 9, 368-373.

53. Shan He*, Hongqiang Wang, Juanjuan Chen, Lijian Ding, Yaru Xu. Rapid Analysis and

Separation of Stilbenes. Current Analytical Chemistry 2013, 9, 352-359.

54. Juanjuan Chen, Lijuan Zhao, Jilin Xu, Rui Yang, Shan He, Xiaojun Yan*. Determination

of oxidized scytonemin in Nostoc commune Vauch cultured on different conditions by

high performance liquid chromatography coupled with triple quadrupole mass

spectrometry. Journal of Applied Phycology 2013, 25, 1001-1007.

55. Juanjuan Chen, Tingting Yan, Jilin Xu, Shan He, Peng Zhao, Xiaojun Yan*.

Simultaneous determination of toxins in algae and water samples by high-performance

liquid chromatography with triple quadrupole mass spectrometry. Journal of Separation

Science 2012, 35, 1094–1101.

56. Liyan Jiang, Shan He, Cuirong Sun, Yuanjiang Pan*. Selective 1O2 quenchers,

oligostilbenes, from Vitis wilsonae: Structural identification and biogenetic relationship.

11 / 13

Phytochemistry 2012, 77, 294–303.

57. Shan He, Jiehong Yang, Bin Wu, Yuanjiang Pan*, Haitong Wan*, Yu Wang, Yueguang

Du, Shudong Wang. Neuroprotective effect of parthenocissin A, a novel antioxidant

and free radical scavenger, in focal cerebral ischemia of rats. Phytotherapy Research

2010, 24, S63- S70.

58. Liyan Jiang, Shan He, Kezhi Jiang, Cuirong Sun, Yuanjiang Pan*. Resveratrol and Its

Oligomers from Wine Grapes Are Selective 1O2 Quenchers: Mechanistic Implication by

High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass

Spectrometry and Theoretical Calculation. Journal of Agricultural and Food Chemistry

2010, 58, 9020-9027.

59. Liyan Jiang, Shan He, Yuanjiang Pan, Cuirong Sun*. Bioassay-guided isolation and

EPR-assisted antioxidant evaluation of two valuable compounds from mango peels.

Food Chemistry 2010, 119, 1285-1292.

60. Shan He, Liyan Jiang, Bin Wu, Chang Li, Yuanjiang Pan*. Chunganenol: An Unusual

Antioxidative Resveratrol Hexamer from Vitis chunganensis. Journal of Organic

Chemistry 2009, 74, 7966-7969.

61. Shan He, Liyan Jiang, Bin Wu, Yuanjiang Pan, Cuirong Sun*. Pallidol, a resveratrol

dimer from red wine, is a selective singlet oxygen quencher. Biochemical and

Biophysical Research Communications 2009, 379, 283–287.

62. Shan He, Yanbin Lu, Liyan Jiang, Bin Wu, Feiying Zhang, Yuanjiang Pan*. Preparative

isolation and purification of antioxidative stilbene oligomers from Vitis chunganensis

using high-speed counter-current chromatography in stepwise elution mode. Journal

of Separation Science 2009, 32, 2339-2345.

63. Shan He, Liyan Jiang, Bin Wu, Jing Zhou, Yuanjiang Pan*. Two Novel Antioxidative

Stilbene Tetramers from Parthenocissus laetevirens. Helvetica Chimica Acta 2009, 92,

1260-1267.

64. Juanjuan Chen, Shan He, Hui Mao, Cuirong Sun, Yuanjiang Pan*. Characterization of

polyphenol compounds from the roots and stems of Parthenocissus laetevirens by

high-performance liquid chromatography/tandem mass spectrometry. Rapid

Communications in Mass Spectrometry 2009, 23, 737-744.

65. Cuirong Sun, Jindi Fu, Shan He, Yuanjiang Pan*. An integrative approach for the

isolation, screening and analysis of antitumor agents by liquid chromatography

combined with mass spectrometry. Analytica Chimica Acta 2009, 655, 86–91.

66. Liyan Jiang, Juanjuan Chen, Shan He, Cuirong Sun*. High-throughput Structural

Elucidation of Amides in Mallotus lianus Croiz Plant Materials by LC-ESI-MS-MS.

Chromatographia 2009, 70, 439-445.

67. Shan He, Bin Wu, Yuanjiang Pan*, Liyan Jiang. Stilbene Oligomers from

Parthenocissus laetevirens: Isolation, Biomimetic Synthesis, Absolute Configuration

and Implication of Antioxidative Defense System in the Plant. Journal of Organic

Chemistry 2008, 73, 5233-5241.

68. Shan He, Cuirong Sun, Yuanjiang Pan*. Red Wine Polyphenols for Cancer Prevention.

International Journal of Molecular Sciences 2008, 9, 842- 853.

69. Bin Wu, Shan He, Xiaodan Wu, Yuanjiang Pan*. New Tyrosinase Inhibitory

Sesquiterpenes from Chloranthus henryi. Chemistry & Biodiversity 2008, 5, 1298-1303.

12 / 13

70. Liyan Jiang, Yanbin Lu, Shan He, Yuanjiang Pan*, Cuirong Sun, Tianxing Wu.

Preparative isolation and purification of two amides from Mallotus lianus Croiz by high-

speed counter-current chromatography. Journal of Separation Science 2008, 31, 3930-

3935.

71. Shan He, Yanbin Lu, Bin Wu, Yuanjiang Pan*. Isolation and purification of antioxidative

isomeric polyphenols from the roots of Parthenocissus laetevirens by counter-current

chromatography. Journal of Chromatography A 2007, 1151, 175- 179.

72. Bin Wu, Shan He, Yuanjiang Pan*. Sesquiterpenoid with new skeleton from

Chloranthus henryi. Tetrahedron Letters 2007, 48, 453–456.

73. Bin Wu, Shan He, Xiaodan Wu, Dekang Wu, Yuanjiang Pan*. Cadinane and

Eudesmane Sesquiterpenoids from Chloranthus henryi. Helvetica Chimica Acta 2007,

90, 1586-1592.

74. Bin Wu, Shan He, Xiaodan Wu, Yuanjiang Pan*. Bioactive terpenes from the roots of

Chloranthus henryi. Planta Medica 2006, 72, 1334-1338.

75. Bin Wu, Shan He, Yuanjiang Pan*. New dihydrodibenzoxepins from Bulbophyllum

kwangtungense. Planta Medica 2006, 72, 1244-1247.

授权发明专利 Patents：

序

号

专利名称 发明人 授权公告日 专利号

1 大环内酯抗生素 Macrolactin

A 发酵菌及其发酵工艺

何山、严小军、王洪强 2014.04.30 ZL2012104350236

2 一种生物碱类化合物及其制

备方法和应用

何山、严小军、丁立建 2015.02.25

ZL201210437136X

3 一种白藜芦醇低聚茋类化合

物及其制备方法和应用

吴丹、何山、王洪强、

顾斌斌

2015.04.29

ZL2013102244311

4 一种色胺衍生物类化合物及

其制备方法和用途

金海晓、何山、丁立

建、张金荣

2015.08.12

ZL2013104871878

5 二酮哌嗪类化合物及其制备

方法和用途

何山、严小军、顾斌

斌、丁立建

2016.05.04 ZL2014102130989

6 一种从海藻中提取高纯度岩

藻黄素的方法

张金荣、严小军、陈海

敏、何山、骆其君、许

亚如

2015.06.03 ZL2014100602608

7 一种海绵共生蓝藻的分离培

养方法

何山、骆其君、严小

军、张金荣、蒋莹

2015.12.30 ZL2014100592485

8 一种海洋青霉菌及其次级代

谢产物 Flufuran 的发酵工艺

何山、严小军、王婷婷 2016.08.31 ZL2014102145838

9 一种呋喃酮类化合物及其制

备方法和用途

丁立建、何山、严小军 2018.07.27 ZL201610895132.4

10 一种四氢呋喃类化合物及其

制备方法与用途

丁立建、何山、严小

军、吴小凯

2018.09.21 ZL201610901163.6

11 一种 6-溴色胺衍生物及其制

备方法和用途

黄春辉、何山、丁立

建、崔巍、申屠杰益、

赵佳颖、王敏君、斯拉

2019.09.03 ZL201710238250.2

13 / 13

瓦

12 一种γ-吡喃酮衍生物及其制

备方法和应用

张云阳、丁立建、何

山、肖烨、姚佳晓、严

小军

2019.09.03 ZL201711017128.9

13 一种苯并二氢吡喃酮类化合

物及其制备方法和应用

丁立建、何山、严小

军、吴小凯、斯拉瓦

2019.09.03 ZL201711017125.5

14 一种环戊烯酮类化合物及其

制备和用途

丁立建、何山、严小军 2019.02.15 ZL201610895077.9

15 一种α吡喃酮衍生物及其制

备方法和应用

丁立建、何山、原野 2019.05.10 ZL201710038849.1

16 一种 3,4,6 三取代-α-吡喃酮

衍生物及其制备方法和应用.

肖烨、丁立建、何山、

姚佳晓、孙晴镁

2019.09.03 ZL201711011005.4