学会発表（海外） minoru horiehqmed1/blog/img/conference... · 2020-04-16 ·...

学会発表（海外） Minoru Horie

2018 年

1. Hasegawa K. Ventricular Fibrillation And QT Prolongation During Oral s Stimulators In A

Patient Carrying An RYR2 Mutation. HRS2018(2018.9.5. America)

2. Okuyama Y, Ozawa T, Sakata K, Fujii Y, Sugimoto Y, Horie M, Ashihara T: Low voltage area

could be diminished after pulmonary vein isolation in patients with atrial fibrillation. The

82nd Annual Scientific Meeting of Japanese Circulation Society(2018.03.23-25. Osaka)

3. Ashihara T, Sakata K, Okuyama Y, Ozawa T, Haraguchi R, Nakazawa K, Tsuchiya T, Horie

M: Modulation of non-PAF driver is not always reflected by the increase in global AF cycle

length: ExTRa Mapping project. Heart Rhythm 2018 Scientific Sessions(2018.05.09-

12.Boston. U.S.A)

4. Horie M. T wave alternans. ECG change specific to the inherited arrhythmia.

JASHNE2018(2018.6.29. Chiba)

5. Inada S, Nakazawa K, Shibata N, Ashihara T, Ikeda T. Effects of autonomic nerve activity on

atrioventricular node conduction. A simulation study. The 11th Asia-Pacific Heart Rhythm

Society Scientific Session (APHRS 2018) in conjunction with the 14th Asia Pacific Atrial

Fibrillation Symposium and the 4th International Forum of Ventricular

Arrhythmia( 2018.10.17-20. Taipei)

6. Haraguchi R, Ashihara T, Matsuyama T, Yoshimoto J. Computer simulation of anterograde

conduction of the accessory pathways in Wolff-Parkinson-White syndrome with a simplified

heart wall model. The 11th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS

2018) in conjunction with the 14th Asia Pacific Atrial Fibrillation Symposium and the 4th

International Forum of Ventricular Arrhythmia(2018.10.17-20. Taipei)

7. Yoshinaga T, Kubo T, Asakura K, Abe Y, Saito R, Shirakawa T, Furukawa Y, Ashihara T.

Challenge for the translation of Na channel blockade effects on ECG parameters in human

using in silico models. SPS 2018 Annual Meeting(2018.09.30-10.03. Washington DC)

8. Tsumoto K, Naito N, Ashihara T, Amano A, Kurachi Y. Cellular mechanisms underlying

anisotropic conduction in ventricle: insights from computational models. The 65th Annual

Meeting of the Japanese Heart Rhythm Society (JHRS 2018)(2018.07.11-14. Tokyo)

2017 年

1. Watanabe R, Ohno S, Aiba T, Ishikawa T, Nakano Y, Aizawa Y, Hayashi K, Murakoshi N,

Nakajima T, Yagihara N, Shigemizu D, Mishima H, Sudo T, Higuchi C, Takahashi A, Sekine

A, Minamino N, Makiyama T, Tanaka Y, Murata H, Hayashi M, Iwasaki Y, Watanabe A,

Tachibana M, Morita H, Miyamoto Y, Yoshiura K, Tsunoda T, Watanabe H, Kurabayashi M,

Nogami A, Kihara Y, Makita N, Shimizu W, Horie M, Tanaka T. Identification of novel long

QT syndrome-associated mutations by targeted sequencing analyses. European Society of

Human Genetics Conference.(2017.5.27-30. Denmark)

2. Horie M. Cardiac Sodium Channelopathy. overlapping syndromes and diverse mechanisms.

TSOC meeting,(2017.5.06. taiwan)


3. Sakata K, Okuyama Y, Ozawa T, Tsuchiya T, Haraguchi R, Nakazawa K, Horie M, Ashihara

T. Not All Non-Paroxysmal Atrial Fibrillation Drivers Are Included in Complex Fractionated

Electrogram Area or Low Voltage Area: ExTRa Mapping Project. 44th International Congress

on Electrocardiology/17th Congress of the International Society for Holter and Noninvasive

Electrocardiology.(2017.5.24-27. Portland, USA)

4. Ashihara T, Sakata K, Okuyama Y, Ozawa T, Tsuchiya T, Haraguchi R, Horie M. ExTRa

Mapping-guided non-passive activation ablation is very effective for non-paroxysmal AF.

Heart Rhythm 2017 Scientific Sessions( 2017.05.10-13. Chicago)

5. Fukui A, Tsuchiya T, Yamaguchi T, Kawano Y, Takahashi Y, Otsubo T, Ashihara T. Ablation

of arrhythmogenic low voltage zone harboring atrial fibrillation rotors frequently terminates

atrial fibrillation. Heart Rhythm 2017 Scientific Sessions(2017.05.10-13. Chicago)

6. Horie M. Molecular Genetics Have Opened a New Era for Arrhythmia Research, but Also

Pandora's Box? APHRS2017(2017.9.14-17. Yokohama)

7. Horie M. Cardiac Ryanodine Receptor Channel and Inherited Arrhythmia Syndrome.

APHRS2017(2017.9.14-17. Yokohama)

8. Wada Y, Ohno S, Wuriyanghai Y, Makiyama T, Horie M. Exercise Inducible Polymorphic

Ventricular Tachycardia Depending on the Different RYR2 Mutation Spectrum. APHRS2017

(2017.9.14-17. Yokohama)

9. Fukumoto D, Ohno S, Wada Y, Fujii Y, Ichikawa M, Takayama K, Fukuyama M, Itoh H, Ding

WG, Matsuura H, Horie M. Novel N-Terminal KCNH2 Mutations Identified in Symptomatic

Long QT Syndrome Patients. APHRS2017 (2017.9.14-17. Yokohama)

10. Hirose S, Makiyama T, Melgari D, Wu J, Yokoi F, Wuriyanghai Y, Kohjitani H, Yamamoto Y,

Nishiuchi S, Hayano M, Harita T, Yoshimoto J, Ohno S, Yoshida Y, Horie M, Kimura T.

Modelling Long-QT Syndrome Type 3 Associated with Near-Miss Sudden Infant Death

Syndrome Using Human-Induced Pluripotent Stem Cells. APHRS2017(2017.9.14-17.

Yokohama)

11. Aiba T, Ohno S, Ono M, Shigemizu D, Toyoda F, Miake J, Hagiwara A, Shinohara T, Okumura

S, Toda T, Satake W, Tsunoda T, Shimamoto K, Sekine A, Takahashi A, Miyamoto Y, Tanaka

T, Kusano K, Horie M, Shimizu W. KCNJ3 N496H A Rare Variant in Japanese as a Cause of

Susceptible Gene for Ventricular Fibrillation in Overlap Syndromes between LQT and CPVT.

APHRS2017 (2017.9.14-17. Yokohama)

12. Nishiuchi S, Makiyama T, Aiba T, Nakajima K, Ishikawa T, Murakoshi N, Watanabe H, Ohno

S, Doi T, Shizuta S, Minamino T, Saito Y, Oginosawa Y, Nogami A, Aonuma K, Kusano K,

Makita N, Shimizu W, Horie M, Kimura T. Gene-Based Risk Stratification for Cardiac

Disorders in LMNA Mutation Carriers. APHRS2017.(2017.9.14-17. Yokohama)

13. Yokoi F, Makiyama T, Harita T, Yamamoto Y, Hayano M, Nishiuchi S, Kohjitani H,

Wuriyanghai Y, Hirose S, Toyoda F, Yoshida Y, Makita N、Horie M, Kimura T. lL-cis-Diltiazem

Ameliorates Impaired Calcium Channel Inactivation in a Patient-Specific Stem Cell Model

of Long-QT Syndrome with a Calmodulin Mutation. APHRS2017 (2017.9.14-17. Yokohama)


14. Kyodo A, Sakatani T, Shimoo S, Takamatsu K, Tsuji Y, Mera K, Koide M, Isodono K,

Tsubakimoto Y, Matsuo A, Inoue K, Fujita H, Ichikawa M, Ohno S, Horie M. Drug-Induced

Long QT Syndrome in a Patient with an ANK2 Mutation. APHRS2017(2017.9.14-17.

Yokohama)

15. Imai Y, Higashi Y, Yoshino T, Tarutani Y, Ichikawa M, Ohno S, Horie M. Ankyrin-B mutation

identified in a patient with chronic atrial fibrillation, atrioventricular conduction disturbance

and left ventricular dysfunction. APHRS2017(2017.9.14-17. Yokohama)

16. Dharmawan T, Nakajima T, Ohno S, Iizuka T, Irie T, Kaneko Y, Horie M, Kurabayashi M.

Inherited Primary Arrhythmia Syndrome Presenting with Phenotypic Features of

Catecholaminergic Polymorphic Ventricular Tachycardia Plus Prominent U-Waves.

APHRS2017(2017.9.14-17. Yokohama)

17. Wu Q, Hira D, Hayashi H, Sonoda K, Ohno S, Makiyama T, Terada T, Horie M. Score System

for Diagnosis of Syncope after Alcohol Intake in Brugada Syndrome. APHRS2017(2017.9.14-

17. Yokohama)

18. Sakata K, Ozawa T, Okuyama Y, Haraguchi R, Tsuchiya T, Horie M, Ashihara T. Non-

Paroxysmal Atrial Fibrillation Wave Dynamics Were Determined by Age Rather than

Echocardiographic Measurements or BNP: Extra Mapping Project. APHRS2017(2017.9.14-

17. Yokohama)

19. Ashihara T, Sakata K, Okuyama Y, Ozawa T, Haraguchi R, Fukui A, Yamaguchi T, Tsuchiya

T, Horie M. Extra Mapping-Guided Ablation Targeting NonPassively Activated Area Is Very

Effective for Long-Standing Persistent Atrial Fibrillation. APHRS2017(2017.9.14-17.

Yokohama)

20. Aizawa Y, Fujisawa T, Katsumata Y, Ohno S, Sonoda K, Hayashi H, Hojo R, Fukamizu S,

Nakajima K, Kunitomi A, Nishiyama T, Kimura T, Nishiyama N, Kurita Y, Takatsuki S,

Ogwa S, Kosaki K, Nakazato Y, Horie M, Fukuda K. Sex Dependent Risk of Sudden Death or

Sick Sinus Syndrome in a Family with Brugada Syndrome. APHRS2017(2017.9.14-17.

Yokohama)

21. Takayama K, Ohno S, Horie M.Severe Phenotype of Catecholaminergic Polymorphic

Ventricular Tachycardia Caused by Double RYR2 Mutations. APHRS2017(2017.9.14-17.

Yokohama)

22. Nakajima K, Aiba T, Nishiuchi S, Makiyama T, Onoue K, Kamakura T, Wada M, Ishibashi K,

Inoue Y, Miyamoto K, Okamura H, Nagase S, Noda T, Ohno S, Miyamoto Y, Saito Y, Horie M,

Kimura T, Shimizu W, Kusano K. Is Cardiac Resynchronization Therapy Able to Improve

Mortality of Heart Failure in Patients with Laminopathy? APHRS2017(2017.9.14-17.

Yokohama)

23. Fukuyama M, Ohno S, Takayama K, Ichikawa M, Fukumoto D, Horie M. Novel RYR2

Mutations Causative for Long QT Syndromes. APHRS2017(2017.9.14-17. Yokohama)

24. Yamamoto Y, Makiyama T, Harita T, Hayano M, Nishiuchi S, Wuriyanghai Y, Kohjitani H,

Hirose S, Yokoi F, Ishikawa T, Ohno S, Chinabayashi K, Suda K, Yoshida Y, Horie M, Makita


N, Kimura T. CALM2-D134H Mutation Associated with Long-QT Syndrome Prevents

Inactivation of L-type Ca2+ Currents in Human iPS Cell Derived Cardiomyocytes.

APHRS2017(2017.9.14-17. Yokohama)

25. Ichikawa M, Ohno S, Fukumoto D, Takayama K, Wada Y, Fukuyama M, Makiyama T, Itoh

H, Horie M. Next-Generation Sequencing Is One of the Promising Ways for Identifying Copy

Number Variations in Patients with Inherited Primary Arrhythmia Syndromes. APHRS2017

(2017.9.14-17. Yokohama)

26. Sakata K, Okuyama Y, Ozawa T, Haraguchi R, Horie M, Ashihara T: Using large-tip ablation

catheter markedly decreases bipolar signal amplitude near spiral wave center but this is not

the case with using multi-electrode mapping catheter: A simulation study. The 39th Annual

Congress of the European Society of Cardiology. ESC Congress 2017 (2017. 8. 26-30. Spain)

27. Sakata K, Ozawa T, Okuyama Y, Haraguchi R, Tsuchiya T, Horie M, Ashihara T: Non-

paroxysmal atrial fibrillation wave dynamics were determined by age rather than

echocardiographic measurements and BNP: A clinical study using the ExTRa Mapping

system. The 39th Annual Congress of the European Society of Cardiology. ESC Congress 2017

(2017. 8. 26-30. Spain)

28. Sakata K, Ozawa T, Okuyama Y, Haraguchi R, Tsuchiya T, Horie M, Ashihara T: Not all non-

paroxysmal atrial fibrillation drivers are included in complex fractionated electrogram area

or low-voltage area: ExTRa Mapping project. The 39th Annual Congress of the European

Society of Cardiology. ESC Congress 2017 (2017. 8. 26-30. Spain)

29. Kawatou M, Masumoto H, Fukushima H, Morinaga G, Sakata R, Ashihara T, Yamashita JK.

Human iPS cell-engineered heart tissue to reproduce “Torsade de Pointes” arrhythmia in

vitro. The 39th Annual Congress of the European Society of Cardiology. ESC Congress

2017(2017. 8. 26-30. Spain)

30. Aoki H, Ohno S, Fukuyama M, Yoshinaga M, Horie M. SCN10A Mutations Related with

Bradycardia and Conduction Block in Young Patients. ESC Congress 2017(2017. 8. 26-30.

Spain)

31. Fukuyama M, Ohno S, Takayama K, Ichikawa M, Horie M. Novel RYR2 mutations causative

for long QT syndromes. ESC Congress 2017(2017. 8. 26-30. Spain)

32. Ichikawa M, Ohno S, Fukumoto D, Takayama K, Wada Y, Fukuyama M, Makiyama T, Itoh

H, Horie M. Identification of copy number variations by next generation sequencer in patients

with inherited primary arrhythmia syndromes. ESC Congress 2017 (2017. 8. 26-30. Spain)

33. Hayano M,Makiyama T, Kamakura T, Watanabe H, Sasaki K, Funakoshi S, Wuriyanghai Y,

Nishiguchi S, Harita T, Yamamoto Y,.Kohjitani H, Hirose S, Yokoi F, Chen J, Baba O, Horie

T, Chonabayahi K, Ohno S, Toyoda F, Yoshida Y, Ohno K, Horie M, Kimura T. Human iPSC-

Derived Myocyte Mmodel of SCN5A-D1275N-Related Cardiac Sodium Channelopathy

Reveals Diminished Sodium Currents Resulting From Enhanced Protein Degradation.

AHA2017(2017.11.11–13. Anaheim）

34. Yamamoto Y, Makiyama T, Harita T, Hayano M, Suguru N, Wuriyanghai Y, Kohjitani H,


Hirose S, Yokoi F, Ishikawa T, Ohno S, Chonabayashi K, Suda K, Yoshida Y, Horie M,

Makita N, Kimura T. CALM2-D134H Mutation Associated with Long-QT Syndrome Delayed

Inactivation of L-type Ca2+ Currents in Human iPS Cells Derived Cardiomyocytes.

AHA2017(2017.11.11–13. Anaheim）

35. Wuriyanghai Y. Establishment of Homozygous LMNA Knockout Human Induced Pluripotent

Stem Cells For Analyzing Disease-causing Mechanism of Laminopathies. AHA2017

(2017.11.11–13. Anaheim）

36. Takayama K, Ohno S, Ding W-G, Kise H, Hoshiai M, Matsuura H, Horie M. Early

Repolarization Syndrome Caused by a de novo KCND3 Gain-of-Function Mutation.

AHA2017(2017.11.11–13. Anaheim）

37. Hirose S, Makiyama T, Melgari D, Wu J, Yokoi F, Wuriyanghai Y, Yamamoto Y, Kohjitani H,

Nishiguchi S, Harita T, Hayano M, Yoshimoto J, Ohno S, Yoshida Y, Horie M, Kimura T.

Propranolol Inhibits Late Sodium Current in Long-QT Syndrome Type 3 Human Induced

Pluripotent Stem Cell-drived Myocyte Model. AHA2017(2017.11.11–13. Anaheim）

38. Kohjitani K, Kouda S, Himeno Y, Makiyama T, Hirose S, Wuriyanghai Y, Yamamoto Y, Horie

M, Kimura T, Noma A, Amano A. Novel Mathematical Modeling of Human Induced

Pluripotent Stem Cell Derived Cardiomyocyte can Recapitulate Action Potentials of All

Subtypes Including Nodal Like Cells, and Reproduced Drug Testing and Gene Mutation

Model Accurately. AHA2017(2017.11.11–13. Anaheim）

39. Pham T, Fujiyoshi A, Hisamatsu T, Kadota A, Kadowaki S, Zaid M, Horie M, Miura K,

Ueshima H, for the SESSA Research Group. SMOKING ASSOCIATES WITH HIGHER

INCIDENCE AND PROGRESSION OF CORONARY ATHEROSCLEROSIS IN A

COMMUNITY-BASED SAMPLE OF JAPANESE MEN. THE SHIGA EPIDEMIOLOGICAL

STUDY OF SUBCLINICAL ATHEROSCLEROSIS (SESSA). VJSE 2017(2017.9.9. TOKYO)

40. Sakata K, Ozawa T, Okuyama Y, Haraguchi R, Tsuchiya T, Horie M, Ashihara T. Not all

non-paroxysmal atrial fibrillation drivers are included in complex fractionated electrogram

area or low voltage area: ExTRa Mapping project. The 44th International Congress on

Electrocardiology (ICE)/The 17th Congress of the International Society for Holter and

Noninvasive Electrocardiology (ISHNE), 2017/06/24-27, Young Investigators Competition

Finalists, Portland (Collaborative Life Sciences Building, U.S.A.)

41. Inada S, Inoue Y, Shibata N, Yamamoto T, Ashihara T, Aiba T, Kusano K, Ikeda T, Mitsui K,

Nakazawa K. Analyzing vectorcardiograms synthesized from 12-lead electrocardiogram to

predict the origin of sinus rhythm and premature contraction. The 44th International

Congress on Electrocardiology (ICE)/The 17th Congress of the International Society for

Holter and Noninvasive Electrocardiology (ISHNE(2017.06.24-27. Portland, U.S.A.)

42. Kawatou M, Masumoto H, Fukushima H, Morinaga G, Sakata R, Ashihara T, Yamashita JK.

Human iPS cell-engineered heart tissue to reproduce “Torsade de Pointes” arrhythmia in

vitro. International Society for Stem Cell Research (ISSCR) Annual Meeting

2017(2017.06.14-17. New Orleans, U.S.A.)


43. Sakata K, Ozawa T, Okuyama Y, Haraguchi R, Tsuchiya T, Horie M, Ashihara T. Not all non-

paroxysmal atrial fibrillation drivers are included in complex fractionated electrogram area

or low-voltage area: ExTRa Mapping Project. The 10th Asia-Pacific Heart Rhythm Society

Scientific Session (APHRS) in conjunction with the Annual Meeting of the Japanese Heart

Rhythm Society (JHRS) 2017(2017.09.14-17. Yokohama)

44. Inada S, Inoue Y, Shibata N, Yamamoto T, Ashihara T, Aiba T, Kusano K, Ikeda T, Mitsui K,

Nakazawa K. Analyzing vectorcardiograms synthesized from 12-lead electrocardiogram to

predict the origin of sinus rhythm and premature contraction. The 44th International

Congress on Electrocardiology (ICE)/The 17th Congress of the International Society for

Holter and Noninvasive Electrocardiology (ISHNE)(2017.06.24-27. Portland, U.S.A.)

45. Inada S, Aiba T, Haraguchi R, Ashihara T, Kusano K, Shimizu W, Ikeda T, Nakazawa K.

Ventricular arrhythmias initiated from conduction delay zone around right ventricular

outflow tract epicardium: A simulation study. The 10th Asia-Pacific Heart Rhythm Society

Scientific Session (APHRS) in conjunction with the Annual Meeting of the Japanese Heart

Rhythm Society (JHRS) 2017(2017.09.14-17. Yokohama)

46. Ashihara T, Sakata K, Okuyama Y, Ozawa T, Haraguchi R, Fukui A, Yamaguchi T, Tsuchiya

T, Horie M. ExTRa Mapping-guided ablation targeting non-passively activated area is very

effective for long-standing persistent atrial fibrillation. The 10th Asia-Pacific Heart Rhythm

Society Scientific Session (APHRS) in conjunction with the Annual Meeting of the Japanese

Heart Rhythm Society (JHRS) 2017(2017.09.14-17. Yokohama)

2016 年

1. Sakata K, Ashihara T, Ozawa T, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.

A clinical observational study employing a novel real-time phase mapping system (ExTRa

Mapping). Heart Rhythm 2016 Scientific Sessions, Poster(2016.5.4-7. San Francisco)

2. Ozawa J, Ohno S, Toyoda F, Itoh H, Fukuyama M, Harita T, Makiyama T, Hiroshi Suzuki,

Akihiko Saitoh, Matsuura H, Horie M. A novel CACNA1C mutation identified in a patient

with atypical Timothy syndrome exerts both loss- and gain-of-function effects on Cav1.2. ESC

CONGRESS 2016 (2016.8.26-9.1. Rome, Italy)

3. Ohno S, Wu J, Sonoda K, Itoh H, Makiyama T, Horie M. Triple mutations in three major

genes for long QT syndrome are very rare but produce severe phenotypes. ESC CONGRESS

2016 (2016.8.26-9.1. Rome, Italy)

4. Sonoda K, Ohno S, Ozawa J, Hayano M, Ichikawa M, Ito H, Makiyama T, Horie M : Copy

Number Variations in SCN5A associated with Brugada Syndrome. ESC CONGRESS 2016

(2016.8.26-9.1. Rome, Italy)

5. Kubo T, Ashihara T, Tsubouchi T, Bando K, Horie M. SIMULATION OF IQ-CSRC

PROSPECTIVE STUDY USING INTEGRATED IN SILICO 2-DIMENSIONAL

TRANSMURAL HUMAN VENTRICULAR WEDGE PREPARATION MODEL. Safety

Pharmacology Society(2016.9.18-21. Canada)


6. Horie M Professor Durrer visiting professorship. Adrenergic Modulation of long QT

Syndromes(2016.9.5. Amsterdam)

7. Ohno S, Wu J, Mizusawa Y, Sonoda K, Itoh H, Makiyama T, Horie M. Triple mutations in

three major genes for long QT syndrome are very rare and cause complicated phenotypes

with ventricular arrhythmia. ESC2016(2016.8.29. Rome)

8. Harita T, Makiyama T, Toyoda F, Nishiuchi S, Hayano M, Yamamoto Y, Wuriyanghai Y,

Kohjitani H, Ohno S, Yoshida Y, Ueyama T, Yamanaka S, Shimizu A, Horie M, Kimura T. l-

cis diltiazem rescues impaired calcium channel inactivation in a patient-specific stem cell

model of long QT syndrome with a CACNA1C mutation. ESC2016(2016.8.29. Rome)

9. Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, Seki T, Aizawa Y, Hattori T, Okata S,

Tanaka A, Horigome H, Kokubun N, Horie M, Kamiya K, Fukuda K. Flecainide suppresses

an arrhythmogenic substrate in Andersen-Tawil syndrome-induced pluripotent stem cell-

derived cardiomyocytes.ESC2016 (2016.8.29. Rome)

10. Shimamoto K, Aiba T, Ishibashi K, Kamakura T, Wada M, Miyamoto K, Inoue-Yamada Y,

Okamura H, Nagase S, Noda T, Kamakura S, Miyamoto Y, Horie M, Shimizu W, Kusano K.

Clinical characteristics and long-term prognosis of patients with genotype-unknown long-QT

syndrome. ESC2016(2016.8.29. Rome)

11. Sonoda K, Ohno S, Ozawa J, Hayano M, Ito H, Makiyama T, Horie M. Copy number

variations in SCN5A associated with Brugada syndrome. ESC2016(2016.8.29. Rome)

12. Ashihara T, Sakata K, Ozawa T, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.

Quickly remapping by novel online phase mapping system complemented by in silico

prediction of excitations is very useful for confirming the effectiveness of non-PAF ablation

(ExTRa Mapping Project). ESC2016 (2016.8.29. Rome)

13. Wada A, Matsumoto T, Fujii M, Taniguchi A, Hara T, Kinoshita M, Horie M: New insights in

molecular therapeutic mechanism of statin in heart failure using high-throughput

tanscriptome analysis. ESC2016(2016.8.29. Rome)

14. Ohno S, Ozawa J, Fujii Y, Itoh H, Horie M. Specific phenotypes caused by RYR2 mutations

relate with bradycardia but not with mutation locations in RYR2. ESC2016(2016.8.30. Rome)

15. Fukuyama M, Ohno S, Ichikawa M, Makiyama T, Horie M. Rare single nucleotide

polymorphism of scn10a in patients with inherited primary arrhythmia syndromes.

ESC2016(2016.8.30. Rome)

16. Fujii Y, Itoh H, Ohno S, Blancard M, Aoki H, Nakagawa Y, Yamamoto S, Matsui Y, Ichikawa

M, Sonoda K, Ozawa T, Ohkubo K, Watanabe I, Guicheney P, Horie M. ?RYR2 mutations

underlying in patients with short-coupled variant of torsade de pointes. ESC2016(2016.8.30.

Rome)

17. Taniguchi T, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Horie M, Kimura T. Incidence

of heart failure hospitalization in patients with ST-segment elevation myocardial infarction

who underwent primary percutaneous coronary intervention. ESC2016(2016.8.30. Rome)

18. Fukumoto D, Ohno S, Wada Y, Fujii Y, Ichikawa M, Ito H, Ding WG, Matsuura H, Horie M.


KCNH2 mutation in patients with long QT syndrome type 2. 9th APHRS Scientific

Session(2016.10.12-15. Korea)

19. Wuriyanghai Y, Makiyama T, Nishiuchi S, Yokoi F, Hayano M, Yamamoto Y, Harita T,

Kohjitani H, Hirose A, Ohno S, Yoshida Y, Horie M, Kimura T. Generation of lmna knock out

human induced pluripotent stem cells using the crispr-cas9 nickase system. 9th APHRS

Scientific Session(2016.10.12-15. Korea)

20. Ichikawa M, Aiba T, Ohno S, Shigemizu D, Ozawa J, Sonoda K, Fukuyama M, Itoh H,

Miyamoto Y, Tsunoda T, Makiyama T, Tanaka T, Shimizu W, Horie M. Various ANK2

mutations in patients with inherited primary arrhythmia syndromes. 9th APHRS Scientific


21. Takayama K, Ohno S, Wada Y, Horie M. Non desmosomal mutations detected in japanese

patients with arrhythmogenic right ventricular cardiomyopathy. 9th APHRS Scientific


22. Hayashi H, Tobita R, Iwai K, Horie M. Roles of Skeletal Muscle in Ventilatory Response to

Exercise.Comparison between Myocardial Infarction and Diabetes Mellitus.

AHA2016(2016.11.12-16. New Orleans)

23. Ohno S. The RYR2 Mutations Identified Not Only in CPVT But Also Short Coupled Variant

of Torsade De Pointes and LQTS. APHRS2016(2016.10.12-15. Korea)

24. Ohno S. What’s New in 2016. Genetics in ARVC/D. APHRS2016(2016.10.12-15. Korea)

25. Ohno S, Ozawa J, Fukuyama M, Makiyama T, Horie M. High prevalence of late onset T in

patients with long QT syndrome type 8. AHA2016(2016.11.12-16. New Orleans, USA)

26. Wada Y, Ohno S, Aiba T, Horie M. A Unique Genetic Background and Prognostic Impact on

Non-Caucasian ARVD/C Probands. AHA2016(2016.11.12-16. New Orleans, USA)

27. Yoshinaga M, Ohno S, Ushinohama H, Sato S, Miyamoto T, Tauchi N, Horigome H, Sumitomo

N, Shiraishi H, Ichida F, Hata T, Nomura Y, Horie M, Makita N, Nagashima M. ECG

Screening of 1-Month-Old Infants May Prevent Out-of-Hospital Cardiac Arrest in Infancy.

AHA2016(2016.11.12-16. New Orleans, USA)

28. Yamamoto Y, Makiyama T, Harita T, Sasaki K, Hayano M, Nishiuchi S, Wuriyanghai Y,

Kohjitani H, Hirose S, Chen J, Ishikawa T, Motomura H, Ohno S, Chonabayashi K, Yoshida

Y, Horie M, Makita N, Kimura T. Allele-specific Disruption Rescues Electrophysiological

Abnormalities in Human iPS Cell Model of Long-QT Syndrome With a CALM2 Mutation .

AHA2016(2016.11.12-16. New Orleans, USA)

29. Tsumoto K, Ashihara T, Nakazawa K, Kurachi Y: A generating mechanism of phase-2 reentry

in Brugada syndrome.insights from changes in the Na+ channel expression. The 63rd Annual

Meeting of the Japanese Heart Rhythm Society. JHRS 2016(2016.07.14-17. Sapporo)

30. Kawatou M, Masumoto H, Fukushima H, Morinaga G, Minakata K, Ikeda T, Sakata R,

Ashihara T, Sekino Y, Yamashita JK. Development of a drug-induced spiral wave re-entrant

tachycardia model in human induced pluripotent stem cell-derived mini-3D cardiac tissue

sheets. American Heart Association Scientific Sessions 2016(2016.11.12-16. New Orleans,


U.S.A.)

31. Sakata K, Ashihara T, Ozawa T, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.

Stationary rotors are not therapeutic targets in patients with non-paroxysmal atrial

fibrillation?A clinical study employing a novel "online" real-time phase mapping system

(ExTRa Mapping). Heart Rhythm 2016 Scientific Sessions(2016.5.4-7. San Francisco, U.S.A.)

2015 年

1. Horie M. Genetic counselling for inherrited cardic arrhythmia.Cardio Rhythm

2015(2015.1.30-2.1. Hong Kong,China)

2. Horie M. Genetics of Early Repolarization Syndromes. Expert Consensus Symposium on J

Wave Syndrome (2015.4.21-23. Shanghai, China)

3. Horie M. Progress in Diagnosis and Treatment of Malignant Ventricular Arrhythmias.

Fourth Conference on Severe Heart Diseases in China (2015.6.12-13. Beijing, China)

4. Ashihara T, Ozawa T, Hattori T, Kato K, Tsuchiya T, Yamaguchi T, Haraguchi R, Inada S,

Nakazawa K, Horie M. Possible mechanisms of rotor ablation for chronic atrial fibrillation:

A simulation study. Heart Rhythm 2015 Scientific Sessions,Poster(2015.5.13-16.

Boston,USA)

5. Ashihara T, Kurokawa J, Kanda Y, Haraguchi R, Nakazawa K, Horie M. Spiral wave

behaviors and antiarrhythmic drug efficacy in human induced pluripotent stem cell-derived

myocardial sheet are different from those in original heart.A simulation study. Heart Rhythm

2015 Scientific Sessions, Poster.(2015.5.13-16. Boston)

6. Itoh H, Spazzolini C, Crotti L, Aiba T, Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno S,

Makiyama T, Wu J, Hasegawa K, Mastantuono E, Dagradi F, Pedrazzini M, Yamagishi M,

Berthet M, Murakami Y, Shimizu W, Guicheney P, Schwartz PJ, Horie M. The genetics

underlying the acquired long QT syndrome. Impact on management. The Heart Rhythm

Society's 36th Annual Scientific Sessions (2015.5.13-16. Boston, USA)

7. Ohno S, Aizawa Y,Fukuyama M,Makiyama T,Kosaki K,Fukuda K,Horie M:desmosome gene

mutations cause or modify the Brugada syndrome? (05.13-16, Boston, USA)

8. Sonoda K,Ohno S,Otsuki S,Yagihara N,Watanabe H,Horie M: Quantitative Analysisof PKP2

and Neighboring Genesin a Patient with Arrhythmogenic Right Ventricular Cardiomyopathy

Caused by Heterozygous PKP2 Deletion. (05.13-16, Boston, USA)

9. Ichikawa M, Ohno S, Fujii Y, Ozawa J, Sonoda K, Fukuyama M, Kato K, Itoh H,Horie M.

Arrhythmogenic ventricular cardiomyopathy with peculiar ventricular aneurysm and

TMEM43 mutations(2015.6.21-24. Milan, Italy)

10. Fukuyama M, Ohno S, Ichikawa M, Makiyama T, Horie M. SCN10A polymorphisms are

associated with the clinical severity of probands with sodium channelopathies(2015.6.21-24,

Milan, Italy)

11. Sonoda K, Ohno S, Ichikawa M, Fujii Y, Wang Q, Kato K, Fukuyama M, Ito H, Hayashi H,

Horie M. AKAP9 mutations identified in young patientswith idiopathic ventricular


fibrillation or polymorphic ventricular tachycardia. ESC CONGRESS 2015 (2015.8.29-9.2,

London, England)

12. Chen J, Makiyama T, Wuriyanghai Y, Ohno S, Ueyama T, Shimizu A, Horie M, Kimur T.

Cardiac sodium channel mutation associated with epinephrine-induced QT prolongation and

sinus node dysfunction. ESC CONGRESS 2015 (2015.8.29-9.2. London, England)

13. Nishiuchi S, Makiyama T, Sasaki K, Kohjitani Y, Ohno S, Yoshida Y, Doi T, Shizuta S,

Horie.M, Kimura T. Abnormal expression of cardiac ion channels-associated genes in lamin

A/C-related cardiomyopathy-specific induced pluripotent stem cell derived cardiomyocytes.

ESC CONGRESS 2015 (2015.8.29-9.2. London, England)

14. Ozawa J, Ohno S, Fujii Y, Makiyama T, Suzuki H, Saitoh A, Horie M. Differential Diagnosis

of Catecholaminergic Polymorphic Ventricular Tachycardia vs. Long QT Syndrome Type 1: A

Modified Schwartz Scoring. AHA Scientific Sessions 2015 (2015.11.7-11. Orlando, FL, U.S.A.)

15. Yamamoto Y, Makiyama T, Harita T, Sasaki K, Hayano H, Nishiuchi S, Wuriyanghai Y,

Kohjitani H, Hirose S, Chen J, Ishikawa T, Ohno S, Yoshida Y, Horie M, Makita N, Kimura

T. Modelling Long-QT Syndrome Associated With a Calmodulin Mutation Using Human

Induced Pluripotent Stem Cells. AHA Scientific Sessions 2015 (2015.11.7-11. Orlando, FL,

U.S.A.)

16. Ashihara T, Sakata K, Ozawa T, Kato K, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K,

Horie M. Development of a novel real-time phase mapping system, called ExTRa Mapping,

using in silico technique for identifying unstable rotors in patients with non-paroxysmal

atrial fibrillation. The 8th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS)

(2015.11.19-22. Melbourne, Australia)

17. Sakata K, Ashihara T, Ozawa T, Kato K, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K,

Horie M. No stationary rotors are observed in patients with non-paroxysmal atrial

fibrillation: A combined clinical and in silico study employing a novel real-time phase

mapping system (ExTRa Mapping). The 8th Asia-Pacific Heart Rhythm Society Scientific

Session (APHRS) (2015.11.19-22. Melbourne, Australia)

18. Ashihara T, Sakata K, Ozawa T, Kato K, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K,

Horie M. Rotor distribution does not always match with the anatomic distribution of complex

fractionated atrial electrogram sites in patients with non-paroxysmal atrial fibrillation: A

clinical observational study employing a novel real-time phase mapping system (ExTRa

Mapping). The 8th Asia-Pacific Heart Rhythm Society Scientific Session

(APHRS)(2015.11.19-22. Melbourne, Australia)

19. Ohno S. Case 4.Learning from Challenging Genetic Heart Disease Cases. The 8th Asia-

Pacific Heart Rhythm Society Scientific Session (APHRS)(2015.11.19-22. Melbourne,

Australia)

20. Ohno S. CPVT.Challenging inherited arrhythmia syndromes: the latest. The 8th Asia-Pacific

Heart Rhythm Society Scientific Session (APHRS)(2015.11.19-22. Melbourne, Australia)

21. Ohno S. Brady and Atrial Arrhythmias in CPVT Patients with RYR2 Mutations. The 8th


Asia-Pacific Heart Rhythm Society Scientific Session (APHRS)(2015.11.19-22. Melbourne,

Australia)

22. Ohno S, Horie M. Pitfalls in genetic analysis for inherited arrhythmias in the era of next

generation sequencer. The 8th Asia-Pacific Heart Rhythm Society Scientific Session

(APHRS)(2015.11.19-22. Melbourne, Australia)

23. Horie M Consensus expert meeting on J wave syndrome. Genetic basis for Early

Repolarization Syndrome. organized by Prof C. Antzelevitch (2015.4.21-24. Shanghai)

24. Horie M. Invited lecture at APHRS2016: Left ventricular non-compaction. The 8th Asia-

Pacific Heart Rhythm Society Scientific Session (2015.11.19-22. Melbourne, Australia)

25. Horie M. Invited Keynote Lecture: Critically ill heart patients ? Treament progress and

transform of malignant arrhythmias. The 4th China Cardiac Intensive Care Congress

(2015.6.12. Beijing)

26. Inada S, Aiba T, Harrell DT, Haraguchi R, Ashihara T, Makita N, Shimizu W, Ikeda T,

Nakazawa K. Conduction delay of right ventricular outflow tract and ventricular

tachyarrhythmia: A simulation study for Brugada syndrome. The 42nd International

Congress on Electrocardiology (ICE)(2015.06.24-27. Comandatuba Island, Brazil)

27. Kurokawa J, Okada J, Hayashi E, Ashihara T, Yoshinaga T, Sugiura S, Li M, Kanda Y, Sekino

Y, Furukawa T. A novel approach for evaluation of drug-induced QT prolongation using

human induced pluripotent stem cell-derived cardiomyocytes. 58th Annual Meeting of the

Biophysical Society(2015.02.07-11. Boston)

2014 年

1. Ohno S. Genetic analysis for inherited arrhythmias using benchtop next generation

sequencer. International Research Symposium on Inherited Arrhythmias 2014(2014.03.22.

Tokyo,Japan)

2. Miyamoto K, Aiba T, Kimura H, Hayashi H, Nakajima I, Ishibashi K, Okamura H, Noda

T,Kamakura S, Kusano K, Horie M, Shimizu W. Electrocardiographic Characteristic of

Flecainide Therapy for Ventricular Arrhythmia in Patients with Andersen-Tawil Syndrome

with KCNJ2 Mutation.Heart Rhythm2014(2014.05.06-11. San Francisco,Ca,U.S.A)

3. Hasegawa K, Ohno S, Kimura H, Itoh H, Makiyama T, Yoshida Y, Horie M. Mosaic KCNJ2

Mutation in Andersen-Tawil syndrome:Targeted Deep Sequencing is Useful for the Detection

of Mosaicism.Heart Rhythm2014(2014.05.06-11. San Francisco,Ca,U.S.A)

4. Kawata H, Funasako M, Ishibashi K, Nakamura I, Miyamoto K, Sakaguchi H, Miyazaki A,

Okamura H, Noda T, Aiba T,Kusano K, Kamakura S, Shimizu W. Catecholaminergic

Polymorphic Ventricular Tachycardia (CPVT) associated with Ryanodine Receptor (RyR2)

gene mutations:Long term prognosis after initiation of optimal medical treatment.Heart

Rhythm2014(2014.05.06-11. San Francisco,Ca,U.S.A)

5. Sonoda K, Watanabe H, Nogami A, Ohkubo K, Makiyama T, Takehara N, Kawamura

Y,Hosaka Y, Sato M,Fukae S, Chinushi M, Oda H, Okabe M, Shimizu W, Kimura A, Maemura


K, Watanabe I, Kamakura S, Burashnikov E, Antzelevitch C, Horie M, Aizawa Y,Minamino

T, Makita N. Genotype-phenotype associations in early repolarization syndrome.Heart

Rhythm2014(2014.05.06-11. San Francisco,Ca,U.S.A)

6. Pedrazzini M, Itoh H, Crotti L, Aiba T, Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno

S, Makiyama T, Wu J, Hasegawa K, Mastantuono E, Dagradi F, Yamagishi M, Berthet M,

Shimizu W, Guicheney P, Schwartz PJ, Horie M. Genetics in acquired long QT syndrome.

ESHG 2014 (2014.5.31-6.3. Milano, Italy)

7. Toyota T, Shiomi H, Taniguchi T, Morimoto T, Kadota K, Ando K, Nakagawa Y, Furukawa Y,

Horie M, Kimura T. Clinical characteristics and long-term outcome of ST-segment elevation

myocardial infarction patients with multivessel disease: An appraisal of percutaneous

coronary intervention strategies. ESC CONGRESS 2014(2014.8.30-9.3. Barcelona, Spain)

8. Ashihara T, Haraguchi R, Kurokawa K, Nakazawa K, Horie M. Spiral wave behaviors and

antiarrhythmic drug efficacy in human induced pluripotent stem cell-derived myocardial

sheet are different from those in original heart: A simulation study. ESC CONGRESS

2014(2014.8.30-9.3. Barcelona, Spain)

9. Wijeyeratne Y, Probst V, Veltmann C, Shimizu W, Crotti L, Horie M, Mckeown P, Makita N,

Roden D, Behr ER. Ethnicity and phenotype in the SCN5A E1784K mutation. ESC

CONGRESS 2014(2014.8.30-9.3. Barcelona, Spain)

10. Hayano M, Makiyama T, Sasaki K, Yamamoto Y, Harita T, Nishiuchi S, Wuriyanghai Y, Ohno

S, Horie M, Kimura T. Cardiac sodium channel gene mutations associated with dilated

cardiomyopathy. ESC CONGRESS 2014(2014.8.30-9.3. Barcelona, Spain)

11. Wang Q, Ohno S, Fukuyama M, Sasaki K, Makiyama T, Horie M. A novel SCN4B intronic

variant identified in patients with Brugada syndrome and idiopathic ventricular fibrillation

caused an exon skipping. ESC CONGRESS 2014(2014.8.30-9.3. Barcelona, Spain)

12. Wuriyanghai Y, Makiyama T, Sasaki K, Yoshida Y, Ohno S, Watanabe K, Horie M, Kimura T.

Novel abnormal splicing variants identified in induced pluripotent stem cell-derived

cardiomyocytes from a long-QT syndrome patient with KCNQ1-A344A. ESC CONGRESS

2014(2014.8.30-9.3. Barcelona, Spain)

13. Ohno S, Fukuyama M, Itoh H, Makiyama T, Horie M. Identification of latent mutations in

primary inherited arrhythmia syndromes using benchtop next generation sequencer. ESC


14. Ohno S, Fukuyama M, Itoh H, Makiyama T, Horie M. High frequency of ANK2 mutations in

patients with non-genotyped primary inherited arrhythmia syndromes. ESC CONGRESS

2014(2014.8.30-9.3, Barcelona. Spain)

15. Fukuyama M, Ohno S, Makiyama T, Hasegawa K, Itoh H, Horie M. Identification of novel

SCN10A variants in Brugada syndrome patients. ESC CONGRESS 2014(2014.8.30-9.3.

Barcelona, Spain)

16. Nishiuchi S, Makiyama T, Sasaki K, Wuriyanghai Y, Yoshida Y, Ohno S, Aiba T, Shimizu W,

Horie M, Kimura T. Recepitulation of lamin A/C-related cardiomyopathy using patient-


specific induced pluripotent stem cells.a novel splicing mutation in LMNA gene. ESC


17. Nakatsuma K, Shiomi H, Watanabe H, Morimoto T, Taniguchi T, Toyota T, Furukawa Y,

Nakagawa Y, Horie M, Kimura T. Lack of association between living alone and long-term

mortality in patients with acute myocardial infarction undergoing percutaneous coronary

intervention. ESC CONGRESS 2014(2014.8.30-9.3. Barcelona, Spain)

18. Taniguchi T, Shiomi H, Toyota T, Makiyama T, Shizuta S, Morimoto T, Furukawa Y,

Nakagawa Y, Horie M, Kimura T. Association of pre-infarction angina and total ischemic time

with long-term survival in patients with ST-segment elevation myocardial infarction

undergoing primary percutaneous coronary intervention. ESC CONGRESS 2014(2014.8.30-

9.3. Barcelona, Spain)

19. Ohno S, Kawamura M, Hasegawa K, Horie M. Gender differences in the inheritance mode of

RYR2 mutations in catecholaminergic polymorphic ventricular tachycardia patients. ESC


20. Horie M.Genetic background of fatal arrhythmias. The 41st International Systemic

Functional Congress,ISFC 2014(2014.10.24-26. Dalian,China)

21. Kubo T, Ashihara T, Kadotsuji K, Katsura Y, Kobayashi A, Nomura N, Funabashi H, Horie

M. in silico assessment of cardiac safety of drugs using integrated computer model of failing

heart. The 14th Annual Meeting of Safety Pharmacology Society (2014.10.28-30. Washington

DC. U.S.A.)

22. Itoh H. Acquired long QT syndrome. 7th APHRS 2014(2014.10.29-11.1, New Delhi, India)

23. Horie M. Underlying genetics of the acquired LQTS Impact on management.7th APHRS

2014(2014.10.29-11.1. New Delhi, India)

24. Ohno S. ARVC:Sudden cardiac death risk assessment.7th APHRS 2014(2014.10.29-11.1.

New Delhi, India)

25. Ohno S. Which genetic tests: Single genes,panels or genomes?:Challenges of genetic testing

in inherited arrhythmia syndromes.7th APHRS 2014(2014.10.29-11.1. New Delhi, India)

26. Wang Q, Ohno S, Ding WG, Bai J, Makiyama T, Matsuura H, Horie M. Functional analysis

of a novel KCNH2 Mutation identified in Familial Short QT Syndrome. AHA Scientific

Sessions 2014(2014.11.15-19. Chicago, IL, U.S.A.)

27. Ozawa J, Ohno S, Itoh H, Makiyama T, Horie M. Young long QT syndrome patients with

KCNH2 mutations have late onset but severe symptoms. AHA Scientific Sessions

2014(2014.11.15-19. Chicago, IL, U.S.A.)

28. Kato K, Ohno S, Makiyama T, Horie M. LMNA Cardiomyopathy Mimicking Arrhythmogenic

Right Ventricular Cardiomyopathy. AHA Scientific Sessions 2014(2014.11.15-19. Chicago, IL,

U.S.A.)

29. Kimura H, Itoh H, Ohno S, Fukuyama M, Kato K, Ichikawa M, Fujii Y, Makiyama T, Horie

M. The Prognosis of Andersen-Tawil syndrome is not so benign as ever thought. AHA

Scientific Sessions 2014(2014.11.15-19. Chicago, IL, U.S.A.)


30. Yamamoto Y, Makiyama T, Sasaki K, Hayano M, Harita T, Nishiuchi S, Wuriyanghai Y, Chen

J, Kamakura T, Yoshida Y, Ohno S, Horie M, Kimura T. Electrophysiological Characteristics

and Transcriptional Profiles in Human Induced Pluripotent Stem Cell-Derived

Cardiomyocytes During a Long-Term Culture. AHA Scientific Sessions 2014(2014.11.15-19.

Chicago, IL, U.S.A.)

31. Nishiuchi S, Makiyama T, Sasaki K, Kohjitani Y, Wuriyanghai Y, Hayano M, Harita T,

Yamamoto Y, Kamakura T, Chen J, Ohno S, Yoshida Y, Doi T, Shizuta S, Aiba T, Shimizu W,

Horie M, Kimura T. Lamin A/C-Related Cardiomyopathy Specific Induced-Pluripotent Stem

Cells-Derived Cardiomyocytes Stressed by Adrenergic-Stimulation Recapitulate the Aging-

Related Phenotype in an Early Phase of Differentiation. AHA Scientific Sessions

2014(2014.11.15-19. Chicago, IL, U.S.A.)

32. Matsumoto T, Wada A, Fujii M, Taniguchi A, Mori K, Tamagawa Y, Isono T, Horie M. Next

Generation Sequencing of Cardiac Gene Expression Changes Associated With Heart Failure

in Chronic Inflammation Inhibition. AHA Scientific Sessions 2014(2014.11.15-19. Chicago,

IL, U.S.A.)

33. Katsuumi G et al. Efficacy of Bepridil to Prevent Ventricular Fibrillation in Serve Form of

Early Repolarization Syndrome. Internarional Research Symposium on Inherited

Arrhythmias 2014-Advances in Two Decades and Cutting Edge Technologies Towards the

Future- (2014.3.22. Tokyo)

34. Ohno S, et al. Genetic Analysis for Inherited Arrhythmias Using Benchtop Net Generation

SequencerInternarional Research Symposium on Inherited Arrhythmias 2014 (2014.3.22.

Tokyo)

35. Makiyama T. et al. Induced Pluripotent Stem Cells in the Study of Inherited

Arrhythmias.Internarional Research Symposium on Inherited Arrhythmias 2014 -Advances

in Two Decades and Cutting Edge Technologies Towards the Future- (2014.3.22. Tokyo)

2013

1. Ohno S, Hasegawa K, Makiyama T, Doi S, Horie M. Different regulation of IKS channels by

two KCNE 1 C- terminus variants predicts the QTc response to the exercise stress. The Heart

Rhythm Society's 34th Annual Scientific Sessions (2013.05.08-11. Denver, CO, U.S.A.)

2. Itoh H, Berthet M, Fressart V, Denjoy I , Maugenre S, Klug D, Mizusawa Y, Makiyama T,

Hofman N, Husemann A, Shimizu W, Wilde AA , Schulze-Bahr E, Horie M, du Montcel ST,

Guicheney P. Asymmetry of parental origin in Long QT syndrome. European Human

Genetics Conference (2013.06.08-11. Paris, France)

3. Ohno S, Omura M, Kawamura M, Kimura H, Itoh H, Makiyama T, Ushinohama H, Makita

N, Horie M. Exon-3 deletion of RyR2 encoding cardiac ryanodine receptor related to left

ventricular non-compaction (LVNC) with ventricular arrhythmia and bradycardia. EHRA

EUROPACE 2013 (2013.06.23- 26. Athens, Greece)

4. Itoh H. Underlying Mechanisms in Forme Fruste Long QT Syndrome Manifested by Acquired


Factors. The 2nd HD Physiology International Symposium (2013.6.28-29. Tokyo)

5. Harrell DT, Ashihara T, Tominaga I, Abe K, Sumitomo N, Uno K, Takano M, Makita N.

Electrophysiological characteristics and in-silico simulations of K channel mutations

responsible for short QT syndrome. The 2nd HD Physiology International Symposium:

Integrative Multi-level Systems Biology for In Silico Cardiology and Pharmacokinetics

(2013.6.28-29. Tokyo)

6. Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y. Proarrhythmic effects of

class-I antiarrhythmic agents enhanced by ischemia-induced subcellular remodeling of

sodium channels. The 2nd HD Physiology International Symposium: Integrative Multi-level

Systems Biology for In Silico Cardiology and Pharmacokinetics (2013.6.28-29. Tokyo)

7. Li M, Kanda Y, Ashihara T, Sekino Y, Furukawa T, Kurokawa J: Functional optimization of

commercially available human induced pluripotent stem cell-derived cardiomyocytes for

evaluation of drug-induced QT prolongation, (2013.6.28-29. Tokyo)

8. Haraguchi R, Ashihara T, Inada S, Ikeda T, Nakazawa K. Rotational anisotropy prevents

transition of tachycardia to fibrillation in ventricles under the large transmural dispersion of

repolarization. The 2nd HD Physiology International Symposium: Integrative Multi-level

Systems Biology for In Silico Cardiology and Pharmacokinetics (2013.6.28-29. Tokyo)

9. Inada S, Harrell DT, Haraguchi R, Ashihara T, Makita N, Nakazawa K. Reentrant beat in

the Purkinje network associated with gap junction mutation: A simulation study. The 2nd

HD Physiology International Symposium: Integrative Multi-level Systems Biology for In

Silico Cardiology and Pharmacokinetics (2013.6.28-29. Tokyo)

10. Inada S, Harrell DT, Ono T, Haraguchi R, Ashihara T, Dobrzynski H, Honjo H, Shibata N,

Ikeda T, Mitsui K, Kodama I, Boyett MR, Nakazawa K. Multi-scale simulation studies of

excitation conduction from the sinoatrial node to the ventricles in the heart. The 2nd HD

Physiology International Symposium: Integrative Multi-level Systems Biology for In Silico

Cardiology and Pharmacokinetics (2013.6.28-29. Tokyo)

11. Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y. Simulation of excitation

propagation in the novel brick-wall model of ventricular myocardium. 35th Annual

International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS)

in conjunction with 52nd Annual Conference of Japanese Society for Medical and Biological

Engineering (JSMBE) (2013.07.3-7. Osaka)

12. Haraguchi R, Ashihara T, Inada S, Ikeda T, Nakazawa K. Simulation studies of

tachyarrhythmias in a 3-D ventricular wall model: Implications for electrophysiological

heterogeneity and rotational anisotropy. 35th Annual International Conference of the IEEE

Engineering in Medicine and Biology Society (EMBS) in conjunction with 52nd Annual

Conference of Japanese Society for Medical and Biological Engineering (JSMBE) (2013.7.3-

07. Osaka)

13. Inada S, Ono T, Shibata N, Iwata M, Haraguchi R, Ashihara T, Mitsui K, Boyett MR.

Simulation study of complex action potential conduction in atrioventricular node. 35th


Annual International Conference of the IEEE Engineering in Medicine and Biology Society

(EMBS) in conjunction with 52nd Annual Conference of Japanese Society for Medical and

Biological Engineering (JSMBE) (2013.7.3-7. Osaka)

14. Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y. Ischemia-induced subcellular

remodeling of sodium channels as a mechanism of ventricular proarrhythmia by class-I

antiarrhythmic drug. The 37th International Congress of Physiological Sciences (IUPS 2013)

(2013.7.21-26. Birmingham, U.K.)

15. Ashihara T,Haraguchi R, Inaba S,Nakazawa K Ikeda T,Ozawa T,Ito M, Trayanova N,Horie

M. Functional properties of complex fractionated atrial electrograms during atrial fibrillation

can be explained by structural remodeling:A simulation study(2013.8.7-10. Glasgow, U.K.)

16. Inada S, Ono T, Shibata N, Iwata M, Haraguchi R, Ashihara T, Abe A, Ikeda T, Mitsui K,

Boyett MR, Dobrzynski H, Nakazawa K. Simulation study of ventricular rate control therapy

during atrial fibrillation using one-dimensional cable model with two conduction pathways.

The 40th International Congress on Electrocardiology (ICE) (2013.8.7-10. Glasgow, U.K.)

17. Fukuyama M, Wang Q, Kato K, Ohno S, Kimura H, Makiyama T, Itoh H, Ito M, Matsuura H,

Horie M. Novel CACNA1C mutations in Long QT syndrome patients- The subtype of Long

QT syndrome type 8. Denis Escande Symposium 2013(2013.8.30-31. Amsterdam, The

Netherlands)

18. Ohno S, Fukuyama M, Itoh H, Makiyama T, Horie M. Copy number variation in KCNQ1 gene

were frequently identified in the pediatric patients of long QT syndrome and caused exercise

related QT prolongation. ESC CONGRESS 2013(2013.8.31-9.4. Amsterdam, The

Netherlands)

19. Kokunai Y, Kino Y, Li M, Itoh H, Nakamori M, Kimura T, Matsumura T, Fujimura H, Nukina

N, Sakoda S, Horie M, Imoto K, Ishiura S, Swanson MS, Charlet-Berguerand N, Takahashi

MP. Altered splicing of cardiac sodium channel might be responsible for cardiac conduction

defects in myotonic dystrophy. the 9th International Myotonic Dystrophy

Consortium(2013.10.16-19. Basque, Spain)

20. Horie M. Genetic and Molecular Basis of ARVC. VT Workshop 2-ARVC Session. 6th APHRS

& CardioRhythm 2013(2013.10.3-6. Hong Kong, China)

21. Horie M. Genetic Testing in ARVC. Genetic and Inherited Syndrome 1-Update on Clinical

Applications of Genetic Testing. 6th APHRS & CardioRhythm 2013.(2013.10.3-6, Hong Kong,

China)

22. Ohno S, Wang Q, Hasegwas K, Itoh H, Makiyama T, Horie M. Phenotypic characterization of

three patients with lethal arrhythmia related to KCNH2-R148W missense mutation. 6th

APHRS & CardioRhythm 2013.(2013.10.3-6. Hong Kong, China)


transition of tachycardia to fibrillation in the ventricular wall model: a simulation study. 6th

APHRS & CardioRhythm 2013(2013.10.3-6, Hong Kong, China)

24. Hasegawa K, Watanabe H, Ohno S, Itoh H, Makiyama T, Ashihara T, Hayashi H, Horie M.


The high prevalence of early repolarization in genotyped long-standing persistent atrial

fibrillation. The 10th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS) in

conjunction with the Annual Meeting of the Japanese Heart Rhythm Society (JHRS)

2017(2017.9.14-17. Yokohama)

25. Hasegawa K, Watanabe H, Ohno S, Itoh H, Makiyama T, Ashihara T, Hayashi H, Horie M.

The high prevalence of early repolarization in genotyped long QT syndrome. American Heart

Association (AHA) 85th Scientific Sessions(2013.11.16-20. Dallas)

2012 年

1. Takada S, Hashiodani K, Fukumizu Y, Yamauchi H, Sakai H, Horie M. Automatic Detecting

Stenotic Murmur Method for Portable Medical System based on Time-domain PCA and EM

Algorithm. 2012 RISP International Workshop on Nonlinear Circuits, Communications and

Signal Processing (2012.3.4-06. Hawaii, U.S.A.)

2. Ashihara T, Haraguchi R, Inada S, Nakazawa K, Ikeda T, Ozawa T, Ito M, Horie M,

Trayanova N: Theoretical basis of optimal strategy for CFAE-targeted ablation during

chronic atrial fibrillation. The Heart Rhythm Society's 33rd Annual Scientific Sessions

(2012.5.9-12. Boston, MA, U.S.A.)

3. Makita N, Makiyama T, Seki A, Nogami A, Ohkubo K, Watanabe I, Shimizu W, Watanabe H,

Sumitomo N, Horie M, Delmar M. Clinical features and genetic basis of 63 patients with

progressive cardiac conduction defect. The Heart Rhythm Society's 33rd Annual Scientific

Sessions (2012.5.9-12. Boston, MA, U.S.A.)

4. Kimura H, Ohno S, Itoh H, Kawamura M, Naiki N, Wang Q, Makiyama T, Ito M, Horie M.

KCNJ2-R218Q/W is a hot spot with strong phenotype in Andersen-tawil syndrome. The

Heart Rhythm Society's 33rd Annual Scientific Sessions (2012.5.9-12. Boston, MA, U.S.A.)

5. Hisamatsu T, Miura K, Ohkubo T, Okuda N, Murakami Y, Miyagawa N, Horie M, Okamura

T, Okayama A, Ueshima H. Effect modification of dietary n-3 fatty acids on cardiovascular

mortality risk by resting heart rate in japanese general population: NIPPON DATA80. ESC

CONGRESS 2012 (2012.8.25-29. Munich, Germany)

6. FukuyamaM, Ohno S, Wang Q, Kimura H, Miyamoto A, Makiyama T, Itoh H, Itoh M, Horie

M. Novel CACNA1C mutations identified in Japanese patients caused both Brugada

syndrome and Idiopathic Ventricular Fibrillation without QT shortening. ESC CONGRESS

2012 (2012.8.25-29. Munich, Germany)

7. Horie M. Hypertension and atrial fibrillation involvement of RAS, role of candesartan - The

1st International Forum of Wuhan Geriatrics Society 2012 (2012.09.22, 2012 Wuhan, China)

8. Horie M. Inherited arrhythmia in Asia. The 5th Asia-Pacific Heart Rhythm Society Scientific

Session (APHRS) in conjunction with The 8th Asia-Pacific Atrial Fibrillation Symposium

(APAFS) (2012.10.3-6. Taipei, Taiwan)

9. Ashihara T. Application of biological simulations to the studies of ventricular defibrillation.

The 5th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS) in conjunction with


The 8th Asia-Pacific Atrial Fibrillation Symposium (APAFS) (2012.10.3-6. Taipei, Taiwan)

10. Ashihara T. Mechanisms of CFAE-targeted ablation for chronic AF: A simulation study. The

5th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS) in conjunction with The

8th Asia-Pacific Atrial Fibrillation Symposium (APAFS) (2012.10.3-06. Taipei, Taiwan)

11. Sasaki K, Makiyama T, Wuryanghai Y, Chen J, Kamakura T, Kimura T, Yoshida Y, Yamanaka

S, Ohno S, Horie M. One year assessment of ion channel gene expression in cardiomyocytes

derived from human induced pluripotent stem cells. The 5th Asia-Pacific Heart Rhythm

Society Scientific Session (APHRS) in conjunction with The 8th Asia-Pacific Atrial

Fibrillation Symposium (APAFS) (2012.10.3-6 Taipei, Taiwan)

12. Horie M. Acquired long QT syndrome. The 5th Asia-Pacific Heart Rhythm Society Scientific


(APAFS) (2012.10.3-6. Taipei, Taiwan)

13. Ohno S, Nishio Y, Nagaoka I, Fukuyama M, Kimura H, Itoh H, Makiyama T, Shimizu A,

Horie M. Age dependent clinical and genetic characteristics in Japanese patients with

arrhythmogenic right ventricular cardiomyopathy/dysplasia. The 5th Asia-Pacific Heart

Rhythm Society Scientific Session (APHRS) in conjunction with The 8th Asia-Pacific Atrial

Fibrillation Symposium (APAFS) (2012.10.3-6. Taipei, Taiwan)

14. Wang Q, Ohno S, Miyamoto A, Ding WG, Wu J, Kimura H, Itoh H, Makiyama T, Matsuura

H, Horie M. Functional analysis of novel KCNH2. The 5th Asia-Pacific Heart Rhythm Society

Scientific Session (APHRS) in conjunction with The 8th Asia-Pacific Atrial Fibrillation

Symposium (APAFS) (2012.10.3-6. Taipei, Taiwan)

15. Kawamura M, Ohno S, Naiki N, Nagaoka I, Dohchi K, Kimura H, Hasegawa K, Wang Q, Itoh

H, Makiyama T, Horie M. Mutations identified in Brugada syndrome patients with or without

ventricular fibrillation. The 5th Asia-Pacific Heart Rhythm Society Scientific Session

(APHRS) in conjunction with The 8th Asia-Pacific Atrial Fibrillation Symposium (APAFS)

(2012.10.3-6. Taipei, Taiwan)

16. Ito M, Ozawa T, Nakazawa Y, Sugimoto Y, Itoh H, Ashihara T, Dochi K, Kato K, Horie M.

Genetic background of catecholaminergic polymorphic ventricular tachycardia in Japan

CHA2DS2-VASc score and left atrial size are important to predict recurrence of atrial

fibrillation after pulmonary vein isolation: usefulness of event ECG home monitoring. The

5th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS) in conjunction with The

8th Asia-Pacific Atrial Fibrillation Symposium (APAFS) (2012.10.3-6. Taipei, Taiwan)


transition of tachycardia to fibrillation in ventricles under the large transmural dispersion of

repolarization. The 5th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS) in

conjunction with The 8th Asia-Pacific Atrial Fibrillation Symposium (APAFS) (2012.10.3-6.

Taipei, Taiwan)

18. Hasegawa K, Ohno S, Itoh H, Makiyama T, Horie M. A Rare KCNE1 Polymorphism, D85N,

is a Genetic Modifier in Congenital Long QT Syndrome. The 5th Asia-Pacific Heart Rhythm


Society Scientific Session (APHRS) in conjunction with The 8th Asia-Pacific Atrial


19. Makiyama T, Sasaki K, Kamakura T, Shizuta S, Cheng J, Wuriyanghai Y, Ohno S, Itoh H,

Horie M, Kimura T. Genotype-Phenotype Relationships in Patients with Familial

Bradyarrhythmias; SCN5A Versus LMNA Gene Mutations. The 5th Asia-Pacific Heart

Rhythm Society Scientific Session (APHRS) in conjunction with The 8th Asia-Pacific Atrial


20. Fukuyama M, Ohno S, Wang Q, Kimura H, Itoh H, Makiyama T, Ito M, Horie M. CACNA1C

Mutations in Japanese Patients with Brugada Syndrome or Idiopathic Ventricular

Fibrillation. The 5th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS) in


Taipei, Taiwan)

21. Fumimoto T, Fukuda M, Katoh T, Shimizu A, Ueyama T, Yoshiga Y, Masahiro Doi, Matuzaki

M, Ohno S, Horie M. The Smaller R/S Ratio in Lead I is Characteristic of Arrhythmogenic

Right Ventricular Cardiomyopathy/Dysplasia in Patients having Desmosomal Gene

Mutations. The 5th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS) in


Taipei, Taiwan)

22. Kamakura T, Makiyama T, Wuriyanghai Y, Chen J, Sasaki K, Shizuta S, Hasegawa K, Ohno

S, Horie M, Kimura T. Genetic Backgrounds in Patients with Early-Onset and Familial Atrial

Fibrillation. The 5th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS) in


Taipei, Taiwan)

23. Ashihara T, Haraguchi R, Nakazawa K, Ikeda T, Ozawa T, Ito M, Horie M, Trayanova N,

Hopkins J. Functional Properties of Complex Fractionated Atrial Electrograms During Atrial

Fibrillation Can be Explained by Structural Remodeling: A Computational Study. AHA

Scientific Sessions 2012(2012.11.3-7. Los Angeles, California,U.S.A.)

24. Aiba T, Toyoda F, Makita N, Matsuura H, Makimoto H, Yamagata K, Horie M, Fukushima N,

Ogawa S, Aizawa Y, Ohe T, Kusano KF, Yamagishi M, Tanaka T, Makiyama T, Yoshinaga M,

Hagiwara N, Sumitomo N, Kamakura S, Shimizu W. Biophysical Properties of Na Channel

in the S5-S6 High Risk LQT3 Mutations of the Long QT Syndrome. AHA Scientific Sessions

2012(2012.11.3-7. Los Angeles, California,U.S.A.)

25. Yagihara N, Watanabe H, Atack TC, Ohno S, Shimizu W, Chatel S, Koopmann TT, Ping Yang,

Marylyn D Ritchie, Turner S, Hasegawa K, Wakasugi M, Onodera O, Kuwano R, Duboscq-

Bidot L, Horie M, Schott JJ, Takayama M, Nakano Y, Bezzina CR, Wilde AA.M., Momotsu T,

Endo N, Darbar D, Roden DM, Makita N. Arrhythmia-associated variants in the SCN5A

promoter and regulatory regions. AHA Scientific Sessions 2012(2012.11.3-7. Los Angeles,

California,U.S.A.)

26. Yamada Y, Sakaguchi T, Nakajima I, Miyamoto K, Okamura H, Noda T, Satomi K, Aiba T,


Anzai T, Ishihara M, Yasuda S, Ogawa H, Kamakura S, Horie M, Shimizu W. Different

response to exercise testing between Andersen-Tawil syndrome and catecholaminergic

polymorphic ventricular tachycardia. AHA Scientific Sessions 2012(2012.11.3-7. Los Angeles,

California,U.S.A.)

27. Kawaguchi T, Hayashi H, Miyamoto A, Yoshino T, Naiki N, Taniguchi A, Sugimoto Y, Itoh M,

Murakami Y, Horie M. Prognostic significance of temporal increase in QRS duration and

morphological development of QRS complex. AHA Scientific Sessions 2012(2012.11.3-7. Los

Angeles, California,U.S.A.)

28. Hasegawa K, Ohno S, Itoh H, Hattori T, Makiyama T, Toyoda F, Ding WG, Chinushi M,

Matsuura H, Horie M. Novel KCNQ1 missense mutation associated with juvenile-onset atrial

fibrillation. AHA Scientific Sessions 2012(2012.11.3-7. Los Angeles, California,U.S.A.)

29. Watanabe H, Werf Cvd, Roses-Noguer F, Viskin S, Sumitomo N, Veltmann C, Rosso R,

Bhuiyan Z, Till J, Kannankeril P, Horie M, Knollmann B, Wilde A. Effects of flecainide on

exercise-induced arrhythmias and recurrences in genotype-negative patients with

catecholaminergic polymorphic ventricular tachycardia. AHA Scientific Sessions 2012．

(2012.11.3-7. Los Angeles, California,U.S.A.)

30. Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y: Roles of subcellular sodium

channel distribution in the mechanism of cardiac conduction. The 1st HD Physiology

International Symposium: Integrative Multi-level Systems Biology for In Silico Cardiology

and Pharmacokinetics(2012.1.20-21. Tokyo)

31. Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y: Phase-2 reentry associated

with subcellular sodium channel remodeling: A possible mechanism of fibrillation induction

in brugada syndrome. The 1st HD Physiology International Symposium: Integrative Multi-

level Systems Biology for In Silico Cardiology and Pharmacokinetics(2012.1.20-21. Tokyo)

32. Inada S, Ashihara T, Haraguchi R, Arafune T, Sakuma I, Yamazaki M, Honjo H, Kodama I,

Nakazawa K. Epicardial cooling increases opportunity of spiral wave termination. a

simulation study. The 34th Annual Congress of the European Society of Cardiology (ESC

Congress 2012)(2012.8.25-29. Munich)

2011 年

1. Horie M. Molecular genetics of ARVC. Cardiorhythm 2011 (2011.2.25-27. Hong Kong, China)

2. Hisamatsu T, Miura K, Ohkubo T, Miyagawa N, Fujiyoshi A, Takashima N, Kadota A, Okuda

N, Murakami Y, Horie M, Okamura T, Okayama A, Ueshima H. Interaction of Dietary n-3

Fatty Acids on Cardiac Risk by J-point elevation in Japanese Men: NIPPON DATA80. AHA

Epidemiology & Prevention and Nutrition, Physical Activity & Metabolism 2012 (2012.5.13-

16. San Diego, California, U.S.A.)

3. Horie M. Genetics and Molecular mechanisms of ventricular tachyarrhythmia. Taiwan

Society of Cardiology -2011Annual Meeting (2011.5.14-15. Taipei Taiwan)

4. Horie M. Challenging ECG of sudden cardiac death. Taiwan Society of Cardiology -


2011Annual Meeting (2011.5.14-15. Taipei, Taiwan)

5. Kimura H, Zhou J, Itoh H., Mizusawa Y, Miyamoto A, Kawamura M, Makiyama T, Ito M,

Matsuura H, Horie M. Phenotype variability in patients carrying KCNJ2 mutations. ESC

Congress 2011 (2011.8.27-31. Paris, France)

6. Sakai H, Kawahara C, Fujii M, Yamaji M, Ohnishi M, Matsumoto T, Wada A, Horie M. Effects

of aliskiren on Left ventricular remodeling in patients with dilated cardiomyopathy. ESC

Congress 2011 (2011.8.27-31. Paris, France)

7. Tsutamoto T, Sakai H, Kawahara C, Fujii M, Yamaji M, Ohnishi M, Matsumoto T, Wada A,

Yamamoto T, Horie M. Sitagliptin, a dipeptidyl peptidase-4 inhibitor, increases bioactive BNP

level with the improvement of left ventricular mass index in patients with chronic heart

failure.ESC Congress 2011 (2011.8.27-31. Paris, France)

8. Hattori T, Makiyama T, Akao M, Ehara E, Ohno S, Iguchi M, Sasaki K, Itoh H, Horie M,

Kimura T. Over-expression of heterozygous KCNJ2-M301K channels, identified in a patient

with short QT syndrome, shortened action potential durations in neonatal rat ventricular

myocytes. ESC Congress 2011 (2011.8.27-31. Paris, France)

9. Ashihara T: Overview: Recent progress of the computer simulation and computed ECG.

(APHRS2011 & 26th JHRS 28th JSE 合同学会)(2011.9.18-22. 福岡)

10. Horie M, Ohno S, Wu J, Zankov DP, Toyoda F, Ding WG, Matsuura H: Mutations of KCNE

gene family in inherited arrhythmia syndromes. Special Symposium(APHRS2011 & 26th

JHRS 28th JSE 合同学会(2011.9.18-22. 福岡)

11. Horie M, Itoh H, Shimizu W, Hayashi K, Ohno S, Makiyama T, Yamagishi M, Kamakura S:

Long QT Syndromes are heterogeneous disease entities presenting not only QT prolongation

but multiple phenotypes - Cases with compound heterozygous mutations. JHRS-JSE Joint

Symposium(APHRS2011 & 26th JHRS 28th JSE 合同学会)(2011.9.18-22. 福岡)

12. Horie M: Renin-Angiotensin-Aldosterone system and atrial fibrillation. Evening Seminar 1


13. Makimoto H, Horie M, Ogawa S, Aizawa Y, Ohe T, Yamgagishi M, Makita N, Makiyama T,

Aiba T, Kamakura S, Miyamoto Y, Shimizu W. Clinical and genetic features of japanese

patient with congenital long QT syndrome. JHRS-JSE Joint Symposium(APHRS2011 & 26th

JHRS 28th JSE 合同学会)(2011.9.18-22. 福岡)

14. Wu J, Naiki N, Ding WG, Matsuura H, Horie M. A weak dominant negative mutation of

KCNQ1-G269S affects PKA-Mediated up-regulation of IKs channels and causes adrenergic

triggered long QT syndrome. Mini-Symposium(APHRS2011 & 26th JHRS 28th JSE 合同学

会)(2011.9.18-22. 福岡)

15. Naiki N, Hayashi H, Miyamoto A, Sugimoto Y, Ito M, Horie M. Prognostic significance of J

wave in patients who underwent device therapy for ventricular defibrillation. Mini-

Symposium (APHRS2011 & 26th JHRS 28th JSE 合同学会)(2011.9.18-22. 福岡)

16. Nakazawa Y, Ashihara T, Miyamoto A, Ozawa T, Sugimoto Y, Ito M, Horie M. Importance of

long-term follow-up after pulmonary vein isolation: A study using event-ECG monitors. Mini-



17. Ozawa T, Ito M, Nakazawa Y, Ashihara T, Miyamoto A, Sugimoto Y, Yao T, Horie M:

Ventricular fibrillation triggered during radiofrequency energy delivery for verapamil-

sensitive idiopathic left ventricular tachycardia. Mini-Symposium(APHRS2011 & 26th JHRS

28th JSE 合同学会)(2011.9.18-22. 福岡)

18. Makita N, Makiyama T, Nogami A, Watanabe H, Seki A, Sumitomo N, Shimizu W, Horie M.

Clinical features and genetic basis of progressive cardiac conduction defect: Japanese PCCD

registry. JHRS-JSE Joint Symposium(APHRS2011 & 26th JHRS 28th JSE 合同学

会)(2011.9.18-22. 福岡)

19. Ashihara T, Haraguchi R, Inada S, Nakazawa K, Ozawa T, Nakazawa Y, Ito M, Horie M,

Trayanova N. Mechanisms of complex fractionated electrogram-targeted ablation in a model

for chronic atrial fibrillation. Mini-Symposium(APHRS2011 & 26th JHRS 28th JSE 合同学

会)(2011.9.18-22. 福岡)

20. Wang Q, Ohno S, Makiyama T, Kimura H, Naiki N, Kawamura M, Kato K, Horie M.

Mutation analysis of the KCNJ8 gene in Japanese patients with J-wave syndrome and

idiopathic ventricular fibrillation. Mini-Symposium(APHRS2011 & 26th JHRS 28th JSE 合

同学会)(2011.9.18-22. 福岡)

21. Nakashima T, Ohkusa T, Yoshida M, Yamada J, Okamura T, Ueyama T, Miura T, Shimizu A,

Horie M, Matsuzaki M. New diagnostic test for arrhythmogenic right ventricular

cardiomyopathy. Mini-Symposium(APHRS2011 & 26th JHRS 28th JSE 合同学会)(2011.9.18-

22. 福岡)

22. Taniguchi A, Hayashi H, Miyamoto A, Yoshino T, Kawaguchi T, Naiki N, Nakae I, Matsumoto

T, Horie M: Relationship between nonspecific electrocardiographic abnormalities and left

ventricular performance in coronary atherosclerosis. Poster Session(APHRS2011 & 26th


23. Yoshino T, Hayashi H, Miyamoto A, Taniguchi A, Kawaguchi T, Naiki N, Sugimoto Y, Ito M,

Horie M. Biphasic P wave in lead II is a novel electrophysiologic marker for atrial fibrillation.

Poster Session (APHRS2011 & 26th JHRS 28th JSE 合同学会)(2011.9.18-22. 福岡)

24. Kawamura M, Nagaoka I, Kenichi, Nishio Y, Itoh H, Kimura H, Miyamoto A, Mizusawa Y,

Jito Y, Ishida K, Ito M, Makiyama T, Ohno S, Sumitomo N, Oyama K, Horie M. Mutations of

the cardiac ryanodine Recepter (RyR2) gene in catecholaminergic polymorphic ventricular

tachycardia. (APHRS2011 & 26th JHRS 28th JSE 合同学会)(2011.9.18-22. 福岡)

25. Ozawa T, Ito M, Itoh H, Nakazawa Y, Sugimoto Y, Yao T, Miyamoto A, Ashihara T, Horie M.

Site-specific arrhythmogenesis in structurally normal heart of non-brugada patients with

ventricular arrhythmias originating from ventricular outflow tract. Mini-


26. Sumitomo N, Shimizu W, Horigome H, Nakamura Y, Arakaki Y, Sakurada H, Watanabe H,

Nishizaki H, Kamakura S, Horie M, Hiraoka M. Recent advancement of treatment in

catecholaminergic polymorphic ventricular tachycardia. Mini-Symposium(APHRS2011 &


26th JHRS 28th JSE 合同学会)(2011.9.18-22. 福岡)

27. Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, Igawa O, Nakai A, Higaki K,

Toyoda F, Wu J, Horie M, Matsuura H, Yoshida A, Shirayoshi Y, Hiraoka M, Hisatome I.

Reciprocal control of hERG stability by hsp70 and hsc70 with implication for restoration of

LQT2 mutant stability. JSE Academic Award Competition (APHRS2011 & 26th JHRS 28th

JSE 合同学会)(2011.9.18-22. 福岡)

28. Ohno S, Zankov DP, Ding WG, Itoh H, Makiyama T, Doi T, Shizuta S, Hattori T, Miyamoto

A, Naiki N, Matsuura H, Horie M. KCNE5 variants are novel modulators of brugada

syndrome and idiopathic ventricular fibrillation. Young Investigator Award Competition


29. Horie M, Ohno S, Wu J, Zankov DP, Toyoda F, Ding WG, Matsuura H. Mutations of KCNE

gene family in inherited arrhythmia syndromes. Special Symposium (APHRS2011 & 26th


30. Horie M, Itoh H, Shimizu W, Hayashi K, Ohno S, Makiyama T, Yamagishi M, Kamakura S.

Long QT syndromes are heterogeneous disease entities presenting not only QT prolongation

but multiple phenotypes - cases with compound heterozygous mutations. JHRS-JSE Joint

Symposium (APHRS2011 & 26th JHRS 28th JSE 合同学会)(2011.9.18-22. 福岡)

31. Horie M. Renin-Angiotensin-Aldosterone system and atrial fibrillation. Evening Seminar 1


32. Watanabe H, Nogami A, Ohkubo K, Makiyama T, Hayashi, Shimada T, Nagao S, Yagihara N,

Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M,

Oda H, Okabe M, Maemura K, Horie M, Watanabe I, Aizawa Y, Makita N. Clinical,

electrocardiographic, and genetic characteristics of patients with idiopathic ventricular

fibrillation associated with early repolarization. AHA Scientific Sessions 2011(2011.11.12-16.

Orlando, Florida, U.S.A.)

33. Ohno S, Miyamoto A, T Makiyama, Itoh H, Horie M. Clinical differences between KCNH2

and SCN5A mutation carriers with Brugada syndrome and Brugada-like ECG patients in

Japan. AHA Scientific Sessions 2011(2011.11.12-16. Orlando, Florida, U.S.A.)

34. Horie M. Short QT and Early Repolarization Syndromes. ICPES 2011 (2011.12.11-14. Ahens,

Greece)

35. Horie M. Basic characteristics of Brugada syndrome in Japan. ICPES 2011 (2011.12.11-14.

Athens, Greece)

36. Ohno S, Nishio Y, Nagaoka I, Miyamoto A, Kimura H, Itoh H, Makiyama T, Horie M. Clinical

and genetic characterization of Japanese patients with arrhythmogenic right ventricular

cardiomyopathy. ICPES 2011 (2011.12.11-14. Athens, Greece)

37. Inada S, Ashihara T, Haraguchi R, Iwata M, Nakazawa K. Stability of ventricular fibrillation

is altered by wall deformation after the onset of fibrillation. Stability of ventricular

fibrillation is altered by wall deformation after the onset of fibrillation. The 4th Asia-Pacific

Heart Rhythm Society Scientific Session (APHRS) in conjunction with The 7th Asia-Pacific


Atrial Fibrillation Symposium (APAFS) / 26th Annual Scientific Session of the Japanese

Heart Rhythm Society (JHRS) / 28th Annual Scientific Session of the Japanese Society of

Electrocardiology (JSE)(2011.9.18-22. Fukuoka)

38. Haraguchi R, Ashihara T, Tsumoto K, Inada S, Nakazawa K. Rotational anisotropy prevents

transition of tachycardia to fibrillation in the ventricular wall model with large transmural

dispersion of repolarization: A simulation study. The 4th Asia-Pacific Heart Rhythm Society

Scientific Session (APHRS) in conjunction with The 7th Asia-Pacific Atrial Fibrillation

Symposium (APAFS) / 26th Annual Scientific Session of the Japanese Heart Rhythm Society

(JHRS) / 28th Annual Scientific Session of the Japanese Society of Electrocardiology

(JSE)(2011.9.18-22. Fukuoka)

39. Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y. Effects of subcellular sodium

channel distribution on the initiation of phase-2 reentry: A possible mechanism of fibrillation

induction in Brugada syndrome. The 4th Asia-Pacific Heart Rhythm Society Scientific


(APAFS) / 26th Annual Scientific Session of the Japanese Heart Rhythm Society (JHRS) /

28th Annual Scientific Session of the Japanese Society of Electrocardiology (JSE)(2011.9.18-

22. Fukuoka)

40. Zhu B, Iwata M, Haraguchi R, Ashihara T, Umetani N, Igarashi T, Nakazawa K. Sketch-

based dynamic illustration of fluid systems. The 4th ACM SIGGRAPH Conference and

Exhibition on Computer Graphics and Interactive Techniques in Asia (SIGGRAPH ASIA

2011)(2011.12.12-15. Hong Kong)

41. Ijiri T, Ashihara T, Umetani N, Igarashi T, Haraguchi R, Yokota H, Nakazawa K. An effcient,

robust framework for simulating the brating heart. 23rd Conference of the Society for Medical

Innovation and Technology (SMIT2011)(2011.11.13-16. Israel)

2010 年

1. Ashihara T, Haraguchi R, Nakazawa K, Namba T, Ikeda T, Nakazawa Y, Itoh H, Sugimoto Y,

Ito M, Horie M. Roles of fibroblasts in the mechanism of complex fractionated atrial

electrograms during chronic atrial fibrillation. Heart Rhythm Society Meeting 2010

(2010.5.11-15. Denver, U.S.A.)

2. Turker I, Chang PC, Li H, Kim JJ, Brugada R, Brugada P, Brugada J, Makiyama T, Ueyama

T, Shimizu W, Shimizu A, Horie M, Ackerman MJ., Ai T, Vatta M. A telethonin mutation

R154C attenuates hNav1.5 in Brugada syndrome. Heart Rhythm Society Meeting 2010

(2011.5.11-15. Denver, U.S.A )

3. Miyamoto A, Hayashi H, Ishida K, Yoshino T, Sugimoto Y, Ito M, Horie M. P pulmonale and

atrial fibrillation. ISHR2010 (2010.5.13-16. Kyoto)

4. Matsumoto T, Nakae I, Hayashi H, Takashima H, Horie M. Impact of oxidized low-density

lipoprotein on coronary microvascular endothelial function. ISHR2010 (2010.5.13-16. Kyoto)

5. Yamaji M, Takayoshi Tsutamoto T, Kawahara C, Nishiyama K, Yamamoto T, Fujii M, Horie


M. Effect of eplerenone versus spironolactone on cortisol and hemoglobin A1c levels in

patients with chronic heart failure. ISHR2010 (2010.5.13-16. Kyoto)

6. Fujii M, Tsutamoto T, Kawahara C, Nishiyama K, Yamaji M, Yamamoto T, Horie M.

Prognostic role of highly sensitive cardiac troponin I in patients with systolic heart failure.

ISHR2010 (2010.5.13-16. Kyoto)

7. Wada A, Matsumoto A, Ohnishi M, Takayama T, Tsutamoto T, Horie M: Chymase inhibition

suppresses excessive oxidative stress through NADPH oxidase and improves cardiac

dysfunction in heart failure. ISHR2010 (2010.5.13-16. Kyoto)

8. Yoshino T, Hayashi H, Nakae I, Miyamoto A, Ishida K, Matsumoto T, Horie M. Adenosine

attenuates the appearance of myocardial ischemia-induced J wave. ISHR2010 (2010.5.13-16.

Kyoto)

9. Hayashi H, Miyamoto A, Ishida K, Yoshino T, Sugimoto Y, Ito M, Horie M. J wave and

intrathoracic tumor. ISHR2010 (2010.5.13-16. Kyoto)

10. Itoh H, Shimizu W, Hayashi K, Yamagata K, Sakaguchi T, Makiyama T, Miyamoto Y,

Yamagishi Y, Kamakura S, Horie M; Long QT syndrome with compound mutation is

associated with a severer phenotype: a Japanese multicenter study. ESC Congress 2010

(2010.8.27- 9.1. Stockholm, Sweden)

11. Horie M: Electrical Cardiomyopathy: Ion Channel Diseases. CJCF2010 (2010.10.15-16.

Beijing, China)

12. Nakazawa Y, Ashihara T, Miyamoto A, Ozawa T, Itoh H, Sugimoto Y, Ito M, Horie M.

Influence of pulmonary vein isolation on heart rate. A clinical study using event-ECG

monitors. APHRS2010/APAFS2010 (2010.10.28-30. Jeju Island, Korea)

13. Ashihara T, Haraguchi R, Nakazawa K, Namba T, Ikeda T, Nakazawa Y, Ozawa T, Itoh H,

Ito M, Horie M. Roles of fibroblasts in the mechanisms of complex fractionated atrial

electrograms and catheter ablation during chronic atrial

fibrillation.APHRS2010/APAFS2010 (2010.10.28-30. Jeju Island, Korea)

14. Horie M. Genetic Background of Japanese Patients with Long QT Syndrome.

APHRS2010/APAFS2010 (2010.10.28-30. Jeju Island, Korea)

15. Itoh H, Oka Y, Ding WG, Sakaguchi T, Kimura H, Mizusawa Y, Miyamoto A, Wu J, Ohno S,

Makiyama T, Ito M, Matsuura H, Horie M. Latent genetic backgrounds and molecular

pathogenesis inacquired long QT syndrome with distinct arrhythmic triggers. AHA Scientific

Sessions 2010(2010.11.14-17. Chicago Illinois U.S.A.)

16. Kimura H, Itoh H, Mizusawa Y, Miyamoto A, Oka Y, Kawamura M, Nishio Y, Sakaguchi T,

Makiyama T, Ito M, Horie M. Carvedilol, an α1- and Non-selective β-adrenoceptor Blocker,

for Prevention of Cardiac Events in Patients with Type 2 Long QT Syndrome. AHA Scientific

Sessions 2010(2010.11.14-17. Chicago Illinois U.S.A.)

17. Namba T, Todo T, Ashihara T, Haraguchi R, Nakazawa K, Ikeda T, Ohe T. Waveform

similarity between unipolar and bipolar electrical potential at QRS complex and P wave in

precordial leads of electrocardiogram. The 3rd Asia-Pacific Heart Rhythm Society Scientific



(APAFS)(2010.10.27-30. Jeju Island)

2009 年

1. Ohno S, Tsuji K, Makiyama T, Nishio Y, Akao M, Kita T , Horie M. Multiple mechanisms

underlie long QT syndrome by the change of amino acid R259 in the intracellular S4-S5 linker

of KCNQ1．Cardiorhythm2009（2009.2.20-22. Hong Kong）

2. Zankov DP: Negative regulation of LQT2-associated Kv11.1 mutant channels by alpha(1A)-

adrenoceptors in mammalian cell line．Biophysical Society 53rd Annual Meeting（2009.2.28-

3.4. Boston, U.S.A.）

3. Ito M. Validation of AF Ablations Efficiency. The 17th asian pacific congress of cardiology.

(2009.5.20-23. Kyoto).

4. Nishiyama K, Tsutamoto T, Yamaji M, Kawahara C, Fujii M, Yamamoto T, Horie M.

Comparison of BNP and Nt-proBNP based on the prognostic value for stable outpatients with

nonischemic chronic heart failure. The 17th asian pacific congress of cardiology (2009.5.20-

23. Kyoto).

5. Yamaji M, Tsutamoto T, Kawahara C, Nishiyama K, Yamamoto T, Fujii M, Horie M. Serum

cortisol as a cardiac event predictor of patients with chronic heart failure - Comparison with

aldosterone and ACTH. The 17th asian pacific congress of cardiology. (2009.5.20-23. Kyoto)

6. Kawahara C, Tsutamoto T, Yamaji M, Nishiyama K, Yamamoto T, Fujii M, Horie M.

Relationship between renal function and serum cardiac troponin T in patients with chronic

heart failure. The 17th asian pacific congress of cardiology(2009.5.20-23. Kyoto)

7. Horie M. Overlap syndromes in inherited arrhythmia disorders. ISHNE 2009(2009.6.4-6.

横浜)

8. Ito M. Evaluation of atrial fibrillation recurrence after PV isolation. Impact of event ECG

recorder. ISHNE 2009(2009.6.4-6. 横浜)

9. Hayashi H. Early repolarization in a hospital-based population: The prevalence and QT

interval in relation to age. ISHNE 2009(2009.6.4-6. 横浜).

10. Ashihara T, Yao T, Haraguchi R, Nakazawa K, Namba T, Ikeda T, Ito M, Horie M. Steep

restitution slope is not an essential factor for microvolt-level T-wave alternans:.Insights from

computer simulations. The 13th Congress of the International Society for Holter and

Noninvasive Electrocardiology (ISHNE)(2009.6.4-6. Yokohama)

11. Yao T. At-Home AED. An alternative strategy for patients with sudden cardiac death and the

risk of ICD implantation. ISHNE 2009(2009.6.4-6. 横浜).

12. Ishida K. Prognostic value of early repolarization in short QT syndrome. ISHNE

2009(2009.6.4-6. 横浜)

13. Matsumoto T, Nakae I, Yamane T, Takashima H, Horie M：Inhibition of Angiotensin-

Converting Enzyme Augments Coronary Tissue Plasminogen Activator Release in

hypertensive women. European Society of Cardiology Congress 2009(2009.8.29-9.2.


Barcelona,Spain)

14. Horie M. Structure-function relationships of K channels. 2nd Asia pacific heart rhythm

society science session(APHRS2009) (2009.10.22-25. Beijin,China)

15. Nishiyama K，Tsutamoto T，Kawahara C，Yamaji M，Tanaka T，Yamamoto T，Fujii M，

Horie M． Long-term Effect of Efonidipine Therapy on Plasma Aldosterone and Left

Ventricular Mass Index in Patients with Essential Hypertension. AHA Scientific Sessions

2009(2009.11.14-18. Orlando, Florida, U.S.A.)

16. Matsumoto T, Wada A, Ohnishi M, Takayama T, Dohke T, Yamamoto T, M Fujii, Tsutamoto

T, Horie M. Cardiac Mast Cell Stabilization Prevents the Progression of Cardiac Remodeling

17. AHA Scientific Sessions 2009(2009.11.14-18. Orlando, Florida, U.S.A.)

18. Yamagata K, Horie M, Ogawa S, Aizawa Y, Kusano K F, Ohe T, Yamagishi M, Makita N,

Tanaka T, Makiyama T, Akao M, Hagiwara N, Kishi Y, Yamada Y, Okamura H, Noda T,

Satomi K, Suyama K, Aihara N, Miyamoto Y, Kamakura S, Shimizu W. Clinical Phenotype

and Prognosis of Probands With Brugada Syndrome in Relation to SCN5A Mutation. -

Japanese Brugada Syndrome Multicenter Registry. AHA Scientific Sessions 2009(2009.11.14-

18. Orlando, Florida, U.S.A.)

19. Ohno S, Zankov DP, Ding W-G, Makiyama T, Hattori T, Doi T, Shizuta S, Kimura T, Matsuura

H, Horie M. Novel KCNE5 Mutations Are Associated With Brugada Syndrome and Idiopathic

Ventricular Fibrillation. AHA Scientific Sessions 2009(2009.11.14-18. Orlando, Florida,

U.S.A.)

20. Watanabe H, Makiyama T, Prince J K, Seto S, Okamura S, Oda H, Ito H, Horie M, Aizawa Y,

Shimizu W. Association of Early Repolarization With Arrhythmic Events in Short QT

Syndrome. AHA Scientific Sessions 2009(2009.11.14-18. Orlando, Florida, U.S.A.)

21. Hattori T, Makiyama T, Akao M, Ehara E, Ohno S, Nishio Y, Itoh H, Yokode M, Kimura T,

Horie M. A Novel Gain-of-function KCNJ2 Mutation Associated With Short QT Syndrome

Impairs Inward Rectification of Kir 2.1 Currents. AHA Scientific Sessions 2009(2009.11.14-

18. Orlando, Florida, U.S.A.)

22. Tsutamoto T, Nishiyama K, Yamaji M, Kawahara C, Fujii M, Hayashi M, Horie M. Effect of

Eplerenone Versus Spironolactone on Adiponectin and Hemoglobin A1c Levels in Patients

With Chronic Heart Failure. AHA Scientific Sessions 2009(2009.11.14-18. Orlando, Florida,

U.S.A.)

23. Namba T, Todo T, Ashihara T, Haraguchi R, Nakazawa K, Ikeda T: Analogy of QRS complex

between precordial unipolar potential (used in standard 12-lead electrocardiograph) and

precordial bipolar potential (often used in event electrocardiograph). The 13th Congress of

the International Society for Holter and Noninvasive Electrocardiology (ISHNE)(2009.6.4-06.

Yokohama)

24. Nakazawa Y, Ashihara T, Yao T, Jo H, Ito H, Sugimoto Y, Ito M, Horie M. Usefulness of event-

ECG monitor in detection of atrial fibrillation recurrence after pulmonary vein isolation. The

13th Congress of the International Society for Holter and Noninvasive Electrocardiology


(ISHNE)(2009.06.4-6. Yokohama)

25. Haraguchi R, Ashihara T, Namba T, Tsumoto K, Murakami S, Kurachi Y, Ikeda T, Nakazawa

K. Scroll wave dynamics in a simulated ventricular wall model: Role of transmural dispersion

of repolarization. The 13th Congress of the International Society for Holter and Noninvasive

Electrocardiology (ISHNE)(2009.06.4-6. Yokohama)

26. Yao T, Jo H, Nakazawa Y, Itoh H, Ashihara T, Sugimoto Y, Ito M, Horie M: At-home AED.

An alternative strategy for patients with sudden cardiac death and the resk of ICD

implantation. The 13th Congress of the International Society for Holter and Noninvasive

Electrocardiology (ISHNE)(2009.6.4-6. Yokohama)

27. Haraguchi R, Ashihara T, Todo T, Namba T, Murakami S, Kurachi Y, Nakazawa K. In silico

analyses of filament dynamics during spiral wave reentry in three-dimensional ventricular

wall model. The 36th International Congress of Physiological Sciences (IUPS

2009)(2009.7.27-8.01. Kyoto)

28. Ito M, Ashihara T, Nakazawa Y, Yao T, Jo H, Ito H, Sugimoto Y, Horie M. Validation of AF

ablations efficiency. 17th Asian Pacific Congress of Cardiology (APCC)(2009.5.20-23. Kyoto)

2008 年

1. Ozeki Y，Fujii K，Kurimoto N，Tsuji K，Yamada N，Okawa M，Aoki T， Takahashi J，

Ishida N，Narita M，Saito O，Horie M，Kunugi H．RISK FACTORS OF QTC INTERVAL

PROLONGATION IN 1000 PATIENTS WITH SCHIZOPHRENIA．14th Biennial winter

workshop on schizophrenia and bipolar disorders（2008.2.3-7. Switzerland）

2. Horie M．A KCNE1 polymorphism,D85N,is a disease-causing gene variant in congenital long

QT syndrome．ESC Congress 2008(2008.8.31-9.3. Munchen，Germany)

3. Tsutamoto T. Nicorandil:newly approved medication in pts with acute heart failure in

Japan,its mechanism of action and characteristics．Round table discussion focused on the

management of acute heart failure（2008.8.31. Munchen,Germany）

4. Matsumoto T，Yamane T，Eguchi Y，Takashima H，Urade Y，Horie M．Lipocalin-type

Prostaglandin D Synthase is Associated with Coronary Vasomotion in Response to

Acetylcholine in Patients with Coronary Vasospastic Angina ． ESC Congress 2008 ．

（2008.8.31-9.3. Munchen，Germany）

5. Horie M．Plakophili-2 mutations are common in Japanese arrhythmogenic right ventricular

dysplasia/cardiomyopathy ． 2008 Tokyo-Taipei-Seoul Arrhythmia Joint Conference ．

（2008.10.4. Seoul, Korea）

6. Bayer JD，Narayan SM，Ashihara T，Lalani G，Plank G，Trayanova NA．Reduced calcium

uptake explains human action potential phase II and T-wave alternans. A modeling and

clinical study．Heart Rhythm 2008 Scientific Sessions（2008.5.14-17. San Francisco，U.S.A.）

7. Tsuji K，Akao M，Ishii TM，Ashihara T，Makiyama T，Ohno S，Toyoda F，Nishio Y，

Sakaguchi T，Matsuura H，Horie M．Identification and functional characterization of a novel


intronic splicing mutation in KCNQ1 associated with long QT syndrome．American Heart

Association (AHA) 80th Scientific Sessions（2008.11.8-12. New Orleans,U.S.A）

8. Nishiyama K，Tsutamoto T，Kawahara C，Yamaji M，Tanaka T，Yamamoto T，Fujii M，

Horie M．Transcardiac increase in Norepinephrine and prognosis in patients with chronic

heart failure．AHA Scientific Sessions 2008(2008.11.8-12 . New Orleans,U.S.A.)

9. Yao T，Jo H，Nakazawa Y，Itoh H，Ashihara T，Sugimoto Y，Ito M，Horie M．Ventricular

lead of mid-septal position shows voltage reduction after ICD/CRT-D implantation. 1st Asia-

Pacific Heart Rhythm Society Scientific Session（2008.11.27-29. Raffles，Singapore）

10. Nakazawa Y，Ashihara T，Yao T，Jo H，Ito H，Sugimoto Y，Ito M，Horie M．A detection

rate of atrial fibrillation by symptoms decreased after pulmonary vein Isolation: A clinical

study using event-ECG monitors. st Asia-Pacific Heart Rhythm Society Scientific Session

（2008.11.27-29. Raffles，Singapore）

11. Zankov DP，Omatsu-Kanbe M，Matsuura H，Horie M．Involvement of AT1 receptor in

swelling-induced regulation of IKS current in guinea pig atrium．第２５回国際心臓研究学会

（ISHR）日本部会（2008.12.5. 神奈川）

2007 年

1. Horie M．The 1st International Congress of Cardiomyopathies and Heart Failure,（2007.3.10-

13 Kyoto,Japan）

2. Tsutamoto T. Inflammatory biomarkers．The 1st International Congress of Cardiomyopathies

and Heart Failure．（2007.3.10-13. Kyoto）

3. Itoh H, Makiyama T, Oono S, Tsuji K, Oka Y, Sakaguchi T, Nagaoka I, Nakazawa Y, Yao T,

Ashihara T, Ito M, Akao M, Horie M． Variable genetic backgrounds between congenital and

acquired long-QT syndromes( Oral(Japanese)). The 71st Annual Scientific Meeting of

Japanese Circulation Society(2007.3.15-17. Kobe)

4. Nagaoka I, Itoh H, Sakaguchi T, Oka Y, Ashihara T, Yao T, Jo H, Nakazawa Y, Ito M,

Sumitomo N, Horie M. Mutation analysis for the human cariac ryanodine receptor gene

(RyR2) in catecholaminergic polymorphic ventricular tachycardia (CPVT)(Oral(Japanease))

The 71st Annual Scientific Meeting of Japanese Circulation Society(2007.3.15-17. Kobe，

Japan)

5. Harada M, Honjo H, Yamazaki M, Nakagawa H, Ishiguro Y, Okuno Y, Ashihara T, Nakazawa

K, Sakuma I, Horie M, Kamiya K, Kodama I. Moderate hypothermia causes destabilization

of rotors without wavelength shortening in favor of VT/VF self-termination(Poster). The 71st

Annual Scientific Meeting of Japanese Circulation Society(2007.3.15-17. Kobe)

6. Namba T, Ashihara T, Yao T, Nakazawa K, Ikeda T．Electrode potential is available for

evaluating the local repolarization during fibrillation(Oral). The 71st Annual Scientific

Meeting of Japanese Circulation Society(2007.3.15-17. Kobe)

7. Oka Y, Makiyama T, Itoh H, Oono S, Sakaguchi T, Nagaoka I, Ashihara T, Ito M, Akao M,

Horie M. Clinical characteristics for Japanese patients with genotyped long-QT


syndrome(Poster). The 71st Annual Scientific Meeting of Japanese Circulation Society．

(2007.3.15-17. Kobe)

8. Itoh H, Sakaguchi T, Ding WG, Tsuji K, Ashihara T, Nakazawa Y, Jo H, Yao T, Ito M,

Matsuura H, Horie M． A novel KCNH2 mutation associated with the short QT interval of

Brugada syndrome ． Impaired deactivation for the IKr channel(Poster). 56th Annual

Scientific Session of the American College of Cardiology (ACC) ． (2007.3.24-27,New

Orleans,U.S.A.).

9. Itoh H, Makiyama T, Ohno S, Oka Y, Sakaguchi T, Nagaoka I, Ashihara T, Ito M, Akao M,

Horie M ． Variable genetic backgrounds between congenital and acquired long-QT

syndromes(Oral). 56th Annual Scientific Session of the American College of Cardiology (ACC)．

(2007.3.24-27,New Orleans,U.S.A.).

10. Namba T, Todo T, Yao T, Ashihara T, Haraguchi R, Nakazawa K, Ikeda T．Identification of

local myocardial repolarization endpoint by bipolar electrode potential mapping without

determining activation time of each electrode．The 32nd Annual Conference of International

Society for Computerized Electrocardiology．（2007.4.21-26 Cancun）．

11. Namba T, Todo T, Yao T, Ashihara T, Haraguchi R, Nakazawa K, Ikeda T． Bipolar electrode

potential available for evaluating the local myocardial repolarization(Oral). The 31st Annual

Conference of International Society for Computerized Electrocardiology (ISCE)．(2007.4.21-

26, Cancun,Mexico).

12. Ashihara T, Yao T, Ito M, Horie M, Haraguchi R, Nakazawa K, Namba T, Ikeda T, Trayanova

NA．Steep APD restitution curve is not essential for microvolt T-wave alternans(Oral)．

Insights from computer simulations. Heart Rhythm 2007 Scientific Sessions．(2007.5.9-

12,Denver,U.S.A.).

13. Harada M, Honjo H, Yamazaki M, Nakagawa H, Ishiguro YS, Okuno Y, Nakazawa K,

Ashihara T, Horie M, Sakuma I, Kamiya K, Kodama I．Moderate hypothermia increases the

chance of spiral wave collision in favor of self-termination of ventricular

tachycardia/fibrillation(Poster). Heart Rhythm 2007 Scientific Sessions ． (2007.5.9-

12,Denver,U.S.A.)

14. Namba T, Haraguchi R, Igarashi T, Owada S, Yao T, Ashihara T, Todo T, Ikeda T, Nakazawa

K．Development of graphical interface modeling excitation map in the electrophysiological

heart simulator(Poster) ． IEEE/ICME International Conference on Complex Medical

Engineering (CME)． (2007.5.23-27,Beijing,China).

15. Todo T, Haraguchi R, Namba T, Yao T, Ashihara T, Higashi M, Inada H, Nakazawa K．

Development of “Cardiac Arrhythmia Risk Evaluation” system based on computer

simulation(Poster). IEEE/ICME International Conference on Complex Medical Engineering

(CME)．(2007.5.23-27,Beijing,China)．

16. Horie M ． Cardiac arrhythmias and ion channel diseases ． East Asia International

Cardiovascular Symposium（2007.7.27-29 Harbin,China）．


17. Nagaoka I， Shimizu W，Itoh H，Ohno S，Akao M，Miyamoto Y，Kamakura S，Horie M．

Bradycardia before beta-blocker therapy as an arrhythmic risk in LQT2 form of congenital

long-QT syndrome．ESC Congress 2007．（2007.9.1-5 Vienna,Austria）．

18. Yao T, Jo H, Nakazawa Y, Ashihara T, Itoh H, Sugimoto Y, Ito M, Horie M．Prediction and

prevention of T-wave oversensing in patients with implantable cardioverter defibrillators．

10th International Workshop on Cardiac Arrhythmias ．（2007.10.7-10Venice）．

19. Nakazawa Y，Ashsihara T，Yao T，Tanaka T，Jo H，Itoh H，Yagi T，Sugimoto Y，Tsutamoto

T，Ito M，Horie M．Plasma endotheline-1 level before extensive encircling pulmonary vein

isolation as a predict or of atrial fibrillarion recurrences after 6 months. Venice Arrhythmias

（2007.10. 8-10 Italia）．

20. Jie Wu．Inhibitory actions of ly294002,a PI3 kinase inhibitor,on the human kv1.5 channel．

The 3rd Asia-Pacific Atrial Fibrillation Symposium．（2007.10.18 TAIWAN）．

21. Ashihara T．Visualization of the mechanisms of atrial fibrillation:Insights from computer

simulations．The 3rd Asia-Pacific Atrial Fibrillation Symposium．（2007.10.19 TAIWAN）．

22. Horie M ．The same genetics for Brugada syndrome and AF ? ．The 3rd Asia-Pacific Atrial

Fibrillation Symposium．（2007.10.20 TAIWAN）．

23. Wada A，Matsumoto T，Ohnishi M，Takayama T，Tsutamoto T，Horie M．Chronic NADPH

Oxidase Inhibition Improves Cardiac Dysfunction Through The Suppression Of Cardiac

Oxidative Stress And The Renin-Angiotensin System In Heart Failure．The American Heart

Association Scientific Sessions 2007．（2007.11.4，U.S.A）．

24. Makita N，Behr E，Shimizu W，Horie M，Crotti L，Itoh H，Miyamoto K，Kamakura S，

Tsutsui H，Schwartz PJ，George AL Jr，Roden DM．Overlap Between LQT3 and Brugada

Syndrome: Clinical Features in a Common Mutation and Underlying Biophysical

Mechanisms．The American Heart Association Scientific Sessions 2007．（2007.11.5，U.S.A）．

25. Makiyama T，Akao M，Shizuta S，Doi T，Ohno S，Nishio Y，Kimura T，Horie M．Familial

Dilated Cardiomyopathy with Conduction Disease Caused by a Lamin A/C Mutation: Efficacy

of the Cardiac Resynchronization Therapy with a Defibrillator ．The American Heart


26. Zankov DP，Toyoda F，Omatsu-Kanbe M，Matsuura H，Horie M．Angiotensin II Type 1

Receptor Partially Mediates Stretch-Induced Potentiation of the Slow Component of Delayed

Rectifier Potassium Current in Guinea Pig Atrium．The American Heart Association

Scientific Sessions 2007．（2007.11.6，U.S.A）．

27. Sakaguchi T，Shimizu W，Ito H，Noda T，Miyamoto Y，Nagaoka I，Ashihara T，I to M，

Tsuji K，Ohno S，Makiyama T，Kamakura S，Horie M．Age-Related Triggers for Life-

Threatning Arrhythmia in the Genotyped Long QT Syndrome ． The American Heart


28. Hayashi M，Tsutamoto T，Naiki N，Yamaji M，Ohira N，Yokohama H，Horie M． Hyper

Transcardiac Extraction of Aldosterone Promote Ventricular Remodeling and Cardiac Mass


in Patients with Primary Aldosteronism．The American Heart Association Scientific Sessions

2007．（2007.11.6，U.S.A）．

29. Ashihara T, Yao T, Namba T, Nakazawa Y, Jo H, Ito H, Sugimoto Y, Ito M, Haraguchi R,

Nakazawa K, Ikeda T, Horie M．Effects of amiodarone and bepridil on spiral wave reentries

in human atrial model with electrical and structural remodelings．文部科学省リーディング

プロジェクト「細胞・生体機能シミュレーションプロジェクト」京都大学拠点第 4 回国際シンポ

ジウム．（2007.11.12-13Kyoto）．

30. Horie M．Diagnostic criteria for the long QT syndrome．World Congress on Cardiac Pacing

and Electrophysiology（2007.12.2-6 Rome,Italy）．

31. Haraguchi R, Nakazawa K, Ashihara T, Namba T, Todo T, Naito H, Higashi M, Shimizu W,

Suzuki S, Murakami S, Kurachi Y．Scroll wave dynamics in a three-dimensional cardiac

tissue model: Roles of transmural dispersion of repolarization. The 2nd MEI International

Symposium．（2007.12.7-9 Osaka）．

32. Ashihara T．Simulation studies of excitation conduction and cardiac arrhythmias．The 2nd

MEI International Symposium．（2007.12.7-9 Osaka）．

33. Ijiri T, Takayama K, Igarashi T, Ashihara T, Namba T, Yamaguchi T, Shimada T, Haraguchi

R, Nakazawa K ． The use of L-system for modeling Purkinje fibers． The 2nd MEI

International Symposium．（2007.12.7-9 Osaka）．

34. Harada M, Honjo H, Yamazaki M, Nakagawa H, Ishiguro YS, Okuno Y, Nakazawa K,

Ashihara T, Horie M, Sakuma I, Kamiya K, Kodama I: Moderate hypothermia increases the

chance of spiral wave collision in favor of self-termination of ventricular

tachycardia/fibrillation. Heart Rhythm 2007 Scientific Sessions,(2007.05.09-12,Denver)

このページの先頭へ

2006 年

1. Ashihara T, Yao T, Ito M, Horie M, Haraguchi R, Nakazawa K, Trayanova NA. Superiority of

biphasic waveforms in a bidomain model study. Commission investigating the DFT

management and DAVID study (2006.02.17 Osaka).

2. Yamazaki M, Honjo H, Ashihara T, Harada M, Sakuma I, Nakazawa K, Horie M, Trayanova

N, Kamika K, Kodama I. Regional cooling facilitates termination of spiral wave reentry

through unpinning of rotors in 2-dimenshonal rabbit ventricular myocardium. Heart Rhythm

2006 Scientific Sessions. (2006.05.17-20 Boston).

3. Kuo SR, Niwa N, Ashihara T, Nikolski V, Fedorov V, Efimov I, Trayanova N. Role of

electroporation in initiation of spontaneous ectopic postshock activations. Heart Rhythm

2006 Scientific Sessions (2006.05.17-20 Boston).

4. Arafune T, Ashihara T, Nakazawa K, Trayanova NA, Yamazaki M, Honjo H, Kamiya K,

Kodama I, Sakuma I. Analysis of shock induced virtual electrode polarization in various

hypothermia and capture mechanisms. Heart Rhythm 2006 Scientific Sessions (2006.05.17-

20 Boston).


5. Lu J, Nishi T, Ashihara T, Schnider N, Amano A, Matsuda T, Kotera H. The influence of

activation time on the contraction force of myocardial tissue: A simulation study. The 28th

IEEE Engineering in Medicine and Biology Society Annual International Conference.

(2006.08.30-09.03 New York).

6. Horie M, Itoh H, Sakaguchi T, Yamamoto S, Nagaoka I, Zankov DP, Ashihara T, Ito M,

Yoshida H, Tsuji K, Ohno S, Makiyama T, Akao M,Kita T. Long QT syndrome: an ion

channelopathy in cardiovasccular medicine. The 11th La Jolla-Capri-Yamaguchi -Seoul

Research Conference. (2006.10.06-08 Yamaguchi).

7. Matsumoto T, Taruani Y, Yamane T, Takashima H, Matsuo S, Horie M. Regulation of blood

pressure improves both coronary endothelial function and aortic stiffness in hypertensive

patients. International Society of Hypertension 21st Biennial Meeting (2006.10.15-19

Fukuoka).

8. Matsumoto T, Fujita M, Tarutani Y, Yamane T, Takashima H, Matsuo S, Nakae I, Horie M.

Whole-body, periodic acceleration enhances endothelium-dependent flow-mediated

vasodilation of the brachial artery. International Society of Hypertension 21st Biennial

Meeting. (2006.10.15-19 Fukuoka).

9. Tamaki S, Nakamura Y, Yoshino T, Matsumoto Y, Tarutani Y, Okabayashi T, Kawashima T,

Horie M. The association between morning hypertension and metabolic syndrome in

hypertensive patients. International Society of Hypertension 21st Biennial Meeting

(2006.10.15-19 Fukuoka).

10. Tamaki S, Nakamura Y, Tabaa Y, Okamura T, Kita Y, Kadowaki T, Tsujita Y, Horie M, Miki

T, Ueshima H. Relation ship between the metabolic syndrome and Trp64Arg polymorphism

of the β3 adrenergic receptor gene in a general sample (The Shigaraki Study).

International Society of Hypertension 21st Biennial Meeting (2006.10.15-19 Fukuoka).

11. Tamaki S, Kawashima T, Yashino T, Matsumoto Y, Taruani Y, Okabayashi T, Horie M.

Change of medication to Candesartan from Valasartan is effective for patients with morning

hypertension (ATOM-Convert study). International Society of Hypertension 21st Biennial

Meeting (2006.10.15-19 Fukuoka).

12. Tanaka T, Tsutamoto T, Sakai H, Fujii M, Yamamoto T. Efonidipine decreases aldosterone

compared with amlodipine in patients with hypertension. International Society of

Hypertension 21st Biennial Meeting (2006.10.15-19 Fukuoka).

13. Tsutamoto T, Hayashi M, Sakai H, Tanaka T, Ishikawa C, Fujii M, Horie M. The role of

aldosterone on left ventricular remodeling in patients with acute myocardial infarction.

Investigator-Initiated Symposia : Chymase Comprehending Tissue Renin-Angiotensin

Generating System (2006.10.20-21 Takarazuka).

14. Tanaka T, Tsutamoto T, Sakai H, Fujii M, Yamamoto T. Efonidipine decreases aldosterone

compared with amlodipine in patients with hypertension.The 21st Scientific Session,

International Society of Hypertension : Investigator-Initiated Symposia : Chymase

Comprehending Tissue Renin-Angiotensin Generating System (2006.10.20-21 Takarazuka).


15. Sakai H, Tsutamoto T, Tanaka T, Fujii M, Horie M. Direct comparison of brain natriuretic

peptide (BNP) and N-terminal Pro-BNP secretion and extent of coronary artery stenosis in

patients with stable coronary artery disease. The 2th China-Japan Cardiovascular Forum

(2006.11.04 Beijing).

16. Tsutamoto T, Wada A, Sakai H, Ishikawa C, Tanaka T, Hayashi M, Fujii M, Yamamoto T,

Dohke T, Ohnishi M, Kinoshita M, Horie M. Relationship between renal function and plasma

brain natriuretic peptide in patients with heart failure. The 2th China-Japan Cardiovascular

Forum (2006.11.04 Beijing).

17. Tanaka T, Tsutamoto T, Sakai H, Fujii M, Yamamoto T. Effect of T-Type calcium channel

blocker versus L-Type calcium channel blocker on aldosterone in patients with hypertension.

79th American Heart Association Scientific Sessions (2006.11.12-15 Chicago).

18. Suyama T, Taniguchi R, Haruna Y, Shizuta S, Tamura T, TOma M, Furukawa Y, Ehara N,

Horie M, Asai T, Araki M, Doyama K, Fujino Y, Imai Y, Teramukai S, Kita T, Kimura T.

Impact of complete revascularization on long-term outcome after percutaneous coronary

intervention in the bare metal stent era : from the coronary revascularization demonstrating

outcomes in Kyoto (CREDO-Kyoto). 79th American Heart Association Scientific Sessions

(2006.11.12-15 Chicago).

19. Zhang L, Benson W, Riera A, Paulo S, Ptacek L, Tristani-Firouzi M, Ackerman M, George A,

Horie M, Lux R, Schwartz P, Vincent M. KCNJ2-Specific ECG abnormalities in type 1

Andersen-Tawil syndrome: The enlarged U wave, prolonged QU interval and left ventricular

arrhythmias. 79th American Heart Association Scientific Sessions (2006.11.12-15

Chicago).

20. Matsumoto T, Yamane T, Takashima H, Horie M. Chronic smoking impairs endogenous

coronary fibrinolytic function in women with angiographically normal coronary arteries.

79th American Heart Association Scientific Sessions (2006.11.12-15 Chicago).

21. Matsumoto T, Yamane T, Takashima H, Horie M. Angiotensin II receptor blockade improves

endogenous coronary fibrinolytic function in patients with coronary artery disease. 79th

American Heart Association Scientific Sessions (2006.11.12-15 Chicago).

22. Wada A, Matsumoto T, Takayama T, Dohke T, Ohnishi M, Tsutamoto T, Horie M. Chronic

chymase inhibition improves cardiac dysfunction through the suppression of excessive

oxidative stress in heart failure. 79th American Heart Association Scientific Sessions

(2006.11.12-15 Chicago).

23. Matsumoto T, Wada A, Tsutamoto T, Ohnishi M, Fujii M, Yamamoto T, Takayama T, Dohke

T, Horie M. Chymase inhibitor improves renal dysfunction under long-term angiotensin-

converting enzyme inhibition in heart failure. 79th American Heart Association Scientific

Sessions (2006.11.12-15 Chicago).

24. Tsuji K, Akao M, Ishii T, Ohno S, Makiyama T, Doi T, Haruna Y, Yoshida H,Nakashima T,

Kita T, HorieM. Mechanistic basis for the pathogenesis of long QT syndrome caused by a

splicing mutation in KCNQ1 gene. 79th American Heart Association Scientific Sessions


(2006.11.12-15 Chicago).

25. Hata N, Seino Y, Tsutamoto T, Suzuki H, Hiramitsu S, Yoshikawa T, Yokoyama Y, Tanaka K,

Mizuno K, Nejima J, Kinoshita M. PROTECT. Effects of carperitide (hANP) treatment on

long-term Pprognosis in patients with acute decompensated heart failure. 79th American

Heart Association Scientific Sessions (2006.11.12-15 Chicago).

26. Schwartz PJ, Spazzolini C, Crotti L, Vicentini A, Horie M, Moss AJ, Shimizu W, Schulze-

Bahr E, Munster U, Munster, Wilde AA. The Common LQT1 Mutation KCNQ1/A341V

Predicts High Risk of Cardiac Events in Different Ethnic Backgrounds. 79th American

Heart Association Scientific Sessions (2006.11.12-15 Chicago).

27. Horie M, Dimitar PZ, Zhang C, Yasuno S, Kuwahara K, Omatsu-Kanbe M, Isono T, Toyoda F,

Ding WG, Makiyama T, Matsuura H. Angiotensin (AT1) receptor and atrial fibrillation. The

2nd Asia-Pacific Atrial Fibrillation Symposium (2006.11.23-25 Tokyo).

28. Yao T, Nakazawa Y, Ashihara T, Jo H, Itoh H, Yagi T, Sugimoto Y, Ito M, Horie M.

Effectiveness of horizontal linear ablation in left atrial posterior wall to terminate the

refractory atrial fibrillation. The 2nd Asia-Pacific Atrial Fibrillation Symposium (2006.11.23-

25 Tokyo).

29. Ashihara T, Nakazawa Y, Yao T, Jo H, Itoh H, Yagi T, Sugimoto Y, Ito M, Horie M. Usefulness

of portable electocardiograph in detecting a recurrence of atrial fibrillation after catheter

ablation. The 2nd Asia-Pacific Atrial Fibrillation Symposium (2006.11.23-25 Tokyo).

30. Nakazawa Y, Ashihara T, Yao T, Tanaka T, Sakai H, Jo H, Itoh H, Yagi T, Sugimoto Y,

Tsutamoto T, Ito M. Recurrence of atrial fibrillation after catheter ablation can be predicted

by neurohormonal factors and oxidative stress-related markers in early phase. The 2nd Asia-

Pacific Atrial Fibrillation Symposium (2006.11.23-25 Tokyo).

31. Namba T, Ashihara T, Yao T, Todo T, Haraguchi R, Nakazawa K, Ikeda T, Ohe T. Availability

of electrode mapping for evaluating repolarization dynamics over myocardium during atrial

fibrillation.The 2nd Asia-Pacific Atrial Fibrillation Symposium (2006.11.23-25 Tokyo).


2005 年

1. Sakai H, Tsutamoto T, Tsutsui T, Ishikawa C, Horie M. Serum level of uric acid, partly

secreted from the failinf heart, is a prognostic marker in japanese patients with condestive

heart failure. 54th Annual Scientific Session, American College of Cardiology (2005.03.06-09

Florida).

2. Tsutamoto T, Wada A, Fujii M, Sakai H, Ohno K, Ishikawa C, Yamamoto T, Takayama T,

Dohke T, Horie M. Relationship between renal function and plasma level of BNP and N-

terminal proBNP in patients with condestive heart failure. 54th Annual Scientific Session,

American College of Cardiology (2005.03.06-09 Florida).

3. Hori K, Nishi T, Lu J, Shimayoshi T, Ashihara T, Amano A, Matsuda T. Development of

distributed biodynamics simulator on DynaBioS architecture. Satellite Symposium of


International Union of Physiological Sciences (IUPS).,35th International Congress of

Physiological Sciences : Poster (2005.03.28-30, San Diego).

4. Honjo H, Yamazaki M, Ashihara T, Sakuma I, Nakazawa K, Trayanova NA, Kamiya K,

Kodama I. Control of functional reentry by regional cooling in an epicardial layer of rabbit

ventricular myocardium. Heart Rhythm 2005 Scientific Sessions : Poster (2005.05.04-07,

New Orleans).

5. Ashihara T, Trayanova NA, Nakazawa K, Yamazaki M, Honjo H, Sakuma I, Kamiya K,

Kodama I. Spiral wave control by regional cooling in a bidomain model. Heart Rhythm 2005

Scientific Sessions : Poster (2005.05.04-07, New Orleans).

6. Ashihara T, Trayanova NA, Yao T, Ozawa T, Ito M, Horie M. Mechanisms underlying

Andersen syndrome in a human ventricular model. Heart Rhythm 2005 Scientific Sessions :

Poster (2005.05.04-07, New Orleans).

7. Matsuo S, Matsumoto T, Nakae I, Masuda D, Horie M. Impact of endothelial dysfunction

on left ventricular remodeling after primary coronary angioplasty for acute myocardial

infarction: quantitative ECG-gated SPECT. 7th International Conference of Nuclear

Cardiology (2005.05.08-11, Lisbon).

8. Haraguchi R, Igarashi T, Owada S, Yao T, Namba T, Ashihara T, Ikeda T, Nakazawa K.

Electrophysiological heart simulator equipped with sketchy 3-D modeling. The 1st

International Conference on Complex Medical Engineering (CME). : Poster (2005.05.15-18,

Takamatsu).

9. Toda H, Ding WG, Yasuda Y, Toyoda F, Horie M, Matsuura H. PK Ce isoform

10. preferentially mediates the α1-adrenergic potentiation of IKs in guineapig

11. cardiac myocytes. The Proceedings of the 82nd Annual Meeting (2005.05.18-20 Sendai).

12. Namba T, Ikeda T, Yao T, Ashihara T, Haraguchi R, Nakazawa K, Ohe T. Amiodarone

organizes multiple wavelets into a simple spiral reentry. The 27th Annual Congress of the

European Society of Cardiology (ESC). : Poster (2005.09.03-07 Stockholm).

13. Ohno S, Yoshida K, Tsuji K, Makiyama T, Takenaka K, Akao H, Kita T, Horie M. Positive

arginine residue (R259). in S4-S5 linker affects activation properties of KCNQ1 potassium

channne. ESC Congres (2005.09.03-07 Stockholm).

14. Ashihara T. Myocardial cooling could control ventricular fibrillation anddecrease

defibrillation threshold. Cardiac Arrhythmia and DefibrillationWorkshop-CADP Group

Meeting (2005.10.10 Nagoya).

15. Ashihara T. Fibrillation control by myocardial cooling in a bidomain model. Integrated

Biology Workshop in University of Oxford(2005.09.29-30 Oxford).

16. Hayashi M, Tsutamoto T, Kimura H, Taniguchi A, Nozato Y, Takayama T, Morigami N, Horie

M. Angiotensine receptir bocker combined with spironolactone has more beneficial effect on

cardiac protection than thiazide in patients with essential hypertension. 78th American

Heart Association Scientific Sessions(2005.11.13-16 Dallas).

17. Hayashi M, Tsutamoto T, Kimura H, Taniguchi A, Nozato Y, Takayama T, Morigami N, Horie


M. Relationship between transcardiac gradient of endothelin-1 and the desases activity of

coronary spasmus in patients with coronary spastic angina 78th American Heart Association

Scientific Sessions(2005.11.13-16 Dallas).

18. Ishikawa C, Tsutamoto T, Sakai H, Tanaka T, Dohke T, Fujii M, Wada A, Horie M. Plasma

active renin concentration as an independent prognostic predictor in patients with chronic

heart failure. 78th American Heart Association Scientific Sessions(2005.11.13-16 Dallas).

19. Wada A, Takayama T, Tsutamoto T, Dohke T, Fujii M, Yamamoto T, Matsumoto Horie M.

Chronic NADPH oxidase inhibition improves cardiac dysfunction through the supression od

oxidative stress in faling heart. 78th American Heart Association Scientific

Sessions(2005.11.13-16 Dallas).

20. Matsuoka S, Saito R, Jo H, Oka C, Ashihara T, Asakura K, Noma A: Simulation of cardiac

energy homeostasis on SimBio platform. International Symposium on Leading Project for

Biosimulation(2005.07.06-07,Tokyo)


2004 年

1. Ikeda T, Kawase A, Yusu S, Nakazawa K, Ashihara T, Namba T, Yao T, Yoshino H. Effects of

antiarrhythmic drugs on electrophysiological action and wavefront dynamics during atrial

fibrillation. The 68th Annual Scientific Meeting of Japanese Circulation Society (2004.03.27-

29 Tokyo).

2. Ozawa T, Ito M, Tamaki S, Yao T, Ashihara T, Kita Y, Ueshima H, Nakamura Y, Horie M.

Ventricular repolarization abnormality in Japanese carriers of G643S single nucleotide

polymorphism of KCNQ1 gene. The 31st International Congress On Electrocardiology

(2004.06.27-07.01 Kyoto).

3. Kobori A, Sarai N, Matsuoka S, Takano M, Noma A, Kita T, Horie M. A simulation study for

risk estimation of arrhythmogenesis additional gene variants affect the phenotype of long QT

syndrome. 細胞・生体機能シュミレーションプロジェクト (2004.02.27-28 Kyoto）.

4. Ohno K, Tsutamoto T, Ishikawa C, Sakai H, Tsutsui T, Hayashi M, Wada A, Horie M.

Relationship between the transcardiac increase of plasma heart-type fatty acid-binding

protein and left ventricular remodeling in patients with dilated cardiomyopaty. ACC

(2004.03.07-10 New Orleans).

5. Matsuo S, Matsumoto T, Nakae I, Masuda D, Koh T, Horie M. Noninvasive evaluation of

coronary artery plaque with ECG-gated multislice computed tomography. ACC (2004.03.07-

10 New Orleans).

6. Tsutamoto T, Ishikawa C, Ohno K, Sakai H, Wada A, Ohnishi M, Horie M. Torasemide

inhibits transcardiac extraction of aldosteron in patients with congestive heart failure. ACC

(2004.03.07-10 New Orleans).

7. Namba T,Yao T, Ikeda T, Nakazawa K, Nakagawa H, Yamasaki M, Honjo H, Kodama I,

Arafune T, Mishima A, Sakuma I, Ohe T: Coronary artery affects the wave propagation in a


thin ventricular myocardium study by the optical mapping and computer graphics techniques.

The 68th Annual Scientific Meeting of Japanese Circulation Society (2004.03.29 Tokyo).

8. Ashihara T, Trayanova N. Mechanism of shock-induced arrhythmogenesis: role of tissue

discontinuity and electroporation in the initiation of focal repetitive postshock activations.

The 31st International Congress On Electrocardiology (2004.06.27-07.01 Kyoto).

9. Ashihara T, Trayanova N. Shock-induced changes in transmembrane potential: what is the

asymmetry due to insights from bidomain simulations. The 31st International Congress On

Electrocardiology (2004.06.27-07.01 Kyoto).

10. Kobori A, Inoue T, Hosaka Y, Washizuka T, Murakami T, Yamanouchi H, Ushinohama

H,Nakamura Y, Ai T, Aizawa Y, Kita T, Horie M. The 31st International Congress On


11. Kubota T, Tsuchiya K, Hirano T, Yamaguchi K, Nishigaki K, Minatoguchi S, Fujiwara H,

Gouya M, Iesaka Y, Takahashi A. A case of tachycardia-induced cardiomyopathy caused by

ectopic atrial tachycardia originating from the right atrial appendage. The 31st International

Congress On Electrocardiology (2004.06.27-07.01 Kyoto).

12. Namba T, Yao T, Nakagawa H, Yamasaki M, Ikeda T, Nakazawa K, Honjo H, Kamiya K,

Kodama I, Arafune T, Mishima A, Sakuma I, Ohe T. Unexcited core of spiral wave reentry

has a small but obviously depolarized potential-study by optical mapping and computer

graphics-. The 31st International Congress On Electrocardiology (2004.06.27-07.01 Kyoto).

13. Toda H, Ding W, Toyoda F, Yasuda Y, Ito M, Horie M, Matsuura H. Potentiation of IKS

potassium current in guinea-pig ventricular myocytes by sphingosine-1-phosphate. The 31st

International Congress On Electrocardiology (2004.06.27-07.01 Kyoto).

14. Toyoda F, Zankov D, Ding W, Matsuura H. Differential effects of mefenamic acid on cardiac

IKS and KCNQ1/KCNE1 channeles. The 31st International Congress On Electrocardiology

(2004.06.27-07.01 Kyoto).

15. Yasuda Y, Toda H, Ding W, Toyoda F, Ito M, Horie M, Matsuura H. Heterogeneous distribution

of the muscarinic K+ channels in guinea-pig atria. The 31st International Congress On


16. Zankov D, Toyoda F, Ding W, Matsuura H, Horie M. Stimulatory action of angiotensin II on

IKS potassium current in guinea-pig atrial cells. The 31st International Congress On


17. Zankov D, Toyoda F, Ding W, Matsuura H, Horie M. Acute Inhibition on IKS by amiodarone

in guinea-pig ventricular myocytes. The 31st International Congress On Electrocardiology

(2004.06.27-07.01 Kyoto).

18. Matsumoto T, Wada A, Ohnishi M, Fujii M, Yamamoto T, Takayama T, Dohke T, Tsutamoto

T, Horie M. Chronic chymase inhibition prevented cardiac fibrosis and improved diastolic

dysfunction in the progression of heart failure. A Symposium of DEFINING THE TARGETS

FOR TREATMENT OF HEART FAILURE at the XVIII World Congress of the International

Society for Heart Research and the 52nd Annual Scientific Meeting of the Cardiac Society of


Australia and New Zealand (2004.08.09 Brisbane).

19. Hayashi M, Tsutamoto T, Kimura H, Miyamoto A, Taniguchi A, Nozato Y, Morigami N, Horie

M. Aldosterone blocker spironolactone prevents postinfarction left ventricular late

remodeling in patients with first anterior acute myocardial infarction. American Heart

Association (2004.11.07 New Orleans).

20. Matsuo S. Non-invasive evaluation of coronary artery plaque with ECG-gated multislice

computed tomography. Takeda Fireside - Conference for young investigators～AHA Scientific

Sessions 2004～ (2004.11.07 New Orleans).

21. Takayama T, Wada A, Fujii M, Yamamoto T, Dohke T, Matsumoto T, Tsutamoto T, Horie M.

Myocardial NADPH oxidase is a major source of reactive oxgen species in heart failure.

American Heart Association (2004.11.07-10 New Orleans).

22. Matsuo S, Matsumoto T, Nakae I Masuda D, Takashima H, Koh T, Tarutani Y, Horie M.

Impaired sympathetic nerve function may play an important role in enhanced coronary

vasoconstriction in patients with hypertrophic cardiomyopathy. American Heart Association

(2004.11.07-10 New Orleans).

23. Horie M. Genetic basis for sudden cardiac death: A lesson from inherited fatal arrhythmias.

ISHR, The 21st Annual Meeting of the Japanese Section (2004.11.23-25 Yamanashi).

24. Ashihara T, Horie M. Mechanisms of predominant U wave and bigeminal premature

ventricular contractions in a computer model of Andersen-Tawil syndrome. 2nd Kyoto

University International Symposium of Leading Project for Biosimulation: The heart

simulation: From cell metabolism to clinical application (2004.11.26-27 Kyoto).

25. Nakazawa K, Haraguchi R, Namba T, Yao T, Ikeda T, Igarashi T, Ashihara T. Semiautomatic

method for reproducing realistic excitation propagation via Purkinje fibers in human

ventricular model. 2nd Kyoto University International Symposium of Leading Project for

Biosimulation: The heart simulation: From cell metabolism to clinical application

(2004.11.26-27 Kyoto).

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