celox

7/28/2019 CELOX

http://slidepdf.com/reader/full/celox 1/8

VISIT US CTOMS.CA | TOLL FREE 1.888.832.7096 | E-MAIL [email protected] | 2919 ELLWOOD DRIVE, EDMONTON, AB, CANADA T6X 0B1

LEAVE NOTHING TO CHANCE. CONTROL THE CHAOS.SM

MISSIONESSENTIALEQUIPMENT ™

7/28/2019 CELOX


RAPID PACKINGCelox™ RAPID 5’Z-Fold packs aster than other

12’competitive gauzes. RAPID has demonstrated aster

packing in both In Vitro and Field Testing. On average, the

time taken with Celox™ RAPID was hal o the time with

either o the other two products1 (Combat Gauze™ and ChitoGauze™)

RAPID COMPRESSIONCelox™ RAPID speeds up compression time. This is demonstrable based on in vivo results that are similar or better

ater one minute than results ater three minutes compression or ChitoGauze or Quikclot Combat Gauze in previous

studies. Based on independent study, Celox™ Rapid can eliminate the compression step entirely ater packing.2

REDUCED BLOOD LOSSCelox™ RAPID demonstrated decreased secondary blood loss in comparison to Combat Gauze.4

STABILITY IN EVACUATION

Celox™ RAPID maintains its volume and adhesion to wet tissue during use, helping it to stay in place during patient

transport and maintain hemostasis during transit. In comparative testing against Chitogauze and Combat Gauze,

Celox™ RAPID demonstrated signicantly stronger adhesion ater treatment at time intervals o one minute, three

minutes and twenty minutes. Because Celox™ RAPID sticks to wet tissue, its use results in perormance benets

including hemostasis speed, reduced blood loss and saer transit o severely wounded patients.3

Chito-R™The positively charged activated chitosan in Chito-R™ rapidly absorbs blood. This process creates a robust gel plug

over the bleeding source independent o the body’s intrinsic clotting cascade. The activated chitosan in Chito-R is a

compound o glucosamine and N-acetyl glucosamine, naturally occurring basic sugars.

Celox™ RAPID with Chito-R™, addressing the signicant capability gap o the current standard o treatment or

hemorrhage control. Celox™ RAPID can eliminate the compression step entirely ater packing.

(1) Reduced Application Time with a Rapid Packing Gauze Hemostat

Andrew Hoggarth, Craig Hardy, Guy Eason, Chris Marsden (Medtrade Products Ltd, Crewe, UK)

(2) Testing a new gauze hemostat with reduced treatment time Hoggarth A1, Hardy C1, Millner R2, Lyon A1 (1: Medtrade Products Ltd, UK, 2: Blackpool Victoria Hospital, UK )

(3) Mechanism o action o rapid-action gauze hemostat Authors: Andrew Hoggarth, Craig Hardy, Guy Eason, Andrew Lyon, Chris Marsden (Medtrade Products Ltd, Crewe, UK)

(4) Chitosan based advanced hemostatic dressing is associated with decreased blood loss in a swine uncontrolled hemorrhage model. Presented at the Region X Committee

on Trauma annual meeting, Olympia, Wash., Dec, 2011.

7/28/2019 CELOX


CTOMS.

TACTICAL APPLICATION As the occurrences o violent and brutal acts escalates, s

too have the demands to provide care under increasingly

chaotic and lie threatening conditions. Celox™ RAPID

denes Tactical Hemostasis and bridges the signicant

capability gap between emerging tactics and the current

standard o treatment or hemorrhage control.

MEDICAL FORCE MULTIPLIERThe medical and downstream tactical implications o

active shooter, ocer down or mass-casualty situations

demand high-speed, easy-to-use ‘Tactical Hemostatic’

products.

With Rapid Packing and Minimal Compression, Celox™

RAPID can reduce hemostasis to a minute or less expandi

the frst responders capabilities to care or other wounds

or casualties.

A 5’ Celox™ RAPID packs aster, requires minimal

post-application compression, reduces blood loss, and

provides greater stability in evacuation compared to

competitive products.

Independent in vivo testing showed 100 % success in

achieving hemostasis and reduced blood loss compared

other treatments*.

Celox™ RAPID has also been tested in a model o casua

evacuation, achieving 100% successul transport withou

re-bleeding*.

* RAPID Gauze could be rapidly applied on the

wound on average within half the time of the

predicate devices. Has been proven in controlled

trials to stop major arterial bleeding by

coagulating the blood within 1 minute,

reducing blood loss.

IMMEDIATE

HEMOSTASIS

POST-

TREATMENT

BLOOD LOSS (ml)

SUCCESSFUL

TRANSPORT WITHOUT

RE-BLEED

WET STICK

AFTER

1 MINUTE

ACTUAL FIELD

TESTING IN

SECONDS...

IN VITRO TIME TOPACK A WOUND

IN SECONDS...

MAKE EVERY SECOND COUNT.

YOU DON’T ALWAYS

HAVE THREE MINUTES

BECAUSE YOU DON’T

KNOW WHAT’SCOMING NEXT.

7/28/2019 CELOX


Celox™ Gauze, designed and intended for the control of severe bleeding, offers numerous

Clinical, Tactical, and Economical advantages over other ‘3-Minute’ hemostatic dressings

such as Combat Gauze™, Combat Gauze™ XL, and ChitoGauze™.

CLINICALWhen placed directly into a bleeding wound and subjected to pressure Celox™ Gauze absorbs blood and orms a

muco-adhesive gel that seals the wound to stop the fow o blood.

In a recent Navy Study1, Celox™ Gauze clearly and consistently outperormed competitors in several areas relevant

to a Combat or Tactical Medic. They include: Immediate Hemostasis (dened as a 3 minute compression period),

Post-Application Blood Loss, and most notably, Survival.

These eatures present initial and ‘downstream’ benets or both the casualty and the medic making Celox™ Gauze

the preerred choice o the ‘3-Minute’ Gauzes.

TACTICALYOU DON’T ALWAYS GET TO CHOOSE YOUR PHASE OF CARE.

‘3 Minutes’ o direct pressure begins ater dressing application ends. ‘Packs aster’ can be the dierence between

your saety and tactical medical superiority or your casualty. Celox™ 5’ Gauze is nearly 60% shorter in length

compared to competitive products while lling the same size wound. The shorter gauze allows signicantly aster

wound packing. Celox™ 5’ Z-Fold Gauze is intuitive, easy to handle, and reduces application time during all phases

o care.

ECONOMICALCelox™ Gauze does not double in price or double the volume. For massive traumatic wound packing, Celox™ Gauze

10’ Z-Fold can provide the clinically desired additional volume WITHOUT the double Extra Large product price***.

A unit o Celox™ 10’ Gauze is capable o packing more than twice the wound volume o some o its competitors.

(1) Rall JM et al. Comparison o Novel Hemostatic gauzes to Quikclot Combat Gauze in a standardized swine model o uncontrollable hemorrhage.

THE ‘3-MINUTE GAUZES’...ARE YOU CARRYING THE BEST? Celox™ Gauze had the highest observed survival rate with 90% o the animals surviving, while Combat Gauze had a 60% survival rate.

7/28/2019 CELOX


ONR 2012(1) Standard Swine Model o Uncontrolled Hemorrhage

CELOX™ GAUZE IS A HIGH PERFORMANCE

HEMOSTATIC GAUZE THAT OFFERS CLINICAL,

TACTICAL, AND ECONOMICAL ADVANTAGES

OVER COMPETITIVE ‘3-MINUTE’ GAUZES.CELOX™ UTILIZES CHITOSAN, A

COMPOUND OF GLUCOSAMINE,

A SUGAR THAT IS NORMALLY

FOUND IN THE BODY.

7/28/2019 CELOX


ACCELERATEDDelivers 6g directly

Promotes Rapid Coagulation

Works in hypothermic conditions

Clots heparnized blood

The applicator was designed to give the caregiver a simple and eective tool to apply

Celox™ to the source o severely bleeding wounds. The Celox-A™ Applicator has

been integrated into thousands o IFAKs to create a comprehensive ‘bleeder’ kit or

shrapnel, IED, gunshot, and knie wounds.

When placed directly into a bleeding wound and subjected to pressure CELOX™

absorbs blood and orms an adhesive gel that seals the wound to stop the fow o

blood. Celox™ has repeatedly and reliably demonstrated the ability to stop arterial

bleeding in independent US Navy severe bleeding tests1.

In a published 2011 comparison2, Celox™-A outperormed Combat Gauze in a lethal

penetrating trauma model in both Initial Hemostasis and Survival.

(1) Kozen B et al. An alternative hemostatic dressing: comparison o CELOX, Hemcon and Quikclot. J Acad Emerg Med 2008: 15;

74-81. January 2008, Vol 15 No 1.

(2) Littlejohn LF et al. Acad Emerg Med 2011: 18; 340-350.

Celox™-A

THE FIRST HIGH-SPEED HEMOSTATIC

DELIVERY SYSTEM FOR GUNSHOT,

BLAST, OR STAB WOUNDS.

7/28/2019 CELOX


DYNAMIC APPLICATIONSGranular presentation provides or the most diverse set o uses

Works in hypothermic conditions

FDA cleared to work on anti-coagulated blood

No chemical exothermic reaction

Celox™ can stop even potentially lethal bleeding ast. It is easy to use (just pour,

pack and apply pressure), very sae (tested to class 3 CE Mark standards) and

extremely eective.

When mixed with blood, Celox™ orms a robust gel-like clot in 30 seconds. When

mixed with blood, Celox™ orms a robust gel-like clot in 30 seconds.It works

independently o the body’s normal clotting processes. Celox’s™ clotting ability has

been proven to work in the cold (hypothermia) or in the presence o common anti-

coagulants such as wararin. It generates no heat and will not burn the casualty or

care giver.

In pre-clinical tests by the US Navy, Celox™ was the only product to give 100% survival. It gave

a strong stable MAP (mean arterial blood pressure) and was also the only product to give robust

clotting with no rebleeding*.

Celox’s™ saety has been tested to the intense class 3 CE mark standards. Celox™ is made

with chitosan. Chitosan is made up o compounds o glucosamine, a sugar that is normally

ound in the body.

Celox™ does NOT use non-degrading procoagulant minerals or nano particles such as smectite

or kaolin, which will remain in the body indenitely unless completely removed.CTOMS

Celox™-GRANULES

WHEN MIXED WITH BLOOD, CELOX™

FORMS A ROBUST GEL-LIKE CLOT IN

30 SECONDS.

7/28/2019 CELOX


celox

Documents