Other bioactive productsU 1300 DOI: 10.1002/chin.201120194

An Efficient One-Pot Synthesis of Benzothiazolo-4β-anilino-podophyllotoxin Congeners: DNA Topoisomerase-II Inhibition and Anticancer Activity. — Title compounds (III) and (IV), respectively are prepared by employing ZrCl4/NaI reagent system to form highly reactive 4β-iodo intermediates in the initiatory step. It is inter-esting that in dichloromethane as the solvent 4-O-demethylation products (IV) are ob-tained. The newly synthesized compounds are screened for their cytotoxicity on select-ed human cancer cell lines. — (KAMAL*, A.; KUMAR, B. A.; SURESH, P.; SHANKARAIAH, N.; KUMAR, M. S.; Bioorg. Med. Chem. Lett. 21 (2011) 1, 350-353, http://dx.doi.org/10.1016/j.bmcl.2010.11.002 ; Div. Org. Chem., Indian Inst. Chem. Technol., Hyderabad 500 607, India; Eng.) — H. Haber

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