Organo-phosphorus compoundsS 0080 DOI: 10.1002/chin.201129172

Asymmetric Organocatalytic Electrophilic Phosphination. — The one-pot three--step sequence for the synthesis of 2-diarylphosphoryl-substituted β-amino acid esters is based on the (DHQD)2-PYR-catalyzed asymmetric phosphination of esters (I) and (VI) with diaryl phosphine chlorides (II). Concomitant reduction of the ester and phos-phine oxide moiety in product (IVa) followed by borane protection of the trivalent phos-phine is achieved without loss of stereochemical integrity. — (NIELSEN, M.; JACOBSEN, C. B.; JOERGENSEN*, K. A.; Angew. Chem., Int. Ed. 50 (2011) 14, 3211-3214, http://dx.doi.org/10.1002/anie.201007188 ; Dep. Chem., Univ. Aarhus, DK-8000 Aarhus, Den.; Eng.) — Mais

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