cheminform abstract: new synthetic route to 1,2,4-thiadiazolines and 1,3-thiazolines via...
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1997 thiadiazole derivatives
thiadiazole derivativesR 0300
17 - 114New Synthetic Route to 1,2,4-Thiadiazolines and 1,3-Thiazolines viaThiadiazolopyridinium Salts. — The base-promoted reaction of chlorides(I) with nitriles provides an efficient synthesis of the 1,2,4-thiadiazolines (III).A similar condensation with acetone yields the thiazolines (V) and the dimers( VI) as side products. — (MARTINEZ, A.; CASTRO, A.; FONSECA, I.;MARTINEZ-RIPOLL, M.; CANO, F. H.; ALBERT, A.; Heterocycles 43 (1996)12, 2657-2666; Inst. Quim. Med., CSIC, E-28006 Madrid, Spain; EN)
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