cheminform abstract: practical method for the synthesis of 2,3-disubstituted indole derivatives...

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ChemInform 2010, 41, issue 20 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim www.cheminform.wiley-vch.de Indole derivatives R 0140 DOI: 10.1002/chin.201020084 Practical Method for the Synthesis of 2,3-Disubstituted Indole Derivatives Pro- moted by β-(Benzotriazol-1-yl)allylic O-Stannyl Ketyl Radicals. — Treatment of readily prepared E/Z-mixtures of benzotriazolyl-substituted ketones (IV) according to A) affords good yields of the desired target compounds. However, when a tert-butyl group is present at the α-position [cf. (VI)], 3-acylindoles and minor amounts of phen- anthridines are obtained. — (KIM*, T.; KIM, K.; Tetrahedron Lett. 51 (2010) 5, 868-871; Kolon Life Sci., Inc., Yongin, Gyeonggi 449-797, S. Korea; Eng.) — Mais 20- 084

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Page 1: ChemInform Abstract: Practical Method for the Synthesis of 2,3-Disubstituted Indole Derivatives Promoted by β-(Benzotriazol-1-yl)allylic O-Stannyl Ketyl Radicals

www.cheminform.wiley-vch.de

201020.fm Page 96 Tuesday, April 20, 2010 8:54 AM

Indole derivativesR 0140 DOI: 10.1002/chin.201020084

Practical Method for the Synthesis of 2,3-Disubstituted Indole Derivatives Pro-moted by β-(Benzotriazol-1-yl)allylic O-Stannyl Ketyl Radicals. — Treatment of readily prepared E/Z-mixtures of benzotriazolyl-substituted ketones (IV) according to A) affords good yields of the desired target compounds. However, when a tert-butyl group is present at the α-position [cf. (VI)], 3-acylindoles and minor amounts of phen-anthridines are obtained. — (KIM*, T.; KIM, K.; Tetrahedron Lett. 51 (2010) 5, 868-871; Kolon Life Sci., Inc., Yongin, Gyeonggi 449-797, S. Korea; Eng.) — Mais

20- 084

ChemInform 2010, 41, issue 20 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Page 2: ChemInform Abstract: Practical Method for the Synthesis of 2,3-Disubstituted Indole Derivatives Promoted by β-(Benzotriazol-1-yl)allylic O-Stannyl Ketyl Radicals

www.cheminform.wiley-vch.de

201020.fm Page 97 Tuesday, April 20, 2010 8:54 AM

ChemInform 2010, 41, issue 20 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

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