cheminform abstract: synthesis and conformational study of β-hydroxy sulfones, bioisosteres of...

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1997 general general (heterocyclic compounds) R 0010 01 - 126 Synthesis and Conformational Study of β-Hydroxy Sulfones, Bioisosteres of Oxisuran Metabolites, and Their O-Methyl Deriva- tives. The conformational stability of the title compounds (II), (IV), and ( VII) is primarily controlled by electrostatic interactions. Steric effects and intramolecular hydrogen bonding are less important factors. — (ALVAREZ- IBARRA, C.; CUERVO-RODRIGUEZ, R.; FERNANDEZ-MONREAL, M. C.; RUIZ, M. P.; Tetrahedron 52 (1996) 34, 11239-11256; Dep. Quim. Org., Fac. Cienc. Quim., Univ. Complutense, E-28040 Madrid, Spain; EN) 1

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Page 1: ChemInform Abstract: Synthesis and Conformational Study of β-Hydroxy Sulfones, Bioisosteres of Oxisuran Metabolites, and Their O-Methyl Derivatives

1997 general

general (heterocyclic compounds)R 0010

01 - 126Synthesis and Conformational Study of β-Hydroxy Sulfones,Bioisosteres of Oxisuran Metabolites, and Their O-Methyl Deriva-tives. — The conformational stability of the title compounds (II), (IV), and( VII) is primarily controlled by electrostatic interactions. Steric effects andintramolecular hydrogen bonding are less important factors. — (ALVAREZ-IBARRA, C.; CUERVO-RODRIGUEZ, R.; FERNANDEZ-MONREAL, M. C.;RUIZ, M. P.; Tetrahedron 52 (1996) 34, 11239-11256; Dep. Quim. Org., Fac.Cienc. Quim., Univ. Complutense, E-28040 Madrid, Spain; EN)

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