chitosan
TRANSCRIPT
Mr. Sagar Kishor savaleDepartment of Pharmaceutics
Department of Pharmacy (Pharmaceutics) Department of Pharmacy (Pharmaceutics) | | Sagar savaleSagar savale05/01/23 1
Chitosan (2-amino-2deoxy-(1→4)-β-D-glucopyranan), a polyaminosaccharide, normally obtained by alkaline deacetylation of chitin is the principal component of living organisms such as fungi and crustacea.
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The degree of N-acetylation (DA) together with the molecular weight are the most important parameters for its characterization. The DA, which is by definition the molar fraction of N-acetylated units, is a structural parameter influencing charge density, crystallinity and solubility, including the propensity to enzymatic degradation, with higher DAs leading to faster biodegradation rates
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1) Biocompatibility 2) Nonantigenicity 3) Nontoxicity (Its Degradation Products Are
Known Natural Metabolites) 4) The Ability To Improve Wound Healing/Or
Clot Blood 5) The Ability To Absorb Liquids And To Form
Protective Films And Coatings6) Selective Binding Of Acidic Liquids, Thereby
Lowering Serum Cholesterol Levels.05/01/23 4
It is cationic polyamide Chitosan reacts chemically with anionic system It undergoes reactions typical of amines (For ex. N-acetylation & Schiff reaction) Acidity-Alkalinity: PH= 4.0-6.0 Density: 1.35-1.40 g/cm3
Glass transition temperature: 2030c05/01/23 5
Moisture content: - It absorbs moisture from atmosphere - Particle size distribution: <30 mm
Solubility: - Sparingly soluble in water - Practically insoluble in ethanol and other organic
solvents - Solubility is affected by degree of deacetylation
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Viscosity: - The viscosity of chitosan increases with
increasing chitosan concentration, decreasing temperature, and increasing degree of deacetylation.
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Preparation of microspheres Taste marked by spray drying Preliminary study on film dosage form
prepared from chitosan for oral drug delivery Increased stability of drug Solubility increases as well as taste masking Orthopaedic patient
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Cosmetic industry Dental medicine Enhanced bone formation by transforming
growth factor Cholesterol lowering effect Chitosan as a permiation enhancer Chitosan as mucoadhesive excipient
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Aloe Vera Toothpaste Opthalmic drug delivery Gene delivery
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Biomedical: - Drug delivery - Cell delivery - Orthopedics - Wound healing - Surgical sutures - Ophthalmology
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- Skin treatments - Pharmaceuticals - Dentistry - Bone healing Nutritional - Cholesterol-lowering effects - Fiber and weight loss effects
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Cosmetic - Hair care - Skin care - Oral care.
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1)Rarymod C. Rowe, Paul. J.Shesky, and Sian. C.Owen, Handbook of pharmaceutical exicipient 5th edition, P.no 159-160.
2) http://www.phama info.net
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