compact b1 atii adh aldosterone α 1 na↑ k↓ na↑ ca↑ mg↑ k↑ na↑ hco3↓ no pg b2 na↑...
TRANSCRIPT
![Page 1: Compact B1 ATII ADH Aldosterone α 1 Na↑ K↓ Na↑ Ca↑ Mg↑ K↑ Na↑ HCO3↓ NO PG B2 Na↑ Na Cl↑ + K↓ ANP GI Vasculature AfterloadPreload Conductivity M2 - B1 +](https://reader036.vdocuments.pub/reader036/viewer/2022062421/56649e0d5503460f94af7176/html5/thumbnails/1.jpg)
Compact
B1
ATII
ADH
Aldosterone
α 1
Na↑ K↓
Na↑ Ca↑Mg↑ K↑
Na↑HCO3↓
NO
PG
B2
Na↑
Na Cl↑+ K↓
ANP
AfterloadPreload
Conductivity
M2 - B1+
CNS α 2
Vagus Nerve
I-1
BaroreflexBaroreflex
Renin
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B1
ATII
ADH
Aldosterone
α 1
Na↑ K↓
Na↑ Ca↑Mg↑ K↑
Na↑HCO3↓
NO
PG
B2
Na↑
Na Cl↑+ K↓
ANP
AfterloadPreload
Conductivity
M2 - B1+
CNS α 2
Vagus Nerve
I-1
BaroreflexBaroreflex
Renin
Expanded
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Cardiac Pharmacology
Ted WilliamsPharm D Candidate
OSU/OHSU College of Pharmacy
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The big, scary picture
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Breaking it Down
• Direct Cardiac Agents• Peripheral Vascular Agents• Renal Agents
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Reality Check
• The pharmacology really isn’t that simple, but it is a helpful framework
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Direct Cardiac Agents
1. Beta Blockers (BB)2. Non-Dihydropyridine Calcium Channel
Blockers (CCB)3. Digitalis Glycoside (De-GOX-in)4. Aldosterone antagonists – Well explain why this is here later
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Peripheral Vascular Agents
1. Nitrates2. Dihydropyridine CCB3. Phosphodiesterase Inhibitors4. Quinazolines (Alpha 1 Antagonists)5. Hydralazine6. Celiprolol7. Phentolamine
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Renal Agents
1. ACE Inhibitors2. Angiotensin 2 Inhibitors3. Diuretics
i. Carbonic Anhydrase Inhibitorsii. Loopiii. Thiazide Diureticsiv. Aldosterone Antagonistsv. Potassium Sparing Diuretics
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Mixed Bag
• Selective I-1 Imidazoline Receptor Agonists
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Direct Cardiac Agents – BB
• Selectivity– Beta 1 Selective– Beta 1/2 Non-Selective– Alpha 1, Beta 1/2 Non-Selective– Alpha 2, Beta 1/2 Non-Selective
• Intrinsic Sympathomimetic Activity (ISA)– ISA
• No long term mortality benefit Post MI • Non-ISA do have benefit post MI
– Non-ISA
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Targets of Beta Blockers
B1
ATII
ADH
Aldosterone
α 1
Na↑ K↓
Na↑ Ca↑Mg↑ K↑
Na↑HCO3↓
NO
PG
B2
Na↑
Na Cl↑+ K↓
ANP
AfterloadPreload
Conductivity
M2 - B1+
CNS α 2
Vagus Nerve
I-1
BaroreflexBaroreflex
Renin
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Targets of Beta Blockers
• Beta 1 blockade– “Cardioselective”– Inhibits sympathetic contractility, inotropy, and
conductivity of the heart– Inhibits sympathetic renin secretion in the kidneys
• Best Tolerated Beta 1 Blockers– Atenolol – Acebutolol – Bisoprolol – Metoprolol
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Targets of Beta Blocker
• Beta 2 blockade– Beta 2 receptors inhibit smooth muscle
contractions in the lungs and GI tract– Beta 2 blockade is useful for restricting hepatic
blood flow for patient with Liver Cirrhosis, but generally not a therapeutic effect for CVD
• Commonly Used Beta 2 Blockers– Propranolol – Nadolol
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Targets for Non-Dihydropyridine Calcium
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Targets of Digoxin
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Targets of Aldosterone Antagonists
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Targets of Aldosterone Antagonists
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Peripheral Vascular Agents
1. Nitrates2. Dihydropyridine CCB3. Phosphodiesterase Inhibitors4. Quinazolines (Alpha 1 Antagonists)5. Hydralazine6. Celiprolol7. Phentolamine
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Targets of Nitrates
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Targets of Nitrates
• Preferential vasodilation of veins– Decreases Preload– Decreases Afterload
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Targets of Dihydropyridine CCB
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Targets of Dihydropyridine CCB
• Peripheral Vasodilation• State dependent binding to the Inactive State– Tissues more often in the inactive state have
tissue selectivity– Targets vascular smooth muscle, generally arterial
• Decreases afterload and increases stroke volume
• Reduces blood pressure
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Targets of Phosphodiesterase Inhibitors
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Targets of Phosphodiesterase inhibitors
• Promotes vasodilation by increases cGMP• Decreases Afterload– Good for Heart Failure– Secondary decrease in preload
• Reflex tachycardia via the baroreflex– No so good for heart failure patients
• Resistance develops rapidly with continuous use, limiting therapeutic uses to acute decompensated heart failure
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Hydralazine
• Mechanism not well understood
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Celiprolol
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Phentolamine
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Targets for Alpha Blockers
B1
ATII
ADH
Aldosterone
α 1
Na↑ K↓
Na↑ Ca↑Mg↑ K↑
Na↑HCO3↓
NO
PG
B2
Na↑
Na Cl↑+ K↓
ANP
AfterloadPreload
Conductivity
M2 - B1+
CNS α 2
Vagus Nerve
I-1
BaroreflexBaroreflex
Renin
![Page 30: Compact B1 ATII ADH Aldosterone α 1 Na↑ K↓ Na↑ Ca↑ Mg↑ K↑ Na↑ HCO3↓ NO PG B2 Na↑ Na Cl↑ + K↓ ANP GI Vasculature AfterloadPreload Conductivity M2 - B1 +](https://reader036.vdocuments.pub/reader036/viewer/2022062421/56649e0d5503460f94af7176/html5/thumbnails/30.jpg)
Targets for Alpha Blockers• Alpha 1 Blockade– Peripheral Vasodilation by inhibition of Gq Signaling
pathway – Carvedilol (alpha-1, beta 1/2)– Labetalol (alpha-1, beta 1/2)– Quinazolines
– (Prazosin, Tamsulosin, Terasozin, Alfazosin)• Alpha 2 Blockade– CNS Inhibition the inhibition of the baroreflex– Peripheral inhibition of the negative feedback on vagal
cardiac stimulation– Celiprolol (alpha-2, beta-1 blockade)
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