curriculum vitae - cairo universityscholar.cu.edu.eg/fmae/files/c.v._fadi_0.pdf1 curriculum vitae...

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Curriculum Vitae

Name: Fadi Mohsen Awadallah

Date of birth: 30/12/1971

Nationality: Egyptian

Languages: English and French

School: College de La Salle

Address: Sheraton Heliopolis- Misr Eltaamir, zone 3, bldg 2,

flat 18, Heliopolis, Cairo.

Tel: 01223483941-01069312000

e-mail: [email protected], [email protected],

[email protected]

Certificates:

- B.Sc. (Pharmacy and Pharmaceutical Sciences, Cairo University, Excellent honor,

1993)

- M.Sc. (Pharmaceutical Chemistry, Cairo University, 2000)

MSc thesis entitled:” Synthesis of certain pyranoquinolines as potential

antimicrobial agents”; from which one article was published:

”Synthesis of certain pyranoquinolones as potential antimicrobial agents”

Abou-Shady, H.A., Amin, K.M., Hanna, M.M. and Awadallah, F.M.,

Bull.Fac.Pharm.Cairo Univ. (2003), 41(3), 59-73

- Ph.D. (Pharmaceutical Chemistry, Cairo University, 2004)

PhD thesis entitled: ”Synthesis of some pyranoquinolines and related tetracyclic

derivatives as potential antineoplastic agents”; from which two articles were

published:

“Synthesis of some pyranoquinoline derivatives with anticipated antineoplastic

activity”

Amin, K.M., El-Sayed, N.M., Mohammed, S.R. and Awadallah, F.M.,

Bull.Fac.Pharm. Cairo Univ. (2005), 43(3), 87-94

”Synthesis of some new pyranoquinoline derivatives of potential antineoplastic

activity”

Amin, K.M., El-Sayed, N.M., Mohammed, S.R. and Awadallah, F.M.,

mailto:[email protected]



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Egypt.Pharm.J.(2006), 5(1), 157-173

Positions held:

Demonstrator of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo

University, 1994-2000.

Assistant lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo


Lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University,

2004-2011.

Associate professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo

University, since 2011.

Part-time lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Beni-Sweif


Part-time lecturer of Pharmaceutical Chemistry, Faculty of Pharmaceutical

sciences and Pharmaceutical industries, Future University, since 2008-2010.

Part-time associate professor of Pharmaceutical Chemistry, Faculty of

Pharmaceutical sciences and Pharmaceutical industries, Future University, since

2011.

Supervisor of the NMR lab. since 2007-2011.

Director of the Microanalytical Unit (MAU) since Nov. 2012.

A) Teaching activities:

1) Undergraduate courses:

- Participating in teaching the undergraduate Pharmaceutical Chemistry (old curriculum)

for fourth year students in Faculty of Pharmacy, Cairo University.

- Participating in teaching the undergraduate Pharmaceutical Chemistry (curricula 801,

802 and 803) for fourth and fifth year students in Faculty of Pharmacy, Cairo University.

- Participating in teaching the undergraduate Medicinal Chemistry 1 & 2 (curricula 509,

610) for Clinical Pharmacy programme students, Faculty of Pharmacy, Cairo University.

- Course coordinator of Medicinal Chemistry 2 (PC610) for Clinical Pharmacy

programme students, Faculty of Pharmacy, Cairo University.(spring and summer

semesters 2013).

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- Participating in teaching the undergraduate Pharmaceutical Chemistry (curricula 801,

802, 803) for fourth and fifth year students in Faculty of Pharmacy, Beni-Sweif

University.

- Teaching drug design and combinatorial chemistry courses for Drug design programme

students Ain-shams university (summer 2012).

- Participating in teaching the undergraduate Pharmaceutical Chemistry for third and

fourth year students (Pharmaceutical Chemistry 1 and 2 and drug design) in Faculty of

Pharmaceutical sciences and Pharmaceutical industries, Future University.

- Oral examiner for undergraduate students in Colleges of Pharmacy in a number of

Egyptian Universities e.g. Cairo, Beni-Sweif, Quanat El-Suez, Ain-Shams, 6th of

October, Egyptian Russian, Assiut, Mansoura, Alexandria and Zagazig Universities.

2) Postgraduate courses:

- Participating in teaching postgraduate Pharmaceutical Chemistry students (Reactions

and reagents in drug synthesis and Drug Design 1 (2801)) in faculty of Pharmacy Cairo

and Beni-sweif Universities.

B) Research activities:

1) Post doctoral publications:

1- Fadi M. Awadallah, Franziska Mϋller, Jochen Lehmann, Ashraf H. Abadi

“Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine

receptors, leading to a D4-selective ligand.”

Bioorg. Med. Chem. 2007, 15, 5811-5818.

**This publication received the Cairo University award for international publications.

2- Fadi M. Awadallah “Synthesis, Pharmacophore modeling, and Biological Evaluation

of Novel 5H-thiazolo[3,2-a]pyrimidin-5-one Derivatives as 5-HT2A Receptor

Antagonists”

Sci. Pharm. 2008, 76, 415-438.


3- Safinaz E. Abbas, Fadi M. Awadallah, Nashwa A. Ibrahim and Ahmed M. Gouda

“Novel substituted and fused pyrrolizine derivatives: synthesis, anti-inflammatory and

ulcerogenecity studies” Eur. J. Med. Chem. 45 (2010) 482-491. **This publication received the Cairo University award for international publications.

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4- Nehad A. El-Sayed, Fadi M. Awadallah, Nashwa A. Ibrahim, Mohammed T. El-

Saadi, “Synthesis, anti-inflammatory and ulcerogenicity studies of some substituted

pyrimido[1,6-a]azepine derivatives “ Eur. J. Med. Chem., 45 (2010) 3147-3154.


5- Kamilia M. Amin, Hanan, H. Georgy, Fadi M. Awadallah, “EGRF tyrosine kinase

targeted compounds: Synthesis, Docking study and In-vitro antitumor activity of some

new quinazoline and benzo[d]isothiazole derivatives” Med. Chem. Res. 20 (2010) 1042-

1053. **This publication received the Cairo University award for international publications.

6- Safinaz E. Abbas, Fadi M. Awadallah, Nashwa A. Ibrahim, Ahmed M. Gouda and

Bassem A. Shehata, “Design, Synthesis and Preliminary Evaluation of Some Novel

[1,4]Diazepino [5,6-b]pyrrolizine and 6-(2-Oxopyrrolidino)-1H-pyrrolizine Derivatives

as Anticonvulsant Agents.” Med. Chem. Res. 20 (2011) 1015-1023. **This publication received the Cairo University award for international publications.

7- Nehad A. El-Sayed, Fadi M. Awadallah, Nashwa A. Ibrahim, Mohammed T. El-

Saadi. "Potential anti-inflammatory activity and ulcerogenicity study of some novel

pyrimido[4',5':4,5]pyrimido[1,6-a]azepine derivatives" Med. Chem. Res. 21 (2012) 395–

405.


8- Kamilia M. Amin, Fadi M. Awadalla, Amal A.M. Eissa, Sahar M. Abou-Seri,

Ghaneya S. Hassan. "Design, synthesis and vasorelaxant evaluation of novel coumarin–

pyrimidine hybrids" Bioorg. Med. Chem. 19 (2011) 6087-6097. **This publication received the Cairo University award for international publications.

9- Fadi M. Awadallah, Wafaa I. El-Eraky, Dalia O. Saleh. "Synthesis, vasorelaxant

activity, and molecular modeling study of some new phthalazine derivatives" Eur. J. Med.

Chem. 52 (2012) 14-21.


10- Safinaz E. Abbas, Fadi M. Awadallah, Nashwa A. Ibrahim, Eman G. Said, Gihan

M. Kamel. "New quinazolinone-pyrimidine hybrids: Synthesis, anti-inflammatory,

and ulcerogenicity studies" Eur. J. Med. Chem. 53 (2012) 141-149.


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11- Kamilia M. Amin, Amal A.M. Eissa, Sahar M. Abou-Seri, Fadi M. Awadallah,

Ghaneya S. Hassan. "Synthesis and biological evaluation of novel coumarin-pyrazoline

hybrids endowed with phenylsulfonyl moiety as antitumor agents" Eur. J. Med. Chem. 60

(2013) 187-198.


12- Safinaz El-Sayed Abbas, Fadi Mohsen Awadallah, Nashwa Ahmed Ibrahim,Eman

Gaber Said,and Gihan Kamel. “Design and Synthesis of Some 3-Substituted-2-[(2,4-

dichlorophenoxy)methyl]quinazolin-4(3H)-one Derivatives as Potential Anticonvulsant

Agents” Chem. Pharm. Bull. 61 (2013) 679–687.


13- Fadi M. Awadallah, Gary A. Piazza, Bernard D. Gary, Adam B. Keeton, Joshua C.

Canzoneri. “Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline

moiety and evaluation of their antiproliferative activity” Eur. J. Med. Chem. 70 (2013)

273-279.


14- Safinaz E.-S. Abbas, Enayat I. Aly, Fadi M. Awadallah and Walaa R. Mahmoud.

"4-Substituted-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine Derivatives: Design, Synthesis,

Antitumor and EGFR Tyrosine Kinase Inhibitory Activity" Chem. Biol. Drug Des, 85

(2015) 608-622.

15- Kamilia M. Amin, Sahar M. Abou-Seri, Fadi M. Awadallah, Amal A.M. Eissa,

Ghaneya S. Hassan, Mohamed M. Abdulla "Synthesis and anticancer activity of some 8-

substituted-7-methoxy-2H-chromen-2-one derivatives toward hepatocellular carcinoma

HepG2 cells" Eur. J. Med. Chem. 90 (2015) 221-231.

16- Fadi M. Awadallah, Sahar M. Abou-Seri, Mohamed M. Abdulla, Hanan H.

Georgey. "Design and synthesis of potent 1,2,4-trisubstituted imidazolinone derivatives

with dual p38αMAPK and ERK1/2 inhibitory activity" Eur. J. Med. Chem. 94 (2015)

397-404.

17- Fadi M. Awadallah, Tamer A. El-Waei, Mona M. Hanna, Safinaz E. Abbas,

Mariangela Ceruso, Beyza Ecem Oz, Ozen Ozensoy Guler, Claudiu T. Supuran.

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"Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based

sulfonamide derivatives" Eur. J. Med. Chem. 96 (2015) 425-435.

18- Ghaneya S. Hassan, Fadi M. Awdallah, Mohamed T. El-Saadi, Ahmed O. Elgendi

and Loah R. Hemeda. "Synthesis of some benzothiazole derivatives evaluated as

antimicrobials and antibiofilms" J. Chem. Pharm. Res. 7 (2015) 1125-1143.

2) Patents:

- Antiproliferative active fluoro-substituted spiro-alkaloids, number 1975/2013;

25/12/2013.

3) Projects:

- Co-worker in a project entitled: ”Design, Synthesis and Evaluation of Cardiovascular

Activity of Novel Substituted Coumarin Derivatives”, funded by Cairo university (1 Jan

2009- 31 Dec 2010).

4) Peer reviewer for some international journals:

- Such as: European journal of Medicinal chemistry (Eur. J. Med. Chem.) and

Letters in drug design and discovery (Lett. Drug Des. Discov.), Medicinal

Chemistry Research (Med. Chem. Res.) Archiv der Pharmazie (Arch. Pharm),

Molecules, International journal of medicinal chemistry (Intl. J. Med. Chem.),

British Journal of Pharmacology (Br. J. Pharmacol.), Bulletin of Faculty of

Pharmacy Cairo University (Bull. Fac. Pharm. Cairo Univ.), Journal of advanced

research (J. Adv. Res.), Molecular Biodiversity (Mol. Biodiv.), Organic

Communications (Org. Comm.), Medicinal Chemistry

Communications(MedChemComm).

5) Conferences:

1- The 1st Scientific Conference of Faculty of Pharmacy Cairo University, under the

theme of “Pharmacy role in Community Health Promotion”, March 29th 2008.

Dissertation: “Synthesis, Pharmacophore modeling, and Biological Evaluation of Novel

5H-thiazolo[3,2-a]pyrimidin-5-one Derivatives as 5-HT2A Receptor Antagonists”

2- The 2nd Conference of Egyptian Humboldtians, under the theme of "Humboldtians in

Natural Sciences and Engeneering", German University in Cairo, September 8-9, 2007.

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3- The 1st International Conference of the Quality Assurance and Accreditation Center

Cairo University, under the theme of "Quality and Accreditation, The Present and The

Prospective", April 15 2008.

4- The 2nd Scientific Conference of Faculty of Pharmacy, Cairo University, April 26th

2010.

Dissertation:”Synthesis, anti-inflammatory and ulcerogenicity studies of some substituted

pyrimido[1,6-a] azepine derivatives”.

5- The 13th Assembly of Arab Universities (AARU) Conference of the Pan Arab colleges

of Pharmacy, College of Pharmacy and Pharmaceutical Manufacture, Misr University for

Science and Technology 25-27 May 2010.

Dissertation: “EGRF tyrosine kinase targeted compounds: Synthesis, Docking study and

In-vitro antitumor activity of some new quinazoline and benzo[d]isothiazole derivatives”.

6- The 3rd Scientific Conference of Faculty of Pharmacy, Cairo University, “Good

Pharmacy Practice” April 25&26th 2012.

Dissertation:” Design, synthesis and anticonvulsant activity of some 2,3-disubstituted

quinazolinone and 3,4-annelated quinazoline derivatives”.

7- Future University International Conference on Pharmaceutical Technologies

February 6-9, 2012.

Dissertation:" Synthesis and molecular modeling study of some new phthalazine

derivatives of potential vasorelaxant activity"; and " New quinazolinone-pyrimidine

hybrids: synthesis, anti-inflammatory and ulcerogenecity studies".

8- The 4th Scientific Conference of Faculty of Pharmacy, Cairo University, "Pharmacy

Education and Community Expectations" April 24th and 25th, 2013.

Dissertation: ” Synthesis of some 8-substituted-7-methoxy-2H-chromen-2-one derivatives

and their in vitro screening for antineoplastic activity”.

9- The 5th International Scientific Conference of Faculty of Pharmacy Cairo University,

"Pharmacy at the cutting-edge: Facing future challenges" April 23rd and 24th, 2014.

Dissertation: "Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline

moiety and evaluation of their antiproliferative activity".

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And,

Oral presentation: "Molecular modeling in Pharmaceutical R&D:Considerations for the

design of Pharmaceuticals.

10- FUE International Conference of Pharmaceutical Sciences, February 9-11, 2015.

Dissertation: "Design and synthesis of potent 1,2,4-trisubstituted imidazolinone

derivatives with dual p38αMAPK and ERK1/2 inhibitory activity".

11- 16th Tetrahedron Symposium, "Challenges in Bioorganic and Organic Chemistry"

June 16-19, 2015, Berlin, Germany.

Dissertation: "Design and synthesis of potent 1,2,4-trisubstituted imidazolinone

derivatives with dual p38αMAPK and ERK1/2 inhibitory activity".

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6) Supervision of MSc. And PhD theses:

Candidate name University Degree Registration/

approval date

Theses title (arabic/English)

والء رمضان محمود محمد

ابو زيد

Cairo PhD 13/12/2007

Approved

16/1/2014

يدين ذات تشييد بعض المشتقات الجديدة من البيرازولوبيريم

االهتمام البيولوجى

Synthesis of novel pyrazolopyrimidine

derivatives of biological interest

تامر عبد اللطيف عبد

الرحمن

Cairo MSc 15/9/2009

Approved

22/9/2014

لبنزوبيرانتشييد و الفاعلية المضادة للسرطان لبعض مشتقات ا

Synthesis and anticancer activity of some

benzopyran derivatives

Cairo MSc 13/7/2011 نهال عصام

Approved

11/11/2015

فثاالزين لتشييد و الفاعلية المضادة للسرطان لبعض مشتقات ا

الجديدة

Synthesis and anticancer activity of some new

phthalazine derivatives

ات تشييد و دراسة النشاط المضاد للسرطان لبعض الحلق Cairo MSc 16/4/2014 حسام حمودة ندا حمودة

النيتروجينية الجديدة

Synthesis and anticancer activity study of some

new nitrogeneous heterocycles.

انسة تصميم و تشييد بعض المشتقات الحلقية الغير متج Cairo PhD 16/9/2015 غادة احمد فتحى

كمضادات للسرطان من خالل تثبيط انزيم بارب

Design, synthesis and anticancer activity

evaluation of new heterocyclic derivatives as

PARP inhibitors

Beni-Suef PhD 20/5/2007 د محمود جودة سعيداحم

approved

29/7/2009

جينية تشييد بعض المشتقات الجديدة من المركبات النيترو

الحلقية الغير متجانسة ذات فاعلية بيولوجية متنوعة

Synthesis of some novel azaheterocyclic

derivatives of diverse biological activities

Beni-Suef PhD 20/5/2007 السعدى محمد طه

approved

2/6/2010

ة محتملة تشييد بعض مشتقات البيريمدين الجديدة ذات فاعلي

ضد االلتهابات

Synthesis of some pyrimidine derivatives of

potential anti-inflammatory activity

Beni-Suef MSc 29/10/2006 ايمان جابرسيد

approved

19/6/2012

من المتوقع تصميم و تشييد بعض مشتقات األكردين المستبدلة

أن يكون لها فاعلية اقربازينية

Design and Synthesis of some substituted

acridine derivatives of anticipated

pharmacological activity

Beni-Suef MSc 20/6/2010 رمضان حميدة ةلؤ

approved

21/10/2015

د و الفاعلية المضادة للميكروبات لبعض المشتقات الحلقية تشيي الغير متجانسة الجديدة

Synthesis and Antimicrobial activity of some

new heterocyclic derivatives

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7) Membership of examination committee of MSc theses:

- Member of the examination committee of MSc thesis Beni-Suef University.

C) Faculty activities:

- Organizing and participating in a drug design workshop for undergraduate students;

summer 2011.

- Supervising the summer training of undergraduate students in Faculty of Pharmacy,

Cairo University and Beni-Sweif University.

- Coordinator of the ‘Performance Appraisal and Quality Assurance Unit (PAQU) in the

department of Pharmaceutical Chemistry; for Pharmaceutical Chemistry 1 (801), Faculty

of Pharmacy, Cairo University 2008-2010.

- Coordinator of the ‘Performance Appraisal and Quality Assurance Unit (PAQU) in the

department of Pharmaceutical Chemistry, for postgraduate curriculum (drug design 1

(2801), Faculty of Pharmacy, Cairo University since 2011.

- Participating in the preparation of the course specifications of undergraduate

Pharmaceutical Chemistry I course (801), undergraduate elective courses (804 and 805),

as well as some post-graduate courses.

Candidate name University Degree Registration/

approval date

Theses title (arabic/English)

احمد يلريهام اسماع

اسماعيل

Nahda

NUE

MSc 12/7/2012 تقات تصميم، تشييد و الفاعلية المضادة لألورام لبعض مش

الكينازولين الجديدة

Design, synthesis and antitumor activity of new

quinazoline derivatives

Future هبة هللا احمد ابراهيم

FUE

MSc 10/10/2013 مستبدالت-2لبعض المضاد للسرطان النشاط شييد وتقييمت

الجديدة بنزايميدازولال

Synthesis and Anticancer Activity Evaluation

of Some New 2-Substituted Benzimidazoles

Future ميراي ميشيل يسي برسوم

FUE

MSc 17/6/2015 امينو حمض -تصميم و تشييد مشتقات جديدة من اورثو

ربوكسيليك ذات حلقات غير متجانسة كناهضات مزدوجة لـ الك

FXR وPPARs .

Design and synthesis of new heterocyclic o-

aminocarboxylic acid derivatives as dual FXR

and PPARs agonists.

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- Department representative in the research committee of the Performance Appraisal and

Quality Assurance Unit (PAQU). Preparing the matrix of the research plan of the

department 2009-2013.

- Department representative in the Performance Appraisal and Quality Assurance Unit

(PAQU) for organizing the preparation of undergraduate and postgraduate course files

2011/2012.

- Participating in the committee of national academic reference standard (NARS) for

updating standards of Pharmacy education.

- Member of the ' academic advising committee' 2011-2012.

- Member of the supreme committee of centers and units in Faculty of Pharmacy Cairo

University.

- Member of the committee of the Microanalytical Unit.

- Member of the International Relation Bureau (IRB) Faculty of Pharmacy Cairo

University (2012) and participating in "Job sheet writing" for the Pharmacy profession as

part of the TEMPUS-OIPULES project.

- Academic advisor for Clinical Pharmacy Program student since fall 2013.

- Member of the examination control of undergraduate students.

- Participating in preparing the program ILO's of Bachelor of Pharmaceutical Sciences.

- Participating in material collection and editing of the department booklet.

- Supervising the elections of Student Union.

- Participating in committees of purchasing and inspection of chemicals.

D) Training courses and Workshops:

1) Courses organized by Faculty and Leadership Development Centre (FLDC):

- Methods of scientific research 25-29/3/2006.

- Quality assurance and accreditation 7,8/5/2006.

- E-learning 12-14/2/2007.

- Scientific writing and international publishing 26-29/2/2007.

- Evaluation of teaching 26-28/3/2007.

- New tendencies in teaching 21-23/5/2007.

- The credit hour systems 30/1-1/2/2012.

- Exams and student evaluation systems 11-12/2/2013.

- Strategic planning 11-12/9/2013

- Communication skills 22-23/1/2014.

- Research ethics 21-22/6/2014.

- University code of ethics 15-16/10/2014.

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2) Other workshops:

- Workshop on course and program report, Faculty of Pharmacy Cairo University

4/6/2007.

- Workshop on Computer aided drug design using molecular modeling programs, Faculty

of Pharmacy Cairo University, 1-2/7/2009.

- Risk and crisis management and emergency plan 15/4/2010.

- Workshop on Computer aided drug design using molecular modeling programs, Faculty

of Pharmacy Cairo University 10-11/10/2010.

- Workshop on Structure-based and ligand-based drug design, Faculty of Pharmacy MIU,

June 2014.

- Attending the training programs “Staff member 1” and Staff member 2” of the Central

Unit of ICT training (CUICTT)- Improving Higher Education Worktorce ICT skills

project; Supreme Council of Universities (SCU): Basic concepts of IT, using computer

and managing files, word processing, spreadsheets, PC maintenance and protection,

presentations, database, information and communication.

- Workshop on NMR "Avance 1D/2D, Introduction to Avance spectrometer operation",

Zurich, Switzerland, 16-20 March 2015,

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