curriculum vitae - university of hong...

Curriculum Vitae

Xin-Yuan Guan (關新元)Department of Clinical Oncology, Li Ka Shing Faculty of Medicine

The University of Hong KongTel: 852-39179782; 852-28169126

Email: [email protected] Page: http://www.oncology.hku.hk/staff_xyguan.html

Education:Feb. 88-May 93 Ph.D., Department of Genetics, University of Arizona, Tucson, AZ, USA

Brief Chronology of Employment:Mar. 93-Aug. 93 Postdoctoral Fellow, Department of Radiation Oncology,

The University of Michigan, Ann Arbor, MI, USASept. 93-Mar. 99 Senior Staff Fellow, Laboratory of Cancer Genetics,

National Human Genome Research Institute, National Institutes Health, Bethesda, MD, USA

Dec. 94-Mar. 99 Unit Head, Unit of Microdissection Technology,National Human Genome Research Institute, National Institutes Health, Bethesda, MD, USA

Mar. 99-Mar. 07 Associate Professor, Department of Clinical Oncology,The University of Hong Kong, Hong Kong

June 00-present Director, Lab of Cancer Genetics, Department of Clinical Oncology,The University of Hong Kong, Hong Kong

April 07-May 18 Professor, Department of Clinical Oncology,The University of Hong Kong, Hong Kong

Sept. 10-present Deputy Director, State Key Laboratory for Liver Research (肝病研究国家重点实验室), HKU Sept. 13-Dec. 17 Director, Centre for Cancer Research, HKUApril 16-present Sophie YM Chan Professor of Cancer ResearchMay 18-present Chair Professor (Chair of Cancer Genetics)

Awards:1998 National Outstanding Young Research Award (Type B), National Natural Science

Foundation of China.2006 Faculty Outstanding Research Output Award, Li Ka Shing Faculty of Medicine,

The University of Hong Kong.2007 Science and Technology Prize of Higher Education of China (Natural Science,

First-class). Qin LX, Ye QH, Tang ZY, Wang XW, Guan XY, Jia HL, Ren N, Sun HX, Liu YK, Wang Lu. 钦伦秀，叶青海，汤钊猷，王心伟，关新元，贾户亮，任宁，孙惠川，刘银坤，王鲁。肝癌转移机理的新发现及其意义。2007 年度高等学校科学技术奖一等奖. Awarded by the Ministry of Education of PR China.

2009 Natural Science Prize of Shanghai (First-class). Qin LX, Ye QH, Tang ZY, Wang XW, Guan XY, Jia HL, Ren N, Sun HX, Liu YK, Wang Lu. 钦伦秀，叶青海，汤

1

钊猷，王心伟，关新元，贾户亮，任宁，孙惠川，刘银坤，王鲁。肝癌转移的分子基础与分子预测。2009 年度上海市自然科学奖一等奖。Awarded by the Government of Shanghai.

2010 State Natural Sciences Award of China (Second-class). Qin LX, Ye QH, Tang ZY, Guan XY, Jia HL.钦伦秀，叶青海，汤钊猷，关新元，贾户亮。肝癌转移机理的新发现及其意义, 2010 年度国家自然科学奖二等奖。Awarded by the Ministry of Science and Technology of PR China.

2011 Faculty Outstanding Research Output Award, The University of Hong Kong Li Ka Shing Faculty of Medicine (miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1).

2012 Outstanding Research Award, The University of Hong Kong.2012 State Scientific and Technological Progress Award of China (First-class). Bian

XW, Guan XY, Shou C, Jiang BH, Yang Z, Lin-Li J, Peng HW, Fang WG, Lou JN. 卞修武，关新元，寿成超，江秉华，杨治华，林李家宓，彭红卫，方伟岗，娄晋宁，孔祥复，平轶芳，刘凌志，姚小红，余时沧，蒋雪峰。肿瘤血管生成机制及其在抗血管生成治疗中的应用, 国家科技进步奖一等奖。(Investigation of mechanisms of angiogenesis in tumor and their application in the anti-angiogenic therapy). Awarded by the Ministry of Science and Technology of PR China.

2014 Faculty Outstanding Research Output Award, The University of Hong Kong Li Ka Shing Faculty of Medicine (Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma).

2014 Science and Technology Prize of Higher Education of China (Natural Science, Second-class, 2014). Guan XY, Chen L, Ma S, Li Y, Liu M, Ma NF, Hu L, Chan TM. Investigation of the molecular mechanisms of the development and progression of hepatocellular carcinoma. 關新元 ,陳蕾蕾,馬桂宜,李妍,劉铭,馬宁芳,胡亮,陳漢文。肝癌發生發展的分子機制研究，2014年度高等學校科學研究优秀成果奖(自然科學二等奖)。Awarded by the Ministry of Education of PR China.

2016 Science and Technology Prize of Higher Education of China (Natural Science, Second-class, 2016). Song L, Li J, Guan XY, Xie D, Zeng MS, Lin CY. The function and regulatory mechanism of microenvironment of esophageal squamous cell carcinoma. 宋立兵、李隽、关新元、谢丹、曽木圣、林楚勇。食管鳞癌肿瘤微环境的调控机制及其功能。2016 年度高等學校科學研究优秀成果奖(自然科學二等奖)。

2016 Outstanding Research Student Supervisor Award 2015/2016. The University of Hong Kong.

2017 Science and Technology Prize of Guangdong Province (First-class, 2017). Song L, Li J, Guan XY, Xie D, Zeng MS, Lin CY. The function and regulatory mechanism of microenvironment of esophageal squamous cell carcinoma. 宋立兵、李隽、关新元、谢丹、曽木圣、林楚勇。食管鳞癌肿瘤微环境的调控机制及其功能。2017 年度广东省科學技术奖(一等奖)。

2017 Science and Technology Prize of Medical Acadamy of China (Second-class, 2017). Song L, Li J, Guan XY, Xie D, Zeng MS, Lin CY. The function and regulatory mechanism of microenvironment of esophageal squamous cell

2

carcinoma. 宋立兵、李隽、关新元、谢丹、曽木圣、林楚勇。食管鳞癌肿瘤微环境的调控机制及其功能。2017 年度中华医学会科學技术奖(二等奖)。

Honors & Other Special Scientific Recognition:1998-2001 Visiting Professor, Peking Union Medical College, Chinese Academy of Medical

Sciences1997-2000 Visiting Professor, Sun Yat-Sen University of Medical Sciences1997-1999 Visiting Professor, Sun Yat-Sen University of Medical Sciences1997-2000 Consultant Professor, Harbin Medical University1998-2001 Visiting Professor, Hunan Medical University1998-present Visiting Professor, Jinan University2001-2003 Visiting Professor, Daliang Medical University1999-2004 Consultant, National Key Basic Research Project (973 Project) “Fundamental

Investigation of Human Carcinogenesis”2001-2004 Consultant, Chinese Society of Tumor Markers Oncology, Chinese Anti-Cancer

Association2005-present Visiting Professor, Sun Yat-Sen University2017-2021 Scientific Advisory Board Member, The translational and clinical research

flagship programme, Ministry of Health, Singapore.

Professional Membership:Active Member American Association for Cancer Research (AACR)Member The American Society of Human Genetics (ASHG)2011-2015 Member, Chinese Society of Protiomics, Chinese Association of Biochemistry and Molecular Biology 2012-2016 Member, Chinese Society of Cancer, Chinese Association of Pathophysiology

Members of Editorial Board of Journals:2008-present Board member, Acta Pharmacologica Sinica2008-present Board member, Journal of Biomedicine and Biotechnology2008-present Board member, Chinese Journal of Cancer2010-present Academic Editor, PLoS ONE2010-present Senior Editorial Board member, American Journal of Cancer Research2017-present Editorial Board member, Hepatoma Research

Postgraduate Students supervised:As Supervisor: Terence TANG (MPhil, 1999-2001)Liang HU (PhD, 2000-2004)Dan XIE (PhD, 2001-2004)Amy TAI (PhD, 2002-2005)Dong-Jiang TANG (PhD, 2003-2006)Muhan CHEN (PhD, 2003-2007)Betty CHOW (PhD, 2003-2007)Billy Sze-Hang LAU (PhD, 2004-2007)Li FU (PhD, 2004-2007)Cailei ZHU (MPhil, 2005-2007)

3

Suisui DONG (PhD, 2006-2010)Leilei CHEN (PhD, 2006-2010)Jian LI (PhD, 2007-2011)Jian WANG (PhD, 2007-2011)Cailei ZHU (PhD, 2007-2011)Yan LI (PhD, 200802012)Hon Man Tim CHAN (PhD, 2009-2012)Alissa M WONG (PhD, 2009-2013)Ming LIU (PhD, 2009-2013)Yangyang SONG (PhD, 2010-2014)Tingting Cao (PhD, 2011-2014)Jinna CHEN (PhD, 2011-2015)Yun LI (PhD, 2012-2016)Xiaoyan MING (PhD, 2012-2016)Xiaodong YANG (PhD, 2013-2017)Shuo FANG (PhD, 2013-2017)Jiali QI (PhD, 2013-2017)Qian YAN (PhD, 2014-2018)Zijun XIAN (PhD, 2015-2018)Krista R Verhoeft (PhD, 2015-)Miao CHEN (PhD, 2016-)Dandan YU (PhD, 2016-)Ying WANG (PhD, 2016-)Yu ZHANG (PhD, 2017-)Ying TANG (PhD, 2017-)Liang-zhan SUN (PhD, 2017-)Lanqi GONG (PhD, 2018-)

As Co-supervisor:Li SUN (PhD, 1999-2003)Terence TANG (PhD, 2002-2005)Stephanie Kwai Yee MA (PhD, 2005-2007)Kar Lok KONG (PhD, 2007-2011)Kwan Ho TANG (PhD, 2007-2011)Zhiyu WANG (PhD, 2008-2012)Juan CHEN (PhD, 2009-2014)Liyi ZHANG (PhD, 2010-2014)Man TONG (PhD, 2010-2014)Lingxi JIANG (PhD, 2012-2016)Chen JIANG (PhD, 2014-2018)Feifei ZHANG (PhD, 2015-)Xia WANG (PhD, 2015-)Jiaozhi HE (PhD, 2015-)Yuzhu CUI (PhD, 2015-)Shayi WU (MPhil, 2016-)Zhaojie LYU (PhD, 2017-)

4

Chaoran SHI (MPhil, 2017-)Beilei LIU (PhD, 2018-)

Student Awards:1. Stephanie KY Ma: Hong Kong Young Scientist Award (Lift Science Panel), Hong Kong

Institution of Science (2008).2. Stephanie KY Ma: Li Ka Shing Prize for the Best Ph.D. Thesis, The University of Hong

Kong (2006-07).3. Stephanie KY Ma: International Society for Stem Cell Research (ISSCR) Travel Award,

USA (2007).4. Leilei Chen: YS and Christabel Lung Postgraduate Scholarship 2008/2009, The University of

Hong Kong.5. Leilei Chen: Hui Pun Hing Scholarship for Postgraduate Research at 2008~2009, The

University of Hong Kong.6. Leilei Chen: YS and Christabel Lung Postgraduate Scholarship 2009/2010, The University of

Hong Kong.7. Suisui Dong: YS and Christabel Lung Postgraduate Scholarship 2009/2010, The University

of Hong Kong.8. Leilei Chen: The Outstanding Presentation award in “14th Rsearch Postgraduate Symposium,

The University of Hong Kong, Dec 2009, Hong Kong.9. Leilei Chen: Hong Kong Young Scientist Award (Honourable Mention, Lift Science Panel),

Hong Kong Institution of Science (2010). 10. Leilei Chen: Dr. KP Stephen Chang Gold Medal for the Best Ph.D. Thesis, The University of

Hong Kong (2009/2010). 11. Leilei Chen: Li Ka Shing Prize for the Best Ph.D. Thesis, The University of Hong Kong

(2009/2010).12. Yangyang Song: 2010 University Postgraduate Fellowship, The University of Hong Kong.13. Alissa Wong: Sir Edward Youde Memorial Fellowship for the Year 2010/2011, Sir Edward

Youde Memorial Fund Council.14. Kar Lok Kong: YS and Christabel Lung Postgraduate Scholarship 2010/2011, The University

of Hong Kong.15. Kwan Ho Tang: YS and Christabel Lung Postgraduate Scholarship 2010/2011, The

University of Hong Kong.16. Alissa Wong: The HKAUW Dr Thomas HC Cheung Postgraduate Scholarship 2011, Hong

Kong Association of University Women.17. Alissa Wong: YS and Christabel Lung Postgraduate Scholarship 2011/2012, The University

of Hong Kong.18. Ming Liu: YS and Christabel Lung Postgraduate Scholarship 2011/2012, The University of

Hong Kong.19. Ming Liu: Mary Sun Postgraduate Medical Scholarships 2011/2012, The University of Hong

Kong.20. Zhiyu Wang: YS and Christabel Lung Postgraduate Scholarship 2011/2012, The University

of Hong Kong.21. Man Tong: Wong Ching Yee Medical Postgraduate Scholarship 2011/2012, The University

of Hong Kong.22. Ming Liu: YS and Christabel Lung Postgraduate Scholarship 2012/2013, The University of

Hong Kong.

5

23. Ming Liu: Joseph Shuk-Cho Lung Memorial Scholarships 2012/2013, The University of Hong Kong.

24. Man Tong: Wong Ching Yee Medical Postgraduate Scholarship 2012/2013, The University of Hong Kong.

25. Juan Chen: Wong Ching Yee Medical Postgraduate Scholarship 2012/2013, The University of Hong Kong.

26. Alissa Wong. Wong Ching Yee Medical Postgraduate Scholarship 2012/2013, The University of Hong Kong.

27. Ming Liu: Mary Sun Postgraduate Medical Scholarships 2012/2013, The University of Hong Kong.

28. Yan Li: Li Ka Shing Prize for the Best Ph.D. Thesis, The University of Hong Kong (2011/2012).

29. Yan Li: Dr. KP Stephen Chang Gold Medal for the Best Ph.D. Thesis, The University of Hong Kong (2011/2012).

30. Yan Li: Hong Kong Young Scientist Award (Lift Science Panel), Hong Kong Institution of Science (2013).

31. Ming Liu: Yu To Sang and Yu Shing Keung Memorial Fund Scholarship 2012/2013, The University of Hong Kong

32. Yangyang Song. 2014 AACR-Glaxo Smith Kline Outstanding Clinical Scholar Award.33. Man Tong: YS and Christabel Lung Postgraduate Scholarship 2013/2014, The University of

Hong Kong.34. Ming Liu: YS and Christabel Lung Postgraduate Scholarship 2013/2014, The University of

Hong Kong.35. Yangyang Song: YS and Christabel Lung Postgraduate Scholarship 2013/2014, The

University of Hong Kong.36. Liyi Zhang: YS and Christabel Lung Postgraduate Scholarship 2013/2014, The University of

Hong Kong.37. Ming Liu: Merit Award for the 2014 International Conference of the Asian Clinical

Oncology Society.38. Yangyang Song: Reaching Out Award under the HKSAR Government Scholarship Fund

2013/2014, Hong Kong.39. Ming Liu: Outstanding Research Postgraduate Student Awards, The University of Hong

Kong (2013/2014).40. Ming Liu: Hong Kong Young Scientist Award (Lift Science Panel), Hong Kong Institution

of Science (2014).41. Ming Liu: Dr. KP Stephen Chang Gold Medal for the Best PhD Thesis, The University of

Hong Kong (2013/2014).42. Yun Li: Outstanding Poster Presentation in 19th Research Postgraduate Symposium (2014),

Li Ka Shing Faculty of Medicine, HKU.43. Xiaoyan Ming: Outstanding Poster Presentation in 19th Research Postgraduate Symposium

(2014), Li Ka Shing Faculty of Medicine, HKU.44. Zijun Xian: Hong Kong PhD Fellowship Scheme 2015/2016, UGC, RGC, Hong Kong.45. Zijun Xian: Wong Ching Yee Medical Postgraduate Scholarship 2016/2017, The University

of Hong Kong.46. Yu Zhang: University Postgraduate Fellowship (2017/18), The University of Hong Kong.

6

Publications and Citations: Top 1% in ISI’s essential science citations (2010-2017) H-index = 77 (Google Scholar, 24/9/2018) Sum of citation: 23,957 (Google Scholar, 24/9/2018)

R esearch A rticles : (*corresponding author) 1. Meltzer PS, Guan XY, Burgess A, Trent JM. Rapid generation of region specific probes

by chromosome microdissection and their application. Nature Genet 1992;1(1):24-8. 2. Guan XY, Meltzer PS, Cao J, Trent JM. Rapid generation of region-specific genomic

clones by chromosome microdissection: isolation of DNA from a region frequently deleted in malignant melanoma. Genomics 1992;14(3):680-4.

3. Zhang J, Meltzer P, Jenkins R, Guan XY, Trent J. Application of chromosome microdissection probes for elucidation of BCR-ABL fusion and variant Philadelphia chromosome translocations in chronic myelogenous leukemia. Blood 1993;81(12):3365-71.

4. Meltzer PS, Guan XY, Trent JM. Telomere capture stabilizes chromosome breakage. Nature Genet 1993;4(3):252-5.

5. Guan XY, Trent JM, Meltzer PS. Generation of band-specific painting probes from a single microdissected chromosome. Hum Mol Genet 1993;2(8):1117-21.

6. Leach FS, Nicolaides NC, Papadopoulos N, Liu B, Jen J, Parsons R, Peltomaki P, Sistonen P, Aaltonen LA, Nystrom-Lahti M, Guan XY, Zhang J, Meltzer PS, Yu JW, Kao FT, Chen DJ, Cerosaletti KM, Fournier REK, Todd S, Lewis T, Leach RJ, Naylor SL, Weissenbach J, Mecklin JP, Jarvinen H, Petersen GM, Hamilton SR, Green J, Jass J, Watson P, Lynch HT, Trent JM, de la Chapelle A, Kinzler KW, Vogelstein B. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 1993;75(6):1215-25.

7. Thompson FH, Emerson J, Alberts D, Liu Y, Guan XY, Burgess A, Fox S, Taetle R, Weinstein R, Makar R, Powell D, Trent JM. Clonal chromosome abnormalities in 54 cases of ovarian carcinoma. Cancer Genet Cytogenet 1994;73(1):33-45.

8. Ray ME, Guan XY, Slovak ML, Trent JM, Meltzer PS. Rapid detection, cloning and molecular cytogenetic characterisation of sequences from an MRP-encoding amplicon by chromosome microdissection. Br J Cancer 1994;70(1):85-90.

9. Guan XY, Meltzer PS, Trent JM. Rapid generation of whole chromosome painting probes (WCPs) by chromosome microdissection. Genomics 1994;22(1):101-7.

10. Su YA, Trent JM, Guan XY, Meltzer PS. Direct isolation of genes encoded within a homogeneously staining region by chromosome microdissection. Proc Nat Aca Sci USA 1994;91(19):9121-5.

11. Mitchell DS, Guan XY, Meltzer PS. Detection of chromosome 12q amplification in sarcomas by chromosome microdissection and interphase fish. Int J Oncology 1994;5:787-92.

12. Guan XY, Meltzer PS, Dalton WS, Trent JM. Identification of cryptic sites of DNA sequence amplification in human breast cancer by chromosome microdissection. Nature Genet 1994;8(2):155-61.

13. Van Den Berg C, Guan XY (equally contributed), Von Hoff D, Jenkins R, Bittner M, Griffin C, Kallioniemi O, Visakorpi T, McGill J, Herath J, Epstein J, Sarosdy M, Meltzer

7

P, Trent J. DNA sequence amplification in human prostate cancer identified by chromosome microdissection: potential prognostic implications. Clinic Cancer Res 1995;1(1):11-8.

14. Trent JM, Weber B, Guan XY, Zhang J, Collins F, Abel K, Diamond A, Meltzer P. Microdissection and microcloning of chromosomal alterations in human breast cancer. Breast Cancer Res Treat 1995;33(2):95-102.

15. Liang BC, Meltzer PS, Guan XY, Trent JM. Gene amplification elucidated by combined chromosomal microdissection and comparative genomic hybridization. Cancer Genet Cytogenet 1995;80(1):55-9.

16. Guan XY, Meltzer PS, Burgess A, Trent JM. Coverage of chromosome 6 by chromosome microdissection: generation of 14 subregion-specific probes. Human Genet 1995;95(6):637-40.

17. Guan XY, Cargile CB, Anzick SL, Thompson FH, Meltzer PS, Bittner ML, Taetle R, McGill JR, Trent JM. Chromosome microdissection identifies cryptic sites of DNA sequence amplification in human ovarian carcinoma. Cancer Res 1995;55(15):3380-5.

18. Guan XY, Zhang HE, Bitter M, Jiang Y, Meltzer PS, Trent JM. Chromosome arm painting probes. Nature Genet 1996;12(1):10-1.

19. Elkahloun AG, Meltzer PS, Guan XY, McNinch JS, Trent JM, de Jong PJ. Isolation of a cosmid sublibrary for a region of chromosome 12 frequently amplified in human cancers using a complex chromosome microdissection probe. Genomics 1996;31(3):343-7.

20. Thompson FH, Nelson MA, Trent JM, Guan XY, Liu Y, Yang JM, Emerson J, Adair L, Wymer J, Balfour C, Massey K, Weinstein R, Alberts DS, Taetle R. Amplification of 19q13.1-q13.2 sequences in ovarian cancer. G-band, FISH, and molecular studies. Cancer Genet Cytogenet 1996;87(1):55-62.

21. Tanner MM, Tirkkonen M, Kallioniemi A, Isola J, Kuukasjarvi T, Collins C, Kowbel D, Guan XY, Trent J, Gray JW, Meltzer P, Kallioniemi OP. Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer. Cancer Res 1996;56(15):3441-5.

22. Guan XY, Xu J, Anzick SL, Zhang H, Trent JM, Meltzer PS. Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer. Cancer Res 1996;56(15):3446-50.

23. Guan XY, Horsman D, Zhang HE, Parsa NZ, Meltzer PS, Trent JM. Localization by chromosome microdissection of a recurrent breakpoint region on chromosome 6 in human B-cell lymphoma. Blood 1996;88(4):1418-22.

24. Stone D, Ning Y, Guan XY, Kaiser-Kupfer M, Wynshaw-Boris A, Biesecker L. Characterization of familial partial 10p trisomy by chromosomal microdissection, FISH, and microsatellite dosage analysis. Human Genet 1996;98(4):396-402.

25. Brooks DJ, Woodward S, Thompson FH, Santos BD, Russell M, Yang JM, Guan XY, Trent J, Alberts D, Taetle R. Expression of the zinc finger gene EVI-1 in ovarian and other cancers. Br J Cancer 1996;74(10):1518-25.

26. Cremer C, Mȕnkel C, Granzow M, Jauch A, Dietzel S, Eils R, Guan XY, Meltzer PS, Trent JM, Langwoski J, Cremer T. Nuclear architecture and the induction of chromosomal aberrations. Mutat Res 1996;366(2):97-116.

27. Meltzer PS, Guan XY, Su YA, Gracia E, Trent JM. Identification of region specific genes by chromosome microdissection. Cancer Genet Cytogenet 1997;93(1):29-32.

8

28. Hu Z, Zhuang L, Guan X, Meng J, Dufau ML. Steroidogenic factor-1 is an essential transcriptional activator for gonad-specific expression of promoter I of the rat prolactin receptor gene. J Biol Chem 1997;272(22):14263-71.

29. Barks JH, Thompson FH, Taetle R, Yang JM, Stone JF, Wymer JA, Khavari R, Guan XY, Trent JM, Pinkel D, Nelson MA. Increased chromosome 20 copy number detected by fluorescence in situ hybridization (FISH) in malignant melanoma. Genes Chromosomes Cancer 1997;19(4):278-85.

30. Chen Z, Grebe TA, Guan XY, Notohamiprodjo M, Nutting PJ, Stone JF, Trent JM, Sandberg AA. Maternal balanced translocation leading to partial duplication of 4q and partial deletion of 1p in a son: cytogenetic and FISH studies using band-specific painting probes generated by chromosome microdissection. Am J Med Genet 1997;71(2):160-6.

31. Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi O-P, Trent JM, Meltzer PS. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 1997;277(5328):965-8.

32. Chaudhary R, Kijas J, Raudsepp T, Guan XY, Zhang H, Chowdhary BP. Microdissection of pig chromosomes: dissection of whole chromosomes, arms and bands for construction of paints and libraries. Hereditas 1998;128(3):265-71.

33. Chaudhary R, Raudsepp T, Guan XY, Zhang H, Chowdhary BP. Zoo-FISH with microdissected arm specific paints for HSA2, 5, 6, 16, and 19 refines known homology with pig and horse chromosomes. Mamm Genome 1998;9(1):44-9.

34. Yan WL, Jacobsen LK, Krasnewich DM, Guan XY, Lenane MC, Paul SP, Dalwadi HN, Zhang H, Long RT, Kumra S, Martin BM, Scambler P, Trent JM, Sidransky E, Ginns EI, Rapoport JL. Chromosome 22q11.2 interstitial deletions among childhood-onset schizophrenics and “multidimensionally impaired”. Am J Med Genet 1998;81(1):41-3.

35. Chen Z, Notohamiprodjo M, Guan XY, Paietta E, Blackwell S, Stout K, Turner A, Richkind K, Trent JM, Lamb A, Sandberg AA. Gain of 9p in the pathogenesis of polycythemia vera. Genes Chromosomes Cancer 1998;22(4):321-4.

36. Guan XY, Zhang H, Yang JM, Wang J, Taetle R, Meltzer PS, Trent JM. Detection of chromosome 6 abnormalities in melanoma cell lines by chromosome arm painting probes. Cancer Genet Cytogenet 1998;107(2):89-92.

37. Shen SX, Weaver Z, Xu X, Li C, Weinstein M, Chen L, Guan XY, Ried T, Deng CX. A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene 1998;17(24):3115-24.

38. Henning KA, Novotny EA, Compton ST, Guan XY, Liu PP, Ashlock MA. Human artificial chromosomes generated by modification of a yeast artificial chromosome containing both human alpha satellite and single-copy DNA sequences. Proc Natl Acad Sci USA 1999;96(2):592-7.

39. Meloni-Ehrig AM, Chen Z, Guan XY, Notohamiprodjo M, Shepard RR, Spanier SS, Trent JM, Sandberg AA. Identification of a ring chromosome in a myxoid malignant fibrous histiocytoma with chromosome microdissection and fluorescence in situ hybridization. Cancer Genet Cytogenet 1999;109(1):81-5.

40. Gu J, Guan XY, Ashlock MA. Isolation of human transcripts expressed in hamster cells from YACs by cDNA representational difference analysis. Genome Res 1999;9(2):182-8.

41. Callen DF, Eyre H, Fang YY, Guan XY, Veleba A, Martin NJ, McGill J, Haan EA. Origins of accessory small ring marker chromosomes derived from chromosome 1. J Med Genet 1999;36(11):847-53.

9

42. Qin LX, Tang ZY, Sham JST, Ma ZC, Ye SL, Zhou XD, Wu ZQ, Trent JM, Guan XY*. The Association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinoma. Cancer Res 1999;59(22):5662-5.

43. Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW. A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. J Biol Chem 1999;274(48):34283-93.

44. Guan XY*, Fang Y, Sham JS, Kwong DL, Zhang Y, Liang Q, Li H, Zhou H, Trent JM. Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer 2000;29(2):110-6.

45. Guan XY*, Fu SB, Xia JC, Fang Y, Sham JST, Du BD, Zhou H, Lu S, Wang BQ, Lin YZ, Liang Q, Li XM, Du B, Ning XM, Du JR, Li P, Trent JM. Recurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization. Cancer Genet Cytogenet 2000;123(1):27-34.

46. Yan W, Guan XY, Green ED, Nicolson R, Yap TK, Zhang J, Jacobsen LK, Krasnewich DM, Kumra S, Lenane MC, Gochman P, Damschroder-Williams PJ, Esterling LE, Long RT, Martin BM, Sidransky E, Rapoport JL, Ginns EI. Childhood-onset schizophrenia/autistic disorder and t(1;7) reciprocal translocation: identification of a BAC contig spanning the translocation breakpoint at 7q21. Am J Med Genet 2000;96(6):749-53.

47. Fang Y, Guan XY (equally contributed), Guo Y, Sham JST, Deng M, Liang Q, Li H, Zhang H, Zhou H, Trent JM. Analysis of genetic alterations in primary nasopharyngeal carcinoma by comparative genomic hybridization. Genes Chromosomes Cancer 2001;30(3):254-60.

48. Guan XY*, Sham JS, Tang TC, Fang Y, Huo KK, Yang JM. Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer. Cancer Res 2001;61(9):3806-9.

49. Qin LX, Tang ZY, Ye SL, Liu YK, Ma ZC, Zhou XD, Wu ZQ, Lin ZY, Sun FX, Tian J, Guan XY, Pack SD, Zhuang ZP. Chromosome 8p deletion is associated with metastasis of human hepatocellular carcinoma when high and low metastatic models are compared. J Cancer Res Clin Oncol 2001;127(8):482-8.

50. Chen Z, Meloni-Ehrig A, Palumbos JC, Guan XY, Carroll KL, Dent KM, Carey JC. Pure trisomy 10p resulting from an extra ring chromosome: Characterization by methods of advanced molecular cytogenetics. Am J Med Genet 2001;102(4):379-82.

51. Sham JS, Tang TC, Fang Y, Sun L, Qin LX, Wu QL, Xie D, Guan XY*. Recurrent chromosome alterations in primary ovarian carcinoma of Chinese women. Cancer Genet Cytogenet 2002;133(1):39-44.

52. Guan XY*, Zhang HE, Zhou H, Sham JS, Fung JMW, Trent JM. Characterization of a complex chromosome rearrangement involving 6q in a melanoma cell line by chromosome microdissection. Cancer Genet Cytogenet 2002;134(1):65-70.

53. Xue WC, Guan XY, Ngan HYS, Shen DH, Khoo US, Cheung AN. Malignant placental site trophoblastic tumor: a cytogenetic study using comparative genomic hybridization and chromosome in situ hybridization. Cancer 2002;94(8):2288-94.

10

54. Wen JM, Huang JF, Hu L, Wang WS, Zhang M, Sham JS, Xu JM, Zeng WF, Xie D, Liang LJ, Guan XY*. Establishment and characterization of human metastatic hepatocellular carcinoma cell line. Cancer Genet Cytogenet 2002;135(1):91-5.

55. Chan KL, Lee JMY, Guan XY, Fan ST, Ng IO. High-density allelotyping of chromosome 8p in hepatocellular carcinoma and clinicopathologic correlation. Cancer 2002;94(12):3179-85.

56. Wang Y, Wu MC, Sham JS, Tai LS, Fang Y, Wu WQ, Xie D, Guan XY*. Different expression of hepatitis B surface antigen between hepatocellular carcinoma and its surrounding liver tissue detected by tissue microarray. J Pathol 2002;197(5):610-6.

57. Cheung ST, Chen X, Guan XY, Wong SY, Tai LS, Ng IO, So S, Fan ST. Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumor. Cancer Res 2002;62(16):4711-21.

58. Wang Y, Wu MC, Sham JS, Zhang W, Wu WQ, Guan XY*. Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma: A broad survey using high-throughput tissue microarray. Cancer 2002;95(11):2346-52.

59. Tang TC, Sham JS, Xie D, Fang Y, Huo KK, Wu QL, Guan XY*. Identification of a candidate oncogene SEI-1 within a minimal amplified region at 19q13.1 in ovarian cancer cell lines. Cancer Res 2002;62(24):7157-61.

60. Guan XY*, Sham JS, Tai LS, Fang Y, Li H, Liang Q. Evidence for another tumor suppressor gene at 17p13.3 distal to TP53 in hepatocellular carcinoma. Cancer Genet Cytogenet 2003;140(1):45-8.

61. Ng IO, Guan XY, Poon RT, Fan ST, Lee JM. Determination of the molecular relationship between multiple tumour nodules in hepatocellular carcinoma differentiates multicentric origin from intrahepatic metastasis. J Pathol 2003;199(3):345-53.

62. Deng W, Tsao SW, Guan XY, Lucas JN, Cheung AL. Role of short telomeres in inducing preferential chromosomal aberrations in human ovarian surface epithelial cells: A combined telomere quantitative fluorescence in situ hybridization and whole-chromosome painting study. Genes Chromosomes Cancer 2003;37(1):92-7.

63. Chow LW, Cheung MN, Loo WT, Guan XY. A rat cell line derived from DMBA-induced mammary carcinoma. Life Sci 2003;73(1):27-40.

64. He QJ, Zeng WF, Sham JS, Xie D, Yang XW, Lin HL, Zhan WH, Lin F, Zeng SD, Nie D, Ma LF, Li CJ, Lu S, Guan XY*. Recurrent genetic alterations in 26 colorectal carcinomas and 21 adenomas from Chinese patients. Cancer Genet Cytogenet 2003;144(2):112-8.

65. Xie D, Sham JS, Zeng WF, Lin HL, Che LH, Wu HX, Wen JM, Fang Y, Hu L, Guan XY*. Heterogenous expression and association of beta-catenin, p16 and c-myc in multistage colorectal tumorigenesis and progression detected by tissue microarray. Int J Cancer 2003;107(6):896-902.

66. Hu L, Wen JM, Sham JS, Wang W, Xie D, Tjia WM, Huang JF, Zhang M, Zeng WF, Guan XY*. Establishment of cell lines from a primary hepatocellular carcinoma and its metastatis. Cancer Genet Cytogenet 2004;148(1):80-4.

67. Wang Y, Lau SH, Sham JS, Wu MC, Wang T, Guan XY*. Characterization of HBV integrants in 14 hepatocellular carcinomas: Association of truncated X gene and hepatocellular carcinogenesis. Oncogene 2004;23(1):142-8.

68. Hu L, Lau SH, Tzang CH, Wen JM, Wang W, Xie D, Huang M, Wang Y, Wu MC, Huang JF, Zeng WF, Sham JS, Yang M, Guan XY*. Association of Vimentin overexpression and hepatocellular carcinoma metastasis. Oncogene 2004;23(1):298-302.

11

69. Wang X, Ling MT, Guan XY, Tsao SW, Cheung HW, Lee DT, Wong YC. Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxolresistance in human cancer cells. Oncogene 2004;23(2):474-82.

70. Tan YQ, Hu L, Lin G, Sham JS, Gong F, Guan XY, Lu G. Genetic changes in human fetuses from spontaneous abortion after in vitro fertilization detected by comparative genomic hybridization. Biol Reprod 2004;70(2):495-9.

71. Hu L, Sham JS, Tjia WM, Tan YQ, Lu GX, Guan XY*. Generation of a complete set of human telomeric band painting probes by chromosome microdissection. Genomics 2004;83(2):298-302.

72. Wang T, Wang Y, Wu MC, Guan XY, Yin ZF. Activating mechanism of transcriptor NF-kappaB regulated by hepatitis B virus X protein in hepatocellular carcinoma. World J Gastroenterol 2004;10(3):356-60.

73. Kwong DL, Lam A, Guan XY, Law S, Tai A, Wong J, Sham J. Chromosomal aberrations in esophageal squamous cell carcinoma among Chinese: gain of 12p predicts poor prognosis after surgery. Human Pathol 2004;35(3):309-16.

74. Tai AL, Yan WS, Fang Y, Xie D, Sham JS, Guan XY*. Recurrent chromosomal imbalances in nonsmall cell lung carcinoma: the association between 1q amplification and tumor recurrence. Cancer 2004;100(9):1918-27.

75. Guan XY*, Fung JM, Ma NF, Lau SH, Tai LS, Xie D, Zhang Y, Hu L, Wu QL, Fang Y, Sham JS. Oncogenic role of eIF-5A2 in the development of ovarian cancer. Cancer Res 2004;64(12):4197-200.

76. Zhu L, Chow LW, Loo WT, Guan XY, Toi M. Her2/neu expression predicts the response to antiaromatase neoadjuvant therapy in primary breast cancer: subgroup analysis from celecoxib antiaromatase neoadjuvant trial. Clin Cancer Res 2004;10(14):4639-44.

77. Chan KL, Guan XY, Ng IO. High-throughput tissue microarray analysis of c-myc activation in chronic liver diseases and hepatocellular carcinoma. Hum Pathol 2004;35(11):1324-31.

78. Deng W, Tsao SW, Guan XY, Lucas JN, Si HX, Leung CS, Mak P, Wang LD, Cheung AL. Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines. Oncogene 2004;23(56):9090-101.

79. Xie D, Lau SH, Sham JS, Wu QL, Fang Y, Liang LZ, Che LH, Zeng YX, Guan XY*. Up-regulated expression of cytoplasmic Clusterin in human ovarian carcinoma. Cancer 2005;103(2):277-83.

80. Tjia WM, Sham JS, Hu L, Tai AL, Guan XY*. Characterization of 3p, 5p, and 3q in two nasopharyngeal carcinoma cell lines, using region-specific multiplex fluorescence in situ hybridization probes. Cancer Genet Cytogenet 2005;158(1):61-6.

81. Lau SH, Guan XY*. Cytogenetic and molecular genetic alterations in hepatocellular carcinoma. Acta Pharmacol Sin 2005;26(6):659-65.

82. Tai AL, FangY, Sham JS, Deng W, Hu L, Xie D, Tsao GS, Cheung AL, Guan XY*. Establishment and characterization of a human non-small cell lung cancer cell line. Oncol Rep 2005;13(6):1029-32.

83. Xie D, Sham JS, Zeng WF, Che LH, Zhang M, Wu HX, Lin HL, Wen JM, Lau ZH, Hu L, Guan XY*. Oncogenic role of clusterin overexpression in multistage colorectal tumorigenesis and progression. World J Gastroenterol 2005;11(21):3285-9.

12

84. Xie D, Sham JS, ZengWF, LinHL,Bi J, Che LH, Hu L, Zeng YX, Guan XY*. Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma. Hum Pathol 2005;36(7):777-83.

85. Chung CM, Man C, Jin Y, Jin C, Guan XY, Wang Q, Wan TS, Cheung AL, Tsao SW. Amplification and overexpression of aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells. Mol Carcinog 2005;43(3):165-74.

86. Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadiñanos J, López-Otín C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z. Genomic instability in laminopathy-based premature aging. Nature Med 2005;11(7):780-5.

87. Qiao GB, Wu YL, Yang XN, Zhong WZ, Xie D, Guan XY, Fischer D, Kolberg HC, Kruger S, Stuerzbecher HW. High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients. Br J Cancer 2005;93(1):137-43.

88. Tang DJ, Hu L, Xie D, Wu QL, Fang Y, Zeng Y, Sham JS, Guan XY*. Oncogenic transformation by SEI-1 is associated with chromosomal instability. Cancer Res 2005;65(15):6504-8.

89. Lung HL, Bangarusamy DK, Xie D, Cheung AK, Cheng Y, Kumaran MK, Miller L, Liu ET, Guan XY, Sham JS, Fang Y, Li L, Wang N, Protopopov AI, Zabarovsky ER, Tsao SW, Stanbridge EJ, Lung ML. THY1 is a candidate tumour suppressor gene with decreased expression in metastatic nasopharyngeal carcinoma. Oncogene 2005;24(43):6525-32.

90. Hui AB, Or YY, Takano H, Tsang RK, To KF, Guan XY, Sham JS, Hung KW, Lam CN, van Hasselt CA, Kuo WL, Gray JW, Huang DP, Lo KW. Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma. Cancer Res 2005;65(18):8125-33.

91. Xie D, Zeng YX, Wang HJ, Tai LS, Wen JM, Tao Y, Ma NF, Hu L, Sham JS, Guan XY*. Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway. Acta Neuropathologica 2005;110(5):481-9.

92. Tai AL, Sham JS, Xie D, Fang Y, Wu YL, Hu L, Deng W, Tsao GS, Qiao GB, Cheung AL, Guan XY*. Co-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma. Cancer 2006;106(1):146-55.

93. Wang LD, Qin YR, Fan ZM, Kwong D, Guan XY, Tsao GS, Sham J, Li JL, Feng XS. Comparative genomic hybridization: comparison between esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-incidence area for both cancers in Henan, northern China. Dis Esophagus 2006;19(6):459-67.

94. Xie D, Zeng YX, Wang HJ, Wen JM, Tao Y, Sham JS, Guan XY*. Expression of cytoplasmic and nuclear Survivin in primary and secondary human glioblastoma. Br J Cancer 2006;94(1):108-14.

95. Lau SH, Sham JS, Xie D, Tzang CH, Tang D, Ma N, Hu L, Wang Y, Wen JM, Xiao G, Zhang WM, Lau GK, Yang M, Guan XY*. Clusterin plays an important role in hepatocellular carcinoma metastasis. Oncogene 2006;25(8):1242-50.

96. Tai AL, Mak W, Ng PK, Chua DT, Ng MY, Fu L, Chu KK, Fang Y, Song YQ, Chen M, Zhang M, Sham PC, Guan XY*. High-throughput loss-of-heterozygosity study of

13

chromosome 3p in lung cancer using single-nucleotide polymorphism markers. Cancer Res 2006;66(8):4133-8.

97. Cheung HW, Chun AC, Wang Q, Deng W, Hu L, Guan XY, Nicholls JM, Ling MT, Wong Y, Tsao WS, Jin DY, Wang X. Inactivation of human MAD2B in nasopharyngeal carcinoma cells leads to chemosensitization to DNA-damaging agents. Cancer Res 2006;66(8):4357-67.

98. Lee TK, Poon RTP, Yuen AP, Man K, Yang ZF, Guan XY, Fan ST. Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression. Clin Cancer Res 2006;12(17):5082-9.

99. Lee TK, Poon RT, Yuen AP, Ling MT, Kwok WK, Wang XH, Wong YC, Guan XY, Man K, Chau KL, Fan ST. Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin Cancer Res 2006;12(18):5369-76.

100. Lee TK, Poon RT, Yuen AP, Ling MT, Wang XH, Wong YC, Guan XY, Man K, Tang ZY, Fan ST. Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma. Clin Cancer Res 2006;12(23):6910-9.

101. Lung HL, Cheung AK, Xie D, Cheng Y, Kwong FM, Murakami Y, Guan XY, Sham JS, Chua D, Protopopov AI, Zabarovsky ER, Tsao SW, Stanbridge EJ, Lung ML. TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma. Cancer Res 2006;66(19):9385-92.

102. Xu FP, Xie D, Wen JM, Wu HX, Liu YD, Bi J, Lv ZL, , Zeng YX, Guan XY. SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomas. Cancer Lett 2007;245(1-2):69-74.

103. Ma S, Guan XY, Beh PS, Wong KY, Chan YP, Yuen HF, Vielkind J, Chan KW. The significance of LMO2 expression in the progression of prostate cancer. J Pathol 2007;211(3):278-85.

104. Zhang Z, Xie D, Li X, Wong YC, Xin D, Guan XY, Chua CW, Leung SC, Na Y, Wang X. Significance of TWIST expression and its association with E-cadherin in bladder cancer. Hum Pathol 2007;38(4):598-606.

105. Tjia WM, Hu L, Zhang MY, Guan XY*. Characterization of rearrangements involving 4q, 13q and 16q in hepatocellular carcinoma cell lines using region-specific multiplex-FISH probes. Cancer Let 2007;250(1):92-9.

106. Ma S, Chan KW, Hu L, Lee TK, Wo JY, Ng IO, Zheng BJ, Guan XY*. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 2007;132(7):2542-56.

107. Hu L, Sham JS, Xie D, Wen JM, Wang WS, Wang Y, Guan XY*. Up-regulation of fibroblast growth factor 3 is associated with tumor metastasis and recurrence in human hepatocellular carcinoma. Cancer Lett 2007;252(1):36-42.

108. Ma S, Guan XY, Lee TK, Chan KW. Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma. Hum Pathol 2007;38(8):1201-6.

109. Lee TK, Poon RT, Man K, Guan XY, Ma S, Liu XB, Myers JN, Yuen AP. Fascin over-expression is associated with aggressiveness of oral squamous cell carcinoma. Cancer Lett 2007;254(2):308-15.

110. Lee TK, Poon RT, Wo JY, Ma S, Guan XY, Myers JN, Altevogt P, Yuen AP. Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous

14

cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model. Cancer Res 2007;67(18):8800-9.

111. Cheung LC, Tang JC, Lee PY, Hu L, Guan XY, Tang WK, Srivastava G, Wong J, Luk JM, Law S. Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of Chinese origin. Cancer Genet Cytogenet 2007;178(1):17-25.

112. Ma S, Hu L, Huang XH, Cao LQ, Chan KW, Wang Q, Guan XY*. Establishment and characterization of a human cholangiocarcinoma cell line. Oncol Rep 2007;18(5):1195-200.

113. Fu L, Qin YR, Xie D, Hu L, Kwong DL, Sirvastava G, Tsao SW, Guan XY*. Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma. Cancer Res 2007;67(22):10720-6.

114. Deng W, Tsao SW, Guan XY, Cheung AL. Microtubule breakage is not a major mechanism for resolving end-to-end chromosome fusions generated by telomere dysfunction during the early process of immortalization. Chromosoma 2007;116(6):557-68.

115. Fu L, Qin YR, Xie D, Chow HY, Ngai SM, Kwong DL, Li Y, Guan XY*. Identification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approaches. Cancer 2007;110(12):2672-81.

116. Xie D, Ma NF, Pan ZZ, Wu HX, Liu YD, Wu GQ, Kung HF, Guan XY*. Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma. Hum Pathol 2008;39(1):80-5.

117. Ma NF, Hu L, Fung JM, Xie D, Zheng BJ, Chen L, Tang DJ, Fu L, Wu Z, Chen M, Fang Y, Guan XY*. Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma. Hepatology 2008;47(2):503-10.

118. Yi X, Luk JM, Lee NP, Peng J, Leng X, Guan XY, Lau GK, Beretta L, Fan ST. Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence. Mol Cell Proteomics 2008;7(2):315-25.

119. Ma S, Lee TK, Zheng BJ, Chan KW, Guan XY*. CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene 2008;27(12):1749-58.(F1000 Rating: 8 Must Read; Mishra L: 2008. F1000.com/1096034#eval552029)

120. Qin YR, Wang LD, Fan ZM, Kwong D, Guan XY. Comparative genomic hybridization analysis of genetic aberrations associated with development of esophageal squamous cell carcinoma in Henan, China. World J Gastroenterol 2008;14(12):1828-35.

121. Liu MZ, Xie D, Mai SJ, Tong ZT, Shao JY, Fu YS, Xia WJ, Kung HF, Guan XY, Zeng YX. Overexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stage. Am J Clin Pathol 2008;129(5):728-34.

122. Wang J, Tai LS, Tzang CH, Fong WF, Guan XY, Yang M. 1p31, 7q21 and 18q21 chromosomal aberrations and candidate genes in acquired vinblastine resistance of human cervical carcinoma KB cells. Oncology Rep 2008;19(5):1155-64.

123. Luo JH, Xie D, Liu MZ, Chen W, Liu YD, Wu GQ, Kung HF, Zeng YX, Guan XY. Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and overexpression of AIB1 is a new independent prognostic marker of patient survival. Int J Cancer 2008;122(11):2554-61.

15

124. Ma S, Chan KW, Lee TK, Tang KH, Wo JY, Zheng BJ, Guan XY*. Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations. Mol Cancer Res 2008;6(7):1146-53. (most cited paper of Mol Cancer Res in 2009)

125. Ma NF, Lau SH, Hu L, Xie D, Wu J, Yang J, Wang Y, Wu MC, Fung J, Bai X, Tzang CH, Fu L, Yang M, Su YA, Guan XY*. COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis. Clin Cancer Res 2008;14(16):5061-8.

126. Qin YR, Fu L, Sham PC, Kwong DL, Zhu CL, Chu KK, Li Y, Guan XY*. Single-nucleotide polymorphism-mass array reveals commonly deleted regions at 3p22 and 3p14.2 associate with poor clinical outcome in esophageal squamous cell carcinoma. Int J Cancer 2008;123(4):826-30.

127. Deng W, Tsao SW, Kwok YK, Wong E, Huang XR, Liu S, Tsang CM, Ngan HY, Cheung AN, Lan HY, Guan XY, Cheung AL. Transforming growth factor beta1 promotes chromosomal instability in human papillomavirus 16 E6E7-infected cervical epithelial cells. Cancer Res 2008;68(17):7200-9.

128. Ma S, Chan KW, Guan XY. In search of liver cancer stem cells. Stem Cell Rev 2008;4(3):179-92.

129. Ma S, Chan YP, Woolcock B, Hu L, Wong KY, Ling MT, Bainbridge T, Webber D, Chan TH, Guan XY, Lam W, Vielkind J, Chan KW. DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancer. Int J Cancer 2008;124(10):2323-32.

130. Chen W, Luo JH, Hua WF, Zhou FJ, Lin MC, Kung HF, Zeng YX, Guan XY, Xie D. Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy. Cancer Epidemiol Biomarkers Prev 2009;18(2):400-8.

131. Fung JM, Smith R, Brown MA, Lau SH, Xie D, Lau GK, Guan XY*. Identification and characterization of a novel melanoma tumor suppressor gene on human chromosome 6q21. Clin Cancer Res 2009;15(3):797-803.

132. Yang GF, Xie D, Liu JH, Luo JH, Li LJ, Hua WF, Wu HM, Kung HF, Zeng YX, Guan XY*. Expression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinoma. Gynecol Oncol 2009;112(2):314-8.

133. Bi J, Lau SH, Hu L, Rao HL, Liu HB, Zhan WH, Chen G, Wen JM, Wang Q, Li B, Guan XY*. Downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer. Int J Cancer 2009;124(7):1587-93.

134. Luo JH, Hua WF, Rao HL, Liao YJ, Kung HF, Zeng YX, Guan XY, Chen W, Xie D. Overexpression of EIF-5A2 predicts tumor recurrence and progression in pTa/pT1 urothelial carcinoma of the bladder. Cancer Sci 2009;100(5):896-902.

135. Chow BH, Chua DT, Sham JS, Zhang MY, Chow LW, Bi J, Ma NF, Xie D, Loo WT, Fung JM, Fu L, Guan XY*. Increased expression of annexin I is associated with drug-resistance in nasopharyngeal carcinoma and other solid tumors. Proteomics Clin Appl 2009;3(6):654-62.

136. Zhang C, Fu L, Fu J, Hu L, Yang H, Rong TH, Li Y, Liu H, Fu SB, Zeng YX, Guan XY*. Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma. Clin Cancer Res 2009;15(12):4017-27.

16

137. Chen L, Hu L, Chan TH, Tsao GSW, Xie D, Huo KK, Fu L, Zheng BJ, Guan XY*. Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1L) gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival. Hepatology 2009;50(1):122-9.

138. Hu XT, Zhang FB, Fan YC, Shu XS, Wong AH, Zhou W, Shi QL, Tang HM, Fu L, Guan XY, Rha SY, Tao Q, He C. Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer. Oncogene 2009;28(26):2466-75.

139. Zhou J, Huang JD, Poon VK, Chen DQ, Chan CC, Ng F, Guan XY, Watt RM, Lu L, Yuen KY, Zheng BJ. Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection. J Hepatol 2009;51(2):322-32.

140. Zhu C, Qin YR, Xie D, Chua DT, Fung JM, Chen L, Fu L, Hu L, Guan XY*. Characterization of tumor suppressive function of P300/CBP-associated factor at frequently deleted region 3p24 in esophageal squamous cell carcinoma. Oncogene 2009;28(31):2821-8.

141. Chen M, Huang JD, Hu L, Zheng BJ, Chen L, Tsang SL, Guan XY*. Transgenic CHD1L expression in mouse induces spontaneous tumors. PLoS ONE 2009;4(8):e6727.

142. Cheung AK, Lung HL, Ko JM, Cheng Y, Stanbridge EJ, Zabarovsky ER, Nicholls JM, Chua D, Tsao SW, Guan XY, Lung ML. Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma. Proc Natl Acad Sci USA 2009;106(34):14478-83.

143. He LR, Liu MZ, Li BK, Rao HL, Deng HX, Guan XY, Zeng YX, Xie D. Overexpression of AIB1 predicts resistance to chemoradiotherapy and poor prognosis in patients with primary esophageal squamous cell carcinoma. Cancer Sci 2009;100(9):1591-6.

144. He LR, Liu MZ, Li BK, Rao HL, Liao YJ, Zhang LJ, Guan XY, Zeng YX, Xie D. Clusterin as a predictor for chemoradiotherapy sensitivity and patient survival in esophageal squamous cell carcinoma. Cancer Sci 2009;100(12):2354-60.

145. Bi J, Lau SH, Lv ZL, Xie D, Li W, Lai YR, Zhong JM, Wu HQ, Su Q, He YL, Zhan WH, Wen JM, Guan XY*. Overexpression of YKL-40 is an independent prognostic marker in gastric cancer. Hum Pathol 2009;40(12):1790-7.

146. Wu GQ, Xie D, Yang GF, Liao YJ, Mai SJ, Deng HX, Sze J, Guan XY, Zeng YX, Lin MC, Kung HF. Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma. Int J Cancer 2009;125(11):2631-42.

147. He LR, Liu MZ, Li BK, Rao HL, Liao YJ, Guan XY, Zeng YX, Xie D. Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma. BMC Cancer 2009;9:461.

148. Wen J, Zheng B, Hu Y, Zhang X, Yang H, Li Y, Zhang CY, Luo KJ, Zang X, Li YF, Guan XY, Fu JH. Comparative proteomic analysis of the esophageal squamous carcinoma cell line EC109 and its multi-drug resistant subline EC109/CDDP. Int J Oncol 2010;36(1):265-74.

149. Bi J, Guo AL, Lai YR, Li B, Zhong JM, Wu HQ, Xie Z, He YL, Lv ZL, Lau SH, Wang Q, Huang XH, Zhang LJ, Wen JM, Guan XY. Overexpression of clusterin correlates with tumor progression, metastasis in gastric cancer: a study on tissue microarrays. Neoplasma 2010;57(3):191-7.

17

150. Tang DJ, Dong SS, Ma NF, Xie D, Chen L, Fu L, Lau SH, Li Y, Li Y, Guan XY*. Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. Hepatology 2010;51(4):1255-63.

151. Chen L, Chan TH, Yuan YF, Hu L, Huang J, Ma S, Wang J, Dong SS, Tang KH, Xie D, Li Y, Guan XY*. CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. J Clin Invest 2010;120(4):1178-91.

152. Yang GF, He WP, Cai MY, He LR, Luo JH, Deng HX, Guan XY, Zeng MS, Zeng YX, Xie D. Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma. BMC Cancer 2010;10:133.

153. Fu L, Dong SS, Xie YW, Tai LS, Chen L, Kong KL, Man K, Xie D, Li Y, Cheng Y, Tao Q, Guan XY*. Down-regulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinoma. Hepatology 2010;51(5):1624-34. (F1000 Rating: 6 Recommended; Donohue T, Casey C: 2010. F1000.com/3309959#eval2996057)

154. Cai MY, Zhang B, He WP, Yang GF, Rao HL, Rao ZY, Wu QL, Guan XY, Kung HF, Zeng YX, Xie D. Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma. Cancer Sci 2010;101(6):1543-9.

155. Wang Y, Liu YH, Mai SJ, He LJ, Liao YJ, Deng HX, Guan XY, Zeng YX, Kung HF, Xie D. Evaluation of serum clusterin as a surveillance tool for human hepatocellular carcinoma with hepatitis B virus related cirrhosis. J Gastroenterol Hepatol 2010;25:1123-8.

156. He LR, Liu MZ, Li BK, Jia WH, Zhang Y, Liao YJ, Chen YC, Zhang LJ, Guan XY, Zeng YX, Kung HF, Xie D. High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Int J Cancer 2010;127(1):138-47.

157. Li Y, Nie CJ, Hu L, Qin Y, Liu HB, Zeng TT, Chen L, Fu L, Deng W, Chen SP, Jia WH, Zhang C, Xie D, Guan XY*. Characterization of a novel mechanism of genomic instability involving the SEI1/SET/NM23H1 pathway in esophageal cancers. Cancer Res 2010;70(14):5695-705.

158. He LR, Zhao HY, Li BK, Zhang LJ, Liu MZ, Kung HF, Guan XY, Bian XW, Zeng YX, Xie D. Overexpression of AIB1 negatively affects survival of surgically resected non-small-cell lung cancer patients. Ann Oncol 2010;21(8):1675-81.

159. Sun JC, Pan K, Chen MS, Wang QJ, Wang H, Ma HQ, Li YQ, Liang XT, Li JJ, Zhao JJ, Chen YB, Pang XH, Liu WL, Cao Y, Guan XY, Lian QZ, Xia JC. Dendritic cells-mediated CTLs targeting hepatocellular carcinoma stem cells. Cancer Biol Ther 2010;10(4): 368-75.

160. Lee NP, Tsang FH, Shek FH, Mao M, Dai H, Zhang C, Dong S, Guan XY, Poon RT, Luk JM. Prognostic significance and therapeutic potential of eukaryotic translation initiation factor 5A (eIF5A) in hepatocellular carcinoma. Int J Cancer 2010;127(4):968-76.

161. Chen L, Chan TH, Guan XY*. Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma. Acta Pharmacol Sin 2010;31(9):1165-71.

162. Rao ZY, Cai MY, Yang GF, He LR, Mai SJ, Hua WF, Liao YJ, Deng HX, Chen YC, Guan XY, Zeng YX, Kung HF, Xie D. EZH2 supports ovarian carcinoma cell invasion

18

and/or metastasis via regulation of TGF-beta1 and is a predictor of outcome in ovarian carcinoma patients. Carcinogenesis 2010;31(9):1576-83.

163. Kong KL, Kwong DL, Fu L, Chan TH, Chen L, Liu H, Li Y, Zhu YH, Bi J, Qin YR, Law SY, Guan XY*. Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma. Cancer Res 2010;70(21):8832-41.

164. Ma S*, Tang KH, Chan YP, Lee TK, Kwan PS, Castilho A, Ng I, Man K, Wong N, To KF, Zheng BJ, Lai PB, Lo CM, Chan KW*, Guan XY*. miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell 2010;7(6):694-707. (2011 Faculty Outstanding Research Output Prize, The University of Hong Kong)

165. Qin YR, Tang H, Xie F, Liu H, Zhu Y, Ai J, Chen L, Li Y, Kwong DL, Fu L*, Guan XY*. Characterization of tumor-suppressive function of SOX6 in human esophageal squamous cell carcinoma. Clin Cancer Res 2011;17(1):46-55.

166. Cai MY, Hou JH, Rao HL, Luo RZ, Li M, Pei XQ, Lin MC, Guan XY, Kung HF, Zeng YX, Xie D. High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients. Mol Med 2011;17(1-2):12-20.

167. Ma S, Chan YP, Kwan PS, Lee TK, Yan M, Tang KH, Ling MT, Vielkind JR, Guan XY, Chan KW. MicroRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2. Cancer Res 2011;71(2):583-92.

168. Li Y, Fu L, Wong AM, Fan YH, Li MX, Bei JX, Jia WH, Zeng YX, Chan D, Cheung KM, Sham P, Chua D, Guan XY*, Song YQ*. Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. PLoS ONE 2011;6(1):e14562.

169. Wang ZY, Wang DM, Loo TY, Cheng Y, Chen LL, Shen JG, Yang DP, Chow LW, Guan XY*, Chen JP*. Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint. J Ethnopharmacol 2011;133(2):751-8.

170. Ma S, Guan XY. MiRegulators in cancer stem cells of solid tumors. Cell Cycle 2011;10(4):571-2.

171. Xie F, Liu H, Zhu YH, Qin YR, Dai Y, Zeng T, Chen L, Nie C, Tang H, Li Y, Fu L*, Guan XY*. Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma. BMC Cancer 2011;11:86.

172. Deng W, Tsao SW, Mak GW, Tsang CM, Ching YP, Guan XY, Huen MS, Cheung AL. Impact of G2 checkpoint defect on centromeric instability. Oncogene 2011;30(11):1281-9.

173. Chen L, Yuan YF, Li Y, Chan TH, Zheng BJ, Huang J, Guan XY*. Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion. Gut 2011;60(4):534-43.

174. Yang G, He W, Cai M, Luo F, Kung H, Guan X, Zeng Y, Xie D. Loss/Down-regulation of tumor suppressor in lung cancer 1 expression is associated with tumor progression and is a biomarker of poor prognosis in ovarian carcinoma. Int J Gynecol Cancer 2011;21(3):486-93.

175. Chen M, Huang JD, Deng HK, Dong S, Deng W, Tzang SL, Huen MS, Chen L, Zan T, Zhu GX, Guan XY*. Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability. BMC Cancer 2011;11:199.

19

176. Cai MY, Tong ZT, Zheng F, Liao YJ, Wang Y, Rao HL, Chen YC, Wu QL, Liu YH, Guan XY, Lin MC, Zeng YX, Kung HF, Xie D. EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies. Gut 2011;60(7):967-76.

177. He LR, Zhao HY, Li BK, Liu YH, Liu MZ, Guan XY, Bian XW, Zeng YX, Xie D. Overexpression of eIF5A-2 is an adverse prognostic marker of survival in stage I non-small cell lung cancer patients. Int J Cancer 2011;129:143-50.

178. Li J, Lau GK, Chen L, Dong SS, Lan HY, Huang XR, Li Y, Luk JM, Yuan YF, Guan XY*. Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression. PLoS ONE 2011;6(7):e21816.

179. Tong CM, Ma S, Guan XY*. Biology of hepatic cancer stem cells. J Gastroenterol Hepatol 2011;26(8):1229-37.

180. Wang J, Chen L, Li Y, Guan XY*. Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. PLoS ONE 2011;6(9):e24967.

181. Li Y, Chen L, Nie CJ, Zeng TT, Liu H, Mao X, Qin Y, Zhu YH, Fu L, Guan XY*. Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma. Cancer Res 2011;71(19):6106-15.

182. Fang JH, Zhou HC, Zeng C, Yang J, Liu Y, Huang X, Zhang JP, Guan XY, Zhuang SM. MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression. Hepatology 2011;54(5):1729-40.

183. Cai MY, Tong ZT, Zhu W, Wen ZZ, Rao HL, Kong LL, Guan XY, Kung HF, Zeng YX, Xie D. H3K27me3 protein is a promising predictive biomarker of patients' survival and chemoradioresistance in human nasopharyngeal carcinoma. Mol Med 2011;17(11-12):1137-45.

184. Fu L, Zhang C, Zhang LY, Dong SS, Lu LH, Chen J, Dai Y, Li Y, Kong KL, Kwong DL Guan XY*. Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. Gut 2011;60(12):1635-43.

185. Ma NF, Lau SH, Hu L, Dong SS, Guan XY*. Hepatitis B virus X gene in the development of hepatocellular carcinoma. Hong Kong Med J 2011;17 Suppl 6:44-7.

186. Lu S, Lu LY, Liu MF, Yuan QJ, Sham MH, Guan XY, Huang JD. Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood. Neurobiol Dis 2012;45(1):219-33.

187. Li J, Yang H, Chen L, Li Y, Zhu Y, Dai Y, Chen K, Ai J, Zeng T, Mao X, Liu L, Li X, Guan XY*. Establishment and characterization of human non-small cell lung cancer cell lines. Mol Med Rep 2012;5(1):114-7.

188. Kong KL, Kwong DL, Chan TH, Law SY, Chen L, Li Y, Qin YR, Guan XY*. MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor. Gut 2012;61(1):33-42. (F1000 Rating: 8 Must Read; Polydorides A, Harpaz N: 2012. F1000.com/13416965#eval14791067)

189. Lin H, Hu L, Chen L, Yu H, Wang Q, Chen P, Hu XT, Cai XJ*, Guan XY*. Chemically-induced cancers do not originate from bone marrow-derived cells. PLoS ONE 2012;7(1):e30493.

20

190. Zheng F, Liao YJ, Cai MY, Liu YH, Liu TH, Chen SP, Bian XW, Guan XY, Lin MC, Zeng YX, Kung HF, Xie D. The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut 2012;61(2):278-89.

191. Wang ZY, Loo TY, Shen JG, Wang N, Wang DM, Yang DP, Mo SL, Guan XY, Chen JP. LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis. Breast Cancer Res Treat 2012;131(3):791-800.

192. Wong AM, Kong KL, Tsang JW, Kwong DL, Guan XY*. Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs. Cancer 2012;118(3):698-710.

193. Chan TH, Chen L, Liu M, Hu L, Zheng BJ, Poon VK, Huang P, Yuan YF, Huang JD, Yang J, Tsao GS, Guan XY*. Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. Hepatology 2012;55(2):491-505.

194. Tong ZT, Cai MY, Wang XG, Kong LL, Mai SJ, Liu YH, Zhang HB, Liao YJ, Zheng F, Zhu W, Liu TH, Bian XW, Guan XY, Lin MC, Zeng MS, Zeng YX, Kung HF, Xie D. EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin. Oncogene 2012:31(5):583-94.

195. Tang KH, Ma S*, Lee TK, Chan YP, Kwan PS, Tong CM, Ng IO, Man K, To KF, Lai PB, Lo CM, Guan XY*, Chan KW*. CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling. Hepatology 2012;55(3):807-20.

196. Zhu W, Cai MY, Tong ZT, Dong SS, Mai SJ, Liao YJ, Bian XW, Lin MC, Kung HF, Zeng YX, Guan XY, Xie D. Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition. Gut 2012;61(4):562-75.

197. Fan H*, Chen L, Zhang F, Quan Y, Su X, Qiu X, Zhao Z, Kong KL, Dong S, Song Y, Chan TH, Guan XY*. MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma. Oncogene 2012;31(18):2298-308.

198. Liu M, Chen L, Chan TH, Wang J, LiY, Li Y, Zeng TT, Yuan YF, Guan XY*. Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma. Hepatology 2012;55(6):1754-65.

199. Hu L, Liu M, Chen L, Chan TH, Wang J, Huo KK, Zheng BJ, Xie D, Guan XY*. SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor suppressive function in the development of hepatocellular carcinoma. Carcinogenesis 2012;33(8):1581-8.

200. Chen J, Fu L, Zhang LY, Kwong DL, Yan L, Guan XY*. Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma. Chin J Cancer 2012;31(5):215-22.

201. Liu H, Qin YR, Bi J, Cuo A, Fu L*, Guan XY*. Overexpression of matrix metalloproteinase 10 is associated with poor survival in patients with early stage of esophageal squamous cell carcinoma. Dis Esophagus 2012;25(7):656-63.

21

202. Wong AM, Tsang JW, Guan XY*. Reply to profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs. Cancer 2012;118(18):4634-5.

203. Wang Z, Cheng Y, Wang N, Wang DM, Li YW, Han F, Shen JG, Yang DP, Guan XY, Chen JP. Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins. Cancer Biology Therapy 2012;13:138-147.

204. Ma S, Bao YJ, Kwan PS, Chan YP, Tong CM, Fu L, Zhang N, Tong AH Qin YR, Tsao SW, Chan KW, Lok S, Guan XY*. Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma. Gastroenterology 2012;143(3):675-86.

205. Chen J, Kwong DL, Zhu CL, Chen LL, Dong SS, Zhang LY, Tian J, Qi CB, Cao TT, Wong AM, Kong KL, Li Y, Liu M, Fu L*, Guan XY*. RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis. PLoS ONE 2012;7(9):e44636.

206. He WP, Zhou J, Cai MY, Xiao XS, Liao YJ, Kung HF, Guan XY, Xie D, Yang GF. CHD1L protein is overexpressed in human ovarian carcinomas and is a novel predictive biomarker for patients survival. BMC Cancer 2012;12(1):437.

207. Li J, Lau GK, Chen L, Yuan YF, Huang J, Luk JM, Xie D, Guan XY*. Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-Kappa B induced Matrix Metalloproteinase 9 expression. PLoS ONE 2012;7(9):e46264.

208. Deng W, Tsao GW, Guan XY, Cheung AL. Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cells. PLoS ONE 2012;7(10):e48576.

209. Tong M, Chan KW, Bao JY, Wong KY, Chen JN, Kwan PS, Tang KH, Fu L, Qin YR, Lok S, Guan XY, Ma S. Rab25 is a tumor suppressor gene with anti-angiogenic and anti-invasive activities in esophageal squamous cell carcinoma. Cancer Res 2012;72(22):6024-35.

210. Chan TH, Chen L, Guan XY*. Role of translationally controlled tumor protein in cancer progression. Biochem Res Int 2012;2012:369384.

211. Li Y, Chen L, Chan TH, Liu M, Kong KL, Qiu JL, Yuan YF, Guan XY*. SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in mice. Gastroenterology 2013;144(1):179-91.

212. Li J, Li X, Chen L, Li Y, Zhu Y, Chen S, Liu H, Dai Y, Chen K, Liu L, Zeng T, Zhou J, Li F, Yang H, Qin YR, Guan XY*. Cell-specific detection of miR-375 downregulation by in situ hybridization predicts the prognosis of esophageal squamous cell carcinoma. PLoS ONE 2013;8(1):e53582.

213. Zhang LY, Lee VH, Wong AM, Kwong D, Zhu YH, Dong SS, Kong KL, Chen J, Tsao GS, Guan XY*, Fu L*. MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. Carcinogenesis 2013;34(2):454-63.

214. Chen L, Li Y, Lin CH, Chan TH, Chow RK, Song Y, Liu M, Yuan YF, Fu L, Kong KL, Qi L, Li Y, Zhang N, Tong AH, Kwong DL, Man K, Lo CM, Lok S, Tenen DG*, Guan XY*. Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nat Med 2013;19(2):209-16.(This work was introduced by Nat Med “News and View”, Gallo A. Nat Med 2013;19:130-1) ("News in Brief", Cancer Discovery, 2013;3:OF12)

22

(2014 Faculty Outstanding Research Output Prize, The University of Hong Kong)215. Li Y*, Zhu CL, Nie CJ, Li JC, Zeng TT, Zhou J, Chen J, Chen K, Fu L, Liu H, Qin

Y, Guan XY*. Investigation of tumor suppressing function of CACNA2D3 in esophageal squamous cell carcinoma. PLoS One 2013;8(4):e60027.

216. Zhu YH, Fu L, Chen L, Qin YR, Liu H, Xie F, Zeng T, Dong SS, Li J, Li Y, Dai Y, Xie D, Guan XY*. Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma. Cancer Res 2013;73(7):2298-309.

217. Tang KH, Dai YD, Tong M, Chan YP, Kwan PS, Fu L, Qin YR, Tsao SW, Lung HL, Lung ML, Tong DK, Law S, Chan KW, Ma S*, Guan XY*. A CD90+ tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer. Cancer Res 2013;73(7):2322-32.

218. Zhu J, Yu Y, Meng X, Fan Y, Zhang Y, Zhou C, Yue Z, Jin Y, Zhang C, Yu L, Ji W, Jia X, Guan R, Wu J, Yu J, Bai J, Guan XY, Wang M, Lee KY, Sun W, Fu S. De novo-generated small palindromes are characteristic of amplicon boundary junction of double minutes. Int J Cancer 2013;133(4):797-806.

219. Li Y, Chen L, Chan TH, Guan XY*. Hepatocellular carcinoma: transcriptome diversity regulated by RNA editing. Int J Biochem Cell Biol 2013;45(8):1843-8.

220. Dai Y, Liu L, Zeng T, Zhu YH, Li J, Chen L, Li Y, Yuan YF, Ma S*, Guan XY*. Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma. Biochem Biophys Res Commun 2013;436(4):711-8.

221. Chen K, Li Y, Dai Y, Li J, Qin Y, Zhu Y, Zeng T, Ban X, Fu L, Guan XY*. Characterization of tumor suppressive function of cornulin in esophageal squamous cell carcinoma. PLoS One 2013;8(7):e68838.

222. Wong AM, Kong KL, Chen L, Liu M, Wong AM, Zhu C, Tsang JW, Guan XY*. Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma. Int J Cancer 2013;133(10):2284-95.

223. Zhu YH*, Yang F, Zhang SS, Zeng TT, Xie X, Guan XY*. High expression of biglycan is associated with poor prognosis in patients with esophageal squamous cell carcinoma. Int J Clin Exp Pathol 2013;6(11):2497-505.

224. Wang FW, Guan XY, Xie D. Roles of eukaryotic initiation factor 5A2 in human cancer. Int J Biol Sci 2013;9(10):1013-20.

225. Liu L, Dai Y, Chen J, Zeng T, Li Y, Chen L, Zhu Y, Li J, Li Y, Xie D, Yuan YF, Guan XY*. Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition via Akt/GSK-3β/Snail signaling. Hepatology 2014;59(2):531-43.

226. Qin YR*, Qiao JJ, Chan TH, Zhu YH, Liu H, Fei J, Li Y, Guan XY*, Chen L*. Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma (ESCC). Cancer Res 2014;74(3):840-51.

227. Liu M, Li Y, Chen L, Chan TH, Song Y, Fu L, Zeng TT, Dai YD, Zhu YH, Li Y, Chen J, Yuan YF, Guan XY*. Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma. Gastroenterology 2014;146(4):1084-96.

228. Li J, Yang H, Li Y, Liu Y, Chen S, Qi C, Zhang Q, Lan T, He X, Guan XY*, Wang L*. microRNA-146 up-regulation predicts the prognosis of non-small cell lung cancer by miRNA in situ hybridization. Exp Mol Pathol 2014;96(2):195-99.

229. Chan TH, Lin CH, Qi L, Fei J, Li Y, Yong KJ, Liu M, Song Y, Chow RK, Ng VH, Yuan YF, Tenen DG, Guan XY, Chen L. A disrupted RNA editing balance mediated by

23

ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma. Gut 2014;63(5):832-43.

230. Zhu YH, Liu H, Song Y, Zhang LY, Zeng T, Qin YR, Li L, Liu L, Li J, Zhang B, Guan XY*. Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma. Carcinogenesis 2014;35(5):1154-61.

231. Li Y*, Fu L, Qin Y, Zeng T, Zhou J, Zeng ZL, Chen J, Cao TT, Ban X, Qian C, Cai Z, Xie D, Huang P, Guan XY*. Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma. Gastroenterology 2014;146(7):1701-13.

232. Liu XB, Cheng Q, Geng W, Ling CC, Liu Y, Ng KT, Yam JW, Guan XY, Lo CM, Man K. Enhancement of cisplatin-based TACE by a hemoglobin-based oxygen carrier in an orthotopic rat HCC model. Artif Cells Nanomed Biotechnol 2014;42(4):229-36.

233. Li JC, Li Y, Ai JY, Chen K, Zhu YH, Fu L, Qin QR, Wang LJ, Guan XY*. Podoplanin-positive cancer cells at the edge of esophageal squamous cell carcinomas are involved in invasion. Mol Med Rep 2014;10(3):1513-8.

234. Cheung CC, Chung GT, Lun SW, To KF, Choy KW, Lau KM, Siu SP, Guan XY, Ngan RK, Yip TT, Busson P, Tsao SW, Lo KW. miR-31 is consistently inactivated in EBV-associated nasopharyngeal carcinoma and contributes to its tumorigenesis. Mol Cancer 2014;13(1):184.

235. Liu M, Jiang L, Guan XY*. The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update. Protein Cell 2014;5(9):673-91.

236. Chai S, Tong M, Ng KY, Kwan PS, Chan YP, Fung TM, Lee T, Wong N, Xie D, Yuan YF, Guan XY, Ma S. Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133. Oncotarget 2014;5(14):5725-35.

237. Wang, FW, Cai MY, Mai SJ, Chen JW, Bai HY, Li Y, Liao YJ, Li CP, Tian XP, Kung HF, Guan XY, Xie D. Ablation of EIF5A2 induces tumor vasculature remodeling and improves tumor response to chemotherapy via regulation of matrix metalloproteinase 2 expression. Oncotarget 2014;5(16):6716-33.

238. Jiang L, Yang YD, Fu L, Xu W, Liu D, Liang Q, Zhang X, Xu L, Guan XY, Wu B, Sung JJ, Yu J. CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma. Oncotarget 2014;5(17):7663-76.

239. Liu M, Guan XY*. Allele imbalance in the transcriptome of human hepatocellular carcinoma: stress-induced gene plays a role. Science Proceedings 2014;1:1-2.

240. Cheung AN, Guan XY, Ngan HY. Cervical cancer screening by enhanced cytology: application of novel markers. Hong Kong Med 2014;Suppl 6:39-43.

241. Li Y*, Guan XY*. EIF5A2 promotes tumor metastasis and angiogenesis. Gastroenterol Transl Invest 2014;1:e221.

242. Song Y, Li J, Zhu Y, Dai Y, Zeng T, Liu L, Li J, Wang H, Qin Y, Zeng M, Guan XY*, Li Y*. MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma. Oncotarget 2014;5(22):11669-80.

243. Li B, Li J, Xu WW, Guan XY, Qin YR, Zhang LY, Law S, Tsao SW, Cheung AL. Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway. Oncotarget 2014;5(22):11576-87.

24

244. Deng W, Zhou Y, Tiwari AF, Su H, Yang J, Zhu D, Lau VM, Hau PM, Yip YL, Cheung AL, Guan XY, Tsao SW. p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells. Int J Cancer 2015;136(6):1361-70.

245. Chen J, Kwong DL, Cao T, Hu Q, Zhang L, Ming X, Chen J, Fu L*, Guan XY*. Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics. Dis Esophagus 2015;28(1):84-9.

246. Zheng F, Liao YJ, Cai MY, Liu TH, Chen SP, Wu PH, Wu L, Bian XW, Guan XY, Zeng YX, Yuan YF, Kung HF, Xie D. Systemic delivery of microRNA-101 potently inhibits hepatocellular carcinoma in vivo by repressing multiple targets. PLoS Genet 2015;11(2): e1004873.

247. Wang J, Liu M, Chen L, Chan TH, Jiang L, Yuan YF, Guan XY*. Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility. Oncotarget 2015;6(3):1618-30.

248. Yeung WH, Lo CM, Ling CC, Qi X, Geng W, Li CX, Ng KT, Forbes SJ, Guan XY, Poon RT, Fan ST, Man K. Alternatively activated (M2) macrophages promoted tumor growth and invasiveness in hepatocellular carcinoma. J Hepatol 2015;62(3):607-16.

249. Tang Z, Li S, Guan XY, Schmitt-Kopplin P, Lin S, Cai Z. Rapid assessment of the coenzyme Q10 redox state using ultrahigh performance liquid chromatography tandem mass spectrometry. Analust 2014;139:5600-4.

250. Wang Y, Su P, Hu B, Zhu W, Li Q, Yuan P, Li J, Guan XY, Li F, Jing X, Li R, Zhang Y, Férec C, Cooper DN, Wang J, Huang D, Chen JM, Wang Y. Characterization of 26 deletion CNVs reveals the frequent occurrence of micro-mutations within the breakpoint-flanking regions and frequent repair of double-strand breaks by templated insertions derived from remote genomic regions. Hum Genet 2015;134(6):589-603.

251. Li J, Deng Z, Wang Z, Wang D, Zhang L, Su Q, Lai Y, Li B, Luo Z, Chen X, Chen Y, Huang X, Ma J, Wang W, Bi J, Guan XY. Zipper-interacting protein kinase promotes epithelial-mesenchymal transition, invasion and metastasis through AKT and NF-kB signaling and is associated with metastasis and poor prognosis in gastric cancer patients. Oncotarget 2015;6(10):8323-38.

252. Li J, Zhu YH, Huang P, Zhang B, Sun J, Guan XY*. ITPKA expression is a novel prognostic factor in hepatocellular carcinoma. Diagn Pathol 2015;10(1):136.

253. Tong M, Fung TM, Luk ST, Ng KY, Lee TK, Lin CH, Yam JW, Chan KW, Ng F, Zheng BJ, Yuan YF, Xie D, Lo CM, Man K, Guan XY, Ma S. ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma. Stem Cell Reports 2015;5(1):45-59.

254. Cheng Y, Ho RL, Chan KC, Kan R, Tung E, Lung HL, Yau WL, Cheung AK, Ko JM, Zhang ZF, Luo DZ, Feng ZB, Chen S, Guan XY, Kwong D, Stanbridge EJ, Lung ML. Anti-angiogenic pathway associations of the 3p21.3 mapped BLU gene in nasopharyngeal carcinoma. Oncogene 2015;34(32):4219-28.

255. Song Y, Pan G, Chen L, Ma S, Zeng T, Chan TH, Li L, Lian Q, Chow R, Cai X, Li Y, Li Y, Liu M, Li Y, Zhu Y, Wong N, Yuan YF, Pei D, Guan XY*. Down-regulation of tumor suppressor ATOH8 increases cancer stemness in hepatocellular carcinoma. Gastroenterology 2015;149(4):1068-81.

256. Jiang L, Kwong DL, Li Y, Liu M, Yuan YF, Li Y, Fu L, Guan XY*. HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma. Carcinogenesis 2015;36(10):1111-20.

25

http://www.ncbi.nlm.nih.gov/pubmed?term=Guan%20XY%5BAuthor%5D&cauthor=true&cauthor_uid=25347745

257. Zhu YH, Zhang B, Li M, Huang P, Sun J, Fu J*, Guan XY*. Prognostic significance of FAM3C in esophageal squamous cell carcinoma. Diagn Pathol 2015;10(1):192.

258. He WP, Li Q, Zhou J, H ZS, Kung HF, Guan XY, Xie D, Yang GF. Decreased expression of H3K27me3 in human ovarian carcinomas correlates with more aggressive tumor behavior and poor patient survival. Neoplasma 2015;62(6):932-7.

259. Yang H, Li XD, Zhou Y, Ban X, Zeng TT, Zhang BZ, Yun J, Xie D, Guan XY, Li Y. Stemness and chemotherapeutic drug resistance induced by EIF5A2 overexpression in esophageal squamous cell carcinoma. Oncotarget 2015;6(28):26079-89.

260. He LR, Ma NF, Chen JW, Li BK, Guan XY, Liu MZ, Xie D. Overexpression of CHD1L is positively associated with metastasis of lung adenocarcinoma and predicts patients poor survival. Oncotarget 2015;6(31):31181-90.

261. Huang PY, Zeng TT, Li MQ, Ban X, Zhu YH, Zhang BZ, Mai HQ, Zhang L, Guan XY, Li Y. Proteomic analysis of a nasopharyngeal carcinoma cell line and a nasopharyngeal epithelial cell line. Tumori 2015;101(6):676-83.

262. Cheng L, Tang X, Liu L, Peng J, Nishiura K, Cheung AK, Guo J, Wu X, Tang HY, An M, Zhou J, Cheung KW, Wang H, Guan XY, Wu Z, Chen Z. Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis. MAbs 2015;7(3):620-9.

263. Li J, Chen JN, Zeng, TT, He F, Chen SP, Ma S, Bi J, Zhu XF, Guan XY*. CD133+ liver cancer stem cells resist interferon-gamma-induced autophagy. BMC Cancer 2016;16(1):15.

264. Li J, Li B, Xu WW, Chan KW, Guan XY, Qin YR, Yue Lee NP, Chan KT, Law S, Tsao SW, Cheung AL. Role of AMPK signaling in mediating the anti-cancer effects of silibinin in esophageal squamous cell carcinoma. Expert Opin Ther Targets 2016;20(1):7-18.

265. Zhang YL, Wu JL, Qiu HB, Dong SS, Zhu YH, Lee VH, Qin YR, Li Y, Chen J, Liu HB, Bi J, Ma S, Guan XY*, Fu L*. PSCA acts as a tumor suppressor by facilitating the nuclear translocation of RB1CC1 in esophageal squamous cell carcinoma. Carcinogenesis 2016;37(3):320-32.

266. Lin SH, Liu T, Ming X, Tang Z, Fu L, Schmitt-Kopplin P, Kanawati B, Guan XY, Cai Z. Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions. Sci Rep 2016;6:21184.

267. Tang Z, Cao T, Lin S, Fu L, Li S, Guan XY, Cai Z. Characterization of oncogene-induced metabolic alterations in hepatic cells by using ultrahigh performance liquid chromatography-tandem mass spectrometry. Talanta 2016;152:119-26.

268. Li B, Xu WW, Guan XY, Qin YR, Law S, Lee NP, Chan KT, Tam PY, Li YY, Chan KW, Yuen HF, Tsao SW, He QY, Cheung AL. Competitive binding between Id1 and E2F1 to Cdc20 regulates E2F1 degradation and thymidylate synthase expression to promote esophageal cancer chemoresistance. Clin Cancer Res 2016;22(5):1243-55.

269. Xu L, Li X, Cai M, Chen J, Li X, Wu WK, Kang W, Tong J, To KF, Guan XY, Sung JJ, Chan FK, Yu J. Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer. Gut 2016;65(4):635-46.

270. Liu M, Chen L, Ma NF, Chow RK, Li Y, Song Y, Chan TH, Fang S, Yang X, Xi S, Jiang L, Li Y, Zeng TT, Li Y, Yuan YF, Guan XY*. CHD1L promotes lineage reversion of

26

http://www.ncbi.nlm.nih.gov/pubmed/?term=Guan%20X%5BAuthor%5D&cauthor=true&cauthor_uid=25692916

http://www.ncbi.nlm.nih.gov/pubmed/?term=Liu%20L%5BAuthor%5D&cauthor=true&cauthor_uid=25692916

http://www.ncbi.nlm.nih.gov/pubmed/?term=Tang%20X%5BAuthor%5D&cauthor=true&cauthor_uid=25692916

http://www.ncbi.nlm.nih.gov/pubmed/?term=Cheng%20L%5BAuthor%5D&cauthor=true&cauthor_uid=25692916

hepatocellular carcinoma through opening chromatin for key developmental transcription factors. Hepatology 2016;63(5):1544-59.

271. Chow LW, Costa L, Teh BT, Li DQ, Feng G, Guan XY, Nair A, Zhu L, Sugimoto M, Dutt A, Toi M, Gupta S, Badwe R, Knapp S, Pillai MR, Kumar R. Cancer genomics and biology 2015-Meeting report. Genes Cancer 2016;1-2:1-6.

272. Li J, Zhang BZ, Qin YR, Bi J, Liu HB, Li Y, Cai MY, Ma S, Chan KW, Xie D, Guan XY*. CD68 and interleukin 13, prospective immune markers for esophageal squamous cell carcinoma prognosis prediction. Oncotarget 2016;7(13):15525-38.

273. Yang J, Lv X, Chen J, Xie C, Xia W, Jiang C, Zeng T, Ye Y, Ke L, Yu Y, Liang H, Guan XY*, Guo X*, Xiang Y*. CCL2-CCR2 axis promotes metastasis of nasopharyngeal carcinoma by activating ERK1/2-MMP92/9 pathway. Oncotarget 2016;7(13):15632-47.

274. Li CP, Cai MY, Jiang LJ, Mai SJ, Chen JW, Wang FW, Liao YJ, Chen WH, Jin XH, Pei XQ, Guan XY, Zeng MS, Xie D. CLDN14 is epigenetically silenced by EZH2-mediated H3K27ME3 and is a novel prognostic biomarker in hepatocellular carcinoma. Carcinogenesis 2016;37(6):557-66.

275. Fung TM, Ng KY, Tong M, Chen JN, Chai S, Chan KT, Law S, Lee NP, Choi MY, Li B, Cheung AL, Tsao SW, Qin YR, Guan XY, Chan KW, Ma S. Neuropilin-2 promotes tumorigenicity and metastasis in esophageal squamous cell carcinoma through ERK MAPK/ETV4/MMP/E-cadherin deregulation. J Pathol 2016;239(3):309-19.

276. Ng KY, Chai S, Tong M, Guan XY, Lin CH, Ching YP, Xie D, Cheng AS, Ma S. C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties. Oncotarget 2016;7(17):24005-17.

277. Huang PY, Zeng TT, Ban X, Li MQ, Zhang BZ, Zhu YH, Hua WF, Mai HQ, Zhang L, Guan XY*, Li Y*. Expression of EIF5A2 associates with poor survival of nasopharyngeal carcinoma patients treated with induction chemotherapy. BMC Cancer 2016;16:669.

278. Bao Y, Liu J, You J, Wu D, Yu Y, Liu C, Wang L, Wang F, Xu L, Wang L, Wang N, Tian X, Wang F, Liang H, Gao Y, Cui X, Ji G, Bai J, Yu J, Meng X, Jin Y, Sun W, Guan XY, Zhang C, Fu S. Met promotes the formation of double minute chromosomes induced by Sei-1 in NIH-3T3 murine fibroblasts. Oncotarget 2016;7(35):56664-75.

279. Stunnenberg HG; International Human Epigenome Consortium. (XY Guan among 228 collaborators), Hirst M. The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. Cell 2016;167(5):1145-9.

280. Chai S, Ng KY, Tong M, Lau EY, Lee TK, Chan KW, Yuan YF, Cheung TT, Cheung ST, Wang XQ, Wong N, Lo CM, Man K, Guan XY, Ma S. Octamer 4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells. Hepatology 2016; 64(6):2062-76.

281. Ming XY, Fu L, Zhang LY, Qin YR, Cao TT, Chan KW, Ma S, Xie D, Guan XY*. Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma. Nat Commun 2016;7:13568.

282. Cao R, Meng Z, Liu T, Wang G, Qian G, Cao T, Guan XY, Dan H, Xiao Y, Wang X. Decreased TRPM7 inhibits activities and induces apotosis of bladder cancer cells via ERK1/2 pathway. Oncotarget 2016;7(45):72941-60.

27

283. Chow RK, Sin ST, Liu M, Li Y, Chan TH, Song Y, Chen L, Kwong DL, Guan XY*. AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways. Oncotarget 2016;8(48):83469-79.

284. Tang H, Wu Y, Qin Y, Wang H, Wang L, Guan XY, Luo S, Wang Q. Reduction of AZGP1 predicts poor prognosis in esophageal squamous cell carcinoma patients in northern China. Onco Targets Ther 2016;10:85-94.

285. Li XD, Zhang JX, Jiang LJ, Wang FW, Liu LL, Liao YJ, Jin XH, Chen WH, Chen X, Guo SJ, Zhou FJ, Zeng YX, Guan XY, Liu ZW, Xie D. Overexpression of maelstrom promotes bladder urothelial carcinoma cell aggressiveness by epigenetically down-regulating MTSS1 through DNMT3B. Oncogene 2016;35(49):6281-92.

286. Qian K, Wang G, Cao R, Liu T, Qian G, Guan XY, Guo Z, Xiao Y, Wang X. Capsaicin induces dysregulation of proliferation, cell cycle and ROS metabolism by interfering FOXO3a in bladder cancer cells in vivo and in vitro. Molecules 2016;21(10):1406.

287. Lyu Z, Wu S, Cai Z, Guan XY. Patient-physician trust in China: health education for the public. Lancet 2017;388(10063):2991.

288. You J, Liu J, Bao Y, Wang L, Yu Y, Wang L, Wu D, Liu C, Wang N, Wang F, Wang F, Xu L, Tian X, Liang H, Gao Y, Guan R, Bai J, Meng X, Sun W, Guan XY, Zhang C, Fu S, Jin Y. SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer. Cancer Lett 2017;385:271-9.

289. Cao TT, Lin SH, Fu L, Tang Z, Che CM, Zhang LY, Ming XY, Liu TF, Tang XM, Tan BB, Xiang D, Li F, Chan OY, Xie D, Cai Z, Guan XY*. Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells. Carcinogenesis 2017;38(1):94-104.

290. Xu WW, Li B, Guan XY, Chung SK, Wang Y, Yip YL, Law SY, Chan KT, Lee NP, Chan KW, Xu LY, Li EM, Tsao SW, He QY, Cheung AL. Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression. Nat Commun 2017;8:14399.

291. Tang PM, Zhou S, Meng XM, Wang QM, Li CJ, Lian GY, Huang XR, Tang YJ, Guan XY, Yan BP, To KF, Lan HY. Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development. Nat Commun 2017;8:14677.

292. Li B, Xu WW, Han L, Chan KT, Tsao S, Lee NP, Law S, Xu LY, Li EM, Chan KW, Qin YR, Guan XY, He QY, Cheung AL. MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF. Oncogene 2017;36(28):3986-4000.

293. Tian B, Chen X, Zhang H, Li X, Wang J, Han W, Zhang LY, Fu L, Li Y, Nie C, Zhao Y, Tan X, Wang H, Guan XY, Hong A. Urokinase plasminogen activator secreted by cancer-associated fibroblasts induces tumor progression via PI3K/AKT and ERK signaling in esophageal squamous cell carcinoma. Oncotarget 2017;8(26):38755-66.

294. Fu L*, Qin YR, Ming XY, Zuo XB, Diao YW, Zhang LY, Ai J, Liu BL, Huang TX, Cao TT, Tan BB, Xiang D, Zeng CM, Gong J, Zhang Q, Dong SS, Chen J, Liu H, Wu JL, Qi RZ, Xie D, Wang LD, Guan XY*. RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer. Pro Nat Aca Sci USA 2017;114(23):E4631-40.

295. Li B, Xu WW, Lam AKY, Wang Y, Hu HF, Guan XY, Qin YR, Saremi N, Tsao SW, He QY, Cheung ALM. Significance of PI3K/AKT signaling pathway in metastasis of

28

esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy. Oncotarget 2017;8(24):38755-66.

296. Zhang B, Li M, Huang P, Guan XY, Zhu YH. Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma. Thorac Cancer 2017;8(4):344-9.

297. Fu P, Tang H, Liu P, Shen J, Guan X, Xie X, Gao J, Jia L, Chen J, Peng C. Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis. Sci Reports 2017;7(1):9022.

298. Li L, Zhu YH, Li Y, Guan XY*. Identification of chemokine CXCL10 in tumor microenvironment by antibody array as a prognostic marker in hepatocellular carcinoma. Neoplasma 2017;64(5):778-86.

299. Jiang L, Yan Q, Fang S, Liu M, Li Y, Yuan YF, Li Y, Zhu Y, Qi J, Yang X, Kwong DLW*, Guan XY*. Calcium binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating ERK signaling pathway. Hepatology 2017;66(5):1529-45.

300. Ng KY, Chan LH, Chai S, Tong M, Guan XY, Lee NP, Yuan YF, Xie D, Lee TK, Dusetti NJ, Carrier A, Ma S. TP53INP1 down-regulation activates a p73-dependent DUSP10/ERK signaling pathway to promote metastasis of hepatocellular carcinoma. Cancer Res 2017;77(17):4602-12.

301. Lau MC, Ng KY, Wong TL, Tong M, Lee TK, Ming XY, Law S, Lee NP, Cheung AL, Qin YR, Chan KW, Ning W, Guan XY, Ma S. FSTL1 promotes metastasis and chemoresistance in esophageal squamous cell carcinoma through NFκB-BMP signaling crosstalk. Cancer Res 2017;77(21):5886-99.

302. Yan Q, Jiang L, Liu M, Yu D, Zhang Y, Li Y, Fang S, Li Y, Zhu YH, Yuan Y, Guan XY*. ANGPTL1 interacts with integrin α1β1 to suppress HCC angiogenesis and metastasis by inhibiting JAK2/STAT3 signaling. Cancer Res 2017;77(21):5831-45.

303. Li L, Zeng TT, Zhang BZ, Li Y, Zhu YH, Guan XY*. Overexpression of HN1L promotes cell malignant proliferation in non-small cell lung cancer. Cancer Biol Ther 2017;18(11):904-15.

304. Cao TT, Xiang D, Liu BL, Huang TX, Tan BB, Zeng CM, Wang ZY, Ming XY, Zhang LY, Jin G, Li F, Wu JL, Guan XY, Lu D, Fu L. FZD7 is a novel prognostic marker and promotes tumor metastasis via WNT and EMT signaling pathways in esophageal squamous cell carcinoma. Oncotarget 2017;8:65957-68.

305. Dai Y, Liu L, Zeng T, Liang JZ, Song Y, Chen K, Li Y, Chen L, Zhu YH, Li J, Li Y, Xie D, Yuan YF, Guan XY*. Overexpression of MUC13, a poor prognostic predictor, promotes cell growth by activating Wnt signaling in hepatocellular carcinoma. Am J Pathol 2018;188(2):378-391.

306. Zhong Q, Liu Z, Lin ZR, Hu ZD, Yuan L, Liu YM, Zhou AJ, Xu LH, Hu LJ, Wang ZF, Guan XY, Hao JJ, Lui VWY, Guo L, Mai HQ, Chen MY, Han F, Xia YF, Grandis JR, Zhang X, Zeng MS. The RARS-MAD1L1 fusion gene Induces cancer stem cell-like properties and therapeutic resistance in nasopharyngeal carcinoma. Clin Cancer Res 2018;24(3):659-673.

307. Bai HY, Liao YJ, Cai MY, Ma NF, Zhang Q, Chen JW, Zhang JX, Wang FW, Wang CY, Chen WH, Jin XH, Xu RH, Guan XY, Xie D. EIF5A2 contributes to the maintenance of CD133(+) hepatocellular carcinoma cells via the c-Myc/microRNA-29b axis. Stem Cell 2018;36(2):180-91.

29

308. Ye W, Ling S, Liu RY, Pan ZZ, Wang G, Gao S, Wu J, Cao L, Dong L, Li Y, Yi Zhou, Du W, Meng X, Chen J, Guan XY, He Y, Pan C, Zheng XF, Xuemei Lu, Chen S, Huang W. Exome sequencing reveals the genetic landscape and frequent inactivation of PCDHB3 in Chinese rectal cancers. J Pathol 2018;245(2):222-234.

309. Ming XY, Zhang X*, Cao TT, Zhang LY, Qi JL, Tang XM, Cui YZ, Zhang BZ, Li Y, Qin YR, Guan XY*. RHCG suppresses tumorigenicity and metastasis in esophageal squamous cell carcinoma via inhibiting NF-κB signaling and MMP1 expression. Theranostics 2018;8(1):185-98.

310. Tian X, Liu C, Wang X, Wang F, Wang L, Xu L, Ma J, Cao Y, Bao Y, Wang F, Sun L, Wei J, Lin C, Zhang H, Zhu G, Guan XY, Fu S, Zhang C. Sei-1 promotes double minute chromosomes formation through activation of the PI3K/Akt/BRCA1-Abraxas pathway and induces double-strand breaks in NIH-3T3 fibroblasts. Cell Death Dis 2018;9(3):341.

311. Zhou Y, Wang L, Ban X, Zeng T, Zhu Y, Li M, Guan XY*, Li Y*. DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma. Oncogene 2018;37(8):1086-94.

312. Zhang B, Zhang Z, Li L, Qin YR, Liu H, Jiang C, Zeng T, Li M, Xie D, Li Y*, Guan XY*, Zhu YH*. TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling. Nat Commun 2018;9(1):1423.

313. Wang L, Li M, Zhan Y, Ban X, Zeng T, Zhu Y, Yun J, Guan XY*, Li Y*. Down-regulation of POTEG predicts poor prognosis in esophageal squamous cell carcinoma patients. Mol Carcinog 2018;57(7):886-95.

314. Li L, Liu YD, Zhan YT, Zhu YH, Li Y, Xie D, Guan XY*. High levels of CCL2 or CCL4 in the tumor microenvironment predict unfavorable survival in lung adenocarcinoma. Thorac Cancer 2018;9(7):775-784.

315. Li L, Yang H, Li Y, Li XD, Zeng TT, Lin SX, Zhu YH, Guan XY*. Hypoxia restrains the expression of complement component 9 in tumor-associated macrophages promoting non-small cell lung cancer progression. Cell Death Discov 2018;4:63.

316. Li Y*, Lin S, Li L, Tang Z, Hu Y, Ban X, Zeng T, Zhou Y, Zhu YH, Gao S, Deng W, Zhang X, Xie D, Yuan Y, Huang P , Li J, Cai Z, Guan XY*. PDSS2 deficiency induces hepatocarcinogenesis by decreasing mitochondrial respiration activity and reprogramming glucose metabolism. Cancer Res 2018;78(16):4471-81.

317. Jiang C, Chen J, Xie S, Zhang L, Xiang Y, Lung M, Kam NW, Kwong DL, Cao S*, Guan XY*. Evaluation of circulating EBV microRNA BART2-5p in facilitating early detection and screening of nasopharyngeal carcinoma. Int J Cancer 2018 Jul 4. doi: 10.1002/ijc.31642. [Epub ahead of print]

318. Chen X, Zhang J, Luo JH, Wu S, Yuan G, Ma NF, Feng Y, Cai M, Chen R, Lu J, Jiang L, Chen JW, Jin XH, Liu H, Chen W, Guan XY, Kang T, Zhou FJ, Xie D. CSTF2-induced shortening of the RAC1 3'UTR promotes the pathogenesis of urothelial carcinoma of the bladder. Cancer Res 2018 Aug 24. pii: canres.0822.2018. doi: 10.1158/0008-5472.CAN-18-0822. [Epub ahead of print]

319. Li L, Li JC, Yang H, Zhang X, Liu LL, Li Y, Zeng TT, Zhu YH, Li XD, Li Y, Xie D, Fu L, Guan XY*. Expansion of cancer stem cell pool initiates lung cancer recurrence before angiogenesis. Proc Natl Acad Sci USA 2018;115(38):E8948-E8957.

Conference Presentations and Posters:

30

http://scholar.google.com/scholar?oi=bibs&cluster=4081299516500537608&btnI=1&nossl=1&hl=en



1. Guan XY, Alberts D, Burgess AC, Thompson FH, Trent JM. Chromosomal analysis of 90 cases of ovarian carcinomas. The 3rd International Workshop on Chromosomes in Solid Tumors, Tucson, Arizona, February 1989. Cancer Genet Cytogenet 1989;41:291.

2. Guan XY, Meese EU, Trent JM, Meltzer PS. Isolation of probes for a region of chromosome 6 deleted in malignant melanoma by chromosome microdissection. The Annual Meeting of AACR, Houston, May 1991.

3. Meltzer PS, Guan XY, Meese EU, Trent JM. Chromosome microdissection of a region of chromosome 6 frequently deleted in malignant melanoma. The 4th International Workshop on Chromosomes in Solid Tumors, Tucson, Arizona, February 1991.

4. Trent JM, Meese EU, Guan XY, Meltzer PS. The biological significance of chromosomal abnormalities in human malignant melanoma. Advances in the Biology and Clinical Management of Melanoma. The 35th Annual Clinical Conference and Anderson Cancer Center, Houston, Texas. November 1991.

5. Meltzer PS, Guan XY, Burgess A, Zhang J, Trent JM. Utilization of chromosome microdissection to generate region-specific probes: Application to the identification of cryptic chromosomal rearrangements. Genome Mapping and Sequencing Conference, Cold Spring Harbor Laboratory, New York. May 1992.

6. Meltzer PS, Guan XY, Trent JM. Microdissection demonstrates that apparent deletions of chromosome 6 in melanoma are frequently terminal translocations. Genome Mapping and Sequencing Conference, Cold Spring Harbor Laboratory, New York. May 1992.

7. Guan XY, Trent JM, Cao J, Burgess A, Meltzer PS. Utilization of chromosome microdissection to generate region-specific probes for chromosome 6 and their application. The 1st International Workshop on Chromosome 6, The University of Michigan, Ann Arbor, Michigan. June 1992.

8. Meltzer PS, Guan XY, Trent JM. Microdissection of homogeneously staining regions on chromosome 12 encoding SAS, GLI, and MDM2. The 1st International Workshop on Chromosome 12, St. Catherine's College, Oxford, England, September 1992. Cytogenet Cell Genet 1993;61:259.

9. Guan XY, Meltzer PS, Burgess A, Cao J, Trent JM. Generation of region-specific library and painting probes on chromosome 6 by microdissection. The 5th International Workshop on Chromosomes in Solid Tumor, Tucson, Arizona. January 1993. Cancer Genet Cytogenet 1993.

10. Meltzer PS, Jankowski S, Guan XY, Gemmill R, MItchell D, Smith S, Hoskins K, Trent JM. Molecular cytogenetic analysis of an amplification unit on chromosome 12q. The 5th International Workshop on Chromosomes in Solid Tumor, Tucson, Arizona. January 1993. Cancer Genet Cytogenet 1993.

11. Meltzer PS, Guan XY, Dennis T, Burgess A, and Trent JM: Stabilization of chromosome breakage by telomere capture: Demonstration by chromosome microdissection. The 5th International Workshop on Chromosomes in Solid Tumor, Tucson, Arizona. January 1993. Cancer Genet Cytogenet 1993.

12. Trent JM, Guan XY, Zhang J, Burgess A, Dennis T, Meltzer PS. Application of chromosome microdissection to the identification of complex chromosomal rearrangements in malignancy. The 5th International Workshop on Chromosomes in Solid Tumor, Tucson, Arizona. January 1993. Cancer Genet Cytogenet 1993.

13. Meltzer PS, Guan XY, Ray M, Slovak ML, Cole SPC, Trent JM. Detection and cloning of amplified DNA in drug resistant cells by chromosome microdissection. General

31

Motors Cancer Research Foundation International Symposium "Resistance against Anticancer Drugs: Molecular Mechanisms and Clinical Opportunities", Toronto, Canada. May 6-8, 1993.

14. Meltzer PS, de Jong P, El Kahloun A, Guan XY, Gurgess A, Trent JM. Isolation of region specific cosmids from chromosome 12 with a complex probe generated by chromosome microdissection. Genome Mapping & Sequencing, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. May 12-16, 1993.

15. Meltzer PS, Guan XY, Zhang J, Trent JM. Isolation of amplified DNA from human tumor cells by chromosome microdissection. The 84th Annul Meeting of the AACR, Orlando, Florida. May 19-22, 1993.

16. Meltzer PS, Guan XY, Zhang J, Trent JM. Identification, cloning and characterization of amplified DNA in tumor cells by chromosome microdissection. Symposium: DNA & Chromosomes, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. June 2-9, 1993.

17. Flejter WL, Bennett-Baker PE, Barcroft CL, Kukowska J, Kiousis S, Guan XY, Meltzer PS, Trent JM, Glover TW, Chamberlain JS. Direct identification of cosmid clones containing tetranucleotide repeats specific to 17q12-q21 using chromosome microdissection and FISH. The 43rd Annual Meeting of the American Society of Human Genetics, New Orleans, Louisiana, Oct 5-9, 1993. Am J Human Genet 1993;53:A543.

18. Meltzer PS, Guan XY, Zhang J, El Kahoun A, Su YA, Trent JM. Analysis of genomic alterations in cancer cells by chromosome microdissection. The 6th Annual Meeting of the German Society of Human Genetics, 1994, Mediainische Genetik 1994;1:91.

19. Cummings L, Bittner ML, McGill JR, Van Den Berg CL, Von Hoff D, Guan XY, Meltzer PS, Trent JM. Generation of full coverage libaries from microdissected DNA: Optimization for FISH of DNA microclone fron an amplified domain. The 44th Annual Meeting of the American Society of Human Genetics, Montreal, Quebec, Canada, Oct 18-22, 1994. Am J Human Genet 1994;55:A369.

20. Su YA, Trent JM, Guan XY, Meltzer PS. Direct isolation of genes encoded within a homogeneously staining region by chromosome microdissection. Cold Spring Harbor Symposium, June 1994.

21. Guan XY, Xu J, Anzick SL, Trent JM, Meltzer PS. Direct isolation of amplified cDNAs from 20q in breast cancer by chromosome microdissection. The 6th International Workshop on Chromosomes in Solid Tumors, Tucson, Arizona, Feb 19-21, 1995. Cancer Genet Cytogenet 1995;84:137.

22. Kroisel PM, Wagner K, Green ED, Guan XY, Meltzer PS, Dejong P, Rosenkranz W. Analysis of the 7p11-14 region using microdissection libraries. Cytogenet Cell Genet 1994;65:69-70.

23. Meltzer PS, Guan XY, Bittner M, Cummings L, Xu J, Zhang H, Zhang J, Gracia E, Elkahloun A, Su YA, Trent JM. Analysis of genomic alterations in cancer cells by chromosome microdissection. The Sixth International Workshop on Chromosomes in Solid Tumors, Tucson, Arizona, Feb 19-21, 1995. Cancer Genet Cytogenet 1995;84:136.

24. Guan XY, Zhang HE, Horsman D, Meltzer PS, Trent JM. Identification of a consistent breakpoint at chromosome 6q11 in human follicular lymphoma by chromosome microdissection. The Sixth International Workshop on Chromosomes in Solid Tumors, Tucson, Feb 19-21, 1995. Cancer Genet Cytogenet 199584:143.

32

25. Cargile CB, Guan XY, Elkahloun A, Meltzer PS, Trent JM. Chromosome microdissection identifies DNA sequence amplification in human ovarian carcinoma. The Sixth International Workshop on Chromosomes in Solid Tumors, Tucson, Feb 19-21, 1995. Cancer Genet Cytogenet 1995;84:144.

26. Thompson FH, Yang JM, Liu Y, Trent JM, Guan XY, Emerson J, Alberts DS, Nelson M, Taetle R. Structural alterations of chromosome 19 in ovarian cancer: G-band, and FISH studies. The 6th International Workshop on Chromosomes in Solid Tumors, Tucson, Feb 19-21, 1995. Cancer Genet Cytogenet 1995;84:156.

27. Lin T, Guan XY, Anzick SL, Xu J, Polymeropoulos MH, Trent JM, Meltzer PS. Identification of a novel amplified gene in human breast cancer containing a polymorphic trinucleotide repeat. The 45th Annual Meeting of the American Society of Human Genetics, Minneapolis, Oct 24-28, 1995. Am J Human Genet 1995;57:A70.

28. Stone D, Guan XY, Ning Y, Biesecker L, Wynshaw-Boris A. Clarification of a chromosomal translocation using a microdissected FISH probe and microsatellite markers. The 45th Annual Meeting of the American Society of Human Genetics, Minneapolis, Oct 24-28, 1995. Am J Human Genet 1995;57:A128.

29. Linder CY, Bader PI, Guan XY, Bray-Ward P, Bittner M, Dutra AS, Zhang H, Meltzer PS, Trent JM. Isolation of an inversion breakpoint region, inv(6)(p11.2;q23.3), implicated in caudal dysgenesis. The 45th Annual Meeting of the American Society of Human Genetics, Minneapolis, Oct 24-28, 1995. Am J Human Genet 1995;57:A218.

30. Guan XY, Xu J, Anzick SL, Zhang H, Trent JM, Meltzer PS. Direct selection of transcribed sequences from microdissected DNA: isolation of genes within a commonly amplified region at 20q11-13.2 in breast cancer. The 46th Annual Meeting of the American Society of Human Genetics, San Francisco, Oct 29-Nov 2, 1996. Am J Human Genet 1996;59:A70.

31. Jacobsen LK, Yan WL, Guan XY, Krasnewich D, Kumra S, Long RT, Sidransky E, Ginns EI, and Rapoport. Interstitial deletion of chromosome 22q11 in very early onset schizophrenia. The 46th Annual Meeting of the American Society of Human Genetics, San Francisco, Oct 29-Nov 2, 1996. Am J Human Genet 1996;59:A120.

32. Zhang H, Guan XY, Meltzer PS, and Trent JM. Chromosomal terminal region painting probe generation and application. The 46th Annual Meeting of the American Society of Human Genetics, San Francisco, Oct 29-Nov 2, 1996. Am J Human Genet 1996;59:A137.

33. Chen Z, Grebe TA, Guan XY, Notohamiprodio M, Nutting PJ, Ston JF, Trent JM, Sandberg AA. A maternal balanced translocation leading to partial duplication of 4q and partial deletion of 1p in a son: cytogenetic and FISH studies using band-specific painting probes generated by chromosome microdissection. The 46th Annual Meeting of the American Society of Human Genetics, San Francisco, Oct 29-Nov 2, 1996. Am J Human Genet 1996;59:A359.

34. Cargile CB, Ried T, Guan X-Y, Schrok E, Taetle R, Meltzer PS, and Trent JM: Chromosome microdissection and spectral karyotyping applied to identify DNA sequence amplification in human ovarian tumors. The 34th Annual American Cytogenetics Conference, Pittsburgh, May 4-7, 1996. Cytogenet Cell Genet 1996;74:309.

35. Guan XY, Jiang Y, Zhang H, Yan W, Meltzer PS, Bittner M, Trent JM. Generation of a complete set of human chromosome band-specific probes (CBPs) by chromosome

33

microdissection. The 47th Annual Meeting of the American Society of Human Genetics, Baltimore, Oct. 28-Nov. 1, 1997. Am J Human Genet 1997;61:A126.

36. Chen Z, Notohamiprodio M, Guan X-Y, Blackwell S, Stout K, Tumer A, Richkind K, Trent JM, Lamb A, Sandberg AA. Amplification of 9p in the pathogenesis of polythemia vera. The 47th Annual Meeting of the American Society of Human Genetics, Baltimore, Oct 28-Nov 1, 1997. Am J Human Genet 1997;61:A120.

37. Cheng RZ, Guan XY, Lau G, Chan JKC, Trent JM, Zhuang ZP, Pack S, Raffeld M, Jaffe ES. Chromosome 1p terminal deletion and loss of chromosome 17p and 16p are common findings in nasal NK/T cell lymphoma by comparative genome hybridization. Modern Pathol 1998;11:126A.

38. Henning KA, Novoting EA, Compton ST, Guan XY, Liu PP, Ashlock MA. Human artificial chromosomes generated by modification of a YAC containing human alpha satellite DNA. The 48th Annual Meeting of the American Society of Human Genetics, Denver, Oct 27-31, 1998. Am J Human Genet 1998;63:A138.

39. Guan XY. Recent advances in cytogenetics. The 2nd Hong Kong Medical Genetics Conference. Hong Kong, October 15-17, 1999.

40. Guan XY, Qin LX, Tang ZY, Sham JST, Ma ZC, Ye SL, Zhou XD, Wu ZQ, Trent JM. The association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinoma. The 49th Annual Meeting of the American Society of Human Genetics, San Francisco, Oct 19-23, 1999. Am J Human Genet 1999;65:A128.

41. He H, Huang W, Guan XY. Generation of repetitive sequence-depleted microdissected chromosome arm painting probe. The 49th Annual Meeting of the American Society of Human Genetics, San Francisco, Oct. 19-23, 1999. Am J Human Genet 1999;65:A164.

42. Yu J, Guan XY, Pober B, Yang-Feng T. Tourette syndrome in two brothers with balanced and unbalanced chromosome 12 rearrangements. The 49th Annual Meeting of the American Society of Human Genetics, San Francisco, Oct 19-23, 1999. Am J Human Genet 1999;65:A364.

43. Guan XY. Application of molecular cytogenetics in solid tumors. The 17th Meeting of the International Academy of Tumor Marker Oncology; The 5th Annual Scientific Symposium of the Hong Kong Cancer Institute. Hong Kong, March 23-24, 2000.

44. Guan XY, Zhou H, Sham JST, Zhang H, Trent JM. Characterization of a complex chromosome rearrangement involving 6q in a melanoma cell line: Isolation of a candidate tumor suppressor gene interrupted by the breakpoint at 6q16. The 50th Annual Meeting of the American Society of Human Genetics, Philadelphia, Oct 3-7, 2000. Am J Human Genet 2000;67:A342.

45. Sun L, Fang Y, Sham JST, Guo Y, Deng M, Liang Q, Zhang H, Zhou H, Tideman H, Trent JM, Guan X-Y. Analysis of genetic alterations in primary nasopharyngeal carcinoma by comparative genomic hybridization (CGH). The 50th Annual Meeting of the American Society of Human Genetics, Philadelphia, Oct 3-7, 2000. Am J Human Genet 2000;67:A331.

46. Tang TCM, Sham JST, Fang Y, Sun L, Qin LX, Guan XY. Recurrent chromosome changes in 31 primary ovarian carcinomas detected by comparative genomic hybridization. The 50th Annual Meeting of the American Society of Human Genetics, Philadelphia, Oct 3-7, 2000. Am J Human Genet 2000;67:A332.

47. Dent KM, Chen Z, Issa B, Meloni-Ehrig A, Shepara R, Forsyth D, Zhu X, Carroll K, Guan XY, Brothman A, Carey J. Two patients with distinct structural anomalies of

34

chromosome 10 determined by advanced molecular cytogenetic techniques. The 50th Annual Meeting of the American Society of Human Genetics, Philadelphia, Oct 3-7, 2000. Am J Human Genet 2000;67:A598.

48. He H, Huang W, Scheller-Malin L, Guan X-Y. Fast-FISH using repeat sequence-deplete painting probes from microdissected DNA. The 50th Annual Meeting of the American Society of Human Genetics, Philadelphia, Oct 3-7, 2000. Am J Human Genet 2000;67: A870.

49. Sham JST, Qian Q, Guan XY, Chua DTT, Kwong DLW. New initiatives in treatment of nasopharyngeal carcinoma. National Conference on Oncology, Beijing, China, Oct. 8-13, 2000.

50. Guan XY. Applications of chromosome microdissection. Asian-Pacific Conference of Tumor Biology 2001, Beijing, Sept. 16-20, 2001. J Tumor Marker Oncology 2001;16: A27.

51. Xie YW, Guan XY. Loss of Tyrosine Aminotransferase may contribute to the pathogenesis of hepatocellular carcinoma. Asian-Pacific Conference of Tumor Biology 2001, Beijing, Sept. 16-20, 2001. J Tumor Marker Oncology 2001;16:B27.

52. Hu L, Wen JM, Huang JF, Sham JST, Wang WS, Zhang M, Xie D, Zeng WF, Guan XY. Characterization of a homogeneously staining region (hsr) in a new established hepatocellular carcinoma cell line. The 51st Annual Meeting of the American Society of Human Genetics, San Diego, Oct 12-16, Am J Human Genet 2001;69:A305.

53. Tang TCM, Sham JST, Guan X-Y: Identification of minimal overlapping amplified region at 19q13.1-q13.2 in four ovarian cancer cell lines. The 51st Annual Meeting of the American Society of Human Genetics, San Diego, Oct 12-16, 2001. Am J Human Genet 2001;69:A361.

54. Guan XY, Xie YW, Sham JST. Loss of tyrosine aminotransferase may contribute to the pathogenesis of hepatocellular carcinoma. The 51st Annual Meeting of the American Society of Human Genetics, San Diego, Oct 12-16, 2001. Am J Human Genet 2001;69:A509.

55. Sham JST, Chua DTT, Kwong DLW, Guan XY, Qian Q. Recent research and development in nasopharyngeal carcinoma in Hong Kong. The 5th Asian Clinical Oncology Society International Conference, Taipei, Taiwan, April 5-8, 2001.

56. Feng ZH, Guan XY, Ho SL, Sham JST, Wong BCY. The role of phosphorylated CREB in ovary tumor cell lines for the expression of human Catechol-O-Methyltransferase gene. The 92nd Annual Meeting of the American Association of Cancer Research, USA, 2001. Proceedings of AACR, 2001;42:897.

57. Cheung ST, Chen X, Guan XY, Wong SY, Tai LS, Ng IOL, So S, Brown P, Fan ST. Identification of metastasis-associated genes in liver cancer. The 93rd Annual Meeting of the American Association for Cancer Research, San Francisco, USA, April 6-10, 2002. Proceedings of the AACR 2002;43:4460.

58. Guan XY. Application of molecular cytogenetics in HCC study. The 2nd Chinese Conference on Oncology, Hengzhou, China, Sept. 24-27, 2002.

59. Tang JCO, Hu YC, Law BFF, Wong KY, Hu L, Guan XY, Lam KY, Law S, Wong J, Srivastava G. Molecular pathogenesis of esophageal squamous cell carcinoma, Proceedings of the 9th Hong Kong International Cancer Congress, Hong Kong, 8 December 2002 , 2002.

35

60. Guan XY, Tang TCM, Sham JST, Tang DJ. Identification of a candidate oncogene SEI-1 within a minimal amplified region at 19q13.1 in ovarian cancer cell lines. The 52nd Annual Meeting of the American Society of Human Genetics, Baltimore, Am J Human Genet 2002;71:250.

61. Hu L, Wen JM, Wang WS, Xie D, Sham JST, Guan XY. The association of cytoplasmic overexpression of cyclin d1 and tumor metastasis in Hepatocellular Carcinoma. The 52nd Annual Meeting of the American Society of Human Genetics, Baltimore, Am J Human Genet 2002;71:231.

62. Tai AL, Kwong DL, Sham JST, Guan XY. Study of chromosomal abnormalities in esophageal squamous cell carcinoma by comparative genomic hybridization. The 52nd Annual Meeting of the American Society of Human Genetics, Baltimore, Am J Human Genet 2002;71:231.

63. Xie D, Zeng WF, Sham JST, Guan XY. Heterogenous expression of beta-catenin, p16, E-cadherin, and c-myc in multi-stage colorectal carcinogenesis detected by tissue microarray. The 52nd Annual Meeting of the American Society of Human Genetics, Baltimore, Am J Human Genet 2002;71:243.

64. Guan XY, Wang Y, Wu MC, Sham JST, Tai LS, Xie D. Different expression of hepatitis B surface antigen between hepatocellular carcinoma and its surrounding liver tissue detected by tissue microarray. Conference on Frontiers in Cancer Prevention Research,Boston, Oct 14-18, 2002. Cancer Epidemiology Biomarkers Prevention 2002;11:1211S.

65. Ng IO, Guan XY, Poon RT, Fan ST, Lee JM. Determination of the molecular relationship between multiple tumor nodules in hepatocellular carcinoma differentiates multicentric origin from intrahepatic metastasis. The 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD), Boston, Nov 01-05, 2002. Hepatology 2002;36:690A.

66. Tang JCO, Hu YC, Law BFF, Wong KY, Hu L, Guan XY, Lam KY, Law SYK, Wong J, Srivastava G., Molecular pathogenesis of esophageal squamous cell carcinoma. Proceedings of the 9th Hong Kong International Cancer Congress, Hong Kong, Dec. 8, 2002.

67. Tang TCM, Poon RTP, Guan XY, Fan ST. The effects of cyclooxygenase-2, Celecoxib, on xenografts of hepatocellular carcinoma in nude mice. The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

68. Cheung ALM, Deng W, Tsao SW, Guan XY, Lucas JN. Loss of telomere signals and chromosomal instability in human ovarian surface epithelial (HOSE) cells undergoing immortalization. Experimental Biology 2003 Meeting, San Diego, April 11-15, 2003. FASEB J 2003;17:A267.

69. Guan XY, Sham JST, Fang Y, Xie Y, Fung JM, Xie D, Ma JF, Hu L. Isolation of a candidate oncogene from a frequently amplified region 1q21 in hepatocellular carcinoma. The 19th International Congress of Genetics, Melbourne, Australia, July 6-11, 2003.

70. Fung MWJ, Sham JST, Guan XY. Characterization of reciprocal-like translocation involving 6q in a melanoma cell line. The 19th International Congress of Genetics, Melbourne, Australia, July 6-11, 2003.

71. Chan KL, Guan XY, Ng IOL. High-throughput tissue microarray analysis of c-myc activation in hepatocellular carcinoma and noncancerous livers, Proceedings of the American Association of Cancer Research Annual Meeting, Toronto, Canada, 2003.

36

http://apps.isiknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&doc=109&db_id=&SID=2AjNH@Dm8gP349AlfAM&field=AU&value=Lucas%20JN&ut=000181733101276&pos=5

http://apps.isiknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&doc=109&db_id=&SID=2AjNH@Dm8gP349AlfAM&field=AU&value=Guan%20XY&ut=000181733101276&pos=4

http://apps.isiknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&doc=109&db_id=&SID=2AjNH@Dm8gP349AlfAM&field=AU&value=Tsao%20SW&ut=000181733101276&pos=3

http://apps.isiknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&doc=109&db_id=&SID=2AjNH@Dm8gP349AlfAM&field=AU&value=Deng%20W&ut=000181733101276&pos=2

http://apps.isiknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&doc=109&db_id=&SID=2AjNH@Dm8gP349AlfAM&field=AU&value=Cheung%20ALM&ut=000181733101276&pos=1

http://apps.isiknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&doc=118&db_id=&SID=2AjNH@Dm8gP349AlfAM&field=AU&value=Lee%20JM&ut=000178301702091&pos=5

http://apps.isiknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&doc=118&db_id=&SID=2AjNH@Dm8gP349AlfAM&field=AU&value=Fan%20ST&ut=000178301702091&pos=4

http://apps.isiknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&doc=118&db_id=&SID=2AjNH@Dm8gP349AlfAM&field=AU&value=Poon%20RT&ut=000178301702091&pos=3

http://apps.isiknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&doc=118&db_id=&SID=2AjNH@Dm8gP349AlfAM&field=AU&value=Guan%20XY&ut=000178301702091&pos=2

http://apps.isiknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&doc=118&db_id=&SID=2AjNH@Dm8gP349AlfAM&field=AU&value=Ng%20IO&ut=000178301702091&pos=1

http://apps.isiknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=2AjNH@Dm8gP349AlfAM&page=12&doc=117&colname=WOS












72. Li YR, Wang LD, Guan XY, Tsao GSW, Sham JST, Fan Z, Yang CS, Zheng S, Kwong DLW. Comparative genomic hybridization of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from Linzhou, Henan, a high-incidenc area of esophageal cancer, Proceedings of the AACR, 2003.

73. Tang TCM, Poon RTP, Guan XY, Fan ST. The effect of cyclooxygenase-2 (COX-2) inhibitor, Celecoxib, on xenograft of hepatocellular carcinoma (HCC) in nude mice (Oral Presentation), AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, USA, Nov. 17-21, 2003.

74. Guan XY. Isolation of a candidate oncogene ALC-1 from a frequently amplified region 1q21 in HCC. The 3rd Chinese Conference on Oncology, Guangzhou, China, Nov. 11-14, 2004.

75. Wang LD, Qin Y, Fan Z, Kwong DLW, He X, Chang ZW, Li JL, Guan XY, Tsao GSW, Sham JST, Zheng S, Yang CS, Li J. Gain of 6p, 20p and loss of 10p, 10q in esophageal squamoud cell carcinoma are associated with lymph node metastasis, Proceedings of the American Association for Cancer Research, 2004.

76. Guan XY. The oncogenic role of eIF-5A2 in the development of ovarian cancer. APCTBM’2004 & 21st IATMO Conference, Xi An, China, Aug. 21-25, 2004.

77. Wang X, Ling MT, Guan XY, Tsao GSW, Cheung HW, Lee DTW, Wong YC. Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells, Proceedings of the American Association for Cancer Research, 2004, 142

78. Deng W, Tsao GSW, Guan XY, Cheung A. The significance of dynamic dysfunction of critically short telomeres in directing the evolution of chromosomal structural instability in human cells undergoing immortalization, Proceedings of the American Association for Cancer Research, 2004, 613-614 No. 2658

79. Tang TCM, Poon RTP, Guan XY, Fan ST. Celecoxib suppresses HCC development via the cell cycle arrest pathway. The 96th Annual Meeting of the American Association for Cancer Research, Anaheim, California, USA, April 16-20, 2005.

80. Tang TCM, Poon RTP, Guan XY, Fan ST. The significance of cyclooxygenase-2 in hepatocellular carcinoma. The 6th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, January 8, 2005.

81. Guan XY. Application of various microarray technologies in solid tumors. The 1st Chinese Symposium for Medical Research Methods and Cross Knowledge Innovation. Beijing, China, August 13-14, 2005.

82. Guan XY. Characterization of oncogenic function of eIF-5A2. Cancer 2006. Hong Kong, April 28, 2006.

83. Ma SKY, Chan KW, Guan XY. Identification and characterization of tumorigenic liver cancer stem cells. Oral Presentation in the Young Investigator Award Session, The 13th Hong Kong International Cancer Congress, Hong Kong, November 15-17, 2006.

84. Cheung CM, Tang JCO, Lee PY, Hu L, Guan XY, Srivastava G, Wong J, Luk JMC, Law SYK. Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of chinese origin. The 11th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, December 7, 2006.

85. Cheung A, Deng W, Tsao GSW, Guan XY. Chromosome/DNA: aneuploidy and centromeres/kinetochores, and cohesion/chromosome condensation, The FASEB J 2006;20:A894

37

86. Poon RTP, Lee KW, Yuen PW, Ling MT, Wang X, Wong YC, Guan XY, Man K, Fan ST. Id-1 promotes angiogenesis in hepatocellular carcinoma through HIF-1a-mediated VEGF upregulation. The 97th Annual Meeting of the American Association of Cancer Research, Washington DC, USA, April 1-5, 2006.

87. Luk JMC, Yi X, Lee PY, Guan XY, Lau G, Fan ST. Mortalin-2 is an accurate prognostic biomarker for early recurrence of liver carcinoma. The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, March 27-30, 2007. Hepatology International 2007;1: 68.

88. Ma SKY, Chan KW, Hu L, Lee KW, Ng IOL, Wo YH, Zheng B, Guan XY. Identification and characterization of tumorigenic liver cancer stem cells. Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, April 14-18, 2007.

89. Zhu C, Guan XY. PCAF as a candidate tumor suppressor gene in esophageal squamous cell carcinoma. Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, April 14-18, 2007. Cancer Res 2007;67 (9 Supplement):1982A.

90. Ma SKY, Chan KW, Woolcock B, Bainbridge T, Webber D, Lam WL, Wong KY, Guan XY, Vielkind J. DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of LMO2 in the progression of prostate cancer. The 98th Annual Meeting of the American Association for Cancer Research. April 14-18, 2007.

91. Ma SKY, Chan KW, Ng IOL, Zheng B, Guan XY. Identification and characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells. The 5th International Society for Stem Cell Research, June 2007, Cairns, Australia.

92. Zhou J, Huang J, Poon KM, Chen D, Chan CS, Ng F, Guan XY, Watt RM, Lu L, Yuen KY, Zheng B. A mechanism underlying susceptibility to HBV infection: HBV down-regulate transferase-1 type I interferon receptor 1 via suppressing poly(ADP-ribose). 2007 International Meeting: The Molecular Biology of Hepatitis B Viruses, 2007.

93. Cheung A, Deng W, Tsao GSW, Guan XY. Centromeric instability in human cells undergoing immortalization. AACR Annual Meeting 2008, San Diego, CA. Apr 12-16, 2008. Cancer Res 2008;68 (9 Supplement):4318.

94. Guan XY, Zhang C, Fu L, Fu J, Hu L, Li Y, Yang H, Liu H. FGFR2-positive fibroblasts provide a suitable microenvirenment for tumor development and progression in esophageal carcinoma. The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, USA, April 18-22, 2009. Cancer Res 2009;69 (9 Supplement):3496.

95. Dong S, Fu, Lu L, Lu S, Guan XY. Loss of tyrosine aminotransferase may involved in the pathogenesis of hepatocellular carcinoma. The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, USA, April 18-22, 2009. Cancer Res 2009;69 (9 Supplement):624.

96. Chan THM, Chen L, Ma S, Hu L, Wang J, Guan XY. CHD1L contributes to hepatocarcinogenesis by transcriptionally activating TCTP-mediated mitotic defects and chromosome missegregation. The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, USA, April 18-22, 2009. Cancer Res 2009;69 (9 Supplement):1274.

97. Ma S, Chan YP, Lee T, Tamg KH, Ng I, Man K, To KF, Zheng BJ, Chan KW, Guan XY. The role of miR-130b in the regulation of CD133+ cancer stem cell-driven hepatocellular carcinoma. The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, USA, April 18-22, 2009. Cancer Res 2009;69 (9 Supplement):3136.

38

http://scholar.google.com/citations?view_op=view_citation&hl=en&user=q0teDowAAAAJ&cstart=180&sortby=pubdate&citation_for_view=q0teDowAAAAJ:fFSKOagxvKUC

http://scholar.google.com/citations?view_op=view_citation&hl=en&user=q0teDowAAAAJ&cstart=180&sortby=pubdate&citation_for_view=q0teDowAAAAJ:fFSKOagxvKUC

98. Kong KL, Fu L, Kwong LW, Guan XY. Characterization of a novel tumor suppressor gene UPK1A in esophageal squanous cell carcinoma. The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, USA, April 18-22, 2009. Cancer Res 2009;69 (9 Supplement):4444.

99. Tang KH, Ma S, Lee T, Ng I, Man K, To KF, Zheng BJ, Guan XY, Chan KW. CD133+ liver cancer stem cells promote tumor growth and angiogenesis through increased interleukin-8 secretion. The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, USA, April 18-22, 2009. Cancer Res 2009;69 (9 Supplement):4886.

100. Chen L, Hu L, Chan THM, Guan XY. CHD1L suppresses the nucleus-to-mitochondria translocation of Nur77 to sustain hepatocellular carcinoma cell survival. The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, USA, April 18-22, 2009.

101. Ma S, Tang KH, Chan YP, Lee TK, Castilho A, Ng IO, Man K, To KF, Zheng BJ, Chan KW, Guan XY. miR-130b is preferentially upregulated in CD133+ liver cancer stem cells and regulates tumor growth and self-renewal via tumor protein p53-induced nuclear protein 1. Gorden Research Conference-Stem Cells and Cancer, Les Diablerets, Switzerland, September 13-18, 2009.

102. Tang KH, Ma S, Guan XY, Chan KW. CD133+ liver cancer stem cells promote tumor growth and angiogenesis through increased interleukin-8 secretion. 16th Hong Kong International Cancer Congress, Hong Kong, November 4-6, 2009.

103. Dong SS, Tang DJ, Ma NF, Fu L, Chen L, Guan XY. Overexpression of EIF5A2 enhances cell motility and promotes HCC metastasis through Rho and Rac signaling pathways. AACR Annual Meeting 2010, Washington DC, USA. Cancer Res 2010;70 (8 Supplement):5119.

104. Ma S, Chan YP, Kwan PS, Tang KH, Vielkind J, Guan XY, Chan KW. microRNA-616 induces androgen-independent growth of prostate cancer cells through suppression of TFPI-2 expression. AACR Annual Meeting 2010, Washington DC, USA. Cancer Res 2010;70 (8 Supplement):2083.

105. Chen L, Chan HM, Guan XY. Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion. 102nd AACR Annual Meeting, Orlando, Florida, USA, April 2-6, 2011.

106. Guan XY, Fu L, Zhang C, Dong SS, Li Y, Chen J. Wnt2 secreted by tumor fibroblasts promotes tumor growth and cell motility in esophageal carcinoma. 102nd AACR Annual Meeting, Orlando, Florida, USA, April 2-6, 2011. Cancer Res 2011;71 (8 Supplement):3109.

107. Li Y, Chan HM, Chen L, Guan XY. Identification and characterization of SPOCK1 in HCC development. 102nd AACR Annual Meeting, April 2-6, Oelando, Florida, USA. Cancer Res 2011;71 (8 Supplement):3057.

108. Chan TH, Chen L, Guan XY. CHD1L upregulates TCTP and induce mitotic defects and chromosome missegregation through decreasing Cdk1 activity by Cdc25C ubiquitination. 102nd AACR Annual Meeting, Orlando, Florida, USA, April 2-6, 2011. Cancer Res 2011;71 (8 Supplement):2985.

109. Tang KH, Ma S, Kwan PS, ChanYP, Lee T, Ng I, Guan XY, Chan KW. CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through activation of the neurotensin/interleukin-8 signaling cascade. 102nd AACR Annual

39

http://scholar.google.com/citations?view_op=view_citation&hl=en&user=q0teDowAAAAJ&cstart=140&sortby=pubdate&citation_for_view=q0teDowAAAAJ:umqufdRvDiIC



http://cancerres.aacrjournals.org/content/70/8_Supplement/5119.short



Meeting, Orlando, Florida, USA, April 2-6, 2011. Cancer Res 2011;71 (8 Supplement):2451.

110. Ma S, Kwan PS, Yuen PC, Fu L, Tang KH, Tong CM, Chan KW, Guan XY. RNA-seq identifies protein tyrosine kinase 6 (PTK6) as a candidate tumor-suppressor gene in esophageal squamous cell carcinoma. 102nd AACR Annual Meeting, Orlando, Florida, USA, April 2-6, 2011. Cancer Res 2011;71 (8 Supplement):2105.

111. Tong CM, Tang KH, Guan XY, Ma S. Loss of Rab25 expression promotes tumor formation and angiogenesis in esophageal squamous cell carcinoma. 102nd AACR Annual Meeting, Orlando, Florida, USA, April 2-6, 2011. Cancer Res 2011;71 (8 Supplement):LB-129.

112. Tang KH, Ma S, Lee TK, Chan YP, Kwan PS, Tong M, Ng IO, Man K, To KF, Zheng BJ, Lai PB, Lo CM, Guan XY, Chan KW. CD133+ liver tumor-initiating cells promote tumor angiogenesis, growth and self-renewal through activation of the neurotensin / IL-8/CXCL1 signaling cascade. 102nd AACR Annual Meeting, Orlando, Florida, USA, April 2-6, 2011.

113. Yeung WH, Lee KW, Geng W, Li CX, Ng TP, Lo CM, Guan XY, Poon TP, Fan ST, Man K. M2 macrophages promotes tumor growth and invasion in hepatocellular carcinoma. 102nd AACR Annual Meeting, Orlando, Florida, USA, April 2-6, 2011. Cancer Res 2011;71 (8 Supplement):471.

114. Guan XY. Role of Wnt2 secreted by tumor fibroblasts in ESCC development and progression. Croucher Advanced Study Institute 2012 “Tumor Microenvironment- New Concepts and Molecular Mechanisms”. Hong Kong, January 9-13, 2012.

115. Zhu Y, Chen PL, Fu L, Liu H, Xie F, Guan XY. Characterization of a candidate tumor suppressor gene DIRAS1 in esophageal squamous cell carcinoma. AACR Annual Meeting 2012, Chicago, USA, March 31- April 4, 2012. Cancer Res 2012;73 (8 Suppement):244.

116. Tong M, Tang KH, Kwan PS, Guan XY, Ma S. Annexin A3 (ANXA3) confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells. Cold Spring Harbor Asia Conferences-Liver Metabolism, Diseases and Cancer, Suzhou, China, May 21-25, 2012.

117. Tong M, Kwan PS, Chan YP, Lin N, Lok S, Guan XY, Ma S. Annexin A3 confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells. 19th Hong Kong International Cancer Congress, Hong Kong, November 8-9, 2012.

118. Wong A, Chen J, Tong C, Ma S, Tsang J, Guan XY. Epstein-Barr virus BART microRNAs facilitate NPC development and progression via deregulation of Wnt signaling. 19th Hong Kong International Cancer Congress, Hong Kong, November 8-9, 2012.

119. Guan XY, Li Y, Chen L, Yuan YF. Poster #5309: Characterization of a novel oncogene SPOCK1 in hepatocellular carcinoma. AACR Annual Meeting 2013, Washington DC, USA, April 6-10, 2013. Cancer Res 2013;73 (8 Suppement):5309.

120. Liu M, Li Y, Chen L, Chan T, Guan XY. Poster #3010: Allele-specific loss of OSGIN1 associated with the progression of hepatocellular carcinoma. AACR Annual Meeting 2013, Washington DC, USA, April 6-10, 2013. Cancer Res 2013;73 (8 Suppement):3010.

121. Fung TM, Tong M, Kwan PS, Chan YP, Guan XY, Ma S. Poster #3023: RNA-seq identifies neuropilin-2 as a novel oncogene in esophageal squamous cell carcinoma.

40

http://scholar.google.com/citations?view_op=view_citation&hl=en&user=q0teDowAAAAJ&cstart=80&sortby=pubdate&citation_for_view=q0teDowAAAAJ:Aul-kAQHnToC

http://scholar.google.com/citations?view_op=view_citation&hl=en&user=q0teDowAAAAJ&cstart=80&sortby=pubdate&citation_for_view=q0teDowAAAAJ:Aul-kAQHnToC

http://scholar.google.com/scholar?oi=bibs&cluster=17205280615387644763&btnI=1&hl=en


http://scholar.google.com/citations?view_op=view_citation&hl=en&user=q0teDowAAAAJ&cstart=120&sortby=pubdate&citation_for_view=q0teDowAAAAJ:9c2xU6iGI7YC

http://scholar.google.com/citations?view_op=view_citation&hl=en&user=q0teDowAAAAJ&cstart=120&sortby=pubdate&citation_for_view=q0teDowAAAAJ:9c2xU6iGI7YC

AACR Annual Meeting 2013, Washington DC, USA, April 6-10, 2013. Cancer Res 2013;73 (8 Suppement):3023.

122. Tong M, Lok S, Yuan YF, Hui LJ, Guan XY, Ma S. Annexin A3 (ANXA3) confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells. Gordon Research Conference-Stem Cells and Cancer, Les Diablerets, Switzerland, April 21-26, 2013.

123. Tong M, Guan XY, Ma S. Functional significance, clinical relevance and therapeutic implications of annexin A3 (ANXA3) in CD133+ cancer stem cells-driven hepatocellular carcinoma. 4th Asia-Pacific Primary Liver Cancer Expert Meeting, Busan, Korea, May 5-7, 2013.

124. Chai S, Tong M, Kwan PS, Ng KY, Chan YP, Guan XY, Ma S. Regulatory role of miR-142-3p on the functional liver cancer stem cell marker CD133. 20th Hong Kong International Cancer Congress, Hong Kong, November 14-15, 2013.

125. Fung TM, Chen J, Chan YP, Tong M, Chan KW, Tsao SW, Law S, Lee NP, Guan XY, Ma S. Neuropilin-2 promotes cell migration and invasion in esophageal squamous cell carcinoma and is associated with lymph node metastasis. 20th Hong Kong International Cancer Congress, Hong Kong, November 14-15, 2013.

126. Wong AM, Chen J, Ma S, Tsang JW, Guan XY. Poster #3064: Epstein-Barr virus encoded BART microRNAs facilitate nasopharyngeal carcinoma development and progression via deregulation of Wnt signaling. AACR Annual Meeting 2013, Washington DC, USA, April 6-10, 2013. Cancer Res 2013;73 (8 Suppement):3064.

127. Tong M, Fung CM, Guan XY, Ma S. Annexin A3 is a therapeutic target for CD133+ liver cancer stem cells. AACR Annual Meeting 2014, San Diego, USA, April 5-9, 2014. Cancer Res 2014;74 (19 Suppement):221.

128. Chai S, Ng KY, Tong M, Guan XY, Ma S. Regulaory role of miRNA-1246 and Wnt/β-catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma. AACR Annual Meeting 2014, San Diego, USA, April 5-9, 2014.

129. Jiang L, Liu M, Li Y, Guan XY. TTC36, a novel chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma. AACR Annual Meeting 2014, San Diego, USA, April 5-9, 2014. Cancer Res 2014;74 (19 Suppement):1559.

130. Ng KY, Chai S, Tong M, Kwan PS, Chan YP, Lee TK, Wang N, Guan XY, Ma S. Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133. AACR Annual Meeting 2014, San Diego, USA, April 5-9, 2014. Cancer Res 2014;74 (19 Suppement):LB-53.

131. Song Y, Guan XY. ATOH8 depletion can reprogram non cancer stem cells into cancer stem cells. AACR Annual Meeting 2014, San Diego, USA, April 5-9, 2014. Cancer Res 2014;74 (19 Suppement):3865.

132. Ming X, Fu L, Zhang L, Guan XY. Identification and characterization of ITGA7 as cancer stem cell marker in esophageal squamous cell carcinoma (ESCC). AACR Annual Meeting 2014, San Diego, USA, April 5-9, 2014. Cancer Res 2014;74 (19 Suppement):3872.

133. Guan XY. EBV encoded microRNA BART19-3p plays an important role in extensively deregulating Wnt signaling. Croucher Foundation Advances in Nasopharyngeal Carcinoma Studies, Hong Kong, Nov 1-4, 2014.

41

134. Guan XY. Complex epigenetic alterations of SLC22A3 predispose susceptible individuals to increased risk of esophageal cancer. Croucher Foundation Advances in Cancer Genetics Cell Signaling and Translational Studies, Hong Kong, Nov 19-20, 2015.

135. Ke L, Chen J, Wang L, Yu Y, Ye Y, Xia W, Lv X, Yang J, Guo X, Xiang Y, Guan XY. Differential expression of stromal cell-related genes between primary nasopharyngeal carcinoma and distant metastasis. AACR Annual Meeting 2015; April 18-22, 2015; Philadelphia, USA.

136. Chen J, Yang J, Yu YH, Li L, Xiang YQ, Guan XY. EGFL6, a potential novel ligand of EGFR, play roles in Nasopharyngeal cacinoma metastasis through establishing invasive and long-distant metastatic niche by paracrine and autocrine. AACR Annual Meeting 2015; April 18-22, 2015; Philadelphia, USA.

137. Yang J, Lv X, Xiang Y, Guo X, Chen J, Guan XY. CCL2/CCR2 axis signaling promotes metastasis of nasopharyngeal carcinoma by activating ERK1/2 pathway via upregulating MMP2 and MMP9. AACR Annual Meeting 2015; April 18-22, 2015; Philadelphia, USA.

138. Chai S, Ng KY, Tong M, Cheung ST, Guan XY, Ma S. Regulatory role of miRNA-1246 and Wnt/β-catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma. AACR Annual Meeting 2015; April 18-22, 2015; Philadelphia, USA.

139. Ng KY, Chai S, Tong M, Guan XY, Cheng AS, Ma S. C-terminal truncated hepatitis B virus X protein promotes hepatocarcinogenesis through enhanced stemness and resistance totherapy. AACR Annual Meeting 2015; April 18-22, 2015; Philadelphia, USA.

140. Yan Q, Jiang L, Guan XY. Angiopoietin-like protein 1 functions as a tumor suppressor in hepatocellular carcinoma. The 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine, October 8-10, 2015, Athens, Greece. Int J Mol Med, 2015;36:S15.

141. Qi J, Zhang L, Guan XY. Exploring the mechanism for cancer-associated fibroblast recruitment and the potential therapeutic value in esophageal squamous cell carcinoma. The 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine, October 8-10, 2015, Athens, Greece. Int J Mol Med, 2015;36:S15.

142. Chen J, Wong AM, Guan XY. Characterization of the role of EBV microRNAs in nasopharyngeal carcinoma. The 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine, October 8-10, 2015, Athens, Greece. Int J Mol Med, 2015;36:S15.

143. Jiang L, Guan XY. CAB39 regulates the MEK/ERK signaling pathway and promotes cell proliferation, invasiveness and metastasis in hepatocellular carcinoma. The 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine, October 8-10, 2015, Athens, Greece. Int J Mol Med, 2015;36:S15.

144. Jiang C, Wong AM, Guan XY. Characterization of the role of EBV microRNAs in nasopharyngeal carcinoma. The 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine, October 8-10, 2015, Athens, Greece. Int J Mol Med, 2015;36:S15.

145. Fang S, Yang X, Guan XY. Identification and characterization of oncogene GMNN in hepatocellular carcinoma. The 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine, October 8-10, 2015, Athens, Greece. Int J Mol Med, 2015;36:S15.

42

146. Zhang LY, Gu L, Guan XY. Reduced expression of PSCA, a novel tumor suppressor gene, is regulated by transcription factor SOX5 in esophageal squamous cell carcinoma. The 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine, October 8-10, 2015, Athens, Greece. Int J Mol Med, 2015;36:S15.

147. Chai S, Ng KY, Tong M, Cheung ST, Guan XY, Ma S. Regulatory role of miRNA-1246 and Wnt/β-catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma. AACR Annul Meeting 2016; April 16-20, 2017, New Orleans, USA. Cancer Res 2016;75 (15 Supplement):2874.

148. Chen J, Jiang C, Yang J, Yu Y, Li L, Xiang Y, Guan XY. EGFL6, a potential novel ligand of EGFR, play roles in Nasopharyngeal cacinoma metastasis through establishing invasive and long-distant metastatic niche by paracrine and autocrine. AACR Annul Meeting 2016; April 16-20, 2017, New Orleans, USA. Cancer Res 2016;75 (15 Supplement):118.

149. Ng KY, Chai S, Tong M, Guan XY, Cheng AS, Ma S. C-terminal truncated hepatitis B virus X protein promotes hepatocarcinogenesis through enhanced stemness and resistance to therapy. AACR Annul Meeting 2016; April 16-20, 2017, New Orleans, USA. Cancer Res 2016;75 (15 Supplement):2223.

150. Yang J, Lv X, Xiang Y, Guo X, Chen J, Guan XY. CCL2/CCR2 axis signaling promotes metastasis of nasopharyngeal carcinoma by activating ERK1/2 pathway via upregulating MMP2 and MMP9. AACR Annul Meeting 2016; April 16-20, 2017, New Orleans, USA. Cancer Res 2016;75 (15 Supplement):2254.

151. Ke L, Chen J, Wang L, Yu Y, Ye Y, Xia W, Lv X, Yang J, Guo X, Xiang Y, Guan XY. Differential expression of stromal cell-related genes between primary nasopharyngeal carcinoma and distant metastasis. AACR Annul Meeting 2016; April 16-20, 2017, New Orleans, USA. Cancer Res 2016;75 (15 Supplement):2177.

152. Liu M, Chen L, Ma NF, Guan XY. Outstanding Poster #a90074: CHD1L promotes poor differentiation and liver ancestral precursor cell properties of human hepatocellular carcinoma. 2016 Japanese Society of Medical Oncology Annual Meeting (JSMO). Kobe, Japan, Jul 27-29, 2016. (Excellent abstract, Travel Award).

153. Qi J, Zhang L, Guan XY. Exploring the mechanism for cancer associated fibroblasts recruitment and the potential therapeutic value in esophageal squamous cell carcinoma. International Congress of Immunology 2016; Aug 21-26, 2016, Melbourne, Australia.

154. Jiang L, Yan Q, Wang X, Shi C, Guan XY. Characterization of the genes specifically expressed in liver progenitor cells of in vitro hepatic differentiation model. 38th Annual Lorne Genome Conference; Feb 12-14, 2017, Lorne, Australia.

155. Fang S, Li L, Liu M, Guan XY. LEF1 negatively regulates differentiation of hepatocellular carcinoma via activation of NOTCH signaling pathway. AACR Annul Meeting 2017; April 1-5, 2017, Washington DC, USA.

156. Kam NW, Guan XY, Kwong DL. Cross talk between tumor cell derived HMGB1 and adaptive B cells in the tumor microenvironment of esophageal squamous cell carcinoma. AACR Annul Meeting 2017; April 1-5, 2017, Washington DC, USA. Cancer Res 2017;77 (13 Supplement):3999.

157. Luk STC, Tong M, Ng KY, Yip KYL, Guan XY, Ma S. Identification of ZFP42/REX1 as a regulator of cancer stemness in CD133+ liver cancer stem cells by genome-wide DNA methylation analysis. AACR Annul Meeting 2017; April 1-5, 2017, Washington DC, USA. Cancer Res 2017;77 (13 Supplement):4842.

43








http://scholar.google.com/citations?view_op=view_citation&hl=en&user=q0teDowAAAAJ&cstart=40&sortby=pubdate&citation_for_view=q0teDowAAAAJ:EYYDruWGBe4C



http://scholar.google.com/citations?view_op=view_citation&hl=en&user=q0teDowAAAAJ&cstart=40&sortby=pubdate&citation_for_view=q0teDowAAAAJ:lmc2jWPfTJgC









158. Jiang C, Li L, Li J, Xie S, Cao S, X Guan XY. Circulating EBV microRNA BART2-5p helps to diagnose nasopharyngeal carcinoma: screen for high risk individuals precisely. AACR Annul Meeting 2017; April 1-5, 2017, Washington DC, USA. Cancer Res 2017;77 (13 Supplement):722.

159. Tong M, Wong TL, Luk ST, Che N, Wong KY, Fung TM, Guan XY, Lee NP, Yuan YF, Lee TK, Ma S. Down-regulation of 4-hydroxyphenylpyruvate dioxygenate (HPD) contributes to the pathogenesis of hepatocellular carcinoma (HCC) through ERK/BCL-2 signalling activation. AACR Annul Meeting 2017; April 1-5, 2017, Washington DC, USA. Cancer Res 2017;77 (13 Supplement):1548.

160. Chai S, Ng KY, Tong M, Lau EY, Lee TK, Chan KW, Yuan YF, Cheung TT, Cheung ST, Wang XQ, Wong N, Lo CM, Man K, Guan XY, Ma S. Octamer-4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells. AACR Annul Meeting 2017; April 1-5, 2017, Washington DC, USA. Cancer Res 2017;77 (13 Supplement):2895.

161. Ng KY, Chan KH, Chai S, Tong M, Guan XY, Lee NP, Yuan YF, Xie D, Lee TK, Carrier A, Dusetti NJ, Ma S. TP53INP1 negatively regulates ERK1/2 via p73-dependent DUSP10 expression to promote metastasis in hepatocellular carcinoma. AACR Annul Meeting 2017; April 1-5, 2017, Washington DC, USA. Cancer Res 2017;77 (13 Supplement):4842.

162. Chan LH, Zhou L, Ng KY, Wong TL, Chai S, Lee TK, Guan XY, Ching YP, Lo CM, Man K, Artegiani B, Clevers H, Yan H, Leung SY, Richard S, Huen MS, Ma S. PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer. AACR Annul Meeting 2017; April 1-5, 2017, Washington DC, USA. Cancer Res 2017;77 (13 Supplement):LB139.

163. Chen M, Guan XY. Characterize the role of cancer associated fibroblast (CAFs) derived IL‐32 in esophageal squamous cell carcinoma (ESCC). The American Association of Immunologists Annual Meeting 2017, May 12-16, Washington, D.C. J Immun 2017;198 (1 Supplement):130.8.

164. Ng KY, Chai S, Tong M, Guan XY, Lin CH, Ching YP, Xie D, Cheng AS, Ma S. C-terminal truncated hepatitis B virus protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like propertues. Health Research Symposium 2017, Hong Kong, June 16, 2017.

165. Liu M, Chen L, Ma NF, Guan XY. CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors. 24th Asia Pacific Cancer Conference (APCC). Seoul, Korea, June 22-26, 2017.

166. Wang X, Jiang L, Shi C, Chen H, Guan XY. Characterization of a stemness-related gene RALYL in the development and progression of hepatocellular carcinoma. 3rd EACR Conference on Cancer Genomics; June 25-28, 2017, Cambridge, UK.

167. Tong M, Wong TL, Luk ST, Che N, Wong KY, Fung TM, Guan XY, Lee NP, Yuan YF, Lee TK, Ma S. Deranged tyrosine metabolism drives tumorigenesis in liver cancer. AACR-Annual Meeting 2018, Chicago, IL, USA, April 14-18, 2018.

168. Chan LH, Zhou L, Ng KY, Wong TL, Lee TK, Ching YP, Yuan YF, Xie D, Richard S, Huen MS, Guan XY, Ma S. Protein arginine methyltransferase PRMT6 regulates cancer stemness through CRAF methylation in hepatocellular carcinoma. AACR-Annual Meeting 2018, Chicago, IL, USA, April 14-18, 2018.

44












169. Che N, Tong M, Ng KY, Guan XY, Huen MS, Ma S. Functional and mechanistic characterization of PRMT6- regulated autophagy in hepatocellular carcinoma. AACR-Annual Meeting 2018, Chicago, IL, USA, April 14-18, 2018.

170. Luk ST, Tong M, Ng KY, Yip KY, Guan XY, Ma S. Identification of ZFP42/REX1 as a regulator of cancer stemness in CD133+ liver cancer stem cells by genome-wide DNA methylation analysis. AACR-Annual Meeting 2018, Chicago, IL, USA, April 14-18, 2018.

171. Yan Q, Zhang Y, Yu DD, Guan XY. Characterization of DPPA3 as cancer stemness gene by regulating DNA methylation in hepatocellular carcinoma. AACR-Annual Meeting 2018, Chicago, IL, USA, April 14-18, 2018.

172. Yu D, Yan Q, Zhang Y, Guo L, Wu C, Guan XY. Identification and characterization of DPPA2 as a potential cancer stem cell marker in hepatocellular carcinoma. AACR-Annual Meeting 2018, Chicago, IL, USA, April 14-18, 2018. Cancer Res 78 (13 Supplement), 3052-3052.

173. Zhou L, Siu HC, Tong M, Chai S, Loong HC, Sin S, Clevers H, Lo CM, Man K, Guan XY, Wong D, Yan HH, Leung SY, Ma S. Establishment of human primary hepatocellular carcinoma-derived organoid cultures for disease modeling and drug screening. International Society for Stem Cell Research- Annual Meeting, Melbourne, Australia, June 20-23, 2018.

Invited speaker1. Guan XY. Recent advances in cytogenetics. The 2nd Hong Kong Medical Genetics

Conference. Hong Kong, October 15, 17, 1999.2. Guan XY. Application of molecular cytogenetics in solid tumors. The 17th Meeting of the

International Academy of Tumor Marker Oncology; The 5th Annual Scientific Symposium of the Hong Kong Cancer Institute. Hong Kong, March 23-24, 2000.

3. Guan XY. Application of chromosome microdissection. Asian-Pacific Conference of Tumor Biology 2001. Beijing, China, September 16-20, 2001.

4. Guan XY. Application of molecular cytogenetics in HCC study. The 2nd Chinese Conference on Oncology, Hengzhou, China, Sept. 24-27, 2002.

5. Guan XY. The oncogenic role of EIF-5A2 in the development of ovarian cancer. Asian-Pacific Conference of Tumor Biology 2004. Xi’An, China, August 21-25, 2004.

6. Guan XY. Isolation of a candidate oncogene ALC-1 from a frequently amplified region 1q21 in HCC. The 3rd Chinese Conference on Oncology, Guangzhou, China, Nov. 11-14, 2004.

7. Guan XY. Application of various microarray technologies in solid tumors. The 1st Chinese Symposium for Medical Research Methods and Cross Knowledge Innovation. Beijing, China, August 13-14, 2005.

8. Guan XY. Application of microarray technology in cancer research. The 4th Cross-Straight Academic Conference on Oncology. Kunming, China, October 20-23, 2005.

9. Guan XY. Oncogenic role of HBV “X” gene in the pathogenesis of HCC. Shanghai-Hong Kong International Liver Congress 2006. Shanghai, China, March 25-28, 2006.

10. Guan XY. Characterization of oncogenic function of eIF-5A2. Cancer 2006. Hong Kong, April 28, 2006.

11. Guan XY. Identification and characterization of HCC-associated cancer stem cells. Cancer 2008. Hong Kong, March 7, 2008.

45



12. Guan XY and Ma S. Identification and characterization of liver cancer stem cells. Hong Kong - Shanghai International Liver Congress. 2008. Hong Kong, June 12-15, 2008.

13. Guan XY. Identification and characterization of tumor suppressor genes at 3p in ESCC. Organization for Oncology and Translational Research 6th Conference. Kyoto, Japan, Feb. 26-27, 2010.

14. Guan XY. Identification and characterization of a novel oncogene CHD1L in hepatocellular carcinoma. The 2nd China-US Forum on Frontiers of Cancer Research: Cancer Prevention and Therapy. Guangzhou, China, Aug. 16-17, 2010.

15. Guan XY. Identification and characterization of a novel oncogene CHD1L at 1q21 in HCC. 2010 Nanjing International Symposium on the Development of Tumor Biological Diagnosis and Treatment. Nanjing, China, June 12-13, 2010.

16. Guan XY. Identification and characterization of cancer stem cell in hepatocellular carcinoma. The 1st International Workshop of the Basic and Translational Cancer Research. Shanghai, China, Oct. 12-15, 2010.

17. Guan XY. Wnt2 secreted by tumor fibroblasts promotes tumor growth and metastasis in esophageal cancer via the activation of Wnt/β-catenin signaling pathway. Organisation for Oncology and Translational Research 7th Conference. Hong Kong, May 13-14, 2011.

18. Guan XY. Advances in liver cancer stem cell. The 2nd Guangzhou International Conference of Cancer Research. Guangzhou, China, May 20-22, 2011.

19. Guan XY. Epithelial-Mesenchymal Transition (EMT) and HCC Metastasis. 18th Hong Kong International Cancer Congress. Hong Kong, Nov. 3-5, 2011.

20. Guan XY. How molecular pathology has provided new insights into carcinogenesis and molecular heterogeneity of hepatocellular carcinoma. Asian Oncology Summit 2012, Singapore, April 13-15, 2012.

21. Guan XY. Characterization of CD133+ cancer stem cells in hepatocellular carcinoma. The 13th Conference of Cancer Society, Chinese Association of Pathophysiology, Zhengzhou, China, June 14-16, 2012.

22. Guan XY. The oncogeneic function of CHD1L in HCC development and progression. The 83rd Shuang-Qing Luntan, Beijing, China, September 1-2, 2012.

23. Guan XY. Recording A-to-I RNA editing of Antizyme inhibitor 1 predisposes to hepatocellular carcinoma. Frontiers in Biomedical Research HKU 2012, Hong Kong, December 14, 2012.

24. Guan XY. Characterization of cancer stem cell in hepatocellular carcinoma. Cancer Science Institute of Singapore, National University of Singapore, Singapore, March 5, 2013.

25. Guan XY. Recording RNA editing of AZIN1 predisposes to hepatocellular carcinoma. The 2013 National Cancer Center of China Annual Conference. Beijing, China, March 16, 2013.

26. Guan XY. Identification and characterization of a novel oncogene CHD1L in hepatocellular carcinoma. National Cancer Institute, NIH, Bethesda, USA, April 4, 2013.

27. Guan XY. A-to-I editing of AZIN1 predisposes to hepatocellular carcinoma. The 9th Asia Pacific Multidisciplinary Meeting for Cancer Research, Hong Kong, April 19, 2013.

28. Guan XY. Identification and characterization of cancer stem cell in hepatocellular carcinoma. The 1st Shagnahi International Workshop on Stem Cells in Cancer. Shanghai, China, April 19-20, 2013.

29. Guan XY. Identification and characterization of cancer stem cell in liver cancer. Seminar on Research and Development of Chinese Medicines. Hong Kong, Sept. 5-6, 2013.

46

30. Guan XY. ATOH8 depletion can reprogram non-cancer stem cells into cancer stem cells. The 2nd International Proteomics Symposium on Inflammation and Cancer. Guangzhou, China, May 10-11, 2014.

31. Guan XY. FGFR2+ fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma. The 2nd Symposium of Cancer in Central China. Zhengzhou, China, May 24-25, 2014.

32. Guan XY. Application of molicular cytogenetics. The 1st Symposium of Molecular Pathology and Molecular Diagnosis in Southern China. Guangzhou, China, June 13, 2014.

33. Guan XY. The effects of cancer microenvironment on cancer progression. The 5th Shanghai symposium of breast cancer research. Shanghai, China, September 17, 2014.

34. Guan XY. Advances of cancer research and their clinical applications. The 7th Symposium of general surgery across the straits. Dalian, China, October 17-19, 2014.

35. Guan XY. Recent advances in hepatocellular carcinoma study. The 1st Hong Kong - Shenzhen International Cancer Congress. Shenzhen, China, November 22, 2014.

36. Guan XY. Molecular characterization of the tumor microenvironment. The 11th OOTR Annual Conference. Shanghai, China, April 10-12, 2015.

37. Guan XY. FGFR2+ cancer-associated fibroblasts provide a suitable microenvironment of tumor development and progression in esophageal carcinoma. The Third International Workshop of Basic and Translational Cancer Research. Hefei, China, April 10-12, 2015.

38. Guan XY. ATOH8 depletion can reprogram non-cancer stem cells into cancer stem cells. International Digestive Disease Forum 2015, Hong Kong, June 6-7, 2015.

39. Guan XY. Down-regulation of Tumor Suppressor ATOH8 Increases Cancer Stemness in Hepatocellular Carcinoma. The 4th China/Bangchui Island International Frontier Forum of Cancer, Dalian, China, July 4-6, 2015.

40. Guan XY. ATOH8 depletion can reprogram non-cancer stem cells into cancer stem cells. Cancer Genomics and Biology 2015, Jiu-Jiang, China, Nov 13-14, 2015.

41. Guan XY. Research progress in hepatocellular carcinoma. Shao Yi-Fu Hospital, Hangzhou, March 7, 2016.

42. Guan XY. ITGA7 plays important roles in regulating cancer stemness in esophageal squamous cell carcinoma. 2016 Tumor Stem Cell Conference, Shanghai, May 6-7, 2016.

43. Guan XY. Integrin ɑ7 is a functional cancer stem cell surface marker in esophageal squamous cell carcinoma. 6th CUHK International Symposium on Stem Cell Biology & Regerative Medicine. Hong Kong, November 11, 2016.

44. Guan XY. ITGA7 plays important roles in regulating cancer stemness in esophageal squamous cell carcinoma. 2016 Tumor Stem Cell Conference, Shanghai, May 6-7, 2016.

45. Guan XY. Identification and characterization of oncogene CHD1L in hepatocellular carcinoma. Shanghai Cancer Hospital, May 5, 2016.

46. Guan XY. Cancer microenvironment in esophageal squamous cell carcinoma. Wuhan People's Hospital, Wuhan, June 30, 2016.

47. Guan XY. Recent advances of cancer stem cell research. Shenzhen University, Shenzhen, April 7, 2017.

48. Guan XY. Integrin ɑ7 is a functional cancer stem cell surface marker in ESCC. The 4th International Workshop of Basic and Translational Cancer Research. Guiyang, China, April 21-23, 2017.

47

49. Guan XY. IGF-1 evokes dormant tumor by switching cancer stem cell division from asymmetric to symmetric in lung cancer. 2017 International Symposium on Genomics and Regenerative Medicine. Hong Kong, August 28-September 1, 2017.

50. Guan XY. Mobilization, recruitment and matuation of cancer-associated fibroblasts in esophageal cancer. Zhi-Jiang Scientic Symposium of Cancer Diagnosis and Treatment. Hangzhou, China, October 20, 2017.

51. Guan XY. Recoding RNA editing of antizyme inhibitor 1 predisposes to hepatocellular carcinoma. International RNA Symposium 2017, Hong Kong, November 14, 2017.

52. Guan XY. PDSS2 deficiency induces the development of hepatocellular carcinoma by reprogramming glucose metabolism. Cold Spring Harbor Asia "Liver Biology , Diseases & Cancer", Suzhou, China, December 4-8, 2017.

53. Guan XY. The advances in cancer stem cell research. 2nd Singapore Liver Cancer Consortium Symposium, Singapore, April 27, 2018.

54. Guan XY. Recent advances in cancer stem cell research. Beijing Qinhua Changgen Hospital, Beijing, July 11, 2018.

55. Guan XY. The advances in esophageal cancer research. Annual Meeting of Henan Province Cancer Society, Zhengzhou, China, August 31-September 2, 2018.

56. Guan XY. How cancer recruit cancer-associated fibroblasts and establish a suitable microenvironment? 2nd Hong Kong International Oncology Forum cum 4th Hong Kong-Shenzhen International Cancer Congress. Shenzhen, China, September 7, 2018.

Book Chapters:

1. Meltzer PS, Guan XY, Zhang J, and Trent JM: Chapter 8: Microdissection and direct PCR amplification of human chromosomes. In Human Chromosomes: Principles and Techniques, 2nd ed, Edited by: R. Verma, McGraw-Hill, Inc., New York, pp271-279, 1995.

2. Bittner M, Guan XY, Zhang J, Burgess A, Meltzer PS, Trent JM: Chapter 3: Chromosome microdissection. In Introduction to Fluorescence In Situ Hybridization: Priciples and Clinical Applications. Edited by: D. Pinkel, Wiley-Liss, Inc., pp53-76, 1999.

3. Guan XY and Trent JM: Chapter 27: Chromosome microdissection for detection of subchromosomal alterations by FISH. In Ovarian Cancer: Methods and Protocols. Edited by: Bartlett, Humana Press Inc., Totowa, NJ, pp247-252, 2000.

4. Guan XY and Cheng Z: Gene therapy in cancer. In The Principles and Applications of Surgery. Edited by C. Yang, People’s Health Press Inc., Beijing, China, in press, 2000.

5. Guan XY: Chapter 13: Chromosome Microdissection. In Molecular Cytogenetics: Protocols and Applications. Edited by: Y. S. Fan, Humana Press Inc., Totowa, NJ, pp67-76, 2002.

6. Guan XY, Lau B, Wang Y. Chapter 11: Role of Hepatitis B Surface Antigen in Hepatocarcinogenesis: Handbook of Immunohistochemistry and In Situ Hybridization of Human Carcinomas (Volume 3, Molecular Genetics: Liver and Pancreatic Carcinomas). Edited by M. A. Hayat, Elsevier Academic Press, Burlingtom, MA, pp229-236, 2005.

7. Hu DG, Guan XY, Hussey N. Chapter 12: Gender determination and detection of aneuploidy in single cells using DNA Array-based comparative genomic hybridization. In Single Cell Diagnostics. Edited by A. Thornhill, Humana Press Inc., Totowa, NJ, 135-152, 2007.

48

8. Guan XY. Editor, Cancer Stem Cells, Transworld Research Network, 2010.9. Ma SKY, Chan KW, Guan XY. Cancer Stem Cells - Concepts, Methodologies and

Therapeutic Implications, In: XY Guan, Cancer Stem Cells. 2010.10. Ma SKY, Tang KH, Chan KW, Guan XY. Liver Cancer Stem Cells - A Review of

Current Literature and Protocols, In: XY Guan, Cancer Stem Cells. 2010.

Patents:1. Guan XY: Chromosome microdissection method. (United States Patent 6,228,587) Issued by

United States Patent and Trademark Office on May 8, 2001.2. Guan XY: A method and a Kit for ovarian cancer diagnosis. Issued by Chinese Patent

Bureau on April 19, 2006 (Patent No.: ZL01117606.7).发明专利：卵巢癌的检测方法和试剂盒（专利号：ZL 01 117606.7），发明人：关新元，授权日：2006 年 4 月 19 日。

3. Guan XY: A new method to remove repetitive sequences and its applications in genomic DNA microarray. Issued by Chinese Patent Bureau on Dec 6, 2006 (ZL01823606.5).发明专利：一种消除基因组重复序列的新方法及其在基因组芯片中的应用（专利号：ZL 01 8 23606.5），发明人：关新元，授权日：2006 年 12 月 6 日。

4. Guan XY: A new method to remove repetitive sequences and its applications in fluorescence in situ hybridization. Issued by Chinese Patent Bureau on Dec 6, 2006 (ZL01823605.7).发明专利：一种消除基因组重复序列的新方法及其在 FISH 探针制备中的应用（专利号：ZL 01 8 23605.7），发明人：关新元，授权日：2006 年 12 月 6 日。

5. Guan XY: A new method to amplify microdissected DNA and its applications. Issued by Chinese Patent Bureau on Dec 6, 2006 (ZL02827308.7). 发明专利：扩增显微切割的染色体DNA 的方法及其应用（专利号：ZL 02 8 27308.7），发明人：关新元、JST 沙母、胡亮。授权日：2006 年 12 月 6 日。

6. 发明人：马宁芳、关新元、黄振倩、熊喜峰。ALC 在制备白血病耐药逆转剂及作为耐药性白血病判断试剂方面的应用（专利号：ZL 2012 1 0019445.5），授权日：2013 年 3 月 27 日。

7. 发明人：关新元、付利、秦燕茹、李焱。一种用于食管癌辅助诊断和/或预后判断的试剂盒（专利号：ZL 3013 1 0331772.9），授权日：2014 年 10 月 29 日.

8. 发明人：关新元、付利、秦燕茹、李焱。一种用于预防或治疗食管癌的药物组合物（专利号：ZL 3013 1 0331306.0），授权日：2015 年 4 月 15 日。

9. 发明人：关新元、宋洋洋、李焱。抑癌基因 ATOH8 及其编码蛋白的应用（专利号：ZL 3013 1 0741165.X），授权日：2016 年 2 月 17 日。

10. 发明人：关新元、李焱。EIF5A2 在制备治疗食管鳞状细胞癌制剂中的应用（专利号：ZL 3013 1 0367825.2），授权日：2016 年 8 月 10 日。

11. Ma SKY, Tong M, Guan XY. Use of annexin A3 as a diagnostic and prognostic biomarker and therapeutic target for treating hepatocellular carcinoma. United States Patent (9,487,831), Issued by United States Patent and Trademark Office on November 8, 2016.

49

curriculum vitae - university of hong...

Documents