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Department of Chemistry

Dr. Sachinkumar G. Modha (Department of Chemistry)

Name Dr. Sachinkumar G. Modha Address Department of Chemistry, Uka Tarsadia University (UTU), Maliba

Campus, Gopal Vidyanagar, Bardoli, Dist: Surat, Gujarat, India. Designation and Current Position

Assistant Professor, Department of Chemistry, UTU

Email [email protected] Educational Qualification

Ph.D. – University of Leuven (KULeuven), Belgium, Supervisor Prof. Dr. Erik Van der Eycken.

Pre doctoral studies University of Leuven (KU Leuven), Belgium, Supervisor Prof. Dr. Erik Van der Eycken.

M.Sc. (Organopharmaceutical Chemistry) Saurashtra University, Rajkot, Gujarat, India, Supervisor Prof. Dr. Anamik Shah

B.Sc. (Chemistry) – M.D. Science College, Porbandar, Saurashtra University.

Area of interest Photochemistry – Mechanistic investigation and effect of various Lewis acids on photochemical transformations.

Multicomponent reactions, Alkyne activation, Transition metal catalysis, etc.

Teaching Experience July-2019 onwards UG and PG courses Research Experience PostDoctoral Research Associate in ERC funded project (April

2018 – March 2019), Research focus on Enantioselective [6π] photocyclization towards Indolines. At Catalysis Research Centre, Technical University of Munich, Lichtenbergstrasse 4, Garching 85747, Munich, Germany.

Host: Prof. Dr. Thorsten Bach

Alexander von Humboldt Post-Doctoral Researcher (April 2016 – March 2018), Research focus on Enantioselective [6π] photocyclization towards Indolines. At Catalysis Research Centre, Technical University of Munich, Lichtenbergstrasse 4, Garching 85747, Munich, Germany.

Host: Prof. Dr. Thorsten Bach

Post-Doctoral Research Associate in EPSRC funded project (July 2013 – Sep 2015), Research focus on Atom economical use of Diaryliodonium reagents. At School of Chemistry, the University of Manchester, Manchester, UK.

Supervisor: Prof. Dr. Michael F. Greaney

Short stay (Nov 2007 – April 2008) In a project “National Facility for Drug Discovery through New Chemical Entities (NCEs)



Development and Instrumentation Support to Small Pharma Enterprises”, At Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India.

Supervisor: Prof. Dr. Anamik Shah Industrial Experience Research Associate (07/08/2006 – 30/10/2007), Oxygen Healthcare

Research Pvt. Ltd. (now acquired by Piramal Healthcare), Contract Research Organization, Ahmedabad Gujarat, India.

Achievements Selected as a post-doctoral research associate in European Research Council (ERC) funded project titled Enantioselective Light-induced Catalysis for Organic Synthesis (ELICOS, project id: 665951) under Horizon-2020 to work with Prof. Thorsten Bach at Technical University of Munich, Germany from April-2018 to March-2019.

Obtained Alexander von Humboldt post-doctoral fellowship along with Carl Friederich von Siemens foundation fellowship for 2 years to work at Catalysis Research Centre, Technical University of Munich, Munich, Germany from April-2016 to March-2018.

Research opportunities week (ROW), Technical University of Munich (TUM), Germany. Oct 19-25, 2014. I was one of the 44 early stage researchers selected from around the world in this programme to visit the university and potential future host. Useful information was provided on the various opportunities available at TUM and Germany in general.

Selected as a post-doctoral research associate in Engineering and Physical Sciences Research Council (EPSRC) funded project to work with Prof. Michael F. Greaney at University of Manchester, United Kingdom from July-2013 to Sep-2015.

Obtained Doctoral fellowship at University of Leuven (KU Leuven), Belgium to work under supervision of Prof. Erik Van der Eycken from April-2009 to July-2012.

Obtained Pre-doctoral fellowship at University of Leuven (KU Leuven), Belgium to work under supervision of Prof. Erik Van der Eycken from May-2008 to March-2009.

Selected for Meritorious doctoral fellowship by Union Grant Commission (UGC) to work with Prof. Anamik Shah at Saurashtra University, Rajkot, Gujarat from October-2007 onwards.

Awards Received Dr. G. L. Talesara memorial award for the best oral presentation in Organic Chemistry Section of 34th Annual conference of Indian Council of Chemists at Uka Tarsadia



University, Bardoli, Gujarat India, December 26-28, 2015.

Received best poster presentation award in ‘The Page Lectures’ symposium, at University of Huddersfield, UK, July 31, 2015.

Received Dr. Sudheer K. Benerjee memorial award for the best oral presentation in Organic Chemistry Section of 31st Annual conference of Indian Council of Chemists at Rajkot, India, December 26-28, 2012.

Selected for Meritorious doctoral fellowship by Union Grant Commission (UGC) to work with Prof. Anamik Shah at Saurashtra University, Rajkot, Gujarat from October-2007 onwards.

Invited Lectures Lecture titled “Lewis acid catalyzed Enantioselective Photocyclization” at the Alexander von Humboldt Network Meeting, April 5-7, 2017, Dresden, Germany.

An invited lecture to Bechelor Students titled “Write your own story” at M.D. Science College Porbandar, 21st Janurary, 2016.

A Lecture titled “Post-Ugi late transition metal catalysis” to doctoral students of Department of Chemistry, Saurashtra University, 20th November, 2012. This lecture was as a part of doctoral course.

A Guest lecture, titled “Diversity-Oriented synthesis of tetra-substituted pyrazines” to Bechelor students at M.D. Science College Porbandar, 24th January 2011.

List of Publications 1) Modha, Sachin G.; Pöthig, Alexander; Dreuw, Andreas; Bach, Thorsten. “[6π] Photocyclization to cis-Hexahydrocarbazol-4-ones: Substrate modification, mechanism and scope” J. Org. Chem. 2019, 84, 1139-1153. (IF: 4.745, Citation:1) (Selected as Featured Article)

2) Modha, Sachin G.; Popescu, Mihai V.; Greaney, Michael F. “Synthesis of Triarylamines via sequential C-N bond formation” J. Org. Chem. 2017, 82, 11933-11938. (IF: 4.805, Citation: 5) (Invited article for a special issue on hypervalent iodine chemistry)

3) Teskey, Christopher J.; Sohel, Shariar M. A.; Bunting, Danielle L.; Modha, Sachin G.; Greaney, Michael F. “Domino N-/C-Arylation via in situ generation of a directing group: Atom-Efficient Arylation uding diaryliodonium salts” Angew. Chem. Int. Ed., 2017, 56, 5263-5266. (IF: 12.102, Citation: 25) (This paper is selected as Hot Paper by the Journal)

4) Modha, Sachin G.; Greaney, Michael F. “Atom-economical



transformations of diaryliodonium salts: Tandem C-H and N-H arylation of indoles” J. Am. Chem. Soc., 2015, 137, 1416-1419. (IF: 13.038, Citation: 96) (This paper featured in Chemical and Engineering News)

5) Vachhani, Dipak D.; Kumar, Amit; Modha, Sachin G.; Sharma, Sunil K.; Parmar, Virinder S.; Van der Eycken, Erik V. “Diversely substituted indoloazepinones and indoloazocinones: A post-Ugi Gold-catalyzed regioselective carbocyclization approach” Synthesis, 2015, 47, 1337-1347.* (IF: 2.652, Citation: 11)

6) Modha, Sachin G.; Van der Eycken, Erik V. “Reactions with [3+2] cycloaddition as the key step” In Science of Synthesis: Multicomponent Reactions, Muller, T. J. J., Ed.; Thieme: Stuttgart, (2014), Vol. 2, pp 287-302. (Book Chapter)

7) Kumar, Amit; Vachhani, Dipak D.; Modha, Sachin G.; Sharma, Sunil K.; Parmar, Virinder S.; Van der Eycken, Erik V. “Post-Ugi Gold-catalyzed diastereoselective domino cyclization for the synthesis of diversely substituted spiroindolines” Beilstein J. Org. Chem., 2013, 9, 2097-2102.* (IF: 2.803, Citation: 22)

8) Kumar, Amit; Vachhani, Dipak D.; Modha, Sachin G.; Sharma, Sunil K.; Parmar, Virinder S.; Van der Eycken, Erik V. “Post Ugi Gold(I)- and Platinum(II)-catalyzed alkyne activation: Synthesis of diversely substituted fused azepinones and pyridinones” Synthesis, 2013, 45, 2571-2582.* (IF: 2.443, Citation: 22)

9) Modha, Sachin G.; Mehta, Vaibhav P.; Van der Eycken, Erik V. “Transition metal-catalyzed C-C bond formation via C-S bond cleavage: an overview” Chem. Soc. Rev., 2013, 42, 5042-5055. (IF: 30.425, Citation: 154)

10)Kumar, Amit; Vachhani, Dipak D.; Modha, Sachin G.; Sharma, Sunil K.; Parmar, Virinder S.; Van der Eycken, Erik V. “Gold(I)-catalyzed post-Ugi hydroarylation: An approach to pyrrolopyridines and azepinoindoles” Eur. J. Org. Chem., 2013, 2288-2292.* (IF: 3.154, Citation: 28)

11)Vachhani, Dipak D.; Kumar, Amit; Modha, Sachin G.; Sharma, Sunil K.; Parmar, Virinder S.; Van der Eycken, Erik V. “Diversely substituted triazolo[1,5-a][1,4]benzodiazepinones: A post-Ugi Copper-catalyzed tandem azide-alkyne cycloaddition/Ullmann C-N coupling approach” Eur. J. Org. Chem., 2013, 1223-1227. (IF: 3.154, Citation: 38)

12)Vachhani, Dipak D.; Modha, Sachin G.; Sharma, Abhishek; Van der Eycken, Erik V. “A facile diversity-oriented synthesis of



imidazo[1,2-a]pyrazinones via Gold-catalyzed regioselective heteroannuation of propynylaminopyrazinones” Tetrahedron, 2013, 69, 359-365. (IF: 2.817, Citation: 18)

13)Mishra, Nigam M.; Vachhani, Dipak D.; Modha, Sachin G.; Van der Eycken, Erik V. “Diversely substituted imidazo[1,2-a]pyrazine-8-oxo-3-carbaldehydes: An iodine-mediated cyclization/oxidation approach” Eur. J. Org. Chem. 2013, 693-700. (IF: 3.154, Citation: 9)

14)Modha, Sachin G.; Kumar, Amit; Vachhani, Dipak D.; Sharma, Sunil K.; Parmar, Virinder S.; Van der Eycken, Erik V. “Gold(I) and Platinum(II) switch: a post-Ugi intramolecular hydroarylation to pyrrolopyridinones and pyrroloazepinones” Chem. Commun., 2012, 48, 10916-10918. (IF: 6.378, Citation: 55)

15)Modha, Sachin G.; Kumar, Amit; Vachhani, Dipak D.; Jacobs, Jeroen; Sharma, Sunil K.; Parmar, Virinder S.; Van Meervelt, Luc; Van der Eycken, Erik V. “A diversity-oriented approach to spiroindolines: Post-Ugi Gold-catalyzed diastereoselective domino cyclization” Angew. Chem. Int. Ed., 2012, 51, 9572-9575. (IF: 13.734, Citation: 89)

16)Mishra, Nigam M.; Peshkov, Vsevolod A.; Pereshivko, Olga P.; Modha, Sachin G.; Van der Eycken, Erik V. “Alkylation of 3,5-dichloro-2(1H)-pyrazinones using malonate esters” Tetrahedron Lett., 2012, 53, 4676-4678. (IF: 2.397, Citation: 4)

17)Modha, Sachin G.; Vachhani, Dipak D.; Jacobs, Jeroen; Van Meervelt, Luc; Van der Eycken, Erik V. “A concise route to indoloazocines via a sequential Ugi-Gold-catalyzed intramolecular hydroarylation” Chem. Commun. 2012, 48, 6550-6552. (IF: 6.378, Citation: 67) (Listed by Synfacts DOI: 10.1055/s-0032-1316700).

18)Modha, Sachin G.; Trivedi, Jalpa C.; Mehta, Vaibhav P.; Ermolat’ev, Denis S.; Van der Eycken, Erik V. “Efficient preparation of tetrasubstituted pyrazines starting from pyrazine-2(1H)-ones” Synthesis, 2012, 44, 1614-1624. (IF: 2.50, Citation: 2)

19)Vachhani, Dipak D.; Mehta, Vaibhav P.; Modha, Sachin G.; Van Hecke, Kristof; Van Meervelt, Luc; Van der Eycken, Erik V. “Microwave-assisted synthesis of pyrazino[2,1-b]quinazolines and 3-indolyl-2(1H)-pyrazinones employing a chemoselective Silver(I)- and Gold(I)-catalyzed reaction” Adv. Synth. Catal., 2012, 354, 1593-1599. (IF: 5.535, Citation: 37)

20)Mehta, Vaibhav P.; Modha, Sachin G.; Ruijter, Eilco; Van Hecke, Kristof; Van Meervelt, Luc; Pannecouque, Christophe; Balzarini,



Jan; Orru, Romano V. A.; Van der Eycken, Erik “A microwave-assisted diastereoselective multicomponent reaction to access dibenzo[c,e]azepinones: Synthesis and biological evaluation” J. Org. Chem., 2011, 76(8), 2828-2839. (Listed by Synfacts DOI: 10.1055/s-0030-1260688). (IF: 4.45, Citation: 57)

21)Mehta, Vaibhav P.; Sharma, Ajendra K.; Modha, Sachin G.; Sharma, Sweta; Meganathan, Thirumal; Parmar, Virinder S.; Van der Eycken, Erik “N-Heterocyclic carbene catalyzed aroylation of 3,5-dichloro-2(1H)-pyrazinones” J. Org. Chem., 2011, 76(8), 2920-2925. (IF: 4.45, Citation: 15)

22)Modha, Sachin G.; Trivedi, Jalpa C.; Mehta, Vaibhav P.; Ermolat’ev, Denis S.; Van der Eycken, Erik V. “An expeditious route toward pyrazine-containing nucleoside analogues” J. Org. Chem. 2011, 76(3), 846-856. (IF: 4.45, Citation: 37)

23)Mehta, Vaibhav P.; Modha, Sachin G.; Van der Eycken, Erik V. “Microwave-assisted Palladium-catalyzed phosphonium coupling of 2(1H)-pyrazinones” J. Org. Chem., 2010, 75, 976-979. (IF: 4.002, Citation: 37)

24)Modha, Sachin G.; Mehta, Vaibhav P.; Ermolat’ev, Denis; Balzarini, Jan; Van Hecke, Kristof ; Van Meervelt, Luc; Van der Eycken, Erik V. “Microwave-assisted synthesis of a novel class of imidazolylthiazolidin-4-ones and evaluation of its biological activities” Mol. Divers., 2010, 14(4), 767-776. (IF: 3.721, Citation: 20)

25)Van Overschelde, Michel; Vervecken, Elias; Modha, Sachin G.; Cogen, Simon; Van der Eycken, Erik; Van der Eycken, Johan “Catalyst-free alcoholysis of phosphane-boranes: a smooth, cheap, and efficient deprotection procedure” Tetrahedron, 2009, 65(32), 6410-6415. (IF: 3.219, Citation: 40)

26)Francois, Isabelle E. J. A.; Cammue, Bruno P. A.; Bresseleers, Sara; Fleuren, Hein; Hoornaert, Georges; Mehta, Vaibhav P.; Modha, Sachin G.; Van der Eycken, Erik V.; Thevissen, Karin “Synthesis and fungicidal activity of 3,5-dichloropyrazine-2(1H)-one derivatives” Bioorg. Med. Chem. Lett., 2009, 19(15), 4064-4066. (IF: 2.65, Citation: 1)

27)Mehta, Vaibhav P.; Modha, Sachin G.; Ermolat'ev, Denis; Van Hecke, Kristof; Van Meervelt, Luc; Van der Eycken, Erik V. “Diversity-oriented synthesis of substituted furo[2,3-b]pyrazines” Aust. J. Chem., 2009, 62(1), 27-41. (IF: 1.681, Citation: 10)

28)Mehta, Vaibhav P.; Modha, Sachin G.; Van der Eycken, Erik “Mild



room-temperature Palladium-catalyzed C3-arylation of 2(1H)-pyrazinones via a desulfitative kumada-type cross-coupling reaction” J. Org. Chem. 2009, 74(17), 6870-6873. (IF: 4.219, Citation: 23)

* Shared corresponding authorship in these articles.

More information Check out the below links for further information Google scholar: https://scholar.google.com/citations?user=WO6iPCUAAAAJ&hl=en ORCID profile: https://orcid.org/0000-0001-5420-2749 h-index: 18, i10-index:21, total impact factor: 155, total citations: 1012 (As of july-2019, Scopus)

Seminar /Conference 1) 26. Lecture Conference on Photochemistry organized by German Chemical Society (GDCh) at Technical University of Munich (host: Prof. Thorsten Bach), Germany, September 10-12, 2018 (Poster presentation).

2) A three-day symposium to honor nobel prize winner Prof. Ben Feringa with TUM distinguished affiliated professorship, Garching campus of Technical University of Munich, Germany July 17-19, 2017.

3) Annual meeting of Alexander von Humboldt foundation at Berlin, Germany, June 28-30, 2017.

4) Summer symposium on its 25th Anniversary of the Bach group, at Garching campus, Technical University of Munich, Germany, June 23, 2017.

5) Center for Integrated Protein Science Munich (CIPSM) Scientific Oktoberfest, Department of Chemistry, Ludwig Maximilians University Munich, Germany, September 15-16, 2016.

6) 34th Annual conference of Indian Council of Chemists (ICC-XXXIV), Uka Tarsadiya University, Bardoli, India, December 26-28, 2015. Oral presentation. (Best oral presentation prize)

7) The Page Lectures, University of Huddersfield, July 31, 2015. (Received poster prize from Prof. Stephan Buchwald)

8) 24th International Symposium Synthesis in Organic Chemistry, RSC conference, Churchill College, Cambridge, UK, July 20-23, 2015.

9) E. J. Thomas Retirement Symposium, School of Chemistry,



University of Manchester, UK, January 8, 2014.

10) Organic Chemistry Symposium, School of Chemistry, University of Manchester, UK, November 20, 2013.

11) 31st Annual conference of Indian Council of Chemists (ICC-XXXI), Rajkot, India, December 26-28, 2012. Oral presentation. (Best oral presentation prize)

12) 13th Belgiun Organic Synthesis Symposium (BOSS XIII), Leuven, Belgium, July 15–20, 2012. (Poster presentation).

13) Groningen Meets Leuven: A One-Day Symposium, Leuven, Belgium, June 16, 2011. (Poster presentation).

14) 15th Indian Society of Chemist and Biologist Conference (ISCBC-2011), Rajkot, Gujarat, India, February 4-7, 2011. (Poster presentation)

15) 14th Sigma-Aldrich Organic Synthesis Meeting, Spa, Belgium, December 2-3, 2010. Oral presentation.

16) 12th Belgiun Organic Synthesis Symposium (BOSS XII), Namur, Belgium, July 11–16, 2010. (Poster presentation)

17) 10th Flemish Youth Conference of Chemistry (VJC-10), Blankenberge, Belgium, March 1-2, 2010. (Poster presentation)

18) 13th Sigma-Aldrich Organic Synthesis Meeting, Spa, Belgium, December 3-4, 2009. (Poster presentation)

19) 12th Sigma-Aldrich Organic Synthesis Meeting, Spa, Belgium, December 5-6, 2008. (Poster presentation)

20) XXIIIrd European Colloquium on Heterocyclic Chemistry (ECHC 08), Antwerp, Belgium, September 9-13, 2008.

21) 11th Belgiun Organic Synthesis Symposium (BOSS XI), Ghent, Belgium, July 13–18, 2008.

22) 12th Indian Society of Chemist and Biologist Conference (ISCBC-2008), Pilani, Rajasthan, India, February 22-24, 2008. (Poster presentation)

Membership Life time member of Indian council of Chemists. Member of Royal Society of Chemistry (RSC) (2015-2016) Alexander von Humboldt foundation alumni (Life time support

for collaborations in Germany)

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