department of molecular and cellular biology29 targeting the p27 e3 ligase scfskp2 results in p27-...
TRANSCRIPT
25
D e p a r t m e n t o f M o l e c u l a r a n d C e l l u l a r B i o l o g y
26
Division of Cell Biology
27
28
1. Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K.,
Miyamoto, K., Yoshiwara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Hayashi, Y., Matsuzaki, Y.,
Nakayama, K., Ikeda, Y., Hata, A., Chiba, S., Nakayama, K. I., Suda, T. 2008.
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.
Genes Dev. 22, 986-991.
2. Inoue, S., Kinoshita, T., Matsumoto, M., Nakayama, K. I., Doi, M., Shimazaki, K. 2008.
Blue light-induced autophosphorylation of phototropin is a primary step for signaling.
Proc. Natl. Acad. Sci. U S A 105, 5626-5631.
3. Mukai, A., Mizuno, E., Kobayashi, K., Matsumoto, M., Nakayama, K. I., Kitamura, N., Komada, M. 2008.
Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis.
J. Cell Sci. 121, 1325-1333.
4. Song, M. S., Song, S. J., Kim, S. J., Nakayama, K., Nakayama, K. I., Lim, D. S. 2008.
Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation
at the G1-S transition.
Oncogene 27, 3176-3185.
5. Shigematsu, N., Fukuda, T., Yamamoto, T., Nishioku, T., Yamaguchi, T., Himeno, M., Nakayama, K. I., Tsukuba,
T., Kadowaki, T., Okamoto, K., Higuchi, S., Yamamoto, K. 2008.
Association of cathepsin E deficiency with the increased territorial aggressive response of mice.
J. Neurochem. 105, 1394-1404.
6. Chen, Q., Xie, W., Kuhn, D. J., Voorhees, P. M., Lopez-Girona, A., Mendy, D., Corral, L. G., Krenitsky, V. P., Xu,
W., Moutouh-de Parseval, L., Webb, D. R., Mercurio, F., Nakayama, K. I., Nakayama, K., Orlowski, R. Z. 2008.
29
Targeting the p27 E3 ligase SCFSkp2
results in p27- and Skp2-mediated cell-cycle arrest and activation of
autophagy.
Blood 111, 4690-4699.
7. Shirane, M., Ogawa, M., Motoyama, J., Nakayama, K. I. 2008.
Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse.
Genes Cells 13, 635-651.
8. Agarwal, A., Bumm, T. G., Corbin, A. S., O'Hare, T., Loriaux, M., VanDyke, J., Willis, S. G., Deininger, J.,
Nakayama, K. I., Druker, B. J., Deininger, M. W. 2008.
Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease.
Blood 112, 1960-1970.
9. Matsumoto, A., Kawamoto, T., Mutoh, F., Isse, T., Oyama, T., Kitagawa, K., Nakayama, K. I., Ichiba, M. 2008.
Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice.
Pharmacogenet. Genomics 18, 847-852.
10. Sakae, N., Yamasaki, N., Kitaichi, K., Fukuda, T., Yamada, M., Yoshikawa, H., Hiranita, T., Tatsumi, Y., Kira, J.,
Yamamoto, T., Miyakawa, T., Nakayama, K. I. 2008.
Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to
psychostimulants.
Hum. Mol. Genet. 17, 3191-3203.
11. Ishikawa, Y., Onoyama, I., Nakayama, K. I., Nakayama, K. 2008.
Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7.
Oncogene 27, 6164-6174.
12. Ohsaki, K., Oishi, K., Kozono, Y., Nakayama, K., Nakayama, K. I., Ishida, N. 2008.
The role of -TrCP1 and -TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2.
J. Biochem. 144, 609-618.
13. Kanei-Ishii, C., Nomura, T., Takagi, T., Watanabe, N., Nakayama, K. I., Ishii, S. 2008.
Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation.
J. Biol. Chem. 283, 30540-30548.
14. Miranda-Carboni, G. A., Krum, S. A., Yee, K., Nava, M., Deng, Q. E., Pervin, S., Collado-Hidalgo, A., Galic, Z.,
Zack, J. A., Nakayama, K., Nakayama, K. I., Lane, T. F. 2008.
A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.
Genes Dev. 22, 3121-3134.
15. Tamamori-Adachi, M., Takagi, H., Hashimoto, K., Goto, K., Hidaka, T., Koshimizu, U., Yamada, K., Goto, I.,
Maejima, Y., Isobe, M., Nakayama, K. I., Inomata, N., Kitajima, S. 2008.
Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2
ubiquitin ligase.
Cardiovasc. Res. 80, 181-190.
16. Minhajuddin, M., Bijli, K. M., Fazal, F., Sassano, A., Nakayama, K. I., Hay, N., Platanias, L. C., Rahman, A. 2008.
Protein kinase Cdelta and PI3-kinase/Akt activate mammalian target of rapamycin to modulate NF- B activation
and ICAM-1 expression in endothelial cells.
30
J. Biol. Chem., in press.
17. Mitra, P., Ghule, P. N., van der Deen, M., Medina, R., Xie, R. L., Holmes, W. F., Ye, X., Nakayama, K. I., Harper,
J. W., Stein, J. L., Stein, G. S., van Wijnen, A. J. 2009.
CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT
and HiNF-P.
J. Cell Physiol., in press.
18. Tsukuba, T., Yanagawa, M., Okamoto, K., Okamoto, Y., Yasuda, Y., Nakayama, K. I., Kadowaki, T., Yamamoto,
K. 2009.
Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient
macrophages.
J. Biochem., in press.
19. Lu, Y., Adegoke, O. A., Nepveu, A., Nakayama, K. I., Bedard, N., Cheng, D., Peng, J., Wing, S. S. 2009.
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1
.
Mol. Cell. Biol. 29, 547-558.
20. Nishiyama, M., Oshikawa, K., Tsukada, Y., Nakagawa, T., Iemura, S., Natsume, T., Fan, Y., Kikuchi, A.,
Skoultchi, A. I., Nakayama, K. I. 2009.
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.
Nat. Cell Biol. 11, 172-182.
21. Minhajuddin, M., Bijli, K. M., Fazal, F., Sassano, A., Nakayama, K. I., Hay, N., Platanias, L. C., Rahman, A. 2009.
Protein kinase C- and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate
NF- B activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells.
J. Biol. Chem. 284, 4052-4061.
22. Endo, A., Matsumoto, M., Inada, T., Yamamoto, A., Nakayama, K. I., Kitamura, N., Komada, M. 2009.
Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.
J. Cell Sci. 122, 678-686.
23. Susaki, E., Nakayama, K., Yamasaki, L., Nakayama, K. I. 2009.
Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model.
Proc. Natl. Acad. Sci. U S A, in press.
1. Onoyama, I., Nakayama, K. I. 2008.
Fbxw7 in cell cycle exit and stem cell maintenance: insight from gene-targeted mice.
Cell Cycle 7, 3307-3313.
2.
3.
31
4.
5.
6.
7.
1. Nakayama, K. I. (2008, 4/9).
2. Ishikawa, Y., Onoyama, I., Okuyama, R., Nakayama, K. I., Nakayama, K. (2008, 5/15).
3. Susaki, E., Nakayama, K., Nakayama, K. I. (2008, 5/16).
4. Nishiyama, M., Tsukada, Y.-i., Oshikawa, K., Nakagawa, T., Nakayama, K. I. (2008, 5/16).
5. Matsumoto, A., Onoyama, I., Matsuoka, S., Oike, Y., Suda, T., Nakayama, K. I. (2008, 5/16).
6. Matsumoto, M., Oyamada, K., Nakayama, K. I. (2008, 5/16).
7. Nakayama, K. I., Onoyama, I., Tsunematsu, R., Matsumoto, A., Nakayama, K. (2008, 5/18).
8. . (2008, 5/24).
32
9. (2008, 6/29).
10. . (2008, 6/30).
11. (2008, 8/29).
12. (2008, 9/12).
13. Nakayama, K. I. (2008, 11/5).
14. Nakayama, K. I. (2008, 11/9).
15. Nakayama, K. I. (2008, 11/12).
16. (2008, 12/9).
17. (2008, 12/9).
18. (2008, 12/10).
33
19. (2008, 12/10).
20. (2008, 12/10).
21. (2008, 12/10).
22. (2008, 12/11).
23. (2008, 12/11).
24. (2008, 12/11).
25. � , , . (2008, 12/11).
26. (2008, 12/11).
27. (2008, 12/11).
28. (2008, 12/11).
29. (2008, 12/12).
30. (2008, 12/12).
34
31. (2009, 2/14).
32. Nishiyama, M., Nakayama, K. I. (2009, 2/16).
33. Matsumoto, A., Susaki, E., Onoyama, I., Nakayama, K. I. (2009, 2/16).
34. (2009, 3/17).
35
Division of Biochemistry and Molecular Biology
36
1. Takeya, R., Taniguchi, K., Narumiya, S., and Sumimoto, H. 2008.
The mammalian formin FHOD1 is activated via phosphorylation by ROCK and mediates thrombin-induced
stress fibre formation in endothelial cells.
EMBO J. 27, 618–628.
2. Mayumi, M., Takeda, Y., Hoshiko, M., Serada, K., Murata, M., Moritomo, T., Takizawa, F., Kobayashi, I., Araki,
K., Nakanishi, T., and Sumimoto, H. 2008.
Characterization of teleost phagocyte NADPH oxidase: molecular cloning and expression analysis of carp
(Cyprinus carpio) phagocyte NADPH oxidase.
Mol. Immunol. 45, 1720–1731.
3. Shono, T., Yokoyama, N., Uesaka, T., Kuroda, J., Takeya, R., Yamasaki, T., Amano, T., Mizoguchi, M., Suzuki,
S. O., Niiro, H., Miyamoto, K., Akashi, K., Iwaki, T., Sumimoto, H., and Sasaki, T. 2008.
Enhanced expression of NAPDH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival.
Int. J. Cancer.123, 787–792, 2008.
4. Maehara Y, Miyano K, Sumimoto H. 2009.
Role for the first SH3 domain of p67phox
in activation of superoxide-producing NADPH oxidases.
Biochem Biophys Res Commun. 379, 589–593.
5. Taura M, Miyano K, Minakami R, Kamakura S, Takeya R, Sumimoto H. 2008.
37
A region N-terminal to the tandem SH3 domain of p47phox
plays a crucial role in the activation of the phagocyte
NADPH oxidase.
Biochem J., in press.
1. Sumimoto, H. 2008.
Structure, regulation, and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
FEBS J. 275, 3249–3277.
Journal of Gastrointestinal Research 16, 199–207.
–
pp. 12–22
38
6.
39
Division of Molecular and Surgical Oncology
Sakashita K, J Surg Oncol 2008 ; Sakashita KAnn
Surg Oncol 2008 ; Sakashita K Ann Surg Oncol 2008 ; Sakashita K. Oncol Rep 2008 ; Nakamura Y, Ann Surg Oncol
2008;
40
41
42
43
44
45
46
1. Yokobori T, Mimori K, Iwatsuki M, Ishii H , Onoyama I, Fukagawa T, Kuwano H, Nakayama K, Mori M ,
p53-altered FBXW7 expression determines poor prognosis in gastric cancer cases.
Cancer Res (in press)
2. Iwatsuki M, Mimori K, Yokobori T, Tanaka F, Tahara K, Inoue H, Baba H, Mori M,
A platinum agent resistance gene, POLB, is a prognostic indicator in colorectal cancer,.
J Surg Oncol (in press)
3. Mimori K, Kataoka A, Yamaguchi H, Masuda N, Kosaka Y, Ishii H, Ohno S, Mori M,
Preoperative u-PAR gene expression in bone marrow indicates the potential power of recurrence in breast cancer
cases.
Ann Surg Oncol (in press)
4. Mimori K, Iwatsuki M, Yokobori T, Mori M,
Important matters to identify robust markers for metastasis and recurrence in solid cancer.
Ann Surg Oncol 1070-1, 2009
5. Kamohara Y, Haraguchi N, Mimori K, Tanaka F, Inoue H, Mori M, Kanematsu T,
The search for cancer stem cells in hepatocellular carcinoma.
Oncology; 119-124, 2008
6. Mimori K, Fukagawa T, Kosaka Y, Kita Y, Ishikawa K, Etoh T, Iinuma H, Sasako M, Mori M,
Hematogenous metastasis in gastric cancer requires isolated tumor cells and expression of vascular endothelial
growth factor receptor-1.
Clin Cancer Res 14(9): 2609-16, 2008
7. Mimori K, Fukagawa T, Kosaka Y, Ishikawa K, Iwatsuki M, Yokobori T, Hirasaki S, Takatsuno Y, Sakashita H,
Ishii H, Sasako M, Mori M,
A large-scale study of MT1-MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in
gastric cancer cases.
Ann Surg Oncol 15(10):2934-42, 2008
8. Mimori K, Ishii H, Inoue H, Barnard GF, Mori M,
Identification of the expression profile of apoptotic esophageal cancer cells by adenoviral-fragile histidine triad
treatment.
J Gastroenterol Hepatorol 23(2) 205-209, 2008
9. Tanaka F, Haraguchi N, Isikawa K, Inoue H, Mori M,
Potential role of dendritic cell vaccination with MAGE peptides in gastrointestinal carcinomas.
Oncol Rep 20:1111-6, 2008.
10. Ishii H, Mimori K, Ishikawa K, Okumura H, Pichiorri F, Druck T, Inoue H, Vecchione A, Saito T, Mori M,
Huebner K,
Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes.
Cancer Res 68(10): 3662-70, 2008
11. Yoshinaga K, Mimori K, Inoue H, Kamohara Y, Yamasshita K, Tanaka F, Mori M,
Activin A enhances MMP-7 activin via the transcription factor AP-1 in an esophageal squamous cell carcinoma cell
line.
Int J Oncol 33: 453-459, 2008
47
12. Nakamura Y, Tanaka F, Yoshikawa Y, Mimori K, Inoue H, Yanaga K,Mori M,
PDGF-BB is a novel prognostic factor in colorectal cancer,
Ann Surg Oncol 15(8): 2129-2136, 2008
13. Ohta M, Mimori K, Fukuyoshi Y, Kita Y, Motoyama K, Yamashita K, Ishii H, Inoue H, Mori M,
Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in esophageal cancer,
Br J Cancer 98: 410-417, 2008
14. Ishii H, Iwatsuki M, Ieta K, Ohta D, Haraguchi N, Mimori K,Mori M,
Cancer stem cells and chemoradiation resistance,
Cancer Science 99(10): 1871-1877, 2008
15. Sakashita K, Tanaka F, Xiang Z, Mimori K, Kamohara Y, Inoue H, Sawada T, Hiraka K, Mori M,
Clinical significance of ApoE expression in human gastric cancer,
Oncol Rep 20: 1313-1319, 2008
16. Haraguchi N, Ohkuma M, Sakashita H, Matsuzaki S, Tanaka F, Mimori K,Kamohara Y, Inoue H, Mori M,
CD133+CD44+ population efficiently enriches colon cancer initiating cells,
Ann Surg Oncol 15(10): 2927-2933, 2008
17. Matsumoto T, Matsumoto T, Shibata K, Ohta M, Iwaki K, Uchida H, Yada K, Mori M, Kitano S,
Laparoscopic distal pancreatectomy and open distal pancreatectomy: a nonrandomized comparative study,
Surg Laparosc Endosc Percutan Tech 18(4) 340-343,2008
18. Sakashita K, Mimori K, Tanaka F, Kamohara Y, Inoue H, Sawada T, Hirakawa K, Mori M,
Prognostic relevance of Tensin4 expression in human gastric cancer,
Ann Surg Oncol 15(9) 2606-2613,2008
19. Sakashita K, Mimori K, Tanaka F, Kamohara Y, Inoue H, Sawada T, Hirakawa K, Mori M,
Clinical significance of loss of Fhl1 expression in human gastric cancer,
Ann Surg Oncol 15(8) 2293-2300,2008
20. Motoyama K,Tanaka F, Kosaka Y, Mimori K, Uetake H, Inoue H, Sugihara K, Mori M,
Clinical significance of BMP7 in human colorectal cancer.
Ann Surg Oncol 15(5) 1530-1537,2008
21. Yamashita K, Kim MS, Park HL, Tokumaru Y, Osada M, Inoue H, Mori M, Sidransky D,
HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal
squamous cell carcinoma,
Mol Cancer Res 6(1) 31-41,2008
22. Sakashita K, Mimori K, Tanaka F, Kamohara Y, Inoue H, Sawada T, Hirakawa K, Mori M,
Prognostic relevance of Tensin4 expression in human gastric cancer,
Ann Surg Oncol 15 58-58,2008
23. Sakashita K, Mimori K, Tanaka F, Tahara K, Inoue H, Sawada T, Ohira M,Hirakawa K, Mori M,
Clinical significance of low expression of prostasin mRNA in human gastric cancer,
J Surg Oncol 98 559-564,2008
24. Yokoe T, Tanaka F, Mimori K, Inoue H, Ohmachi, T, Kusunoki M, Mori M,
M,Efficient identification of a novel cancer/testis antigen for immunotherapy using three-step microarray analysis.
Cancer Res 68: 1074-82, 2008
25. Kawamoto K,Tanemura M, Ito T, Deguchi T, Machida T, Nishida T, Doki Y,Mori M, Sawa Y,
Prolonged survival of pig islets xenograft by adenovirus-mediated expression of either the membrane-bound human
FasL or the human decoy Fas antigen gene,
Xenotransplantation 15(5) 333-343,2008
26. Yamamoto H, Noura S, Okami J, Uemura M, Takemasa I, Ikeda M, Ishii H,Sekimoto M, Matsuura N, Monden M,
Mori M,
Overexpression of MT1-MMP is insufficient to increase experimental liver metastasis of human colon cancer cells,
Int J Mol Med 22(6) 757-761,2008
27. Kawamoto K,Tanemura M, Deguchi T, Machida T, Nishida T, Sawa Y,Mori M, Doki Y, Ito T,
48
In vivo controlling of cellular response to pig islet xenografts by adenovirus-mediated expression of either
membrane-bound human FasL or human decoy fas,
Am J Transplant 8(2) 288-297,2008
28. Tokumaru Y,Yamashita K, Kim MS, Park HL, Osada M, Mori M, Sidransky D,
The role of PGP9,5 as a tumor suppressor gene in human cancer,
Int J Cancer 123(4) 753-759,2008
29. Kim MS, Chang X, Yamashita K, Naqpal JK, Baek JH, Wu G, Trink B,Ratovitski EA, Mori M, Sidransky D,
Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma,
Oncogene 27(25) 3624-3634,2008
30. Park HL, Kim MS, Yamashita K, Westra W, Carvalho AL, Lee J, Jiang WW,Baek JH, Liu J, Osada M, Moon CS,
Califano JA, Mori M, Sidransky D
DCC promoter hypermethylation in esophageal squamous cell carcinoma,
Int J Cancer 122(11) 2498-2502,2008
49
50
51
52
( )
53
54
26. Mimori K, Yokobori Y, Iwatsuki M, Sakashita K, Tanaka F, Kamohara Y, Inoue H, Mori M 2008,3/15
Clinical significance of u-PAR gene expression in peripheral blood and bone marrow in breast cancer cases,
The Society of Surgical Oncology, 61 st Annual Cancer Symposium, Chicago
27. Sakashita K, Mimori K, Tanaka F, Kamohara Y, Inoue H, Hirakawa K, Mori M (2008,3/15)
Prognostic Relevance of Tenisin4 Expression in Human Gastric Cancer
55
The Society of Surgical Oncology, 61st annual cancer symposium, Chicago
28. Mimori K, Mori M(2008,3/14)
“Comprehensive analysis of the mechanism of metastasis in cancer patients”
Department of molecular biology, immunology and medical genetics
Special Seminar of The Ohio State University Comprehensive Cancer Center, Colombus, OH.
29. Mimori K, Ishii H, Inoue H, Barnard GF, Mori M,(2008,4/27-4/28)
Identification of the expression profile of apoptotic esophageal cancer cells by adenoviral-fragile histidine triad
treatment
The 12th Taishotoyama International Symposium on Gastroenterology, Shimoda
30. Ishii H, Ieta K, Tanaka F, Haraguchi N, Kita Y, Sakashita H, Mimori K, Matsumoto T, Inoue H, Kuwano H, Mori
M,(2008,10/5-10/9)
Characteristics of Colon Cancer-Initiating Cells
The 36th Congress of the International Society of Oncology & BioMarkers (ISOBM2008), Tokyo
31. Ishii H, Mori M,(2008,11/9-11/10)
Recent progress of cancer stem cell research in gastrointestinal tumors
Kyushu University Global COE International Symposium, Fukuoka
32. Ohkuma M, Haraguchi N, Ishii H, Yanai K, Mori M,(2008,11/9-11/10)
Identification of cancer stem cells in human gastric adenosquamous cancer
Kyushu University Global COE International Symposium, Fukuoka
33. Ishii H, Haraguchi N, Tanaka F, Mimori K, Inoue H, Takemasa I, Ikeda M,Yamamoto H, Sekimoto M, Mori M
(2008,11/11-11/14)
Identification of colon cancer-initiating cells
21st the Naito conference, Shonan
,
56
Division of Molecular and Clinical Gerontology
57
Akt
SHP-1 Akt
SHP-1 RNA
(RNAi) SHP-1
58
59
1. Guan JZ, T Maeda, M Sugano, J Oyama, Y Higuchi, Makino N. 2008. An analysis of the
telomere length distribution in Parkinson's disease patients. J Gerontol A Biol Sci Med Sci 63,
467-473.
2. Kudo Y, Oyama J, Nishiyama Y, Maeda T, Ikewaki N, Makino N. 2009. Immersion in hot
spring improves cardiovascular functions in patients with heart failure. J Jpc Soc Balneol
Climatol Phys Med. 71, 234-241.
3. Higuchi Y, Maeda T, Oyama J, Makino N. 2009. Diagonal Earlobe Creases Are Associated
with a Shorter Telomere Length in Male Japanese Patients with Metabolic Syndrome - A Pilot
Study- Circulation J. 73, 274-279.
4.
5.
6. Sugano M, Iwasaki Y, Abe M, Maeda T, Tsuchida K, Makino N. 2009 TNF-alpha employs a
protein-tyrosine phosphatase to inhibit activation of hepatocyte growth factor receptor and
hepatocyte growth factor-induced endothelial cell proliferation. Mol Cell Biochem 322,
113-117.
7. Maeda T, Guan JZ, Oyama J, Higuchi Y, Makino N. 2009. Aging-associated alteration of
subtelomeric methylation in Parkinson’s disease. J Gerontol A Biol Sci Med Sci. [Epub ahead
of print]
8.
9. Maeda T, Guan JZ, Oyama J, Higuchi Y, Makino N. (in press) Age-related changes in
subtelomeric methylation in the normal Japanese population. J Gerontol A Biol Sci Med Sci
60
Y Higuchi, Maeda T, Oyama J, Makino N (2008,3/30)
Diagonal Earlobe Creases Are Associated with Shorter Telomere Length
in Patients with Metabolic Syndrome in the Japanese Population
61
T Maeda, J Oyama, Y Higuchi,N Makino (2008, 11/8)
Ageing-related telomeric change and its acceleration by disease conditions.
The 2’nd Global COE International Symposium joint with the 18th Hot
Spring Harbor Symposium of Medical Institute of Bioregulation, Kyushu
University Symposium Theme: Stem Cells and Regenerative Medicine,
Fukuoka
62
Takezako T, Ramchandran R, Saad Y, Makino N, Karnik SS (2008, 12/6)
Angiotensinergic stimulation of vascular endothelium in mice causes
hypotension, bradycardia and attenuated angiotensin response
The 25th Annual Meeting of ISHR Japanese Section, Yokohama
18. Makino N, Maeda T, Oyama J, Higuchi Y, Sugano M (2008,3/29)
Improving insulin sensitivity via activation of PPAR-g affected the telomere length in OLETF
rats.
72
1. Makino N, Maeda T. (08/9/6). Role of insulin sensitivity on telomere biology in experimental
cardiovascular disease. The Japan-Korea Joint Seminar Toward the establishment of Asia Aging
research and educationCenter.
2. Makino N. (08/9/25) Insulin sensitivity and telomerase activity in diabetic heart. Mendel
Symposium II- Gene and Heart from bench to bedside. Plague, Czech Republic.