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生化室 2014 级科硕
柳霞
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abstractRAS proteins are essential components of signalling pathways that emanate from cell surface receptors. Oncogenic activation of these proteins owing to missense mutations is frequently detected in several types of cancer. A wealth of biochemical and genetic studies indicates that RAS proteins control a complex molecular circuitry that consists of a wide array of interconnecting pathways. In this Review, we describe how RAS oncogenes exploit their extensive signalling reach to affect multiple cellular processes that drive tumorigenesis.
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Oncogenic activation – themes and variations
RAS and the transformed phenotype
Promotion of proliferation
Suppression of apoptosis
Metabolism
Remodeling the microenvironment
Evasion of the immune response
Metastasis
The road ahead
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Figure 1. Frequency of mutations at G12, G13 and Q61 in RAS isoforms
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Figure 2. RAS effects on proliferation
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Figure 3. RAS effects on apoptosis
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Figure 4. Effect of RAS on energy metabolism in cancer cells: generating macromolecular precursors
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Figure 5. RAS and angiogenesis
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Thank you for your attention!