4 ,cytokine

interferon IFN

,

IFN-25

IFN- 4

IFN- TNK4 I pH 2601hII

IFN-188189N23165166

human interferon-alpha 2b maltfallva llvlsckssc svgcdlpqth slgsrrtlml laqmrrislf sclkdrhdfg fpqeefgnqf qkaetipvlh emiqqifnlf stkdssaawd etlldkfyte lyqqlndlea cviqgvgvte tplmkedsil avrkyfqrit lylkekkysp cawevvraei mrsfslstnl qeslrske

IFN- IFN-IFN- 802530 IFN-203Cys1

IFN-INF-IFN-

N2314316 kD

IFN-IFN-

IFN-

IFN

IFN

IFN-T

IFN1.5-2.8 h

SchgringPEGIFN,PEG Intron1.5g/kg l

IFN

(r-med IFN-consenseus Interferon)Intergen

11IFN-IFN

NK

IFNIFN(ribavirin)RebetolIFN

IFN-IFNTNF

IFN

l2

232530

IFN-

Interleukin ILIL

23IL-lIL-23

IL-2IL-11IL-6IL-10IL-12

IL-2 TNK, IL-2

133 aa15-17.5kDa6.8-8.23Cys, Cys58Cys1051 myrmqllsci alslalvtns aptssstkkt qlqlehllld lqmilnginn yknpkltrml 61 tfkfympkka telkhlqcle eelkpleevl nlaqsknfhl rprdlisnin vivlelkgse 121 ttfmceyade tativeflnr witfcqsiis tlt interleukin-2 [Homo sapiens].

Cys125,,

Cys125,

N-aa,N-1-20aa

41pH29

IL-2IL-2

IL-2

IL-2T

T(CTL)

NKNK

LAK(TIL)

B

IL-2

(IFN)(TNF)(CSF)NK

()IL-2

IL-2IL-2

(LAK)

IL-2

IL-2 T

IL-2

IL-11IL-11199aaN-21aaCys11.7,80 ,

Met59C-aaIL-11.

Lys42Lys993.

IL-11 IL-11

IL-11

IL-11 G-CSF

IL-11

IL-11N58

IL-Il

ILIL-2()

IL-2

IL-2(PEG)

IL-2

IL-2(DAB3891L-2,ONTAK)1L-2T

Colony stimulating factorCSF G-CSF GM-CSF M-CSF multi-CSF EPO TPO SCF

1. G-CSF()

4,4-8

Cys17,,

2. M-CSF

522 aa32 aa

M-CSFM-CSF

M-CSF

3. GM-CSFT

GM-CSF144 aaN-17 aa

18-32 kDa, 2

2N-O-

GM-CSF

GM-CSF46

56 10 min

pH 2

GM-CSFGM-CSF

4 Erythropoietin EPO193 aa27 aa

EPO165

rhEPOEPO,CHO

EPOEPO

AmgenEpogen

5 Stem cell factor SCF(stem cell growth factorSCGF

(mast cell growth factorMGF)

1990

SCF

SCFSCF

SCF273 aaN2518936

SCF

AmgenSCF

6 Epidermal growth factor, EGFEGF2060533 6 kDa

(hEGF)

EGFBrunner, EGF

EGFEGF203l EGF

NC

-20

6Cys

EGFEGF

EGF

EGF

EGF

EGF ()

EGF EGFEGFEGF

EGF

EGF

EGF

rhEGF

7 Fibroblast growth factor FGF

23

bFGFhFGF1996

bFGF