"

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, , ,

TSE - - - BSE, CJD, vCJD, Inherited diseases

1732

- - BSE -

(1993), (1996). , (2002), (2007), (2008), (2008), (2012)

BSE

, ,

(PrPc) (PrPsc)

Prion protein (PrPc) 256

(PrPsc) (PrPc)

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3 136,154,171

136 (A) (V)

154 (R) (H)

171 (R) (Q)

103 15 ARQ 0.761 ARR 0.065 VRQ ( , )

150 (-, , )2012 6 ARR-ARR 15 ARR-ARR ARR