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الرحمن الله بسمالرحيم
الرحمن الله بسمالرحيم
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Part 1Part 1
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Isthmus
Pyramidal lobe
Right lobe Left lobe
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Ciliary bodyChoroid plexusSalivary glandMammary glandGastric mucosa
Placenta
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proteins
enzymes
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Mechanism of Action Mechanism of Action
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Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs
I – Effects on Metabolism .
I - 1 . Cell Metabolic activity . a – Mitochondria : # & size .
b – Cell membrane ions transport : stimulation of Na / K pump .
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Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs
I - 2 . Body metabolic processes .
a – Carbohydrate metabolism : increased =
glucose absorption by GIT , insulin secretion & uptake by cell : glycolysis , gluconeogenesis . b – Fat metabolism : Increased FA oxidation & depletion of fat stores c – Plasma lipids : decrease plasma cholestrol : increased secretion in bile & stools . Increased # of liver LDL receptors .
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Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs
I - 2 . Body metabolic processes .
a – Carbohydrate metabolism : increased =
glucose absorption by GIT , insulin secretion & uptake by cell : glycolysis , gluconeogenesis . b – Fat metabolism : Increased FA oxidation & depletion of fat stores c – Plasma lipids : decrease plasma cholestrol : increased secretion in bile & stools . Increased # of liver LDL receptors . d – Basal Metabolic Rate : BMR : BEE = normal body wt .
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Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs
II – Effects on Growth . a - Growth & Development of brain . b - Skeletal growth .
III – Effects on body systems . a – Primary effect . b – Secondary effect .
Stimulate O2 consumption : GIT , endocrine , Respiratory , CVS , …..
Except anterior pituitary , adult brain , testes, uterus, lymph nodes & spleen
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Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs
Except
anterior pituitary adult brain testes, uterus, lymph nodes & spleen
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TSH
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Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs
II – Effects on Growth . a - Growth & Development of brain . b - Skeletal growth .
III – Effects on body systems . a – Primary effect .
b – Secondary effect .
CVS : Heart :
Chronotropic : Increased # & affinity of adr. receptors
Inotropic : Enhance response to circulating catecholamines Increased atrial MHC with more ATPase activity .
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TRH
TSH
T4
T3Tissues
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TSH