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(Plasma Lipoproteins and Its Metabolic Disorder)
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AS
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lipidstriacylglycerollipoid
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(TC) (FC) (CE) (PL)(TG)(FFA)
:4.07.0g/L
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( lipoprotein, LP) . +
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:CETGPLFCFCPL
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,
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CMVLDLIDLLDLHDLLp(a)----TG(80-90%)TG(50-70%)TGCEChCE(40-50%)PLCEPLAIB48CCCB100ECCCB100EB100AIA(a)B100 TGTGTGCECECE
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LpaLPa 1LDL(TC) Apo B100Apo 2Lp()Apo(a)Apo(a) LDL 3Lp()LDL 4Apoa
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Lpa 1Lp(a) 2Lp(a)0.2-0.3g/L 0.30 g/LAS2LDL-C CHD5LPa CHD 3Lp(a)CHDLpa 4Lpa
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(apolipoproteinApo) 1972AlaupovicApoABCDEFGHJ
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123
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1ApoAB(a)Apo ,/
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ApoEApoC ApoCII
19q111q2 2 , , ,ApoCApoAApoAApoA
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LDLVLDL
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,
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LDL836 36 115kD, LDLR LDL (LDLR)
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1 ApoB100ApoEApoB-E ApoB48 LDLApoB100VLDL-VLDL 2
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-VLDLVLDL -LP CEApoApoEApoCVLDL
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ApoB/ELDL43 LDLApoB100LDLLDL LDL6570LDLR
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LDLApoB100ELDL
LDLR
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l 2 3 4 5 6 7 LDL LDLRLDLR LDLLDL: CECh+FFA TGFFA ApoBAA LDL
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: FC HMGCoA LDLRLDLRLDLLDLR ACATChCE
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LDLLDL 5
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VLDLRLDLRLDLR,5552193246 1
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VLDLRApoE(VLDL-VLDLVLDL)LDL
2
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VLDL-VLDL LDLR VLDLRVLDL-VLDL VLDLVLDLVLDL VLDLR 3
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SR-A(SR-A6I:scavenger receptor, SR SR:SR-A-B-C-D-E -F
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SR LDL () () LDL
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: LPLHLLCATHMGCoAase: CETP LPL LCAT HMGCoAaseHL(HTGL)
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LPL 60kD LPLLPL ApoC
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1CMVLDLTG 2PL 3PLApoCh 4CM
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/HL/HTGL 53kD: ApoC
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: 1.VLDL-VLDLTG 2HDL3HDL2 3. HDL
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LCAT: HDL41663kD
: Apo AI
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1. ()HDLFCCECEHDL FC CE 2. ChCh
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CoA HMG CoA
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CETP: 74ku
CETPHDLCEHDL-c
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CMCM
VLDLIDL LDL HDL HDL
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(TG)FFAMGTGPL TGTCPLApoB48ApoAICM
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HDL (ApoC,E) CM() CM (TG) LPL MG+FFA
CMLPLCM CM CMTG
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TGApoB100CEVLDLVLDL VLDL:TGVLDL
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LDLVLDLCEHDL(CETP LDL
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HDL2CETPVLDLLDLCETGVLDLLDLFC HDL(RCT) ()HDL HDLHDLn,PLApoA,HDLHDLHDL3CE HDL2
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TCTG CMVLDLLDLHDL
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:
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1967Fredrickson:
1970(WHO)
WHO
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1()412h()?
2TGTC
3LP()LP(%)(?)
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1 ( ) TG TC TC/TG0.2 CM () 10 () ICM
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2LPLApoC TG TG Apo C() LPL CMTG CMCM CM
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1 TCTG TC/TG1.6;LDL -LP AS AS () IIa()
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2LDL (1) LDL LDL LDL(1/2) (2) LDLLDL (3) LDLLDL LDL LDLLDL-ChAS
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1 ;TG,TC, TC/TG>1.0LDLVLDL(- LP -LP) ,AS 2ApoB100VLDL LDL () b-LP-LP
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1 ; TG,TC IDL-LP (-LP-LP )-VLDL AS() (-VLDL- )
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2 ApoE ApoEApoE2E3E4ApoE(LDL)E2LDLApoE3/E3LDLApoE2/E2LDLLDL
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1 TGTCTC/TG 0.6-1.6 VLDL-LP AS 2 VLDL/VLDL () (TGVLDL)
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1 () TGTCTC/TG 0.6 CM-LP 20 2 ApoCLPLLPL CMVLDLTG() (CM-LP)
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TG4:(1)CMVLDLI(2)CMVLDLV(3)4VLDLTC TCIIIIIbTC(4)IIa
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CETPHTGL HDL
HDL HDL-C2.6mmol/LHDLCETPHTGLHDL
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AS AS HDLAS
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ASASAS
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LDL-VLDL oxLDLAS HDLAS AS
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CMVLDLLPLCMIDLApoE -VLDL(ApoE)-VLDLASAS
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LDL LDLLDLLDL,LDL: LDL LDL LDL LDLApoB100LDLLDLAS
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LDL-CAS LDLAB: B(LDL)AS,BLDL,LDLLDLCHD LDL(SD-LDL) BLDL
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LP(a) 0l000mg/LApo(a),Apo(a), 37Kringle-4(K-4),1Kringle-5(K5)1(a) Lp(a) Kringle(3)
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LDL HDLAS
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HDL: : NCEHCEFCHDLNCEH FC: NCEH NCEH
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TG HDL-C X
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(deadly quartet) Kaplan
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IDF IDF
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2002(NCEP)ATP III 33 >102cm >88cm 150mg/dL1.69mmol/L) HDL-C < 40 mg/ dL1.04mmol/L) < 50 mg/dL(1.29mmol/L) 110mg/dL (6.1mmol/L) 130/85 mmHg
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2004 (CDS) 53 85 cm ; 80 cm ) SBP130mmHg / DBP85 mmHg 150mg/dL < 40 mg/ dL 110mg/dL
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ASAS : TCTGLDL HDL AS
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1997: ()
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(mmol/L1997)
TCTGLDL-CHDL-C
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(mmol/L)
AS() TC>5.70>6.213.64>4.145.703.10>3.644.70>5.202.60>3.10
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1993ATP: LDL-C 3.36mmol/L HDL-C 0.9mmol/L 82001ATP LDL-C 2.6mmol/L HDL-C 1.0mmol/L LDL-CAS LDL-C2.6mmol/L ()
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LDL-CHDL-CTCATP(mmol/L)
LDL-CTCHDL-C
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CHDVLDL-CVLDL()VLDL-C TG4 1.7mmol/L 1.7 2.25mmol/L 2.26 5.64mmol/L 5.65mmol/L
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/ ASAS
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CE70FC30
:
1
-
1
-
(2) 70
- 2.85.2mmol/L
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TCTCTC TC TC
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TG: 2 TG
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11 2KOH 3 4(45--27-)(NH4+)
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2 TGTGGKGOD
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0.561.70mmol/L 0.361.50mmol/L
1.70mmol/L (150mg/dl)
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TGTG TG
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3 (PL)PL : , 1.33.2mmol/L
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Cl0(FFA) : (C18:1)54 (C16:1)34 (C18:1)6 (C22:0)(C14:0)(C20:1) FFA12min 4
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FFA: FFA,: 424h30
: 0.40.9mmol/L
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:24h() 4831
24mol/L 4.140.78mol/L 3.970.77mol/L 5
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() 1 (ultracentrifugation method)
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2(electrophoresis Method (TGTC) 12hCM
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4 16h24h: CM,VLDL LDL 3
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HDL-C 0.9mmol/L LDL-C 2.13.1mmol/L 2.8mmol/L4
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() +
(1) (precipitate method)
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PEG2000LDL+VLDL () HDL()HDL-C
HDL+VLDL () LDL()LDL-C
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(2)
(pH)
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HDL-CHDL-C0.9 mmol/L HDL-C1.55mmol/L HDL-CTGHDL-CHDL-CHDL-CHDL-CHDL-C 0.9mmol/L
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LDL-C TCTGHDL-CLDL-CFriedewald1972 LDL-C=TC[HDL-C+(TG1/5)] CM TG4.60mmol/L
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2.1 3.1mmol/L 2.8mmol/L
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LDL-CTCHDL-CLDL-CTCLDL-C
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Lp(a)-C : Lp(a)01000mg/L 300mg/LLp(a):
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ApoApo (1) sApoAApoB100Apoa (2) ApoAangier ApoC
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ApoHDLCLDL , Apo AI Apo B100, , , Apo AI Apo B100 ApoINAITA
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ApoAIHDL ApoBLDLApoAIApoBHDLLDL ApoAIHDLApoBLDLHDLLDLApoAIApoBApoAIApoB
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135 2LDL-CHDL-C1214
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3441-3
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5 (1) 31730 (2)
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(3) 24LDL-C12-2411224
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(4) 510min10-15min9-10
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1.2 2.24h 3. 4.TCTCTG12h 5.5min
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CDC 6.1min 7.EDTA2-81.03 8.24h41-20-70
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NCEP-ATPTCTGHDL-CLDL-CapoAIapoBLp(a)