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Gold nanoparticlesThe Lycurgus Cup dates from Roman times. The glass appears green in daylight (reflected light), but red when light is transmitted from the inside of the vessel.

Gold nanoparticles in assaytheir easily controllable-size distribution

long-term stability

and friendly biocompatibility with antibodies, antigen proteins, DNA and RNA

ssDNA-Au nanoparticlesDNAPCR[G. H. Keller, M. M. Manak and N.Y. Stockton, DNA Probes (1989). ]

1. Thaxton, C.S., Georganopoulou, D.G., Mirkin, C.A. 2006 Clin. Chim. Acta, 363, 120-126. 2. Sato, K., Hosokawa, K., Maeda, M. 2003 JACS, 125 , 8102-8103.

DNA12 TEMDNA- (a) DNA(SH 1,SH2)/ (b)Linker 1(assembly)

(TEM)

Single-Nucleotide PolymorphismJishan Li, Xia Chu, Yali Liu, Jian-Hui Jiang, Zhimin He, Zhiwei Zhang,Guoli Shen and Ru-Qin YuNucleic Acids Research, 2005, Vol. 33, No. 19 e168

Antibody-Au nanoparticles: ()

Li, Alastair W. Wark, Hye Jin Lee, and Robert M. Corn Anal. Chem.2006, 78,3158-3164

Silver Enhancement

Colony PrintingSalmonella

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