Cafe回⑥ryY-KUNINOBU.*T-IWANAGAoT-OMURApK-TAKAI*(OKAYAMAUNIVERSITYANDTHE
UNIVERSITYOrTOKYQJAPAN)
Palladium-Qktalyzedo諭o-SeiectiveC-HBoEylationof2-PhenylpyridmeandltsDerivatives薊tRoomTmnpemtur已
且"geMKC?ie腕嶬mfEti201aJ2,“31-4434
Me2aK-WIed胞廿②H
SynthesIs
K⑧ywcr衝&
Pd-Catalyzedortho-SelectiveC-HBorylation
of2-Pheny1pyridineDerivatives
orrho・seIectiveC-H
borylati、刑
PITenylpWidmederiVatlveS
paHadmm
r、
薊C〔i7鰍′A
upto9796yleld
儒09卦圖《:、譽笹蝋!:蝋[、
〈1equiv)(1.4equiv)
X=・N
Y=QO
R=40Me鞭4.CF⑧02-Me`cc両dei.i量鐘壼aromaMcs
SGI⑨Cted己Xa
局C
A83%yleld
-人一|人
!'
41%ylel仕 93%yield
法 法50%yleld77%yjeld 19%yieId
c〔震八89%yleld
lハ’97%yield 27%yieId
Significance:AnelficientPd-catalyzedborylation
of2-pheny}pyIidinederivativeshasbeendis-
CIC雲蓮.Theregiose{ectMty訂i尊塞fromLewis
acid-baseinteractiorlbetweenthenitrogenand
boron重tDrTis,fumishingthecorrespondingprod-
uctsingoodyields
sYNFAc加sccnMbuto麺:P31J1ZE二cEhE1ChristophS語台詫,Synfn亡循2013,,(7)?O775PubHshedmIine:17-062013
DOI:10-1055/3-0033-1338900:馳殴No.:PO6813SrDP。。■□■巳。■■。■■B■■bdb■凸■■印可凸■B■G■BOO■ウ咀凸■■5口■■■■■凸■■■■00.■■-■わ■●凸■q●、■■中▲で□守らP。■■qDSbo■、■■■企靱。ごSPB■▲■。①P上。■BUS■し■■■■■ロム■L可gc
ZOX3CTHIEMESTUTTGART・NEWYORK
Comme8nt:Thereactionproceedsatroomtem‐
pe虚turebutcarlalsobeconductedwithoutthe
paMadiumcatalystathighertemperatures・Fw-
thenTldc1theauthorshaveshownthatthereac-
tioncanalsobereadilyperformedong旧mscale
775