Download - 2002 Nobel Medicine Prize Apoptosis
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醫學一 B 第二組組員: 53 陳立倫 71 楊尚融 65 黃勁夫 89 賴志揚 82 劉彥君 77 廖冠豪
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APOPTOSIS 簡介希臘文 ~ 如秋天落葉一般生理意義 發育 : 手指 尾巴 新陳代謝:皮膚 維持環境恆定: T 細胞疾病 Apoptosis 未發揮作用 ~ 癌症 Apoptosis 作用太過劇烈 ~ 愛滋病 阿茲海默症Cell cycle
細胞死亡方式 PCD
APOPTOSIS
AUTOPHAGY
NECROSIS
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Autophagy
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得獎人介紹1961年-發現了 mRNA,闡明了 coden triplet(遺傳三字碼 )
1963年-提出線蟲做 為動物模式 (animal model)
1967年-發現 EMS(ethyl methanesulphonate)造成線蟲基因單點突變
1974年-發表第一篇有關線蟲遺傳學操作原理的論文
Sydney Brenner
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1983年-發表線蟲的細胞淵源(cell lineage)找到了參與細胞凋亡(apoptosis)的基因 nuc-1
1986年-找到與計劃性細胞死亡 (programmed cell death)的執行有直接相關的基因- ced-3,ced-4
1993年-發現線蟲的 ced-3 所表現的蛋白是cysteine protease,此蛋白相似於哺乳類的caspase
John E. Sulston Robert Horvitz
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線蟲( C. elegans )
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Apoptotic gene
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Hengartner, M.O. 2000. Nature. 407:770.
Mitochondrial PathwayDeath Receptor Pathway
FasL
Caspase 3
DDD D
Fas/Apo1/CD95
FADD
Procaspase 8
Caspase 8
BID
oxidants ceramide others
Bcl-2D
Cytochrome c
dATP
Procaspase 9
Apaf -1
dATP
Apaf -1Caspase 9
Procaspase 3
apoptosome
DNA damage
Cellular targets
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TNF, TNF receptor
NF-kb Bclx, Bcl2 Mitochondria
Cyto-c
ApoptosomeCaspase9Caspase3, 7
Caspase8
Apoptosis AIF
Smac/ DiabocIAPs, xIAPs
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TNF
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The Diseases Related to ApoptosisThe inordinate apoptosis: Alzheimer’s disease AIDS
The insufficient apoptosis SLE cancer
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Alzheimer’s disease腦部神經細胞的不正常凋亡
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Alzheimer’s disease mechanism
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SLE(Systemic lupus erythematosus)
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參考資料科學月刊第三十三卷第十二期Apoptosis介紹(from Wikipedia)
Replication cycle介紹(from Wikipedia)
細胞凋亡的分子機制Apoptosis簡介和相關圖片科學人雜誌相關報導 Fas Ligand 相關介紹Apoptosis and Cancer 比較報告細胞凋亡簡介及相關表格整理
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