AstaREAL® Astaxanthinfor Human Health
Superior Antioxidant
FDA Disclaimer
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease
• Astaxanthin in Nature
• Astaxanthin Benefits
What is Astaxanthin?
Strong Antioxidant Anti-Inflammatory Provides Eye Fatigue Relief Increase Muscle Endurance Supports Healthy Blood Lipids Aids in Wrinkle Reduction
This Red Color in Nature is Astaxanthin
Antioxidant Powerful antioxidant. Potent singlet oxygen quenching and anti-lipid peroxidation activity.
Anti-inflammatory
Inhibition of cytokines and chemokines expression suppressing NF-kB activation *, **.
Eye Health Eye fatigue *, **, Visual acuity *, **, Accommodation
Sports Related Muscle endurance *, ** and damage *, **, Sports vision *.
Life-style Related Diseases
Hypertension *, LDL cholesterol, H. pylori *, **, Diabetes & Diabetic nephropathy *, **, Metabolic syndrome *, **.
Personal Care Anti-wrinkle (topical *, ** & within *, **), Photo protectant, Melanin-inhibitor, Anti-hyperpigmentation.
Biological Activities of Astaxanthin Over 50 published studies
AstaREAL Published Study *AstaREAL Patented/Patent Pending
Cardio benefit results
Skin health – Anti-Aging results
Muscle endurance / Muscle recovery
Improves Muscle EnduranceAstaxanthin protects muscle at the cellular level from damage of reactive oxygen species (ROS) generated by physical activity. Astaxanthin improves blood flow and modulates vasorelaxation, protecting the endothelium dependent NO effect and vessel elastin band structure from oxidative damage
Accelerates Body Fat ReductionAstaxanthin enhances fat metabolism by activating mitochondrial enzymes such as 3-hydroxyacyl CoA dehydrogenase (3-HAD)Astaxanthin protects carnitine palmitoyl transferase I (CPT I) from oxidative modification caused by ROS
Reduces Lactic Acid Accumulation-Astaxanthin promotes fatty acid utilization vs glucose metabolism for Mitochondrial ATP production-Astaxanthin reduces peroxidation damage during anaerobic exercise resulting in muscle recovery time improvement
Eye Fatigue results
Our 10 Clinical Studies Demonstrate:
• Increased Retinal Blood Flow• Improved Accommodation• Reduced Asthenopia• Increased Visual Acuity• Ocular Inflammation Reduction
VDT Subjects with Eye Strain Symptoms before and after astaxanthin supplementation (Nagaki et al.,2002)
AstaREAL® astaxanthin patents
No. 6,245,818 Muscle and Physical Endurance - increased physical endurance / reduced muscle damage
No. 6,262,316 Gastric Health - Reduces infection/inflammation of Helicobacter pylori
No. 6,335,015 Mastitis - Prophylactic treatment for mastitis
No. 6,410,602Fertility - Method of increasing the production and improving the quality of semen
No. 6,773,708 Immune System - Immunomodulation - autoimmune diseases and chronic viral and intracellular bacterial infections
No. 6,923,967 Dyspeptic Symptoms - Alleviates dyspeptic symptoms
No. 7,078,040Anti-Inflammation - Cytokine regulation - inhibiting the expression of inflammatory cytokines and chemokines
Patent Pending Eye Fatigue - Reduced eye fatigue / improved visual acuity
Patent Pending Cardiovascular – Alleviating vascular failure
Patent PendingDiabetic Nephropathy - Gene expression modulator – suppression of development of diabetic nephropathy
Molecular Formula: Molecular Formula: CC4040HH5252OO44
Molecular Weight:Molecular Weight: 596.82596.82CAS No: CAS No: 472-61-7472-61-7
O
HO
O
OH
AstaxanthinAstaxanthin
-Carotene-CaroteneO H
O H
• 732 known carotenoids*732 known carotenoids*• Humans cannot Humans cannot
synthesise carotenoids.synthesise carotenoids.• Need to obtain Need to obtain
carotenoids from food.carotenoids from food.• Basic carotene structureBasic carotene structure• Xanthophyll ClassXanthophyll Class - Lutein- Lutein
- - AstaxanthinAstaxanthin isolated and identified fromisolated and identified from lobster lobster Astacus gammarusAstacus gammarus in 1938 by Kuhnin 1938 by Kuhn
*G. Britton et al., Carotenoids Handbook, 2004
Member of the Carotenoid Family
LuteinLutein
• Powerful & Safe Antioxidant- Singlet oxygen quenching- Lipid peroxidation suppressing- Without any pro-oxidative nature
Astaxanthin is a Totally Unique Antioxidant
• Superior Position in Cell Membrane- Protection both hydrophillic & lipophillic area
1. Shimizu et al., Carotenoids as singlet oxygen quenchers in marine organisms, Fisheries Science, 62, 134-137 (1996).2. Nishida et al., Quenching Activities of Common Hydrophilic and Lipophilic Antioxidants against Singlet Oxygen Using Chemiluminescence Detection System, Carotenoid Science.,Vol.11:16-20. (2007)
Astaxanthin is the Most Powerful Quencher of
Singlet Oxygen in Nature
Astaxanthin does not Become Pro-Oxidant Astaxanthin does not Become Pro-Oxidant Even under Enormous Oxidative Stress
H.D.Martin, et al. : Chemistry of carotenoid oxidation and free radical reactions, Pure Appl. Chem., 71(12), 2253-2262 (1999).
Why is Astaxanthin Superior?
Superior Position in Membrane
Beta-carotene
Vitamin C
Astaxanthin
Production
Haematococcus pluvialis cultivation
Production
Haematococcus pluvialis cultivation Vegetative cell Immature Aplanospore Aplanospore
40-80 μ m
Haematococcus Pluvialis Haemato (Blood) Coccus (Seed) Pluvialis (Fresh Water)
Microalgae family – includes Chlorella and Spirulina
Single cell fresh water Microalgae (Plant source)
Found in standing pools and ponds world wide (non-GMO)
During harsh environment conditions – Hibernates
• Open Pond SystemOpen Pond System - Outdoor, susceptible to environmental contaminants- Outdoor, susceptible to environmental contaminants - Difficult to control unwanted foreign algae- Difficult to control unwanted foreign algae - Inconsistent production and yield- Inconsistent production and yield
• Closed SystemClosed System - AstaREAL - AstaREAL Indoor closed tank systemIndoor closed tank system consistently has the highest yield with consistently has the highest yield with the longest history of productionthe longest history of production
Con
c.→ Mature
Chlorophyll Astaxanthin
Mass Production of Haematococcus pluvialis
Closed Tank System
• Most cost effective cultivation• Total environmental control• Highest quality, cleanest system• First in the world to commercially
cultivate Haematococcus pluvialis
• Full Acute & Subchronic Tests NO ADVERSE SIDE EFFECTS
REPORTED
• Ames Test & Gene Toxicity NO ADVERSE SIDE EFFECTS REPORTED
• Worldwide Literature Search NO ADVERSE SIDE EFFECTS REPORTED
Health and Safety
30 Safety Studies. Submitted for GRAS.1/6/2010 received FDA non-objection letter.
6mg is the dose