Download - Bioinformatika pro PřfUK 2001
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Jan PačesÚstav molekulární [email protected]
Jiří VondrášekÚstav organické chemie a [email protected]
http://bio.img.cas.cz/PrfUK2002
Bioinformatikapro PřfUK 2001
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Databáze: obsah
principySQLformáty biologických sekvencíIUB kódyDNA databázeproteinové a genomové databázestrukturní databáze
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organizace databází
Relační databáze
c_id identifikátor, číslo
title text
journal krátký text
year datum
… …
a_id identifikátor
c_id identifikátor
name krátký text
k_id identifikátor
c_id identifikátor
keyword krátký text
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SQL: Structured Query Language
c_id identifikátor, číslo
title text
journal krátký text
year datum
… …
CREATE TABLE article (c_id INTEGER,title TEXT,journal VARCHAR(30),year DATE
);
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SQL: Structured Query Language
CREATE TABLE author (a_id INTEGER,c_id INTEGER,name VARCHAR(30)
);
a_id identifikátor
c_id identifikátor
name krátký text
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SQL: Structured Query Language
INSERT INTO article SET c_id = '1',title = 'Something absolutely fantastic',journal = 'Bioinformatics',year = '2002';
INSERT INTO author SETa_id = '1',c_id = '1',name = 'Paces, Jan';
INSERT INTO author SETa_id = '2',c_id = '1',name = 'Vondrasek, Jiri';
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SQL: Structured Query Language
SELECT article.title,article.journal,author.nameFROM article,journalWHERE article.c_id = author.c_id AND
article.year > '2000' ANDauthor.name LIKE 'Paces%';
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kód nukleotidy komplementA A TC C GG G CT T A(U U) AM AC KR AG YW AT SS CG WY CT RK GT MV ACG BH ACT DD AGT HB CGT VN ACGT N- mezera -
kód třípísmenný kód aminokyselinaA Ala alaninC Cys cysteinD Asp asparagová kyselinaG Glu glutamová kyselinaH His histidinI Ile isoleucinK Lys lysinL Leu leucinM Met methioninN Asn asparaginP Pro prolinQ Gln glutaminR Arg argininS Ser serinT Thr threoninV Val valinW Trp tryptofanY Tyr tyrosinB Asx asparagová kys. nebo
asparaginZ Glx glutamová kys. nebo
glutaminX Xxx jakákoliv
aminokyselina* --- stop
nukleotidy aminokyseliny
IUB kódy
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binární s chromatogramy
pro programy
minimální
anotované
textové
SCFALFABI
interní formáty databází
textfasta
EMBLGenBankASNXML
formáty sekvencí
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SCF (standart chromatogram file)
formáty sekvencí - SCF
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EMBL (formát databáze EMBL)ID AF031150 standard; RNA; ROD; 1379 BP.XXAC AF031150;XXSV AF031150.1XXDT 27-FEB-1998 (Rel. 54, Created)DT 27-FEB-1998 (Rel. 54, Last updated, Version 1)XXDE Mus musculus paired-box transcription factor (Pax4) mRNA, complete cds.XXKW .XXOS Mus musculus (house mouse)OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;OC Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.XXRN [1]RP 1-1379RA Inoue H., Nomiyama J., Nakai K., Matsutani A., Tanizawa Y., Oka Y.;RT Isolation of full-length cDNA of mouse PAX4 gene and identification of itsRT human homologue;RL Biochem. Biophys. Res. Commun. 243:628-633(1998).XXRN [2]RP 1-1379RA Inoue H., Nomiyama J., Nakai K., Tanizawa Y., Oka Y.;RT ;RL Submitted (23-OCT-1997) to the EMBL/GenBank/DDBJ databases.RL Third Dept. of Int. Med., Yamaguchi University, 1144 Kogushi, Ube,RL Yamaguchi 755, JapanXXFH Key Location/Qualifiers…
formáty sekvencí - EMBL
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…FH Key Location/QualifiersFHFT source 1..1379FT /db_xref=taxon:10090FT /organism=Mus musculusFT /cell_line=MIN6FT CDS 297..1346FT /codon_start=1FT /gene=Pax4FT /product=paired-box transcription factorFT /protein_id=AAC40046.1FT /translation=MQQDGLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRFT SLKVSNGCVSKILGRYYRTGVLEPKCIGGSKPRLATPAVVARIAQLKDEYPALFAWEIQFT HQLCTEGLCTQDKAPSVSSINRVLRALQEDQSLHWTQLRSPAVLAPVLPSPHSNCGAPRFT GPHPGTSHRNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRFT AKWRRQEKLKWEAQLPGASQDLTVPKNSPGIISAQQSPGSVPSAALPVLEPLSPSFCQLFT CCGTAPGRCSSDTSSQAYLQPYWDCQSLLPVASSSYVEFAWPCLTTHPVHHLIGGPGQVFT PSTHCSNWPXXSQ Sequence 1379 BP; 327 A; 402 C; 347 G; 303 T; 0 other; aaaaaaaaaa aaaaagcggc cgctgaattc tagcagaagg ctgccctctg ctcctgagtg 60 aaggctctgt gaagctctgg accccctggc aggactgaag cagctggagg ctgttacaag 120 accagaccac cagcaaaccc tggagcctgc acaggaccct gagacctctt cctggaattc 180 ccaccttttt tcctccatcc agaaccagtc ccaaagagaa acttccagaa ggagctctcc 240 gttttcagtt tgccagttgg cttcctgtcc ttctgtgagg agtaccagtg tgaagcatgc 300 agcaggacgg actcagcagt gtgaatcagc tagggggact ctttgtgaat ggccggcccc 360… gctgtgggac agcaccaggc agatgttcca gtgacacctc atcccaggcc tatctccaac 1200 cctactggga ctgccaatcc ctccttcctg tggcttcctc ctcatatgtg gaatttgcct 1260 ggccctgcct caccacccat cctgtgcatc atctgattgg aggcccagga caagtgccat 1320 caacccattg ctcaaactgg ccataagagg cctctatttg acagtaataa aaacctttt 1379//
EMBL (formát databáze EMBL)
formáty sekvencí - EMBL
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GenbankLOCUS AF145233 1360 bp mRNA ROD 23-OCT-1999DEFINITION Mus musculus transcription factor PAX4 (Pax4) mRNA, complete cds.ACCESSION AF145233VERSION AF145233.1 GI:6102607KEYWORDS .SOURCE house mouse. ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.REFERENCE 1 (bases 1 to 1360) AUTHORS Kalousova,A., Benes,V., Paces,J., Paces,V. and Kozmik,Z. TITLE DNA binding and transactivating properties of the paired and homeobox protein Pax4 JOURNAL Biochem. Biophys. Res. Commun. 259 (3), 510-518 (1999) MEDLINE 99294619 PUBMED 10364449REFERENCE 2 (bases 1 to 1360) AUTHORS Kalousova,A., Paces,J. and Kozmik,Z. TITLE Direct Submission JOURNAL Submitted (23-APR-1999) Dept. of Transcription Regulation, Institute of Molecular Genetics, Videnska 1083, Prague 142 20, Czech RepublicFEATURES Location/Qualifiers source 1..1360 /organism="Mus musculus" /db_xref="taxon:10090" gene 1..1360 /gene="Pax4" CDS 211..1260 /gene="Pax4" /note="DNA binding protein; paired box protein; homeobox protein" /codon_start=1 /product="transcription factor PAX4" /protein_id="AAF03533.1"…
formáty sekvencí - GenBank
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CDS 211..1260 /gene="Pax4" /note="DNA binding protein; paired box protein; homeobox protein" /codon_start=1 /product="transcription factor PAX4" /protein_id="AAF03533.1" /db_xref="GI:6102608" /translation="MQQDGLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDIS RSLKVSNGCVSKILGRYYRTGVLEPKCIGGSKPRLATPAVVARIAQLKDEYPALFAWE IQHQLCTEGLCTQDKAPSVSSINRVLRALQEDQSLHWTQLRSPAVLAPVLPSPHSNCG APRGPHPGTSHRNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWF SNRRAKWRRQEKLKWEAQLPGASQDLTVPKNSPGIISAQQSPGSVPSAALPVLEPLSP SFCQLCCGTAPGRCSSDTSSQAYLQPYWDCQSLLPVASSSYVEFAWPCLTTHPVHHLI GGPGQVPSTHCSNWP"BASE COUNT 359 a 381 c 328 g 292 tORIGIN 1 tggcaggact gaagcagctg gaggctgtta caagaccaga ccaccagcaa accctggagc 61 ctgcacagga ccctgagacc tcttcctgga attcccacct tttttcctcc atccagaacc 121 agtcccaaag agaaacttcc agaaggagct ctccgttttc agtttgccag ttggcttcct 181 gtccttctgt gaggagtacc agtgtgaagc atgcagcagg acggactcag cagtgtgaat… 1081 tccagtgaca cctcatccca ggcctatctc caaccctact gggactgcca atccctcctt 1141 cctgtggctt cctcctcata tgtggaattt gcctggccct gcctcaccac ccatcctgtg 1201 catcatctga ttggaggccc aggacaagtg ccatcaaccc attgctcaaa ctggccataa 1261 gaggcctcta tttgacagta ataaaaacct tttcttagat gttaaaaaaa aaaaaaaaaa 1321 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa //
Genbank
formáty sekvencí - GenBank
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fasta>gi|6102607|gb|AF145233.1|AF145233 Mus musculus transcription factor PAX4 (Pax4) mRNA, complete cdsTGGCAGGACTGAAGCAGCTGGAGGCTGTTACAAGACCAGACCACCAGCAAACCCTGGAGCCTGCACAGGACCCTGAGACCTCTTCCTGGAATTCCCACCTTTTTTCCTCCATCCAGAACCAGTCCCAAAGAGAAACTTCCAGAAGGAGCTCTCCGTTTTCAGTTTGCCAGTTGGCTTCCTGTCCTTCTGTGAGGAGTACCAGTGTGAAGCATGCAGCAGGACGGACTCAGCAGTGTGAATCAGCTAGGGGGACTCTTTGTGAATGGCCGGCCCCTTCCTCTGGACACCAGGCAGCAGATTGTGCAGCTAGCAATAAGAGGGATGCGACCCTGTGACATTTCACGGAGCCTTAAGGTATCTAATGGCTGTGTGAGCAAGATCCTAGGACGCTACTACCGCACAGGTGTCTTGGAACCCAAGTGTATTGGGGGAAGCAAACCACGTCTGGCCACACCTGCTGTGGTGGCTCGAATTGCCCAGCTAAAGGATGAGTACCCTGCTCTTTTTGCCTGGGAGATCCAACACCAGCTTTGCACTGAAGGGCTTTGTACCCAGGACAAGGCTCCCAGTGTGTCCTCTATCAATCGAGTACTTCGGGCACTTCAGGAAGACCAGAGCTTGCACTGGACTCAACTCAGATCACCAGCTGTGTTGGCTCCAGTTCTTCCCAGTCCCCACAGTAACTGTGGGGCTCCCCGAGGCCCCCACCCAGGAACCAGCCACAGGAATCGGACTATCTTCTCCCCGGGACAAGCCGAGGCACTGGAGAAAGAGTTTCAGCGTGGGCAGTATCCAGATTCAGTGGCCCGTGGGAAGCTGGCTGCTGCCACCTCTCTGCCTGAAGACACGGTGAGGGTTTGGTTTTCTAACAGAAGAGCCAAATGGCGCAGGCAAGAGAAGCTGAAATGGGAAGCACAGCTGCCAGGTGCTTCCCAGGACCTGACAGTACCAAAAAATTCTCCAGGGATCATCTCTGCACAGCAGTCCCCCGGCAGTGTACCCTCAGCTGCCTTGCCTGTGCTGGAACCATTGAGTCCTTCCTTCTGTCAGCTATGCTGTGGGACAGCACCAGGCAGATGTTCCAGTGACACCTCATCCCAGGCCTATCTCCAACCCTACTGGGACTGCCAATCCCTCCTTCCTGTGGCTTCCTCCTCATATGTGGAATTTGCCTGGCCCTGCCTCACCACCCATCCTGTGCATCATCTGATTGGAGGCCCAGGACAAGTGCCATCAACCCATTGCTCAAACTGGCCATAAGAGGCCTCTATTTGACAGTAATAAAAACCTTTTCTTAGATGTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
formáty sekvencí - FastA
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ASNSeq-entry ::= set { class nuc-prot , descr { title "Mus musculus transcription factor PAX4 (Pax4) mRNA, complete cds." , source { org { taxname "Mus musculus" , common "house mouse" , db { { db "taxon" , tag id 10090 } } , orgname { name binomial { genus "Mus" , species "musculus" } , lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus" , gcode 1 , mgcode 2 , div "ROD" } } } , pub { pub { sub { authors { names std
formáty sekvencí - ASN
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Bioinformatic Links
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GenBank
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Swiss-Prot
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Entrez
Entrez•Literature (PubMed)•Nucleotide (GenBank)•Protein (PIR)•Genome•Structure (PDB)•PopSet•Taxonomy•OMIM
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Entrez
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Entrez
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Entrez
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SRS
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SRS
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SRS
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SRS
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SRS
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SRS
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SRS
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SRS - list
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SRS - list
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SRS - list
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PDB
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PDB
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PDB
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PDBHEADER GENE REGULATION/DNA 22-APR-99 6PAX TITLE CRYSTAL STRUCTURE OF THE HUMAN PAX-6 PAIRED DOMAIN-DNA TITLE 2 COMPLEX REVEALS A GENERAL MODEL FOR PAX PROTEIN-DNA TITLE 3 INTERACTIONS COMPND MOL_ID: 1; COMPND 2 MOLECULE: HOMEOBOX PROTEIN PAX-6; COMPND 3 CHAIN: A; COMPND 4 ENGINEERED: YES; COMPND 5 BIOLOGICAL_UNIT: MONOMER; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: 26 NUCLEOTIDE DNA; COMPND 8 CHAIN: B; COMPND 9 ENGINEERED: YES; COMPND 10 BIOLOGICAL_UNIT: MONOMER; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: 26 NUCLEOTIDE DNA; COMPND 13 CHAIN: C; COMPND 14 ENGINEERED: YES; COMPND 15 BIOLOGICAL_UNIT: MONOMER SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 GENE: PAX6; SOURCE 5 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 6 EXPRESSION_SYSTEM_STRAIN: BL21(DE3); SOURCE 7 MOL_ID: 2; SOURCE 8 SYNTHETIC: YES; SOURCE 9 MOL_ID: 3; SOURCE 10 SYNTHETIC: YES KEYWDS PAX, PAIRED DOMAIN, TRANSCRIPTION, PROTEIN-DNA INTERACTIONS, KEYWDS 2 GENE REGULATION/DNA EXPDTA X-RAY DIFFRACTION AUTHOR H.E.XU,M.A.ROULD,W.XU,J.A.EPSTEIN,R.L.MAAS,C.O.PABO REVDAT 1 13-JUL-99 6PAX 0 JRNL AUTH H.E.XU,M.A.ROULD,W.XU,J.A.EPSTEIN,R.L.MAAS,C.O.PABO JRNL TITL CRYSTAL STRUCTURE OF THE HUMAN PAX-6 PAIRED JRNL TITL 2 DOMAIN-DNA COMPLEX REVEALS SPECIFIC ROLES FOR THE JRNL TITL 3 LINKER REGION AND THE CARBOXY-TERMINAL SUBDOMAIN JRNL TITL 4 IN DNA BINDING
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PDBSEQRES 1 A 133 SER HIS SER GLY VAL ASN GLN LEU GLY GLY VAL PHE VAL SEQRES 2 A 133 ASN GLY ARG PRO LEU PRO ASP SER THR ARG GLN ARG ILE SEQRES 3 A 133 VAL GLU LEU ALA HIS SER GLY ALA ARG PRO CYS ASP ILE SEQRES 4 A 133 SER ARG ILE LEU GLN VAL SER ASN GLY CYS VAL SER LYS SEQRES 5 A 133 ILE LEU GLY ARG TYR TYR ALA THR GLY SER ILE ARG PRO SEQRES 6 A 133 ARG ALA ILE GLY GLY SER LYS PRO ARG VAL ALA THR PRO SEQRES 7 A 133 GLU VAL VAL SER LYS ILE ALA GLN TYR LYS GLN GLU CYS SEQRES 8 A 133 PRO SER ILE PHE ALA TRP GLU ILE ARG ASP ARG LEU LEU SEQRES 9 A 133 SER GLU GLY VAL CYS THR ASN ASP ASN ILE PRO SER VAL SEQRES 10 A 133 SER SER ILE ASN ARG VAL LEU ARG ASN LEU ALA SER GLU SEQRES 11 A 133 LYS GLN GLN SEQRES 1 B 26 A A G C A T T T T C A C G SEQRES 2 B 26 C A T G A G T G C A C A G SEQRES 1 C 26 T T C T G T G C A C T C A SEQRES 2 C 26 T G C G T G A A A A T G C FORMUL 4 HOH *84(H2 O1) HELIX 1 1 ASP A 20 HIS A 31 1 12 HELIX 2 2 PRO A 36 LEU A 43 1 8 HELIX 3 3 ASN A 47 THR A 60 1 14 HELIX 4 4 PRO A 78 GLU A 90 1 13 HELIX 5 5 ALA A 96 SER A 105 1 10 HELIX 6 6 VAL A 117 GLU A 130 1 14 SHEET 1 A 2 SER A 3 VAL A 5 0 SHEET 2 A 2 VAL A 11 VAL A 13 -1 N PHE A 12 O GLY A 4 CRYST1 33.840 61.686 171.111 90.00 90.00 90.00 P 21 21 21 4 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.029551 0.000000 0.000000 0.00000 SCALE2 0.000000 0.016211 0.000000 0.00000 SCALE3 0.000000 0.000000 0.005844 0.00000 ATOM 1 N SER A 1 -1.985 -12.356 81.201 1.00 60.11 N ATOM 2 CA SER A 1 -1.709 -12.440 82.636 1.00 60.41 C ATOM 3 C SER A 1 -2.774 -13.282 83.373 1.00 59.35 C ATOM 4 O SER A 1 -3.734 -13.763 82.751 1.00 58.16 O ATOM 5 CB SER A 1 -1.638 -11.029 83.229 1.00 64.08 C ATOM 6 OG SER A 1 -2.862 -10.345 83.045 1.00 69.46 O ATOM 7 H SER A 1 -2.431 -11.538 80.917 1.00 40.00 H ATOM 8 HG SER A 1 -2.887 -9.549 83.596 1.00 40.00 H ATOM 9 N HIS A 2 -2.634 -13.393 84.701 1.00 59.45 N
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SCOP
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PDBsum
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PDBsum
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PDBsum
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CATH
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CATH
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FSSP - Fold classification
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Structural genomics
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Bioinformatické WWW rozcestníky
EBI: http://www.ebi.ac.uk/ToolsExpasy: http://www.expasy.chPasteur: http://bioweb.pasteur.frLyon: http://pbil.univ-lyon1.frNCBI: http://ncbi.nlm.nih.gov
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EBI
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ExPASy
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PBIL
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Pasteur
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Bioinformatic Links