Comparison of ThinPrep cytology and conventional
cytology in bronchial washing
Gachon University Gil Hospital Seung Yeon Ha
서 론• Diagnosis of Lung Cancer
• Cytology– Bronchial washing– Conventional cytology– ThinPrep
재료 및 방법• 2009.03. – 2011.05. Bronchial wahs-
ing Conventional cytology+ThinPrep = 2551 예
• 임상적 폐암 + 조직검사 = 148 예
결 과 1
• 조직진단 폐암 확진 = 124 예 조직진단 정상 확진 = 24 예 • 세포진단 : 폐암 = 116 예
Cytologic Di-agnosis
Cytospin ThinPrep
Negative 24 9
Atypia 38 31
Malignant 53 79
Cellularity Cytospin ThinPrep
0-1 20 8
2 3 1
3 1 0
Cy-tospin
Thin-Prep
결 과 2
• 조직진단Histologic Diagnosis To-
tal
Cytologic Dx
Squamous cell carcinoma 49 47
Adenocarcinoma 41 39
Small cell carcinoma 20 19
Large cell carcinoma 2 2
Poorly differentiated carci-noma
2 2
Large cell neuroendocrine carcinoma
2 2
Dx(%)
95.9
95.9
95
결 과 3
• 조직 검사에 따른 각 방법의 결과 : Conventional cytology
HistologyNega-tive
Atypi-cal
Malig-nant
Total
Squmaous cell carci-noma
9 20 20 49
Adenocarcinoma 10 11 20 41
Small cell carcinoma 3 7 10 20
Large cell carcinoma 1 0 1 2
Others 0 0 3 3
결 과 3
• 조직 검사에 따른 각 방법의 결과 : ThinPrep
HistologyNega-tive
Atypi-cal
Malig-nant
Total
Squmaous cell carci-noma
2 16 31 49
Adenocarcinoma 2 10 29 41
Small cell carcinoma 0 4 16 20
Large cell carcinoma 0 0 2 2
Others 0 0 3 3
Cy-tospin
결 과 4
• Conventional Cytology 결과 : Atypical 38 예
Histologic Dx Cytologic Dx(ThinPrep)Normal Atypical Ma-lignant
Squamous cell carci-noma
1 11 8
Adenocarcinoma 0 7 5
Small cell carcinoma 0 2 3
Large cell neuroen-docrine carcinoma
0 0 1
Total 1 20 17
결 과 4
• ThinPrep 결과 : atypical 31 예
Histologic Dx Cytologic DxNormal Atypical Ma-lignant
Squamous cell carci-noma
5 11 0
Adenocarcinoma 4 7 0
Small cell carcinoma 1 2 1
Total 10 20 1
결 과 4
• Sensitivity and Specificity
Conventional Cytology
Sensitivity (%) Speici-ficity(%)
ThinPrep
Sensitivity (%) Speici-ficity(%)
79.1 96.9 95.7 94.1
논 문 1• 209 명 , SurePath
논 문 2• 197 명 , ThinPrep
감사의 말씀
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