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LIST OF PROTEINS
4-1BBL
4-1BB Receptor
6 Ckine
ACAD8
ACAT2
gAcrp30/Adipolean
Activin A
ACY1
ADAT1
Adiponectin
ADRP
AITRL
Akt1
Alpha-Feto Protein (AFP)
Alpha-Galactosidase A
Angiopoietin-1 (Ang-1)
Angiopoietin-2 (Ang-2)
Angiostatin K1-3
Annexin-V
apo-SAA
Apoliprotein A-1
Apoliprotein E2
Apoliprotein E3
Apoliprotein E4
APRIL
Artemin
ATF2
Aurora A
Aurora B
BAFF
BAFF Receptor
BCA-1 / BLC / CXCL13
BCMA
BD-1
BD-2
BD-3
BDNF
Bivalirudin
BMP-2
BMP-4
BMP-7
BMP-13
sBMPR-1A
Brain Natriuretic Protein
BRAK
Breast Tumor Antigen
C5a
C5L2 Peptide
C-10
C-Reactive Protein
C-Src
Calbindin D-9K
Calbindin D-28K
Calbindin D-29K
Calmodulin
Calcitonin Acetate
Carbonic Anhydrase III
Carcino-embryonicAntigen
Cardiotrophin-1
Caspase-3
Caspase-6
CD4
CD14
CD22
CD40 Ligand / TRAP
CD95 / sFas Ligand
CD105 / Endoglin
CHIPS
CNTF
Collagen
CREB
CTACK/CCL27
CTGF
CTGFL/WISP-2
CTLA-4/Fc
CXCL16
Cytokeratin 8
DEP-1
Desmopressin
Disulfide Oxidoreductase
E-selectin
ECGF
EGF
Elafin/SKALP
EMAP-II
ENA-78
Endostatin
Enteropeptidase
Eotaxin
Eotaxin-2
Eotaxin-3 (TSC)
EPHB2
EPHB4
Eptifbatide
Erk-2
Erythropoietin (EPO)
Exodus-2
Fas Ligand
Fas Receptor
FGF-1 (acidic)
FGF-2 (basic)
FGF-4
FGF-5
FGF-6
FGF-7/ KGF
FGF-8
FGF-9
FGF-10
FGF-16
FGF-17
FGF-18
FGF-19
FGF-20
sFGFR-1 (IIIc) / Fc Chimera
sFGFR-2 (IIIc) / Fc Chimera
sFGFR-3 / Fc Chimera
sFGFR-4 / Fc Chimera
sFlt-1 (native)
sFlt-1 (D3)
sFlt-1 (D4)
sFlt-1 (D5)
sFlt-1 (D7)
Flt3-Ligand
sFlt-4
sFlt-4/ Fc Chimera
Follistatin
FSH
Fractalkine/ CX3C
G-CSF
α-Galactosidase A
Galectin-1
Galectin-3
Gastrointestinal CA
GCP-2
GDF-3
GDF-9
GDF-11
GDNF
GLP-1
Glucagon
Goserelin
GM-CSF
GPBB
GROα
GROβ
GROγ
GRO/MGSA
Growth Hormone
Growth Hormone BP
GST-p21/WAF-1
HB-EGF
HCC-1
HGF
Histdyl-tRNA synthetase
Histrelin
HRG1-β1
I-309
I-TAC
IFN-α
IFN-α A
IFN-α 2a
IFN-α 2b
IFN-β
IFN-γ
IFN-Omega
IGF-I
IGF-II
proIGF-II
IGFBP-1
IGFBP-2
IGFBP-3
IGFBP-4
IGFBP-4
IGFBP-5
IGFBP-6
IGFBP-7
IL-1α
IL-1β
Browse our web site of recombinantproteins, including cytokines, growthfactors, chemokines and neurotrophins.Daily shipping and competitive pricing areoffered. Bulk quantities of many proteinsavailable. Cell Sciences also carries
corresponding antibodies and ELISA kits.
IL-2
IL-3
IL-4
sIL-4 Receptor
IL-5
IL-6
sIL-6 Receptor
IL-7
IL-8 (72 a.a.)
IL-8 (77 a.a.)
IL-9
IL-10
IL-11
IL-12
IL-13
IL-13 analog
IL-15
IL-16 (121 a.a.)
IL-16 (130 a.a.)
IL-17
IL-17B
IL-17D
IL-17E
IL-17F
IL-19
IL-20
IL-22
IL-31
Insulin
IP-10
JE
JNK2a1
JNK2a2
KC / CXCL1
KGF
L-asparaginase
LAG-1
LALF Peptide
LAR-PTP
LC-1
LBP
LD-78β
LDH
LEC/NCC-4
Leptin
LIGHT
LIX
LKM
LL-37
Lymphotactin
sLYVE-1
M-CSF
MCP-1 (MCAF)
MCP-2
MCP-3
MCP-4
MCP-5
MDC (67 a.a.)
MDC (69 a.a.)
MDH
MEC
Mek-1
MIA
Midkine
MIG / CXCL9
MIP-1α / CCL3
MIP-1β / CCL4
MIP-3 / CCL23
MIP-3α / CCL20
MIP-3β / CCL19
MIP-4 (PARC) / CCL18
MIP-5 / CCL15
MMP-3
MMP-7
MMP-13
Myostatin
Nanog
NAP-2
Neurturin
NFAT-1
beta-NGF
NOGGIN
NOV
NP-1
NT-1/BCSF-3
NT-3
NT-4
Ocreotide
Oncostatin M
Osteoprotegerin (OPG)
OTOR
Oxytocin
p38-α
Parathyroid Hormone
PDGF-AA
PDGF-AB
PDGF-BB
Persephin
PF-4
PIGF-1
PIGF-2
PKA α-subunit
PKC-α
PKC-γ
Pleiotrophin
PLGF-1
Polymyxin B (PMB)
PRAS40
PRL-1
PRL-2
PRL-3
Prokineticin-2
Prolactin
Protirelin
PTHrP
PTP1B
PTP-IA2
PTP-MEG2
PTP-PEST
sRANK
sRANKL
RANTES
RELM-α
RELM-β
Resistin
RPTPβ
RPTPγ
RPTPμ
SCF
SCGF-α
SCGF-β
SDF-1α
SDF-1β
Secretin
SF20
SHP-2
STAT1
c-Src
TACI
TARC
TC-PTP
TECK
TFF2
TGF-α
TGF-β1
TGF-β2
TGF-β3
Thymosin α1
sTIE-1/Fc Chimera
sTIE-2/Fc Chimera
TL-1A
TNF-α
TNF-β
sTNFR1
sTNFR2
TPO
TRAIL/Apo2L
sTRAIL R-1 (DR4)
sTRAIL R-2 (DR5)
TSH
TSLP
TWEAK
TWEAK Receptor
Urokinase
VEGF121
VEGF145
VEGF165
VEGF-C
VEGF-C I525
EG-VEGF
VEGF-E
HB-VEGF-E
sVEGFR-1
sVEGFR-2
sVEGFR-3
WISP-1
WISP-2
WISP-3
WNT-1
www.millipore.com/easyCyte5
With the new easyCyte™single-sample flow cytometer,more = less.
+ MORE PARAMETERS
+ MORE ANALYTICS
+ MORE INSIGHTFUL DATA
+ MORE BENCHTOP SPACE
+ MORE SIMPLICITY
+ MORE SOLUTIONS
= LESS $$$
EMD Millipore is a division of Merck KGaA, Damstadt, Germany
The new line of easyCyte™ single-sample flow cytometry
instruments provides all the advantages and quality of the
EMD Millipore guava® solution in an affordable single-sample
device. With up to 8 parameters and 2 lasers, you have more
analytical power, better quality data, validated reagents and
full service support. You would expect to pay more for a
similar instrument, but with the new easyCyte single-sample
solution, more = less.
EMD Millipore and the M logo are trademarks of Merck KGaA, Darmstadt, Germany. easyCyte is a
trademark of Millipore Corporation. © 2011 Millipore Corporation. All rights reserved.
GE HealthcareLife Sciences
Confidencecomes withthe rightinteractions.Join leading scientists from academia and
industry at Developments in Protein Interaction
Analysis (DiPIA), November 12-15, Boston,
Massachusetts, USA.
This scienti�c conference o�ers opportunities
to meet and discuss the latest developments in
label-free interaction and stability analysis using
Biacore™ Surface Plasmon Resonance (SPR) and
MicroCal™microcalorimetry systems.
Register at www.gelifesciences.com/dipia
© 2011 General Electric Company – All rights reserved.GE Healthcare Bio-Sciences AB, Björkgatan 30,
751 84 Uppsala, SwedenK11074. First published May 2011.
To find your local sales office, visitwww.bio-rad.com/contact/
In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723)Visit us at www.bio-rad.com
That’s qquuuaannnttfifififiddeeennnt.
The ChemiDoc™ MP imager can do it all – chemiluminescence,
multiplex fluorescence, routine gel imaging, and more.
■ Superior sensitivity — no need to go back to film
■ Uncompromising image quality — publication-ready images in seconds
■ Versatility and reliability — always meets your laboratory needs
■ Stain-free technology — visualize proteins at every stage of your western
blot experiment, without staining
The new ChemiDoc MP imager operates simply, integrates seamlessly
in your workflow, and offers unmatched versatility. To learn more about
the ChemiDoc MP imager visit www.biorad.com/ad/western.
RReesseeaarccchh. TTToogeettheerrr.
Because resultsalways matter.
IMAGING // CHEMIDOC MP IMAGER SYSTEM
Perform an Apples-to-Apples
Comparison to any
384-Well PCR System
LightCycler® 480 Real-Time PCR System
Does Life Technologies’ launch of the new ViiA 7 Real-Time PCR System
have you seeking a replacement for your 384-well system? Before rushing into
any purchase, check out the time-tested, peer-published LightCycler® 480
Real-Time PCR System from Roche Applied Science — the 384-well solution
of choice for hundreds of researchers during the past five years.
� Generate consistent, reliable data—without Rox dye. Why rely on Rox dye
to normalize data between wells? Achieve reproducible results well-to-well
and between runs through the LightCycler® 480 System’s greater temperature
homogeneity (Figure 1).
� Readily integrate the LightCycler® 480 System into your lab’s robotics.
Why limit your automation choices to only the one robot supplied by your
qPCR instrument manufacturer?
� Rely on >900 publications and your colleagues’ experience with our
service. Ask any LightCycler® 480 System owner about the ongoing
customer support you can expect.
Compare the LightCycler® 480 System to any 384-well system — old or new.
Call 800 262 4911 or visit www.roche-applied-science.com/usa/compare
to learn more.
For life science research only.Not for use in diagnostic procedures.
LIGHTCYCLER is a trademark of Roche.
Other brands or product names are trademarks of their respective holders.
© 2011 Roche Diagnostics. All rights reserved.
Figure 1: Influence of the Therma-Base layer on
temperature homogeneity across a 384-well
plate. (a): LightCycler® 480 Real-Time PCR System
including Therma-Base; (b): 384-well plate on
Applied Biosystems 7900HT without Therma-Base.
Data generated at Roche Applied Science.
Tm
Tm
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21 PK
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Columns Rows
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Roche Diagnostics Corporation
Roche Applied Science
Indianapolis, Indiana
Your local distributor www.eppendorf.com/worldwide · Application Support: [email protected]
Eppendorf AG · Germany · Tel: +49 40 538 01-0 · Eppendorf North America, Inc. · USA · Tel: +1 800 645 3050
Eppendorf Asia Pacific Headquarters · Malaysia · Tel: +60 3 8023 2769
Laboratory consumables can affect bioassays!
Reaction tubes for storing and processing samples
should be selected carefully as they can influence the
quality and reproducibility of your entire workflow.
Original Eppendorf Tubes are produced without additives
that have been shown to influence bioassay results, offer
proven mechanical stability, superior technical perfor-
mance and batch certified purity levels.
Original Eppendorf Tubes® :
Developed with your research results in mind!
‡ No slip agents, no plasticizers or biocides used at
any time of the production process
‡ No leaching of UV-absorbing substances that can
affect DNA quantifications
‡ Automated manufacturing under clean-room conditions
to eliminate human interaction as source for contamination
Experience Eppendorf quality consumables and
order your free sample on:
www.eppendorf.com/consumables
Go for Unaffected Assay Results!Choose the right tubes for your experiments
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Eppendorf Consumables – it’s Your sample
online • forum •mass media • public policy • interactive • society • science fair • exhibit • discussion • invworkshop • interview • television • film • public • radio • blog • festival • hands-on •museum • brainstorm
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tual platform • Web2.0 • deliberate • participation • dialogue • engage • informal science educationpublic outreach • social media • science café • online • forum • mass media • public policy • interactivsociety • science fair • exhibit • discussion • involve • workshop • interview • television • film • publicadio • blog • festival • hands-on • museum • brainstorm • motivate • mutual learning • listen • buildexperiment • contribute • learn • active • virtual platform • Web2.0 • deliberate • participation • dialogueengage • informal science education • public outreach • social media • science café • online • forum
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deliberate • participation • dialogue • engage • informal science education • public outreach • socialmedia • science café • online • forum • mass media • public policy • interactive • society • science fairexhibit • discussion • involve • workshop • interview • television • film • public • radio • blog • festivhands-on • museum • brainstorm • motivate • mutual learning • listen • build • experiment • contributelearn • active • virtual platform • Web2.0 • deliberate • participation • dialogue • engage • informal scienceeducation • public outreach • social media • science café • online • forum • mass media • public policyinteractive • society • science fair • exhibit • discussion • involve • workshop • interview • television • filmpublic • radio • blog • festival • hands-on •museum • brainstorm •motivate •mutual learning • listen • buildexperiment • contribute • learn • active • virtual platform •Web2.0 • deliberate • participation • dialogue
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Nominations are open now through October 15 for the AAAS EarlyCareer Award for Public Engagement with Science.With thisaward, AAAS recognizes early-career scientists and engineers whodemonstrate excellence in their contribution to public engagementwith science activities. The award recipient will receive a monetaryprize of $5,000, a commemorative plaque, and complimentaryregistration and reimbursement of travel expenses to the 2012AAAS Annual Meeting in Vancouver, B.C.
For eligibility information and instructions on submittingnominations, visitwww. aaas.org/go/PESaward.
AAAS Early Career Award forPublic Engagement with Science
... how do YOU engage?
LIFE SCIENCE TECHNOLOGIES
NEW PRODUCTS
AAAS/Science Business Office FeatureLIFE SCIENCE TECHNOLOGIES
NEW PRODUCTS
1320 2 SEPTEMBER 2011 VOL 333 SCIENCE www.sciencemag.org/products
Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are
featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or
materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.
Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.
SMALL RNA SEQUENCING KIT
The NEXTfl ex Small RNA Sequencing Kit provides an easy,
fl exible, cost-effective solution for generating small RNA libraries
using Illumina GAIIx and HiSeq 2000 sequencing platforms. The
NEXTfl ex Small RNA Sequencing Kit incorporates AIR Ligase,
a truncated T4 RNA Ligase, which signifi cantly increases the
effi ciency with which small RNAs are tagged with an adapter,
giving greater sequence depth. Strand-specifi c adapter ligation
of the RNA enables directional sequencing, making it compatible
with mRNA-seq protocols. The new protocol is also designed to
signifi cantly reduce adapter dimer formation prevalent in other
library preparation protocols. In combination with the NEXTfl ex
Small RNA Barcode Primer Kits, 48 samples can be profi led and
studied simultaneously. The ability to pool samples in an effi cient
way signifi cantly decreases hands-on time while providing robust
data quality.
Bioo Scientifi c
For info: 888-208-2246 www.biooscientifi c.com
CELL GROWTH MICROPLATES
BactiGrowth plates provide an optimal microplate solution to en-
able high yield growth of bacteria, yeast, mammalian, or insect
cell lines. Every batch of BactiGrowth plates is rigorously tested
to validate their contamination-free status, ensuring reproduc-
ibility and maintaining the users’ confi dence in the cells that
are grown. BactiGrowth plates are available in a choice of well
formats (24-, 96- and 384-well) and well volumes from 300 µl
to 10 ml per well to suit most cellular growth applications. Pro-
duced under Class 10,000 clean room conditions from ultra-pure
grade polypropylene, BactiGrowth plates contain no molding or
polymer contaminants that may leach out and affect cell growth.
BactiGrowth plates are supplied in packs of fi ve plates with tight
fi tting lids sealed in a virgin polymer bag.
Porvair Sciences
For info: +44-1932-240255 www.porvair-sciences.com
ANGIOGENESIS ASSAYS
Directed In Vivo Angiogenesis Assay (DIVAA) kits address the
AUTOMATED PATCH CLAMP The CytoPatch Instrument is a fully automated device for gigaseal patch clamp
measurements in the whole-cell confi guration. The instrument is the fi rst automated
patch clamp platform in which the patch clamp process takes place inside a sophisticated,
three-dimensional quartz glass microchip with integrated microfl uidic channels. This
chip technology, in combination with a unique perfusion system, is best suited for
measuring the inhibitory effects of slowly acting compounds or measuring very fast
activating and desensitizing ligand-gated ion channels. Each instrument is equipped
with its own patch clamp amplifi er and advanced perfusion system along with its own
cell, buffer, and compound supply. One CytoPatch Instrument can perform either as a
stand-alone device or as a multiple-unit system in which up to 20 individual instruments
can be connected on a network. The CytoPatch Instrument generates gigaseals without
the need for seal-enhancing chemicals, offering higher fl exibility for study design.
Cytocentrics For info: +49-(0)-381-440388-40 www.cytocentrics.com
shortcomings of the traditional plug assay by controlling the
site for angiogenesis, increasing reproducibility, conserving
test compounds, and supplying more statistical data for quan-
titative analysis. This range of kits is designed to test for acti-
vation, inhibition, and tube formation. The kits provide implant
grade silicone cylinders closed at one end, called angioreactors.
The angioreactors are fi lled with 20 microlitres of AMSBIO’s
Basement Membrane Extract (BME) premixed with or without
angiogenesis-modulating factors. These angioreactors are then
implanted subcutaneously in the dorsal fl anks of nude mice.
With the onset of angiogenesis, cellular vascularization pro-
ceeds to invade the angioreactor, and as early as nine days post-
implantation there are enough cells to determine an effective
dose response to angiogenic modulating factors. The DIVAA Kit
is provided with FITC-Lectin for fl uorescent quantitative analy-
sis. Optional protocols are available for analysis with Calcein-AM
and Dextran-FITC.
AMS Biotechnology
For info: +44-1235-828200 www.amsbio.com
ORGANIC AGAROSE GEL
CleverGEL is a new high-grade, more environmentally friendly
agarose for nucleic acid electrophoresis techniques that is
suitable for routine analysis of nucleic acids and is manufactured
using an organic, more environmentally friendly solvent-free
process. CleverGEL’s high resolving capacity across a wide
range of fragment sizes, standard gelling-melting temperatures,
low electroendosmosis, and high resolution results in gels
showing clear and sharp bands, even with small fragments.
Finally, its high gel strength enables easy handling of gels and
compatibility with blotting techniques. CleverGEL from CSL
is available in volumes from 5 g up to 5,000 g and is part of a
range of electrophoresis reagents and consumables that include
buffers, RNAse-freewater, ready-to-use DNA markers, and GelX
disposable gel excision tips.
Cleaver Scientifi c
For info: +44-(0)-1788-565-300 www.cleaverscientifi c.com
Produced by the Science/AAAS Custom Publishing Office
STEMCELLIMAGING:Tips,Tricks, &Best Practices
WEBINAR
The pluripotent nature of stem cells allows them to
divide an apparently unlimited number of times and
develop into many different cell types. Stem cells
can serve as an internal repair system for a range of
tissues, differentiating into cells with specialized
functions. This makes them of particular interest to
researchers looking to use stem cells to treat—
and cure—a number of disorders, including neuro-
degenerative diseases, heart disease, and spinal
cord injuries. To investigate how stem cells function
in vitro and in vivo and react to internal and external
stimuli, researchers require robust methodologies
and accurate imaging capabilities for analysis. In
this webinar, our panel of experts will focus on best
practices for the manipulation and imaging of stem
cells in the laboratory, and explain how they have
successfully applied the latest imaging solutions to
advance our understanding of stem cells and their
application in disease treatment.
Wednesday, September 21, 201112 noon Eastern • 9 a.m. Pacific • 4 p.m. GMT • 5 p.m. UK
SPONSORED BY
Brought to you by the Science/AAAS
CustomPublishing Office
Register NOW to participate. Join our
panel of experts in a live discussion.
Questions can be submitted live to the panel
during the webinar or in advance via e-mail
providedwith registration. To register, visit
www.sciencemag.org/webinar
PARTICIPANTS:
Clemens Cabernard, Ph.D.Biozentrum, University of BaselBasel, Switzerland
Weibo Cai, Ph.D.University of Wisconsin-MadisonMadison, WI
Third Speaker To be Announced
During the webinar, viewers will:
• Learn how to maintain cell viability during imaging
• Obtain tips for fluorescent imaging of stem cells
• Hear how to optimize conditions for time-lapseimaging of stem cells
• Be able to ask questions of the panel live!
bioediting
Bioaccess.Permanently knockout any human, mouse or rat gene with
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mouse and rat genomes. A proven technology with validated
Knockout ZFNs for nearly 60,000 genes.
Create knockout cell lines or animal models
for research with con�dence
sigma.com/knockout
©2011 Sigma-Aldrich Co. LLC. All rights reserved. SIGMA and SIGMA-ALDRICH are trademarks of Sigma-Aldrich Co.LLC, registered in the US and other countries. CompoZr is a registered trademark of Sigma-Aldrich Co. LLC.Where bio begins is a trademark of Sigma-Aldrich Co. LLC.