HEMICELL™ HT FOR BROILERS
β-MANNANS IN VEGETABLE FEED ARE A HOT TOPIC.
Trigger innateimmune system9
Increase gut viscosity71 3
2 4 Viewed by body aspathogens (PAMP response)2,3,10
Cause intestinal inflammation8
WASTES UP TO $11.50/MT FEED
Cause 3% loss offeed engery2,3,10
β-mannans are strong anti-nutritive fibers.4
• Polysaccharide fibers typically with a mannose backbone & galactose sidechains1
• Found in most vegetable feed ingredients5 such as soybean, sunflower and guar meals
• Highly soluble
• Not digestible by non-ruminant animals
• More harmful in challenge periods6
• Amount in typical broiler diets varies from 0.2% - 0.4%* * Depending on feed ingredients
Adverse effects from β-mannan can be reversed.Hemicell™ (β-mannanase) is a health-focused, nutrient-sparing enzyme that breaks down β-mannans in various feedstuffs
• Reduces cost of feeding by using an energy matrix value of up to 90 kcal/kg12,13
• Improves Intestinal Integrity (I2) Index by 1%14
• Reduces severe foot pad lesions by 5%14
β-mannans are immunogenic compounds that hurt your flock and your bottom line.
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Hemicell™ Use RecommendationsHemicell™ HT is a unique, patented enzyme produced by fermentation of Paenibacillus lentus bacteria. The active ingredient is endo-1,4-β-Mannanase.
Use Hemicell™ HT in diets containing at least 0.2% soluble β-mannan.
Species: Broilers Turkeys Swine
Energy Reduction: Formulate Hemicell™ HT to spare up to90 kcal ME (63 kcal NE) per kg of complete feed
Recommended Inclusion:
PRODUCT (form) RECOMMENDED INCLUSION PER TONNE
OF COMPLETE FEED
Broilers Turkeys Weaned Pigs Pigs for Fattening
Hemicell™ HT (liquid)
Hemicell™ HT (dry)
90 ml 82 ml90 ml 80 ml
330 g 330 g 300 g 300 g
HEMICELL™ HT
WITHSTANDSpH FLUCTUATIONSOF THE DIGESTIVE
SYSTEM
WITHSTANDSHEAT FROM
FEED PELLETING
WITHSTANDSDESTRUCTIVE
FORCES OFGASTROINTESTINAL
PROTEASES
1 Whistler RL et al J Am Chem Soc 1957 6055 . “Galactomannan From Soy Bean Hulls.” J. Am. Chem. Soc. 79: 6055-6057.2 Spurlock ME J Anim Sci 1997 1773. “Regulation of Metabolism and Growth During Immune Challenge: An Overview of Cytokine Function.” J. Anim. Sci. 75: 1773-1783. 3 Gabler NK et al J Anim Sci 2008 E64. “Integrating the Immune System with the Regulation of Growth and Effi ciency.” J. Anim. Sci. 86: E64-E74.4 Anderson DM et al Poult Sci 2008 159. “Identifi cation of an Infl ammatory Compound for Chicks in Soybean Meal-II.” Poultry Science 2008; 87: 159.5 Ferrel J et al Poster Presented at the MidWest ASAS 2014. “Content of Soluble Non-Starch Polysaccharides β-mannan and Xylan in Legume Meals, Non-Legume Meals, and Cereal Grains or Cereal Grain by-products.” Poster presented at the MidWest ASAS - Journal Animal Science, 92 2014; n/a: 328.6 Hsiao HY et al Int Poult Sci Form 2004 1790. “Effi cacy of β-mannanase (Hemicell™) in Broiler Chickens Infected with Necrotic Enteritis.” International Scientifi c Forum, Abstract 120, The Southern Conference on Avian Diseases.7 Latham RE et al, 1 February 2018, Poultry Sci 2018 549. “Effi cacy of β-mannanase on Broiler Growth Performance and Energy Utilization in the Presence of Increasing Dietary Galactomannan.” Poultry Science, Volume 97, Issue 2.8 Ikegami S et al J Nutr 1990 353. “Effect of Viscous Indigestible Polysaccharides on Pancreatic-Biliary Secretion and Digestive Organs in Rats.” Journ. of Nutrition. 120: 353-360. 9 Geneic NO et al Int Poultry Sci Forum Georgia World Cong Center 2015 54. “Effect of Hemicell™ HT Enzyme on the Immune System of Chickens and their Performance.” International Poultry Scientifi c Forum.10 Klasing KC Br Poultry Sci 2007 525. “Nutrition and the Immune System.” Br. Poult. Sci. 48(5): 525-537.11 Hsiao, H-Y., Anderson, D.M., Liu, L., and Jackson, M. 2010. “A Heat-tolerant β-mannanase: Its Biochemical Properties and Effect on Broiler Growth Performance.” J. Anim. Sci. 88, E-Suppl. 2.12 van Eerden, E. et al, 2014. “Effect of Hemicell™ on Production Performance and Clinical Scores in Broiler Chickens.” Elanco DoF Evaluate effect of Hemicell™ HT 2013 Trial PPG-53. Report no. 1366.13 Knox, A. 2009. “To Evaluate the Effi cacy of Hemicell™-L and Hemicell™-HT in Broilers Fed on Pelleted Diets Based on Wheat and Soybean Meal.” ChemGen Corp Roslin-Chemgen Broiler Trial 12 Nov 2009 Trial code 2009/3018. Roslin Nutrition Ltd., Scotland. 14 Poulsen K et al DoF Effects of β-Mannanase 2018. “Effects of β-Mannanase on Intestinal Health Analyzed in 30 Experience from EMEA.” Elanco Animal Health. Data on fi le.
Pelleting process addsheat & moisture
Pelleting interfereswith enzymes
At 88°C, Hemicell™ HTretains 95% activity11
(Fig. A)
1
2
3
Enzymes need time atoptimal pH to work.
The optimal pH ofHemicell™ HT matches intestinal pH (Fig. B)
1
2
Hemicell™ HT demonstrated up to91% residual activity after one hourin conditions simulating thestomach/gizzard11 (Fig. C)
In 3 out of 4 treatments, theHemicell™ HT that survived the uppertract retained all of its activity inthe lower tract11
pH
Fig. A Fig. B Fig. CHemicell™ HT
(Fig. A) Hemicell™ HT
A unique & patented feed enzyme specially formulated for pelleted diets thatdefi es a gauntlet of external and internal threats
Elanco Animal HealthPapendorpseweg 83, 3528 BJ Utrecht, Nederland - Plantin en Moretuslei 1a, B-2018 Antwerpen, België [email protected] - www.elanco.com
HemicellTM HT β-mannanase: Versterker verteerbaarheid (zoötechnisch voedseladditief) met gegarandeerd minstens 160 miljoen eenheden endo-1,4-β-mannanase (EC 3.2.1.78) per kg pro-duct Paenibacillus lentus. Europees identifi catienummer: 4a29. Lees voor gebruik de product-informatie. Verantwoordelijke: BE: Eli Lilly Benelux N.V., division Elanco Animal Health, Markies-straat 1, 1000 Brussel (αBE2234), +32 3 334 30 00. NL: Elanco Animal Health, Division of Eli Lilly Nederland BV, Postbus 8580, 3503 RN Utrecht (αNL13196) +31 30 307 92 45
HemicellTM HT-L β-mannanase: Versterker verteerbaarheid (zoötechnisch voedseladditief) Gega-randeerd minstens 590.000 eenheden endo-1,4-β-mannanase (EC 3.2.1.78) per ml product Pae-nibacillus lentus. Europees identifi catienummer: 4a29. Lees voor gebruik de productinformatie.Verantwoordelijke: BE: Eli Lilly Benelux N.V., division Elanco Animal Health, Markiesstraat 1, 1000 Brussel (αBE2234), +32 3 334 30 00. NL: Elanco Animal Health, Division of Eli Lilly Nederland BV, Postbus 8580, 3503 RN Utrecht (αNL13196) +31 30 307 92 45
Hemicell, Elanco, and the diagonal bar logo are trademarks of Elanco or its affi liates. © 2018 Elanco or its affi liates.
PM-B
E-18
-002
2 (B
NL)
100%
90%
80%
70%
60%
50%
40%
30%
20%
10%
0%
% e
nzym
atic
act
ivity
Reaction incubation pH5.00 5.50 6.00 6.60 7.11 7.63 8.02
100%90%80%70%60%50%40%30%20%10%0%
% re
sidu
al a
ctiv
ity
Treatment 1 (pH 2.5) Treatment 2 (pH 3.0) Treatment 3 (pH 3.5) Treatment 4 (pH 4.0)
43.10%
83.40% 86.90% 91.20%
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