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www.cyberrat.eu
Mufti Mahmud, Alessandra Bertoldo, Marta Maschietto, Stefano Girardi, Stefano VassanelliNeuroChip Lab, University of Padova, Padova 35131 Italy
IEEE EMBC 2010 04/09/2010
A UTOMATIC D ETECTION OF L AYER A CTIVATION O RDER IN I NFORMATION P ROCESSING P ATHWAY
OF R AT B ARREL C ORTEX UNDER M ECHANICAL W HISKER S TIMULATION
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W HISKER M APPING
IEEE EMBC2010 - 4 September 2010, NeuroChip Lab, UNIPD, IT
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I MPLANTABLE RECORDING DEVICES
High-spatiotemporal resolution (up to 1000elements, pitch below 10 micrometers)
Recording site EOSFET(Electrolyte-oxide-semiconductor-fieldeffect transistors )
IEEE EMBC2010 - 4 September 2010, NeuroChip Lab, UNIPD, IT
Borosilicate Glass Micropipettes(Resistance 1 M )
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S IGNAL ACQUISITION : E XPERIMENT
Signals are recorded from a barrel column by stimulating theprinciple whisker Rat is anesthetized with a mixture of Katamine and XylineNeurosurgery
ECG
Body temperature controllingElectrode is inserted to a barrel column at a depth of 750 um
The corresponding whisker is found by stimulating one whisker at a timeon the snout and checking the signal amplitude
Custom-made speaker providing dorsal-ventral movements through aconnected metal tube is driven using 1 ms 10 V square pulsesOnce the corresponding or principle whisker is found, the recordingelectrode is brought back to the cortical surface and a depth profile isrecorded with a recording pitch of 90 to 100 um until last cortical layer
IEEE EMBC2010 - 4 September 2010, NeuroChip Lab, UNIPD, IT
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S IGNAL ACQUISITION : RECORDINGS AT DIFFERENT DEPTHS
FET no. 1 Micropipette Layers
IEEE EMBC2010 - 4 September 2010, NeuroChip Lab, UNIPD, IT
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S IGNAL ACQUISITION : S IGNAL C HARACTERISTICS
IEEE EMBC2010 - 4 September 2010, NeuroChip Lab, UNIPD, IT
Response-Onset
Stimulus-Onset
Event 1 (E1)
Event 2 (E2)
Event 3 (E3)Event 4 (E4)
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8/3/2019 Ieee Embc2010 - Mahmud Mufti
7/16Padova 21-01-2010IEEE EMBC2010 - 4 September 2010, NeuroChip Lab, UNIPD, IT
M ETHOD : C ORTICAL L AYER ACTIVATION ORDER USING LFP S [1/7]
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8/3/2019 Ieee Embc2010 - Mahmud Mufti
8/16Padova 21-01-2010IEEE EMBC2010 - 4 September 2010, NeuroChip Lab, UNIPD, IT
M ETHOD : C ORTICAL L AYER ACTIVATION ORDER USING LFP S [2/7]
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8/3/2019 Ieee Embc2010 - Mahmud Mufti
9/16Padova 21-01-2010IEEE EMBC2010 - 4 September 2010, NeuroChip Lab, UNIPD, IT
RESULTS : C ORTICAL L AYER ACTIVATION ORDER USING LFP S [3/7]
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8/3/2019 Ieee Embc2010 - Mahmud Mufti
10/16Padova 21-01-2010IEEE EMBC2010 - 4 September 2010, NeuroChip Lab, UNIPD, IT
RESULTS : C ORTICAL L AYER ACTIVATION ORDER USING LFP S [4/7]
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8/3/2019 Ieee Embc2010 - Mahmud Mufti
11/16Padova 21-01-2010IEEE EMBC2010 - 4 September 2010, NeuroChip Lab, UNIPD, IT
RESULTS : C ORTICAL L AYER ACTIVATION ORDER USING LFP S [5/7]
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8/3/2019 Ieee Embc2010 - Mahmud Mufti
12/16Padova 21-01-2010IEEE EMBC2010 - 4 September 2010, NeuroChip Lab, UNIPD, IT
RESULTS : C ORTICAL L AYER ACTIVATION ORDER USING LFP S [6/7]
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8/3/2019 Ieee Embc2010 - Mahmud Mufti
13/16Padova 21-01-2010IEEE EMBC2010 - 4 September 2010, NeuroChip Lab, UNIPD, IT
RESULTS : C ORTICAL L AYER ACTIVATION ORDER USING LFP S [7/7]
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C ONCLUDING REMARKS AND F UTURE DIRECTION
Layer activation order is important in understanding the signal processing pathways
Tactile information processing pathway can be decoded using the LFPs from the Barrel cortex
The proposed method calculates the layer activation order based on LFPs, thus reducingcalculation time compared to that of the CSD
This work presents an automated solution to the calculation of the layer activation order
IEEE EMBC2010 - 4 September 2010, NeuroChip Lab, UNIPD, IT
The comparison with manual computation and CSD shows that the method works correctly
Incorporation of event definition by the user is the work under progress
Information about the software package will be available at the webpage www.cyberrat.eu
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THANK Y OU FOR Y OUR A TTENTION QUESTIONS / C URIOSITIES?
IEEE EMBC2010 - 4 September 2010, NeuroChip Lab, UNIPD, IT