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Immunologia dei tumori
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Aumento del rischio in pazienti trapiantati (immunosoppressi)
Sarcoma di Kaposi 400-500Malattie linfoproliferative 28-49Carcinoma della vulva e dell'ano 100Ca. epatico 20-38Ca. uterino in situ 14-16
Tumori della pelle (escl. melanomi) 24,7Ca. della tiroide ed altre gh. endocrine 14,3Ca. di bocca lingua e labbro 13,8Ca. di cervice uterina, vulva e vagina 10,8Linfoma non-Hodgkin 10,3Ca. del rene e dell'uretere 9,1Ca. della vescica 5,5Ca. del colon-retto 3,6Ca. del polmone 2,4Tumori cerebrali 2,4Ca. della prostata 2,1Melanoma 1,7Ca. della mammella 1,1
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Tumor Specific Transplantation Antigens
eTumor Associated Transplantation Antigens
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Due modelli
solo i tumori non immunogenici si sviluppano
si sviluppano i tumori che imparanoa resistere al sistema immunitario
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cellula NK
cellula bersaglio
HLA-1MICA/MICB
ULBP1,2,3,4
recettori attivatorirecettori inibitori
Modificata da Backström et al. Scand. J. Immunol. 60:14-22, 2004
Attivazione delle cellule NK
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cellula tumorale
cellule immunitarie
FasFasL
solubileIL-10
TGF-
TT
macrofagidendritiche
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cellula tumorale
Treg
CCL22
IAPs
complemento
membrane-boundComplement Regulatory Proteins
(mCRPs)
CD46, CD55, CD59
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