Introduction to Oral Introduction to Oral Cancer Gene DatabaseCancer Gene Database
.資訊三 朱民晃 .資訊三 朱民晃 B92902025B92902025.資訊三 陳皓遠 .資訊三 陳皓遠 B92902062B92902062
The Tumor Gene Family The Tumor Gene Family DatabasesDatabases
Introduction(1/2)Introduction(1/2)
• http://www.tumor-gene.org/http://www.tumor-gene.org/• The Tumor Gene Family of Databases The Tumor Gene Family of Databases
contains information about genes which are contains information about genes which are targets for cancer-causing mutations; proto-targets for cancer-causing mutations; proto-oncogenes and tumor supressor genes. oncogenes and tumor supressor genes.
• These databases are designed to for These databases are designed to for biomedical researchers who work with biomedical researchers who work with tumor genes. tumor genes.
Introduction(2/2)Introduction(2/2)
• Tumor Gene DatabaseTumor Gene Database
• Breast Cancer Gene DatabaseBreast Cancer Gene Database
• Oral Cancer Gene DatabaseOral Cancer Gene Database
Oral Cancer Gene DatabaseOral Cancer Gene Database
• What information dose the database What information dose the database contain?contain?
• This database contains information This database contains information about genes which are targets for about genes which are targets for cancer-causing mutations in oral cancer-causing mutations in oral cancers.cancers.
• List of Oral Cancer GenesList of Oral Cancer Genes• A member of the Tumor Gene A member of the Tumor Gene
Database familyDatabase family• http://www.tumor-gene.org/Oral/oral.htmlhttp://www.tumor-gene.org/Oral/oral.html
Get the list of Oral Cancer Get the list of Oral Cancer Genes (1/2)Genes (1/2)
Click here to get information of the Oral cancer list
Get the list of Oral Cancer Get the list of Oral Cancer Genes (2/2)Genes (2/2)• List of Oral Cancer GenesList of Oral Cancer Genes
How to search the database How to search the database (1/4)(1/4)
Key in a Gene Name or a word in a fact you want to search
How to search the database How to search the database (2/4)(2/4)
Click the “Search” button to search
How to search the database How to search the database (3/4)(3/4)
Get 1 match of the gene “BAX”
Click the hyperlink of “BAX”
How to search the database How to search the database (4/4)(4/4)
OMIM ID NumberOMIM ID Number of NCBI
What can we get ? (1/2)What can we get ? (1/2)
• Cell Type Distribution Cell Type Distribution
• Clinical Clinical
• Complementation Complementation
• Function Function
• Gene Frequency (Tumors) Gene Frequency (Tumors)
• Protein Binding Protein Binding
• Regulation Regulation
What can we get ? (2/2)What can we get ? (2/2)
Flag
Link to Citation of NCBI
FlagsFlags
Primary Fact from a Full PaperPrimary Fact from an AbstractSecondary Fact from a Full PaperSecondary Fact from an Abstract Primary Fact from a Review Secondary Fact from a Review Unknown
Link to GeneCards (1/2)Link to GeneCards (1/2)
Click here to link to GeneCards website
Link to GeneCards (2/2)Link to GeneCards (2/2)
NCBI – OMIM (1/4)NCBI – OMIM (1/4)
Remember to choose “OMIM”
*600040 , the OMIM ID Number
NCBI – OMIM (2/4)NCBI – OMIM (2/4)
Click here; go to the OMIM homepage.
Click “FAQ” to get details about OMIM
NCBI – OMIM (3/4)NCBI – OMIM (3/4)
What do the symbols preceding a MIM number represent?
NCBI – OMIM (4/4)NCBI – OMIM (4/4)
Ex: An asterisk (*) before an entry number indicates a gene of known sequence.
ConclusionConclusion
• We can search the information about orWe can search the information about oral gene in the database.al gene in the database.
• We can get the OMIM ID about the gene iWe can get the OMIM ID about the gene in the NCBI database.n the NCBI database.
• We can get the list of genes in the oral dWe can get the list of genes in the oral database.atabase.
• We can link to GeneCards website.We can link to GeneCards website.
Thanks for your attention.