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La malattia di castleman
Dottssa Marina Cavaliere
Medicina I° ed Ematologia
Ospedale San Paolo di Savona
Savona, 9 Novembre 2018
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COS’E’?COS’E’?
• Si tratta di 3 distinti disordini immunologici con
linfoproliferazione , accomunati dal presentare linfonodi con
simili caratteristiche istologiche
• Possono presentarsi in individui di qualsiasi età• Possono presentarsi in individui di qualsiasi età
• La prima descrizione di linfonodi con tali caratteristiche risale
al 1954 e fu redatta dal Prof Benjamin Castleman
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CLASSIFICAZIONE
Le 3 forme di malattia di Castleman, molto diverse tra loro, sono
• La forma unicentrica ( UCD) caratterizzata dal coinvolginento di
un solo linfonodo
• La forma Multicentrica associata ad infezione da HHV-8 • La forma Multicentrica associata ad infezione da HHV-8
•• La forma multicentrica Idiopatica La forma multicentrica Idiopatica ( iMCD)
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Negli ultimi 5 anni i migliori progressi per
l’inquadramento diagnostico e per la terapia sono
stati proposti da
David Fajgenbaum
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La malattia di castleman
istologiaistologia
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Caratteristiche istologiche linfonodali “CD-like”, si possono osservare in
molte altre patologie
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La malattia di Casleman deve essere classificata in base alla
sierologia per HHV8 e non per HIV
Il 35-58% dei
MCD sono HHV8
negativi
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Patologie che possono dimostrare istopatologia CD-like e patologie descritte
coesitere con iMCD
Patologie che possono dimostrare istopatologia CD-like e patologie descritte
coesitere con iMCD
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