Download - Metabolisme Purin & Pirimidin_2
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METABOLISME PURIN & PIRIMIDIN
PURIN & PIRIMIDIN MERUPAKAN SALAH SATU BASA PENYUSUN ASAM NUKLEAT (DNA DAN RNA).
NUKLEOPROTEIN
PROTEIN ASAM NUKLEAT
NUKLEOTIDA
NUKLEOSIDA ASAM FOSFAT
PURIN DAN PIRIMIDIN PENTOSA
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• BASA PURIN DI DNA: ADENOSIN & GUANIN
• BASA PIRIMIDIN DI DNA: SITOSIN & TIMIN
• BASA PURIN DI RNA: ADENOSIN & GUANIN
• BASA PIRIMIDIN DI RNA: Sitosin & urasil
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• PERBEDAAN DNA & RNA1. Pentosa di RNA: Ribosa, di DNA:
Deoksiribosa2. Bentuk molekul RNA: rantai
Tunggal terlipat, sdg DNA: Double helik
3. RNA basanya A,G,S,U, sdg DNA: A,G,S,T
4. Jumlah Guanin di RNA tak sama sitosin, sdg DNA sama
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• Nukleotida tbtk dr asam fosfat dan nukleosida. Bbrp jenis Nukleotida: AMP, ADP, ATP, UTP, UMP
• Purin dan pirimidin dpt di biosintesis di tubuh dr bahan-bahan intermediat amfibolik.
• PENCERNAAN:Nukleotida dicerna jd a. Nukleat, kmd oleh enzim ribonuklease, deoksiribinuklease & pOLINUKLEATIDASE. Akan diurai jd mononukleotida. Enzim nukleotidase& fosfatase menghidrolisis mononukleotida jd nukleosida yg kmd diurai oleh enzim fosforilase intestinal jd purin & pirimidin.
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• Purin di katabolisme menjadi asam urat & garam asam Urat, kmd diekskresi lewat urine
adenin
adenosin
Inosin
Hipoxantin
Xantin
Asam Urat
Guanin
guanosin
Guanin
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• Pirimidin dikatabolisme jd senyawa2 yg mudah larut dalam air. Spt: CO2, NH3, β-Alanin, & β-aminoisobutirat.
Sitosin
Urasil
Dihidrourasil
β-ureidopropionat
β-Alanin
Timin
Dihidrotimin
β-ureidosobutirat
β-aminoisobutirat
CO2 & NH3
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• Kelainan Metblm Purin: Hiperurisemia/ Gout, Hipouresemia, Van Glerke & Lesch-nyhan
• Kelainan mtblm Pirimidin: Asiduria Asam Urotat