Download - Mitokondria Fixs
-
8/10/2019 Mitokondria Fixs
1/31
Bella Rhea Lavifa. S.
(120210153038)
Sakalus Wepe
(120210153038)
Nur Kholifatun Nisa
(120210153038)
Maya Umi Hajar
(120210153050)
Saltsa Ridlotul J.
(120210153055)
-
8/10/2019 Mitokondria Fixs
2/31
MITOCHONDI
STRUCTURE
-
8/10/2019 Mitokondria Fixs
3/31
Mitochondria are the sites of cellular respiration, themetabolic process that generates ATP by extracting energyfrom sugars, fats, and other fuels with the help of oxygen.
Function
convert energy to forms that cells canusefor work.
-
8/10/2019 Mitokondria Fixs
4/31
General Characteristics
Enclosed by membranes, they are not part of the endomembrane system.Mitochondria have two membranes separating their innermost spacecytosol.
The membrane proteins of mitochondria are made not by ribosomes boER, but by free ribosomes in the cytosol and by ribosomes contained worganelles themselves.
Contain a small amount of DNA that programs the synthesis of the proon the organelle's ribosomes.
-
8/10/2019 Mitokondria Fixs
5/31
General Characteristics
Mitochondria are semiautonomous organelles that grow and reproduce cell.
Mitochondria are found in nearly all eukaryotic cells, including those animals, fungi, and most protists.
Mitochondria are about 1-10 11m long.
mitochondria moving around, changing their shapes, and fusing or dividing
-
8/10/2019 Mitokondria Fixs
6/31
-
8/10/2019 Mitokondria Fixs
7/31
-
8/10/2019 Mitokondria Fixs
8/31
OUTER MEMBR NE
Consist of :Protein that called porin
lipid
The outer membrane is smooth, outer membrane completely permeable to
molecules, ions, and molecules of ATP ADP. In addition, the outer membrcontains enzymes involved in the biosynthesis of lipids and enzymes involtransport processes into the matrix to undergo -oxidation.
-
8/10/2019 Mitokondria Fixs
9/31
INNER MEMBR NE
Inner Membranes is more complex in structure than the outer membbecause it contains a complex of the electron transport chain and ATsynthetase complex.Inner membrane protein involved in oxidative phosphorylation reactsynthase functioning form ATP in the mitochondrial matrix, as well a
transport proteins that regulate the passage of metabolites from the macross the membrane.
-
8/10/2019 Mitokondria Fixs
10/31
INTERMEMBR NE SP CE
In the mitochondrial matrix contained genetic material, known as mDNA (mtDNA), ribosomes, ATP, ADP, and inorganic phosphate ionsmagnesium, calcium and potassium.
-
8/10/2019 Mitokondria Fixs
11/31
M TRIX
The matrix is a complex mixture of enzymes that are essentiasynthesis of ATP, special mitochondrial ribosomes, RNA and
mitochondrial DNA. In addition, it has oxygen, carbon dioxidother recyclable intermediates.
-
8/10/2019 Mitokondria Fixs
12/31
DNA MITOCHONDRIAThe mitochondria DNA en
organelle proteins that are on ribosomes within the orgorganelle-produced mRNA their amino acid sequence.
The processes of orgatranscription, protein synthereplication take place where
is located in the matrix of mit
DNA mitochondria have regulate the intracellular process, fission and mitochondria.
-
8/10/2019 Mitokondria Fixs
13/31
Different Between DNA Mitochonand DNA Nucleus
DNA Mitochondria DNA Nucleus
Have a lot of amount than DNA nucleus Have a little of amount than DNA mi
DNA mitochondria just generated by Moms Cells DNA nucleus generated by Parents
Smaller genome Bigger genome
In mitochondria matrix In nucleus of cells
Circular DNA mitochondria, double helix. Not circular, double helix
-
8/10/2019 Mitokondria Fixs
14/31
-
8/10/2019 Mitokondria Fixs
15/31
Metabolism Process in Mitochon
KREB CYC
TRANSPO
ELECTRON PR
-
8/10/2019 Mitokondria Fixs
16/31
Kreb Cycle in Mitoc
kreb cycle in occurs in matrixs omitochondria.
In kreb cycle
Piruvat acid 2 ATP + 3 N
NADH
+ CO2
NADH+ CO2
NADH
FADH
CO2
-
8/10/2019 Mitokondria Fixs
17/31
The process of kreaction :
1. condensation
2 and 3. Isomer
4. primary oxyd
5. secondary oxy
6. phosphorilati
7. third oxydatio
8 and 9. oxaloasformation
-
8/10/2019 Mitokondria Fixs
18/31
Transport elektron
-
8/10/2019 Mitokondria Fixs
19/31
Sistem Transpor Elektron melibatkan 5 kompprotein
Complex I (NADH-coenzyme Q oxidoreductase or NADH dehydrogenase)
Complex II (Succinate-Q oxidoreductase or Succinate dehydrogenase)
Complex III (Q-cytochrome c oxidoreductase)
Complex IV (Cytochrome c oxidase)
ATP Synthase
-
8/10/2019 Mitokondria Fixs
20/31
10 NADH + 50 > 10 NAD+ + 10 H
-
8/10/2019 Mitokondria Fixs
21/31
SYNTHASE
10 NADH + 502> 10 NAD+ + 10 H
2 FADH2
+ O2> 2 PAD + 2 H
20
-
8/10/2019 Mitokondria Fixs
22/31
Life Cycle ofMitochondria
-
8/10/2019 Mitokondria Fixs
23/31
-
8/10/2019 Mitokondria Fixs
24/31
-
8/10/2019 Mitokondria Fixs
25/31
-
8/10/2019 Mitokondria Fixs
26/31
-
8/10/2019 Mitokondria Fixs
27/31
Al h i Di
-
8/10/2019 Mitokondria Fixs
28/31
Alzheimers Disease
Beta amyloid increases nitric
oxide, which activates DRP
causing fission and neuronaldamage. One way that motility
is impaired is with too much of
the molecule tau (which holds
microtubules together and ispart of Alzheimers pathology)
then there is no fusion and
mitochondria become shorter.
H i Di d
-
8/10/2019 Mitokondria Fixs
29/31
Huntingtons Disorder
Too much Huntingtin protein
(the critical abnormal protein
in Huntingtons), stops fusion
and mitochondria become
shorter. Huntingtin activates
DRP increasing fission and
apoptosis Mutant Huntingincauses fragmentation and
disease.
ALS Amyotrophic Lateral Sclerosis o
-
8/10/2019 Mitokondria Fixs
30/31
ALS Amyotrophic Lateral Sclerosis oGehrigs Disease
Mutation causes DRP fission and
inhibits axon transport of mitochondria.
-
8/10/2019 Mitokondria Fixs
31/31