![Page 1: NEVROBIOLOGI & TOKSIKOLOGI€¦ · TOKSIKOLOGI . LAKTATRESEPTOR HCAR1 I FIBROBLASTER I HJERNEHINNEN PIA MATER Morland C et al. 2017 Nature Communications kraniet dura mater araknoid](https://reader035.vdocuments.pub/reader035/viewer/2022062307/605c5efe7b1bf2425c66466f/html5/thumbnails/1.jpg)
Cecilie Morland Allmøte 15.02.2018
NEVROBIOLOGI & TOKSIKOLOGI
![Page 2: NEVROBIOLOGI & TOKSIKOLOGI€¦ · TOKSIKOLOGI . LAKTATRESEPTOR HCAR1 I FIBROBLASTER I HJERNEHINNEN PIA MATER Morland C et al. 2017 Nature Communications kraniet dura mater araknoid](https://reader035.vdocuments.pub/reader035/viewer/2022062307/605c5efe7b1bf2425c66466f/html5/thumbnails/2.jpg)
![Page 5: NEVROBIOLOGI & TOKSIKOLOGI€¦ · TOKSIKOLOGI . LAKTATRESEPTOR HCAR1 I FIBROBLASTER I HJERNEHINNEN PIA MATER Morland C et al. 2017 Nature Communications kraniet dura mater araknoid](https://reader035.vdocuments.pub/reader035/viewer/2022062307/605c5efe7b1bf2425c66466f/html5/thumbnails/5.jpg)
LAKTATRESEPTOR HCAR1 I FIBROBLASTER I HJERNEHINNEN PIA MATER
Morland C et al. 2017 Nature Communications
kraniet
dura mater
araknoid
pia mater
mater
![Page 6: NEVROBIOLOGI & TOKSIKOLOGI€¦ · TOKSIKOLOGI . LAKTATRESEPTOR HCAR1 I FIBROBLASTER I HJERNEHINNEN PIA MATER Morland C et al. 2017 Nature Communications kraniet dura mater araknoid](https://reader035.vdocuments.pub/reader035/viewer/2022062307/605c5efe7b1bf2425c66466f/html5/thumbnails/6.jpg)
Photo: Ketil Blom/Khrono
MUSEMODELLER: 1) HCAR1 KO 2) HCAR1 mRFP reporter
![Page 7: NEVROBIOLOGI & TOKSIKOLOGI€¦ · TOKSIKOLOGI . LAKTATRESEPTOR HCAR1 I FIBROBLASTER I HJERNEHINNEN PIA MATER Morland C et al. 2017 Nature Communications kraniet dura mater araknoid](https://reader035.vdocuments.pub/reader035/viewer/2022062307/605c5efe7b1bf2425c66466f/html5/thumbnails/7.jpg)
Photo: Ketil Blom/Khrono
Høyintensiv intervalltrening på tredemølle 10 x 4 min ved 85-95% of maks Aktiv hvile 2 min ved ~50% 5 dager i uken i 7 uker
Laktat 200mg/ml 2g/kg kroppsvekt
Fysiologisk saltvann
BEHANDLING
![Page 8: NEVROBIOLOGI & TOKSIKOLOGI€¦ · TOKSIKOLOGI . LAKTATRESEPTOR HCAR1 I FIBROBLASTER I HJERNEHINNEN PIA MATER Morland C et al. 2017 Nature Communications kraniet dura mater araknoid](https://reader035.vdocuments.pub/reader035/viewer/2022062307/605c5efe7b1bf2425c66466f/html5/thumbnails/8.jpg)
![Page 9: NEVROBIOLOGI & TOKSIKOLOGI€¦ · TOKSIKOLOGI . LAKTATRESEPTOR HCAR1 I FIBROBLASTER I HJERNEHINNEN PIA MATER Morland C et al. 2017 Nature Communications kraniet dura mater araknoid](https://reader035.vdocuments.pub/reader035/viewer/2022062307/605c5efe7b1bf2425c66466f/html5/thumbnails/9.jpg)
Vekst-faktorer
Intracellulære signalveier
![Page 10: NEVROBIOLOGI & TOKSIKOLOGI€¦ · TOKSIKOLOGI . LAKTATRESEPTOR HCAR1 I FIBROBLASTER I HJERNEHINNEN PIA MATER Morland C et al. 2017 Nature Communications kraniet dura mater araknoid](https://reader035.vdocuments.pub/reader035/viewer/2022062307/605c5efe7b1bf2425c66466f/html5/thumbnails/10.jpg)
Samuel Geiseler Postdoc
Linda T. Øverberg Ph.d-student
Alena Hadzic Ph.d-student
Marvin Lambertus Ph.d-student
Malin Sørli masterstudent
Mona Gaarder ingeniør
![Page 11: NEVROBIOLOGI & TOKSIKOLOGI€¦ · TOKSIKOLOGI . LAKTATRESEPTOR HCAR1 I FIBROBLASTER I HJERNEHINNEN PIA MATER Morland C et al. 2017 Nature Communications kraniet dura mater araknoid](https://reader035.vdocuments.pub/reader035/viewer/2022062307/605c5efe7b1bf2425c66466f/html5/thumbnails/11.jpg)
Samarbeidspartnere
Linda H. Bergersen (UiO) Jon Strom-Mathisen (UiO) Ulrik Wisløff (NTNU) Ole Morten Rønning (Ahus) Koen Vervaeke (UiO) Håvard Attramadal (OUS/UiO)
Nasjonale: Internasjonale:
Fred H. (Rusty) Gage Salk institute, La Jolla, USA
Stefan Offermanns Max-Planck-Institute, Bad Nauheim, Germany