![Page 1: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/1.jpg)
RELATION ENTRE L’HYPERGLYCÉMIE & L’ATTEINTE CARDIO VASCULAIRE
![Page 2: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/2.jpg)
RELATION ENTRE L’HYPERGLYCÉMIE & L’ATTEINTE CARDIO VASCULAIRE
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L’ADENOSINE TRIPHOSPHATE (ATP)VEHICULE D’ÉNERGIE
![Page 4: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/4.jpg)
VOIES ÉNERGÉTIQUES.GLYCOLYSE
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O O || ||2CH3 – C – COOH + 2CoA - SH 2CH3 – C –S CoA + 2CO2 – 4HAcide Pyruvique Coenzyme A Acétyle Coenzyme A
HSubstrat | + NAD NADH + H + Substrat H Déshydrogénase
CYCLE DE L’ACIDE CITRIQUE DE KREBS
![Page 6: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/6.jpg)
TRANSPORT INTRA- MITOCHONDRIAL DES
ÉLECTRONS
![Page 7: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/7.jpg)
COMPLEXES ACCEPTEURS D’ELECTRONS
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STRESS OXYDATIF(TRAVERSÉE MITOCHONDRIALE DES IONS
D’HYDROGÈNE)
![Page 9: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/9.jpg)
HYPER OXYDE ET SYSTÈME ANTI OXYDANT
![Page 10: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/10.jpg)
CRITERES DU SYNDROME X
![Page 11: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/11.jpg)
ADIPOKINES SÉCRÉTÉES PAR LE TISSU ADIPEUX
![Page 13: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/13.jpg)
PATHOLOGIES INDUITES PAR LE STRESS OXYDATIF.
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Adipocyte
ACIDES GRAS ++
+
INSULINO-RÉSISTANCE
Altération des voies (PI3k) de signalisation insulinique
HYPERGLYCÉMIE
Hyperplasie cellules β Normo GlycémieÉpuisement Précoce cellules β Tolérance au glucose perturbéeÉpuisement tardif des cellules β DIABÈTE
ROS +++
ADIPOKINE
S
PRÉDISPOSITIONS GÉNÉTIQUES
![Page 15: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/15.jpg)
INHIBITION DU GAPDH PAR LA PPARP
(D’après Hofman et Brownlee)
ROS +++
![Page 16: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/16.jpg)
CONSÉQUENCES DE L’INHIBITION DU GAPDH
(D’après Hofman et Brownlee)
ROS +++
![Page 17: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/17.jpg)
PRODUCTION DE ROS PAR LES ACIDES GRAS PEROXYDÉS
(D’après Hofman et Brownlee)
ROS ++
+
![Page 18: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/18.jpg)
HYPERTENSION & HYPERGLYCÉMIE
HYPERTENSION
ARTÉRIELLE
INSULINO-RÉSISTANCEHYPERGLYCÉ
MIE
PRÉDISPOSITIONS GÉNÉTIQUES
Altération des protéines g notamment de la voie PI3K Inhibition du rôle de l’insuline et de l’ILGF Dislocation Glut 4 NO peroxynitrate
UP REGULATIONDU SYSTÈME RAA
MUTATION DU RÉCEPTEUR AT1R
DE L’ANGIOTENSINE
ROS+++
ALDOSTERONE
![Page 19: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/19.jpg)
VOIES DES PERTURBATIONS MÉTABOLIQUES LIÉES À
L’HYPERGLYCÉMIE
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GLYCOLISATION NON ENZYMATIQUE
![Page 24: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/24.jpg)
CONSÉQUENCES DES AGEs/RAGEs
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CONSÉQUENCES DE L’ACTIVATION DE LA PKC
![Page 26: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/26.jpg)
AUGMENTATION DU FLUX DE LA VOIE DE L’HEXOAMINE
![Page 27: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/27.jpg)
VOIE POLYOL
![Page 28: O O || || 2CH 3 – C – COOH + 2CoA - SH 2CH 3 – C –S CoA + 2CO 2 – 4H Acide Pyruvique Coenzyme A Acétyle Coenzyme A H Substrat | + NAD NADH + H +](https://reader036.vdocuments.pub/reader036/viewer/2022062622/551d9da3497959293b8d3306/html5/thumbnails/28.jpg)
HYPERGLYCÉMIE
Sorbitol
Myoinositol Osmolarité
Altération cellulaire
DAG
HEXOSAMINE
AGEs
LDLGlyco
sylatées
Absorption par scavengers dans intima
Modificationsoxydatives
AGE /RAGE
Processus
athéro scléreu
x
Activation PCK
Expression des gènes
altérés
TGF β
Glusamine
UDP
GFβ1
Ac. Pl.
COMPLICATIONS DU DIABÈTE
POLYOLGLYCOSYLATI
ONACTIVATION
PKC
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Prothrombotic activity
↑
Inflammation↑
ENDOTHELIAL DYSFUNCTION LEADS TO IMBALANCE OF FACTORS, RESULTING IN VASCULAR DISEASE
Vogel (Am J Med)
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DYSFONCTION ENDOTHÉLIALE
STRESS OXYDATIF(SUPEROXYDE)
FACTEURS DE RISQUELDL. Tr. HTA Diabète
Tabac
NF-KbTNFα
Cytokines
Growth FactorsDépôts lipides
I.1 du Pl.Fact. VII
Fibrin.↑ VCAM-1.↑
ThromboseAdhesion
plaquettes GB
Inflammation
ProtéolyseRupture Plaque
Lésions Vx
Remodelage
NO. SRAAProstacyclineEndothéline↑
Thromboxane A2↑
NOONOO
I like GF
VasoConstriction
COMPLICATIONS ATHÉROSCLÉRE
USES DU DIABÈTE
HyperHomocystéiné
mie