Pb09207223 张馨元Pb10206066 张希良Pb10207016 高绪远
Nano-Dendrimers Used in Drug Delivery
OutlineWhy dendrimers?What is dendrimers?How it works?CytotoxicityConjecture
Structures for Drug Delivery Liner polymersLarger nanoparticlesLiposomes
http://www.sciencedirect.com/science/article/pii/S1740674905000107http://trialx.com/curetalk/2012/10/nanotechnology-drug-delivery-systems-an-insight/https://sitn.hms.harvard.edu/sitnflash_wp/2011/06/materials-for-drug-delivery/
What is dendrimers?
Dendrimers are used as well-defined scaffolding or nanocontainers to conjugate, complex or encapsulate therapeutic drugs or imaging moieties.
What is dendrimers?
http://www.nanotechnologies.qc.ca/projects/nanopatterning/nanopatterning
What is dendrimers?
http://www.pharmainfo.net/reviews/dendrimer-overview
What is dendrimers?
Anupa R. Menjoge et. al, Drug Discovery Today, 2010
How it works?
CytotoxicityConcentrationGenerationSurface charge dependent
Conjecture
?
Hybrid treeIf we combine two of the branches of the
core with some other small molecules which can be easily hydrolyzed to release the active site of the core…
Parrott, M. C.; Benhabbour, S. R.; Saab, C.; Lemon, J. A.; Parker, S.; Valliant, J. F.; Adronov, A. J. Am. Chem. Soc. 2009, 131, 2906-2916.
Sub-Hybrid TreeIf we add some other surface molecules
which can combine the pre- surface, When the generation is over 4…
New cocktail?We know that the release of physically
entrapped guest-type drugs in dendrimeric hosts might be controlled by both surface modification and the density of modifying groups.
Well , what can we do?
Thanks!