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PLANTES A ALCALOIDES ET PRODUITS APPARENTES
Bernard WenigerPharmacognosie et Molécules Naturelles Bioactives
UMR 7200, Lab. d’Innovation ThérapeutiqueFaculté de Pharmacie - Université de Strasbourg
PLAN DU COURSPLAN DU COURS1.1. Généralités sur les alcaloïdesGénéralités sur les alcaloïdes
!"#$%$&$'%!"#$%$&$'%!$(&)$*+&$'%,!$(&)$*+&$'%,-- "&.&,%.&+)/0"&.&,%.&+)/01$'(2%&34(/,/&,&25/(,(&)+6&+).+71$'(2%&34(/,/&,&25/(,(&)+6&+).+78.).6&")$(&$9+/( 532($6'8.).6&")$(&$9+/( 532($6'--63$:$9+/(63$:$9+/(8.).6&")$(&$9+/(,532($6'8.).6&")$(&$9+/(,532($6' 63$:$9+/(63$:$9+/(;7&).6&$'%;7&).6&$'%
2.2. Monographies de plantesMonographies de plantes<.&$4)/(,5)/:$4)/(,=,6.#"$%/<.&$4)/(,5)/:$4)/(,=,6.#"$%/>.?'&@,'5$+:,/&,:')53$%/>.?'&@,'5$+:,/&,:')53$%/A+$%9+$%.,/&,9+$%$%/A+$%9+$%.,/&,9+$%$%/B'0.%.6"/(,=,.06.0'CD/(,&)'5.%$9+/(B'0.%.6"/(,=,.06.0'CD/(,&)'5.%$9+/(E06.0'CD/(,.%&$&+:').+7,%.&+)/0(E06.0'CD/(,.%&$&+:').+7,%.&+)/0(
GÉNÉRALITÉS
<"&.*'0$(:/,5)$:.$)/:"&.*'0$(:/,#'%D.:/%&.0,F,:'0"6+0/(,$%D$(5/%(.*0/(,=,0.,?$/,D/,0.,50.%&/.6$D/(,.:$%"(@,6/00+0'(/@,.:$D'%@,630')'53200/@,/&6,GG
<"&.*'0$(:/,(/6'%D.$)/:'0"6+0/(,0'%H&/:5(,6'%($D")"/(,6'::/,I%'%,$%D$(5/%(.*0/(I,=,0.,?$/,D/,0.,50.%&/:"&.*'0$(:/,DJ.D.5&.&$'%,D/,0.,50.%&/,.?/6,0/,:$0$/+,KD"#/%(/@,5)'&/6&$'%LM:'0"6+0/(,6.).6&")$(&$9+/(,D+,:'%D/,?"H"&.05)4(,D/,NO,OOO,(&)+6&+)/(,%.&+)/00/(,6'%%+/(,
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Relations biogénétiques entre les différents types de métabolites secondaires
GÉNÉRALITÉS - DÉFINITION
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
[:5')&.%6/,[:5')&.%6/,D/(,.06.0'CD/(,D/(,.06.0'CD/(, %':*)/,K50+($/+)(,:$00$/)(M%':*)/,K50+($/+)(,:$00$/)(M!$?/)($&",(&)+6&+).0/@,H)'+5/,63$:$9+/:/%&,3"&")'H4%/,!$?/)($&",(&)+6&+).0/@,H)'+5/,63$:$9+/:/%&,3"&")'H4%/,/&,0.)H/,"?/%&.$0,D_.6&$?$&"(,*$'0'H$9+/(,/&,0.)H/,"?/%&.$0,D_.6&$?$&"(,*$'0'H$9+/(,]/):/,`]/):/,` .06.0'CD/(.06.0'CD/( a,$%&)'D+$&,5.),</$(%/),.+,\ba,$%&)'D+$&,5.),</$(%/),.+,\b4:/,4:/,
($460/,($460/, (+*&.%6/,)".H$((.%&,6'::/,0.,('+D/,(+*&.%6/,)".H$((.%&,6'::/,0.,('+D/, .0,c.02,.0,c.02,K D MK D M K &MK &M
GÉNÉRALITÉS - DÉFINITION
K('+D/M,d,K('+D/M,d, K.(5/6&MK.(5/6&M>.(,D/,D"#$%$&$'%,($:50/,:.$(,>.(,D/,D"#$%$&$'%,($:50/,:.$(,/7$(&/%6/,D_+%,6'%(/%(+(,/7$(&/%6/,D_+%,6'%(/%(+(,(+),0.,D"#$%$&$'%,D/,6/,9+_/(&,+%,.06.0'CD/,?).$,(+),0.,D"#$%$&$'%,D/,6/,9+_/(&,+%,.06.0'CD/,?).$,FF
` 8':5'("(,DJ')$H$%/,%.&+)/00/@,0/,50+(,('+?/%&,?"H"&.0/@,.e'&"(@,0/,50+(,('+?/%&,*.($9+/(@,/&,D'+"(,=,#.$*0/,D'(/,D/,
5)'5)$"&"(,532($'0'H$9+/(,:.)9+"/( a,
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>)'&'>)'&'--.06.0'CD/(,'+,5(/+D'.06.0'CD/(,'+,5(/+D'--.06.0'CD/(,F,.06.0'CD/(,F,
.0c20.:$%/(,/&,.)20.:$%/(,.0c20.:$%/(,/&,.)20.:$%/(,D/,0.)H/,D$(&)$*+&$'%D/,0.)H/,D$(&)$*+&$'%
*"&.0.C%/(*"&.0.C%/(
GÉNÉRALITÉS - DÉFINITION
*"&.0.C%/(*"&.0.C%/(
5/5&$D/(,/&,.6G,.:$%"(5/5&$D/(,/&,.6G,.:$%"(
.:$D/(.:$D/(
5')532)$%/(,GG5')532)$%/(,GG
PSEUDOALCALOÏDE : PSEUDOALCALOÏDE : CAPSAÏCINE CAPSAÏCINE
8.5(.C6$%/,/&,D")$?"(F,.((/e,('0+*0/(,D.%(,/.+,/&,3+$0/
E%.0H"($9+/(,&'5$9+/(@,D"(/%($*$0$(.%&,)"6/5&/+)(,D'+0/+)(@ )+*"#$.%&(@D'+0/+)(@,)+*"#$.%&(@,D$.53')"&$9+/(
f)$H$%/,*$'(2%&3"&$9+/,:$7&/,F,53"%205)'5.%/,d,*).%63/:/%&,63.g%/,.0253.&$9+/
>$H:/%&(,.e'&"(,)/&)'+?"(,D.%(,6/)&.$%/(,>$H:/%&(,.e'&"(,)/&)'+?"(,D.%(,6/)&.$%/(,#.:$00/(,*'&.%$9+/(,K)/:50.6/%&,.%&3'62.%/(M#.:$00/(,*'&.%$9+/(,K)/:50.6/%&,.%&3'62.%/(M>)'5)$"&"(,.%&$'7$D.%&/(>)'5)$"&"(,.%&$'7$D.%&/(
PSEUDOALCALOÏDE : PSEUDOALCALOÏDE : BÉTALAÏNES BÉTALAÏNES
0123456547
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GÉNÉRALITÉS - DÉFINITION
E06.0'CD/(,%/,6'%&/%.%&,5.(,D_'72H4%/,FE06.0'CD/(,%/,6'%&/%.%&,5.(,D_'72H4%/,F0$9+$D/(,=,&/:5").&+)/,')D$%.$)/0$9+$D/(,=,&/:5").&+)/,')D$%.$)/
?'0.&$0(@,/%&).g%.*0/(,=,0.,?.5/+),D_/.+,?'0.&$0(@,/%&).g%.*0/(,=,0.,?.5/+),D_/.+,
%$6'&$%/ (5.)&"$%/
SX,SX, 1.6&")$/(,K1.6&")$/(,KPseudomonasPseudomonasMM
83.:5$H%'%(,K5($0'62*/@,.:.%$&/@,/)H'&M83.:5$H%'%(,K5($0'62*/@,.:.%$&/@,/)H'&M
ALCALOÏDESALCALOÏDESDistribution Distribution -- état naturel état naturel
Y2:%'(5/):/(,KY2:%'(5/):/(,KTaxus, EphedraTaxus, EphedraM,M,
Rh,X,D/(,.06.0'CD/(,(/,)/&)'+?/%&,63/e,0/(,,Rh,X,D/(,.06.0'CD/(,(/,)/&)'+?/%&,63/e,0/(,,!$6'&20"D'%/(,,!$6'&20"D'%/(,,U%/,9+$%e.$%/,D/,#.:$00/(,('%&,5.)&$6+0$4)/:/%&U%/,9+$%e.$%/,D/,#.:$00/(,('%&,5.)&$6+0$4)/:/%&)$63/(,/%,50.%&/(,=,.06.0'CD/()$63/(,/%,50.%&/(,=,.06.0'CD/(
ALCALOÏDESALCALOÏDESDistribution Distribution -- état naturel état naturel
i/(,50+(,$:5')&.%&/(,('%&,0/(,(+$?.%&/(,Fi/(,50+(,$:5')&.%&/(,('%&,0/(,(+$?.%&/(,FE%%'%.6"/(@,E5'62%.6"/(@,i.+).6"/(@,E%%'%.6"/(@,E5'62%.6"/(@,i.+).6"/(@,i'H.%$.6"/(@,<"%$(5/):.6"/(@,i'H.%$.6"/(@,<"%$(5/):.6"/(@,>.5.?/).6"/(@,j+*$.6"/(@,B'0.%.6"/(L>.5.?/).6"/(@,j+*$.6"/(@,B'0.%.6"/(L
Y0'*.0/:/%&,F,\OY0'*.0/:/%&,F,\O--\W,X,D/(,E%H$'(5/):/(,,,\W,X,D/(,E%H$'(5/):/(,,,6'%&$/%%/%&,D/(,6'%&$/%%/%&,D/(,.06.0'CD/(,/%,9+.%&$&",%'&.*0/(.06.0'CD/(,/%,9+.%&$&",%'&.*0/(
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ALCALOÏDESALCALOÏDESDistribution Distribution -- état naturel état naturel
k.*$&+/00/:/%&,=,0l"&.&,D/,(/0(,D.%(,0.,50.%&/F,:.0.&/@k.*$&+/00/:/%&,=,0l"&.&,D/,(/0(,D.%(,0.,50.%&/F,:.0.&/@6$&).&/@,&.)&).&/,.$%($,9+_,/%,6':*$%.$('%,.?/6,0/(,&.%$%(6$&).&/@,&.)&).&/,.$%($,9+_,/%,6':*$%.$('%,.?/6,0/(,&.%$%(i'6.0$(.&$'%,i'6.0$(.&$'%, &$((+(,5")$53")$9+/(&$((+(,5")$53")$9+/(j"5.)&$&$'%,D$?/)($#$"/,Fj"5.)&$&$'%,D$?/)($#$"/,F
0.)H/,F,6.#"$%/@,)"&$6+0$%/0.)H/,F,6.#"$%/@,)"&$6+0$%/)/(&)/$%&/,F,32'(6$.:$%/,KB'0.%.6"/(M@,:')53$%/,K)/(&)/$%&/,F,32'(6$.:$%/,KB'0.%.6"/(M@,:')53$%/,KPapaverPapaverM,M,('+?/%&,:"0.%H/,6':50/7/,D_')$H$%/,*$'(2%&3"&$9+/,6'::+%/,('+?/%&,:"0.%H/,6':50/7/,D_')$H$%/,*$'(2%&3"&$9+/,6'::+%/,
]/%/+),F,]/%/+),F,?.)$/,D.%(,D/,0.)H/(,0$:$&/(,F,"&.&,D/,&).6/(,?.)$/,D.%(,D/,0.)H/(,0$:$&/(,F,"&.&,D/,&).6/(, \N,\N,X,K9+$%9+$%.MX,K9+$%9+$%.M?.)$.*$0$&",$:5')&.%&/,K/%?$)'%%/:/%&@,(.$('%@,3/+)/M?.)$.*$0$&",$:5')&.%&/,K/%?$)'%%/:/%&@,(.$('%@,3/+)/M
V'%6&$'%(,D.%(,0.,50.%&/,0.)H/:/%&,:"6'%%+/(,F,V'%6&$'%(,D.%(,0.,50.%&/,0.)H/:/%&,:"6'%%+/(,F,5)'D+$&(,D_/76)"&$'%,D+,:"&.*'0$(:/,.e'&"5)'D+$&(,D_/76)"&$'%,D+,:"&.*'0$(:/,.e'&")"(/)?/,D_.e'&/@,D"#/%(/,6'%&)/,0/(,5)"D.&/+)(,LG)"(/)?/,D_.e'&/@,D"#/%(/,6'%&)/,0/(,5)"D.&/+)(,LG
BIOSYNTHÈSE ET TYPES STRUCTURAUXBIOSYNTHÈSE ET TYPES STRUCTURAUX
BIOSYNTHÈSE ET TYPES STRUCTURAUXBIOSYNTHÈSE ET TYPES STRUCTURAUX
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CARACTÉRISTIQUES PHYSICOCARACTÉRISTIQUES PHYSICO--CHIMIQUES CHIMIQUES
N
5k,.06.0$%,F,5k,.06.0$%,F,
9+$%'0"$%/,9+$%'0"$%/,*.(/,*.(/, ('0+*0/,,,('0+*0/,,,D.%( ('0?.%&( ')H.%$9+/(D.%( ('0?.%&( ')H.%$9+/( /&/&
B'0+*$0$&",D/(,.06.0'CD/(,(/0'%,0/,5k,FB'0+*$0$&",D/(,.06.0'CD/(,(/0'%,0/,5k,F
N
NH
+CH3COO
D.%(,('0?.%&(,')H.%$9+/(,D.%(,('0?.%&(,')H.%$9+/(,/&,/&,0/(,0/(,.06''0(.06''0(
5k,.6$D/,K/7F,.6G,.6"&$9+/M,F
.6"&.&/,D/,9+$%'0"$%/, ('0+*0/D.%(,0_/.+,/&,0/(,.06''0(
CARACTÉRISTIQUES PHYSICOCARACTÉRISTIQUES PHYSICO--CHIMIQUESCHIMIQUES
E+&)/,/7/:50/E+&)/,/7/:50/F,6'6.C%/,*.(/,/&,630')32D).&/,D/,6'6.C%/,F,6'6.C%/,*.(/,/&,630')32D).&/,D/,6'6.C%/,
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CARACTÉRISTIQUES PHYSICOCARACTÉRISTIQUES PHYSICO--CHIMIQUESCHIMIQUES
B'0+*$0$&",D/(,(/0(,D.%(,0J/.+,FB'0+*$0$&",D/(,(/0(,D.%(,0J/.+,F630'32D).&/(,m,(+0#.&/(,m,&.)&).&/(630'32D).&/(,m,(+0#.&/(,m,&.)&).&/(
B'0+*$0$&",D.%(,0_.06''0,F,B'0+*$0$&",D.%(,0_.06''0,F,*.(/( /& (/0( ('%& ('0+*0/( D.%( 0/( .06''0(*.(/( /& (/0( ('%& ('0+*0/( D.%( 0/( .06''0(*.(/(,/&,(/0(,('%&,('0+*0/(,D.%(,0/(,.06''0(*.(/(,/&,(/0(,('%&,('0+*0/(,D.%(,0/(,.06''0(
B'0+*$0$&",D$##")/%&/,($,5+),'+,/%,:"0.%H/,FB'0+*$0$&",D$##")/%&/,($,5+),'+,/%,:"0.%H/,F5)"(/%6/,D/,(.5'%'($D/(,5)"(/%6/,D/,(.5'%'($D/(, :'D$#$/,('0+*$0$&",:'D$#$/,('0+*$0$&",/7/7 F,/7&).6&$'%,D/(,.06.0'CD/(,D/,F,/7&).6&$'%,D/(,.06.0'CD/(,D/,Catharanthus Catharanthus
roseusroseus K.P:.0$6$%/MK.P:.0$6$%/M
EXTRACTION DES ALCALOIDESEXTRACTION DES ALCALOIDES
<"&3'D/,60.(($9+/,KB&.(<"&3'D/,60.(($9+/,KB&.(--f&&'M,/&,6')'00.$)/,Ff&&'M,/&,6')'00.$)/,F
!"50.6/:/%&!"50.6/:/%& D/(,.06.0'CD/(,D/,0/+),D/(,.06.0'CD/(,D/,0/+),6':*$%.$('%6':*$%.$('%5.),0J+&$0$(.&$'%,DJ+%/,*.(/,D$0+"/,F,nk5.),0J+&$0$(.&$'%,DJ+%/,*.(/,D$0+"/,F,nkNNfk@,8.KfkMfk@,8.KfkMQQ'+,n.'+,n.QQ8f8fZZ .P'+&",.+,:.&")$/0,?"H"&.0,(/6,.P'+&",.+,:.&")$/0,?"H"&.0,(/6,
;7&).6&$'%;7&).6&$'% .?/6,('0?.%&,5/+,5'0.$)/.?/6,('0?.%&,5/+,5'0.$)/ F,630')'#'):/@,F,630')'#'):/@,D$630')':"&3.%/@,"&3/)@,.6"&.&/,DJ"&320/D$630')':"&3.%/@,"&3/)@,.6"&.&/,DJ"&320/
>+$(,>+$(,5+)$#$6.&$'%,5.),/7&).6&$'%,0$9+$D/,5+)$#$6.&$'%,5.),/7&).6&$'%,0$9+$D/,-- 0$9+$D/,0$9+$D/,K('0?.%&(,K('0?.%&(,%'%,%'%,:$(6$*0/(M,.5)4(,63.%H/:/%&,D/,5k:$(6$*0/(M,.5)4(,63.%H/:/%&,D/,5k
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éé éé
EXTRACTION DES ALCALOIDESEXTRACTION DES ALCALOIDES
E)&"#.6&(E)&"#.6&( D_/7&).6&$'%,D_/7&).6&$'%,/%,5)"(/%6/,D_.6$D/,#')&,/%,5)"(/%6/,D_.6$D/,#')&,'+,D/,*.(/,#')&/,F'+,D/,*.(/,#')&/,F
;7/:50/,D/(,$)$D'CD/(,K(o")'($D/,D/,0.,H/%&$.%/M,;7/:50/,D/(,$)$D'CD/(,K(o")'($D/,D/,0.,H/%&$.%/M,($,/7&).6&$'%,/%,5)"(/%6/,D_.::'%$.9+/,6'%6/%&)"/,($,/7&).6&$'%,/%,5)"(/%6/,D_.::'%$.9+/,6'%6/%&)"/,H/%&$.%$%/,p,.06.0'CD/,.)&"#.6&H/%&$.%$%/,p,.06.0'CD/,.)&"#.6&
O
O
Glucose
O
EXTRACTION DES ALCALOIDES
8.(,D/(,8.(,D/(,.06.0'CD/(,#.$*0/:/%&,*.($9+/(,.06.0'CD/(,#.$*0/:/%&,*.($9+/(,F,F,/7/:50/,D/,0.,6.#"$%/,/&,D/(,.+&)/(,7.%&3$%/(,/7/:50/,D/,0.,6.#"$%/,/&,D/(,.+&)/(,7.%&3$%/(,KD"0'6.0$(.&$'%,D/(,"0/6&)'%(MKD"0'6.0$(.&$'%,D/(,"0/6&)'%(M
/7&).6&$'%,5'(($*0/,D/(,.06.0'CD/(,*.(/,5.),0_/.+,63.+D/,/7&).6&$'%,5'(($*0/,D/(,.06.0'CD/(,*.(/,5.),0_/.+,63.+D/,
CH3N
NCH3N
NCH3
O
O
CH3N
NCH3N
NH
O
O
NH
NCH3N
NCH3
O
O
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EXTRACTION DES ALCALOIDESEXTRACTION DES ALCALOIDES
E06.0'CD/(,9+.&/)%.$)/(,FE06.0'CD/(,9+.&/)%.$)/(,F;7,F,*/)*")$%/@,32D).(&$%/GG;7,F,*/)*")$%/@,32D).(&$%/GG
n/,5/+?/%&,5.(,^&)/,,,n/,5/+?/%&,5.(,^&)/,,,/7&).$&(,(/0'%,0.,:"&3'D/,/7&).$&(,(/0'%,0.,:"&3'D/, N
+
O
D/,B&.(D/,B&.(--f&&'f&&'
#'):/,*.(/,#'):/,*.(/,F,fkF,fk-- /&,/&, #'):/,(/0,#'):/,(/0,F,80F,80-- kkdd
&'+P'+)(,&'+P'+)(,D$(('6$"(,D$(('6$"(,
&'+P'+)(,('0+*0/(,D.%(,0_/.+,&'+P'+)(,('0+*0/(,D.%(,0_/.+,/&,$%('0+*0/(,D.%(,0/(,('0?.%&(,')H.%$9+/(/&,$%('0+*0/(,D.%(,0/(,('0?.%&(,')H.%$9+/(
NO
OMe
OMe
EXTRACTION DES ALCALOIDES
E06.0'CD/(,53"%'0$9+/(,E06.0'CD/(,53"%'0$9+/(,K,:')53$%/,M,FK,:')53$%/,M,F
OH
V'):.&$'%,D/,53"%.&/,/%,V'):.&$'%,D/,53"%.&/,/%,
n/,5/+?/%&,5.(,^&)/,/7&).$&,(/0'%,0.,:"&3'D/,D/,B&.(n/,5/+?/%&,5.(,^&)/,/7&).$&,(/0'%,0.,:"&3'D/,D/,B&.(--f&&'f&&'
NCH3OH
O55
:$0$/+,.06.0$%,:$0$/+,.06.0$%, 5.((.H/,/%,5.((.H/,/%,53.(/,.9+/+(/,53.(/,.9+/+(/, .+&)/(,.+&)/(,.06.0'CD/(,D/,0_'5$+:.06.0'CD/(,D/,0_'5$+:
EXTRACTION DES ALCALOIDESEXTRACTION DES ALCALOIDES
U&$0$(.&$'%(,D/,)".6&/+)(,D/,H).%D/,&.$00/U&$0$(.&$'%(,D/,)".6&/+)(,D/,H).%D/,&.$00/
8/)&.$%(,('0?.%&(,$%&/)D$&(,K&'7$6$&"@,#0.::.*$0$&"@8/)&.$%(,('0?.%&(,$%&/)D$&(,K&'7$6$&"@,#0.::.*$0$&"@D.%H/) DJ/750'($'%MD.%H/) DJ/750'($'%M
;7&).6&$'%,$%D+(&)$/00/,F;7&).6&$'%,$%D+(&)$/00/,F
D.%H/),D /750'($'%MD.%H/),D /750'($'%M
8'%D$&$'%(,"6'%':$9+/(,/&,5).&$9+/(,D"&/):$%.%&/(8'%D$&$'%(,"6'%':$9+/(,/&,5).&$9+/(,D"&/):$%.%&/(
j/63/)63/,D/,5)'6"D"(,5.)&$6+0$/)(,F,)".6&$'%(,j/63/)63/,D/,5)'6"D"(,5.)&$6+0$/)(,F,)".6&$'%(,D.%(,0/,:$0$/+@,5)"6$5$&.&$'%(,("0/6&$?/(,LGD.%(,0/,:$0$/+@,5)"6$5$&.&$'%(,("0/6&$?/(,LG
![Page 10: PLANTES A ALCALOIDES ET PRODUITS …mastervrv.free.fr/S2/RMA2/Cours/4.pdf · PLANTES A ALCALOIDES ET PRODUITS APPARENTES Bernard Weniger Pharmacognosie et Molécules Naturelles Bioactives](https://reader031.vdocuments.pub/reader031/viewer/2022021902/5b98a98809d3f253748ca644/html5/thumbnails/10.jpg)
EXTRACTION DES ALCALOIDESEXTRACTION DES ALCALOIDES
;7&).6&$'%,D/,0J.P:.0$6$%/,;7&).6&$'%,D/,0J.P:.0$6$%/,D/(,).6$%/(,D/,D/(,).6$%/(,D/,Rauwolfia serpentinaRauwolfia serpentina Ki.*G,>$/))/,V.*)/M,FKi.*G,>$/))/,V.*)/M,F
N
OHOH
NMe
C2H5
EP:.0$6$%/,K,p,).+*.($%/,M,EP:.0$6$%/,K,p,).+*.($%/,M, ..6&$#,%$?/.+,?.(6+0.$)/,6")"*).06&$#,%$?/.+,?.(6+0.$)/,6")"*).0
>)"(/%&/,/%,:"0.%H/,.?/6,.06.0'CD/(,%'%,$%&")/((.%&(,F>)"(/%&/,/%,:"0.%H/,.?/6,.06.0'CD/(,%'%,$%&")/((.%&(,F(/)5/%&$%/,K,*.(/,#')&/,M@,)"(/)5$%/@,*.(/(,#.$*0/(,GG,(/)5/%&$%/,K,*.(/,#')&/,M@,)"(/)5$%/@,*.(/(,#.$*0/(,GG,
EXTRACTION DES ALCALOIDESEXTRACTION DES ALCALOIDES
N+
ON -
MeOOC
N
MeOOC
NH OMe
COO OMe
OMeOMe
EXTRACTION DE L'AJMALICINE DES RACINES DE CATHARANTHUS ROSEUS
11
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j".6&$'%(,D/,6':50/7.&$'%,j".6&$'%(,D/,6':50/7.&$'%,FFKK5)"6$5$&.&$'%@,6'0').&$'%M5)"6$5$&.&$'%@,6'0').&$'%M1.("/(,(+),6.5.6$&",D/,6':*$%.$('%,.?/6,:"&.+7,/&,1.("/(,(+),6.5.6$&",D/,6':*$%.$('%,.?/6,:"&.+7,/&,:"&.0'CD/(,F,1$@,kH@,q@,[:"&.0'CD/(,F,1$@,kH@,q@,[
]'+P'+)(,/%,:$0$/+,.9+/+7,.6$D/]'+P'+)(,/%,:$0$/+,.9+/+7,.6$D/ FF
MISE EN ÉVIDENCE DES ALCALOIDES
P 9P 9<.2/),F,:/)6+)$$'D+)/,D/,r,K*0.%63s&)/M<.2/),F,:/)6+)$$'D+)/,D/,r,K*0.%63s&)/M
!).H/%D')##,F,$'D'*$(:+&3$&/,D/,r,K)'+H/,').%H"M!).H/%D')##,F,$'D'*$(:+&3$&/,D/,r,K)'+H/,').%H"M F,F,.+(($,/%,88<.+(($,/%,88<
1'+63.)D.&F,$'D+)/,D/,r,$'D",K*)+%M1'+63.)D.&F,$'D+)/,D/,r,$'D",K*)+%M
E&&/%&$'%,.+7,#.+7,5'($&$#(,F,E&&/%&$'%,.+7,#.+7,5'($&$#(,F,6'+:.)$%/(@,32D)'726'+:.)$%/(@,32D)'72--#0.?'%/(@,>;Y@,#0.?'%/(@,>;Y@,(.5'%$%/((.5'%$%/(
DOSAGE PHARMACOPEE
!'(.H/,D/(,.06.0'CD/(,&'&.+7,F<"&3'D/,H).?$:"&)$9+/,.*.%D'%%"/
<"&3'D/,?'0+:"&)$9+/,F,.6$D$:"&)$/,/%,)/&'+),.5)4(,/7&).6&$'%,/%,:$0$/+,.06.0$%,KB'0.%.6"/(M
!'(.H/,D_+%,6'%(&$&+.%&,'+,H)G,D/,6'%(&$&+.%&(,F]/63%$9+/(,(5/6&)'53'&':"&)$9+/(,F.06.0'CD/(,9+$%9+$%.,F,.*(')*.%6/,=,Q, (/0'%,(&)+6&+)/
!'(.H/,6'0')$:"&)$9+/,F*.(/(,#.$*0/(,D.%(,).6$%/,D/,Rauwolfia,
!'(.H/,5.),63)':.&'H).53$/,0$9+$D/,F,6.#"$%/@,:')53$%/GG,
MONOGRAPHIESMONOGRAPHIESPlantes à alcaloïdesPlantes à alcaloïdes
\G <.&$4)/(,5)/:$4)/(,=,6.#"$%/Q >.?'& '5$+: /& :')53$%/QG >.?'&@,'5$+:,/&,:')53$%/ZG A+$%9+$%.,/&,9+$%$%/NG B'0.%.6"/(,=,.06.0'CD/(,&)'5.%$9+/(WG >0.%&/(,=,.06.0'CD/(,.%&$&+:').+7
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Matières premières à caféineMatières premières à caféine
CAFE ET CAFEINECAFE ET CAFEINE
8.#"$/),%.&$#,D/,0_E#)$9+/,D/,0_/(&,K(5G,8.#"$/),%.&$#,D/,0_E#)$9+/,D/,0_/(&,K(5G,arabicaarabicaM,/&,*.(($%M,/&,*.(($%D+,8'%H',K(5G,D+,8'%H',K(5G,canephoracanephoraMM
]'))"#$6.&$'%,/&,5)"5.).&$'%,D+,*)/+?.H/,D_')$H$%/,,,]'))"#$6.&$'%,/&,5)"5.).&$'%,D+,*)/+?.H/,D_')$H$%/,,,.).*/.).*/ ;+)'5/ = 0. #$% D+ <'2/%;+)'5/ = 0. #$% D+ <'2/%--.H/ K\S.H/ K\S4:/4:/ ($460/M($460/M
U%/,6'+)&/,3$(&'$)/,D+,6.#",,,,U%/,6'+)&/,3$(&'$)/,D+,6.#",,,,
.).*/,.).*/, ;+)'5/,=,0.,#$%,D+,<'2/%;+)'5/,=,0.,#$%,D+,<'2/% .H/,K\S.H/,K\S ($460/M($460/M
8+0&+)/,0'%H&/:5(,+%,:'%'5'0/,D/,0.,5"%$%(+0/,8+0&+)/,0'%H&/:5(,+%,:'%'5'0/,D/,0.,5"%$%(+0/,.).*$9+/,.).*$9+/,
8+0&+)/,)/5)$(/,5.),0/(,V).%t.$(,/&,0/(,k'00.%D.$(,8+0&+)/,)/5)$(/,5.),0/(,V).%t.$(,/&,0/(,k'00.%D.$(,D.%(,0/+)(,6'0'%$/(D.%(,0/+)(,6'0'%$/(
E6&+/00/:/%&,0.,(/6'%D/,)/(('+)6/,6'::/)6$.0/,.+,E6&+/00/:/%&,0.,(/6'%D/,)/(('+)6/,6'::/)6$.0/,.+,:'%D/,.5)4(,0/,5"&)'0/,K1)"($0@,8'0':*$/,LM:'%D/,.5)4(,0/,5"&)'0/,K1)"($0@,8'0':*$/,LM
Dispersion géographique de la culture Dispersion géographique de la culture du caféierdu caféier
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U%/,6/%&.$%/,D_/(546/(,D/,U%/,6/%&.$%/,D_/(546/(,D/,Coffea Coffea Kj+*$.6"/(M,,,Kj+*$.6"/(M,,,%.&$?/(,5'+),0.,50+5.)&,D_E#)$9+/@,5'+((.%&,D.%(,%.&$?/(,5'+),0.,50+5.)&,D_E#)$9+/@,5'+((.%&,D.%(,D/(,3.*$&.&(,&)'5$6.+7,'+,(+*D/(,3.*$&.&(,&)'5$6.+7,'+,(+*--&)'5$6.+7&)'5$6.+7
A+.&)/,/(546/(,$:5')&.%&/(,D_+%,5'$%&,D/,?+/,,A+.&)/,/(546/(,$:5')&.%&/(,D_+%,5'$%&,D/,?+/,,6'::/)6$.06'::/)6$.0
ASPECTS BOTANIQUES ASPECTS BOTANIQUES
6'::/)6$.0,F6'::/)6$.0,F
Coffea arabicaCoffea arabica iG,iG, SW,X,5)'D+6&$'%,:'%D$.0/SW,X,5)'D+6&$'%,:'%D$.0/
S,S,-- h,:'$(,/%&)/,0.,#0').$('%,/&,0.,:.&+).&$'%h,:'$(,/%&)/,0.,#0').$('%,/&,0.,:.&+).&$'%
D/+7,('+(D/+7,('+(--/(546/(,F,/(546/(,F,
?.)G,?.)G,arabicaarabica F,1)"($0@,E#)$9+/,D/,0_/(&@,E($/F,1)"($0@,E#)$9+/,D/,0_/(&@,E($/?.)G,?.)G,bourbon bourbon F,6.#",D_.0&$&+D/,Ki.,j"+%$'%MF,6.#",D_.0&$&+D/,Ki.,j"+%$'%M
Coffea canephora Coffea canephora >$/))/,>$/))/, .55/0",.55/0",6.#",6.#",robustarobustauu ZO,X,D/,0.,5)'D+6&$'%,:'%D$.0/,K$%(&.%&.%"MZO,X,D/,0.,5)'D+6&$'%,:'%D$.0/,K$%(&.%&.%"Muu b,b,-- \\,:'$(,D/,0.,#0').$('%,=,0.,:.&+).&$'%\\,:'$(,D/,0.,#0').$('%,=,0.,:.&+).&$'%uu 6.#",D/,v*.((/,&/))/w,KE#)$9+/,"9+.&')$.0/M6.#",D/,v*.((/,&/))/w,KE#)$9+/,"9+.&')$.0/Muu ?$H'+)/+7@,)"($(&.%&,.+7,:.0.D$/(@,6.#"$%/,?$H'+)/+7@,)"($(&.%&,.+7,:.0.D$/(@,6.#"$%/,
ASPECTS BOTANIQUESASPECTS BOTANIQUES
uu .)x:/,/&,H'y&,$%#")$/+)(,=,.)x:/,/&,H'y&,$%#")$/+)(,=,C. arabicaC. arabica
C. excelsaC. excelsa EG,83/?GEG,83/?Guu ?$H'+)/+7@,)"($(&.%&,.+7,:.0.D$/(,/&,("63/)/((/?$H'+)/+7@,)"($(&.%&,.+7,:.0.D$/(,/&,("63/)/((/
C. libericaC. liberica qG,1+00G,;7,k$/)%qG,1+00G,;7,k$/)%uu \N,:'$(,D/,0.,#0').$('%,=,0.,:.&+).&$'%\N,:'$(,D/,0.,#0').$('%,=,0.,:.&+).&$'%uu H).$%(,D/,H).%D/,&.$00/,H).$%(,D/,H).%D/,&.$00/,uu \X,D/,0.,5)'D+6&$'%,:'%D$.0/\X,D/,0.,5)'D+6&$'%,:'%D$.0/
Répartition des espèces Répartition des espèces
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>/&$&,.)*)/,F>/&$&,.)*)/,F
V/+$00/(,/%&$4)/(,5/)($(&.%&/(@,V/+$00/(,/%&$4)/(,5/)($(&.%&/(@,6')$.6/(@,0+$(.%&/(6')$.6/(@,0+$(.%&/(
LA PLANTE
V0/+)(,*0.%63/(,'D').%&/(,/%V0/+)(,*0.%63/(,'D').%&/(,/%?/)&$6$00/(?/)&$6$00/(
!)+5/,6':5')&.%&,Q,H).$%/(,!)+5/,6':5')&.%&,Q,H).$%/(,.66'0"/(,?/)&/,.66'0"/(,?/)&/, )'+H/,=,)'+H/,=,:.&+)$&":.&+)$&"
Caféier en fleurCaféier en fleur
Drupe en voie de maturationDrupe en voie de maturation
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LA RECOLTE DU CAFE LA RECOLTE DU CAFE
LA DROGUE VÉGÉTALE LA DROGUE VÉGÉTALE
Structure du fruit et de la graine Structure du fruit et de la graine du du caféier :caféier :\F,($00'%,6/%&).0,\F,($00'%,6/%&).0,QF,H).$%,D/,6.#",K/%D'(5/):/M,QF,H).$%,D/,6.#",K/%D'(5/):/M,ZF,5/.+,D+,H).$%,K&"H+:/%&M,ZF,5/.+,D+,H).$%,K&"H+:/%&M,NF,5.)63/,K/%D'6.)5/M,NF,5.)63/,K/%D'6.)5/M,WF,6'+63/,D/,:+6$0.H/(,WF,6'+63/,D/,:+6$0.H/(,SF,5+05/,K:"('6.)5/M,SF,5+05/,K:"('6.)5/M,RF,5/.+,D+,#)+$&,K/7'6.)5/M,RF,5/.+,D+,#)+$&,K/7'6.)5/M,
f*&/%&$'%,D+,6.#",v/%,H).$%w,F,f*&/%&$'%,D+,6.#",v/%,H).$%w,F,K,:"&3'D/(,3+:$D/,'+,(463/,MK,:"&3'D/(,3+:$D/,'+,(463/,M
!"5+05.H/,!"5+05.H/,F,"0$:$%.&$'%,/7'6.)5/,F,"0$:$%.&$'%,/7'6.)5/,)'+H/,/&,:"('6.)5/,63.)%+)'+H/,/&,:"('6.)5/,63.)%+
!"5.)63.H/!"5.)63.H/ F "0$:$%.&$'% /%D'6.)5/F "0$:$%.&$'% /%D'6.)5/
LA DROGUE VÉGÉTALE
!"5.)63.H/,!"5.)63.H/,F,"0$:$%.&$'%,/%D'6.)5/,F,"0$:$%.&$'%,/%D'6.)5/,(60")$#$",(60")$#$", v#4?/w,p,H).$%/,D/,6.#"v#4?/w,p,H).$%/,D/,6.#"
i.,H).$%/,K6.#",?/)&M,Fi.,H).$%/,K6.#",?/)&M,F'?.0/@,6'%?/7/,(+),#.6/,D')(.0/@'?.0/@,6'%?/7/,(+),#.6/,D')(.0/@.50.&$/,(+),#.6/,?/%&).0/.50.&$/,(+),#.6/,?/%&).0/($00'%,0'%H$&+D$%.0,p,3$0/($00'%,0'%H$&+D$%.0,p,3$0/D+)/,/&,?/)Ds&)/@,$%'D')/D+)/,/&,?/)Ds&)/@,$%'D')/ «« fèvefève » avant torréfaction» avant torréfaction
Drupes de caféDrupes de café
![Page 16: PLANTES A ALCALOIDES ET PRODUITS …mastervrv.free.fr/S2/RMA2/Cours/4.pdf · PLANTES A ALCALOIDES ET PRODUITS APPARENTES Bernard Weniger Pharmacognosie et Molécules Naturelles Bioactives](https://reader031.vdocuments.pub/reader031/viewer/2022021902/5b98a98809d3f253748ca644/html5/thumbnails/16.jpg)
robustaarabica
Café vert :Café vert :WO,X,WO,X,H0+6$D/(H0+6$D/( K(+6)/(,d,5'02(.663.)$D/(M,K(+6)/(,d,5'02(.663.)$D/(M,
\\,X,\\,X,5)'&"$%/(5)'&"$%/(
\O\O \W X\W X 0$5$D/(0$5$D/( K(&")'0( &'6'53")'0( .06''0(K(&")'0( &'6'53")'0( .06''0(
CARACTÈRES CHIMIQUESCARACTÈRES CHIMIQUES
\O,\O,-- \W,X,\W,X,0$5$D/(0$5$D/( K(&")'0(@,&'6'53")'0(@,.06''0(,K(&")'0(@,&'6'53")'0(@,.06''0(,D$&/)5"%$9+/(,0$*)/(,/&,/(&")$#$"(MD$&/)5"%$9+/(,0$*)/(,/&,/(&")$#$"(M
W,W,-- hX,/%?$)'%,D_hX,/%?$)'%,D_.6$D/(,53"%'0(,.6$D/(,53"%'0(,/&,D")$?"(,/&,D")$?"(,K630')'H"%$9+/@,6.#"$9+/MK630')'H"%$9+/@,6.#"$9+/M
O@S,O@S,-- Z,X,D/,Z,X,D/,6.#"$%/6.#"$%/ (/0'%,?.)$"&"(,d,&).6/(,D/,(/0'%,?.)$"&"(,d,&).6/(,D/,&3"'*)':$%/&3"'*)':$%/
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i/(,&/%/+)(,/%,.6$D/(,53"%'0(,/&,6.#"$%/ )/%(/$H%/%&,(+),0_.:/)&+:/,D+,6.#",?/)&,F,
0.,&/%/+),/%,.6$D/(,630')'H"%$9+/(,D'$&,(/,($&+/),/%&)/,R,/&,h,X,0. &/%/+) /% 6.#"$%/ 5'+) +% arabica D'$& ^&)/ z \ NO X
CARACTÈRES SENSORIELS CARACTÈRES SENSORIELS DU CAFÉ VERT MARCHANDDU CAFÉ VERT MARCHAND
0.,&/%/+),/%,6.#"$%/@,5'+),+%,arabica@,D'$&,^&)/,z,\@NO,X
<.&$4)/,H).((/, #$7.&/+),D_.)x:/(F,?.0/+)( 6':5)$(/(,/%&)/,\O,X,KrobustaM,/&,\W,X,KarabicaM]/%/+),/%,(.663.)'(/ D"5/%D,D/,0.,:.&+)$&",/&,D+,&).$&/:/%&,5'(&-)"6'0&/F,&.+7,D/,(.663.)'(/,*.(,%$?/.+,.)':.&$9+/,#.$*0/i.,&/%/+),/%,/.+,D'$&,.?'$),D/(,?.0/+)(,z,\O@W,X
>/)&/,D_3+:$D$&",/&,)".6&$'%(,D/,<.$00.)D,>/)&/,D_3+:$D$&",/&,)".6&$'%(,D/,<.$00.)D, +&$0$(.&$'%,+&$0$(.&$'%,D/(,(+6)/(,/&,D/(,5)'&$D/(,K.6G,.:$%"(M,D+,H).$%,5'+),D/(,(+6)/(,/&,D/(,5)'&$D/(,K.6G,.:$%"(M,D+,H).$%,5'+),#'):/),0/(,%':*)/+(/(,:'0"6+0/(,D/,0_#'):/),0/(,%':*)/+(/(,:'0"6+0/(,D/,0_.)x:/.)x:/@,.$%($,@,.$%($,9+/,D/(,9+/,D/(,6':5'("(,5'02:")$("(,*)+%(6':5'("(,5'02:")$("(,*)+%(i.,&'))"#.6&$'%,(/,D")'+0/,D.%(,D/(,(2(&4:/(,/%,i.,&'))"#.6&$'%,(/,D")'+0/,D.%(,D/(,(2(&4:/(,/%,6'%&$%+ ('+( .$) 63.+D 5+0("6'%&$%+ ('+( .$) 63.+D 5+0("
LA TORRÉFACTIONLA TORRÉFACTION
6'%&$%+,('+(,.$),63.+D,5+0(",6'%&$%+,('+(,.$),63.+D,5+0(",
;00/,D+)/,D/,;00/,D+)/,D/,\O,=,QO,:$%+&/(,\O,=,QO,:$%+&/(,=,D/(,&=,D/(,&{{ 6':5)$(/(,6':5)$(/(,/%&)/,/%&)/,QOO,/&,QhO,QOO,/&,QhO,{{888_/(&,0/,6'+50/,D+)"/8_/(&,0/,6'+50/,D+)"/--&/:5").&+)/,9+$,D"&/):$%/,0/(,&/:5").&+)/,9+$,D"&/):$%/,0/(,5)$%6$5.0/(,6.).6&")$(&$9+/(,D+,6.#",F5)$%6$5.0/(,6.).6&")$(&$9+/(,D+,6.#",F
H).$%(,*0'%D(,D/(,6.#"(,5/+,&'))"#$"(,KE00/:.H%/@,UBEM,H).$%(,*0'%D(,D/(,6.#"(,5/+,&'))"#$"(,KE00/:.H%/@,UBEM,H).$%(,*)+%(,.)':.&$9+/(,D/(,6.#"(,#).%t.$(,H).$%(,*)+%(,.)':.&$9+/(,D/(,6.#"(,#).%t.$(,H).$%(,5)/(9+/,%'$)(,D/(,6.#"(,$&.0$/%(@,#')&/:/%&,&'))"#$"(H).$%(,5)/(9+/,%'$)(,D/(,6.#"(,$&.0$/%(@,#')&/:/%&,&'))"#$"(
E:/)&+:/,/&,.6$D$&",E:/)&+:/,/&,.6$D$&", 550+(,0/,6.#",/(&,&'))"#$"@,50+(,0+(,0/,6.#",/(&,&'))"#$"@,50+(,0_.:/)&+:/,.+H:/%&/,/&,50+(,0_.6$D$&",D$:$%+/,F,0_$D".0,0_.:/)&+:/,.+H:/%&/,/&,50+(,0_.6$D$&",D$:$%+/,F,0_$D".0,/(&,D_.?'$),+%,5.)#.$&","9+$0$*)/,/%&)/,0/(,D/+7,(.?/+)(/(&,D_.?'$),+%,5.)#.$&","9+$0$*)/,/%&)/,0/(,D/+7,(.?/+)(
>3"%':4%/(,532($9+/(,.+,6'+)(,D/,0.,&'))"#.6&$'%,>3"%':4%/(,532($9+/(,.+,6'+)(,D/,0.,&'))"#.6&$'%,*)+%$((/:/%&,D/(,H).$%(,Dy,.+7,)".6&$'%(,D/,<.$00.)D*)+%$((/:/%&,D/(,H).$%(,Dy,.+7,)".6&$'%(,D/,<.$00.)D
#0 & KD SO = hO XM " &$ D & D#0 & KD SO = hO XM " &$ D & D
LA TORRÉFACTIONLA TORRÉFACTION
H'%#0/:/%&,KD/,SO,=,hO,XM@,5.),6)".&$'%,D/,5')/(,/&,D/,H'%#0/:/%&,KD/,SO,=,hO,XM@,5.),6)".&$'%,D/,5')/(,/&,D/,6.?$&"(,)"(+0&.%&,D/(,53"%':4%/(,D/,D"H.e.H/@,/&,+%/6.?$&"(,)"(+0&.%&,D/(,53"%':4%/(,D/,D"H.e.H/@,/&,+%/5/)&/,D/,5'$D(,D/,\W,=,QO,X@,6.+("/,5.),0/,D"5.)&,D/,0_/.+,5/)&/,D/,5'$D(,D/,\W,=,QO,X@,6.+("/,5.),0/,D"5.)&,D/,0_/.+,/&,D+,H.e,6.)*'%$9+//&,D+,H.e,6.)*'%$9+/
E%.02(/,63$:$9+/,D+,6.#",&'))"#$",E%.02(/,63$:$9+/,D+,6.#",&'))"#$",FF&/%/+),/%,/.+,&/%/+),/%,/.+, Kz,\,XMKz,\,XM32D)'02(/,D/(,5'02(.663.)$D/(32D)'02(/,D/(,5'02(.663.)$D/(.)x:/,6':50/7/,K50+($/+)(,6/%&.$%/(,D/,6':5'("(M.)x:/,6':50/7/,K50+($/+)(,6/%&.$%/(,D/,6':5'("(M&/%/+),/%,6.#"$%/,5/+,:'D$#$"/&/%/+),/%,6.#"$%/,5/+,:'D$#$"/
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LA DÉCAFEINISATION DU CAFÉLA DÉCAFEINISATION DU CAFÉ
i/,6.#",?/)&,D"6.#"$%",D'$&,6'%&/%$),z,O@Ob,X,D/,,i/,6.#",?/)&,D"6.#"$%",D'$&,6'%&/%$),z,O@Ob,X,D/,,6.#"$%/,/&,0/,6.#",&'))"#$",D"6.#"$%", ,O@\,X,D/,,6.#"$%/,/&,0/,6.#",&'))"#$",D"6.#"$%", ,O@\,X,D/,,6.#"$%/,6.#"$%/,K%'):/,#).%t.$(/MK%'):/,#).%t.$(/M
U%/,&.((/,D/,6.#",D"6.#"$%",6'%&$/%&,\W,#'$(,:'$%(U%/,&.((/,D/,6.#",D"6.#"$%",6'%&$/%&,\W,#'$(,:'$%(D/,6.#"$%/,9+_+%/,&.((/,D_D/,6.#"$%/,9+_+%/,&.((/,D_arabicaarabica
i.,i.,D"6.#"$%.&$'%D"6.#"$%.&$'% (/,#.$&,&'+P'+)(,(/,#.$&,&'+P'+)(,(+),0/,6.#",?/)&,(+),0/,6.#",?/)&,6.),6.),'%,('+3.$&/,F'%,('+3.$&/,F)/&$)/),(/+0/:/%&,0.,6.#"$%/,/&,0/,:'$%(,5'(($*0/,D/,)/&$)/),(/+0/:/%&,0.,6.#"$%/,/&,0/,:'$%(,5'(($*0/,D/,6':5'("(,?'0.&$0/(,.)':.&$9+/(6':5'("(,?'0.&$0/(,.)':.&$9+/(
*"%"#$6$/),D/,0.,63.0/+),D/,0.,&'))"#.6&$'%,5'+),("63/),*"%"#$6$/),D/,0.,63.0/+),D/,0.,&'))"#.6&$'%,5'+),("63/),0/,6.#",3+:$D$#$",5.),0.,D"6.#"$%.&$'%,0/,6.#",3+:$D$#$",5.),0.,D"6.#"$%.&$'%,
LA DECAFEINISATION DU CAFELA DECAFEINISATION DU CAFE
!"6.#"$%.&$'%,=,0_/.+,F,!"6.#"$%.&$'%,=,0_/.+,F,i/(($?.H/,=,63.+D,D/(,H).$%(,?/)&(,('+(,5)/(($'%i/(($?.H/,=,63.+D,D/(,H).$%(,?/)&(,('+(,5)/(($'%
>+$(,("63.H/,=,0_.$),63.+D,/&,&'))"#$6.&$'%>+$(,("63.H/,=,0_.$),63.+D,/&,&'))"#$6.&$'%
[0,/7$(&/,&)'$(,:"&3'D/(,F
!"6.#"$%.&$'%,5.),('0?.%&,630')",K8k!"6.#"$%.&$'%,5.),('0?.%&,630')",K8kQQ8080QQMMi/(($?.H/,5.),('0?.%&(,630')"(,D/(,H).$%(,?/)&(,5)"i/(($?.H/,5.),('0?.%&(,630')"(,D/(,H).$%(,?/)&(,5)"--3+:$D$#$"(3+:$D$#$"(
;0$:$%.&$'%,D+,('0?.%&,5.),"?.5').&$'%@,5+$(,5.),/%&).g%/:/%&,=,;0$:$%.&$'%,D+,('0?.%&,5.),"?.5').&$'%@,5+$(,5.),/%&).g%/:/%&,=,0.,?.5/+)@,("63.H/,D/(,H).$%(,=,0_.$),63.+D@,5+$(,&'))"#$6.&$'%0.,?.5/+)@,("63.H/,D/(,H).$%(,=,0_.$),63.+D@,5+$(,&'))"#$6.&$'%
!"6.#"$%.&$'%,.+,8f!"6.#"$%.&$'%,.+,8fQQ (+5/)6)$&$9+/(+5/)6)$&$9+/B+),D/(,H).$%(,?/)&(,5)".0.*0/:/%&,3+:$D$#$"(B+),D/(,H).$%(,?/)&(,5)".0.*0/:/%&,3+:$D$#$"(
LE CAFÉ SOLUBLELE CAFÉ SOLUBLE[0,(/,5)"5.)/,$%D+(&)$/00/:/%&,=,5.)&$),D/,6.#",[0,(/,5)"5.)/,$%D+(&)$/00/:/%&,=,5.)&$),D/,6.#",:'+0+@,5.),/7&).6&$'%,('0$D/|0$9+$D/,:'+0+@,5.),/7&).6&$'%,('0$D/|0$9+$D/, 6'%#/6&$'%,6'%#/6&$'%,D_+%,/7&).$&,.9+/+7,&)4(,6'%6/%&)"@,D_.(5/6&,D_+%,/7&).$&,.9+/+7,&)4(,6'%6/%&)"@,D_.(5/6&,($)+5/+7,($)+5/+7,8/& /7&).$& /(& /%(+$&/ 6':504&/:/%& D"(32D).&"8/& /7&).$& /(& /%(+$&/ 6':504&/:/%& D"(32D).&"8/&,/7&).$&,/(&,/%(+$&/,6':504&/:/%&,D"(32D).&"@,8/&,/7&).$&,/(&,/%(+$&/,6':504&/:/%&,D"(32D).&"@,('$&,5.),.&':$(.&$'%@,('$&,5.),02'53$0$(.&$'%,F('$&,5.),.&':$(.&$'%@,('$&,5.),02'53$0$(.&$'%,F
5.),.&':$(.&$'%,5.),.&':$(.&$'%,F,5+0?")$(.&$'%,K:$6)'H'+&&/0/&&/(M,F,5+0?")$(.&$'%,K:$6)'H'+&&/0/&&/(M,D.%(,+%,6'+).%&,D_.$),63.+D,D.%(,+%,6'+).%&,D_.$),63.+D, H).%+0"(@,D/,5'&/%&$/0,H).%+0"(@,D/,5'&/%&$/0,.)':.&$9+/,$%#")$/+).)':.&$9+/,$%#")$/+)
5.),02'53$0$(.&$'%,5.),02'53$0$(.&$'%,F,(+*0$:.&$'%,D/(,5.$00/&&/(,D/,F,(+*0$:.&$'%,D/(,5.$00/&&/(,D/,0_/7&).$&,D/,6.#",6'%H/0"0_/7&).$&,D/,6.#",6'%H/0"
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PRODUCTION MONDIALE DE CAFEPRODUCTION MONDIALE DE CAFE
ASPECTS PHARMACOLOGIQUES ASPECTS PHARMACOLOGIQUES
E6&$?$&"(,D":'%&)"/(,0$"/(,=,0.,5)"(/%6/,D/,6.#"$%/,F.%&.H'%$(&/(,D/(,)"6/5&/+)(,E\,/&,D/,6/)&.$%(,)"6/5&/+)(,EQ,D/,0J.D"%'($%/
$%3$*/,0/(,53'(53'D$/(&").(/(,.$%($,9+/,0.,
n
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f
8kZ
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caféinecaféine
0$*").&$'%,DJ3$(&.:$%/,5.),0/(,:.(&'62&/(
.6&$'%,(&$:+0.%&/,(+),0/(,(2(&4:/(,6.)D$'-?.(6+0.$)/,/&,)/(5$).&'$)/@,/&,(+),0.,D$+)4(/
#.?')$(/,6'%6/%&).&$'%,/&,:":')$(.&$'%
.+H:/%&/,0.,D"5/%(/,"%/)H"&$9+/,
0$5'02&$9+/,5.),?'$/,/7&/)%/
U%/,9+.).%&.$%/,D/,(5"6$.0$&"(,53.):.6/+&$9+/(,/%,V).%6/,K,.(('6$.&$'%,.?/6,.%&.0H$9+/(@,0$5'02&$9+/(,0'6.+7,M
Z
ASPECTS PHARMACEUTIQUES ASPECTS PHARMACEUTIQUES
![Page 20: PLANTES A ALCALOIDES ET PRODUITS …mastervrv.free.fr/S2/RMA2/Cours/4.pdf · PLANTES A ALCALOIDES ET PRODUITS APPARENTES Bernard Weniger Pharmacognosie et Molécules Naturelles Bioactives](https://reader031.vdocuments.pub/reader031/viewer/2022021902/5b98a98809d3f253748ca644/html5/thumbnails/20.jpg)
DOMAINE PHARMACEUTIQUEDOMAINE PHARMACEUTIQUEMonographie analytique du café vertMonographie analytique du café vert>3.):.6'5"/,#).%t.$(/,}>3.):.6'5"/,#).%t.$(/,}4:/4:/ "DG"DG
!)'H+/,!)'H+/,F,H).$%/,5)$?"/,D+,&"H+:/%&,/&,("63"/,D/,F,H).$%/,5)$?"/,D+,&"H+:/%&,/&,("63"/,D/,Coffea arabica Coffea arabica iG@,D/,iG@,D/,Coffea canephora Coffea canephora >$/))/,/7,V)'/3%/),/&,0/+)(,?.)$"&"(,>$/))/,/7,V)'/3%/),/&,0/+)(,?.)$"&"(,
i/,6.#",?/)&,6'%&$/%&,i/,6.#",?/)&,6'%&$/%&,.+,:$%$:+:,\@O,5'+),6/%&,D/,6.#"$%/,.+,:$%$:+:,\@O,5'+),6/%&,D/,6.#"$%/,6.06+0",5.),).55')&,=,0.,D)'H+/,D/(("63"/,6.06+0",5.),).55')&,=,0.,D)'H+/,D/(("63"/,
<$6)'(6'5$/,F,#).H:/%&(,DJ.0*+:/%,6'%&/%.%&,D/(,H'+&&/0/&&/(,<$6)'(6'5$/,F,#).H:/%&(,DJ.0*+:/%,6'%&/%.%&,D/(,H'+&&/0/&&/(,3+$0/+(/(@,D"*)$(,D/,&"H+:/%&,/&,#$*)/(,#+($#'):/(,=,5.)'$(,,,,3+$0/+(/(@,D"*)$(,D/,&"H+:/%&,/&,#$*)/(,#+($#'):/(,=,5.)'$(,,,,6.%.0$6+0"/(,6.%.0$6+0"/(,
[D/%&$&",88<,F,?$(+.0$(.&$'%,/%,U~,/&,5.),5+0?")$(.&$'%,D/,[D/%&$&",88<,F,?$(+.0$(.&$'%,/%,U~,/&,5.),5+0?")$(.&$'%,D/,)".6&$#,)".6&$#,$'D'$'D'--$'D+)",$'D+)",/%,5)"(/%6/,D/,&":'$%,6.#"$%//%,5)"(/%6/,D/,&":'$%,6.#"$%/
>/)&/,=,0.,D/(($6.&$'%,F,>/)&/,=,0.,D/(($6.&$'%,F, b,Xb,X
8/%D)/(,&'&.0/(,F,8/%D)/(,&'&.0/(,F, b,Xb,X
!'(.H/,D/,0.,6.#"$%/,5.),8ik>,!'(.H/,D/,0.,6.#"$%/,5.),8ik>,K:'D$#$6.&$'%,:'%'H).53$/,/%,K:'D$#$6.&$'%,:'%'H).53$/,/%,6'+)(,F6'+)(,F6'6'--$%P/6&$'%,$%P/6&$'%,D_"5$6.&"63'0,5'+),?")$#$/),0.,6'%#'):$&",D+,(2(&4:/M,,,,D_"5$6.&"63'0,5'+),?")$#$/),0.,6'%#'):$&",D+,(2(&4:/M,,,,
LE THEIER : Camellia sinensis (L.) Kuntze
[0,.+).$&,"&",D"6'+?/)&,5.),0J;:5/)/+),B3^%[0,.+).$&,"&",D"6'+?/)&,5.),0J;:5/)/+),B3^%--n+%H,n+%H,KQROO,.?.%&,�G8GM,F,6/,D/)%$/),(/,#$&,.55')&/),+%/,KQROO,.?.%&,�G8GM,F,6/,D/)%$/),(/,#$&,.55')&/),+%/,&.((/,DJ/.+,*'+$00.%&/,/&@,.(($(,=,0J':*)/,DJ+%,&3"$/)@,&.((/,DJ/.+,*'+$00.%&/,/&@,.(($(,=,0J':*)/,DJ+%,&3"$/)@,$0,(J.(('+5$&G,>/%D.%&,('%,('::/$0@,50+($/+)(,#/+$00/($0,(J.(('+5$&G,>/%D.%&,('%,('::/$0@,50+($/+)(,#/+$00/((/ D"&.634)/%& 5'+) .00/) (/ 5'(/) D.%( 0J/.+ *)y0.%&/(/ D"&.634)/%& 5'+) .00/) (/ 5'(/) D.%( 0J/.+ *)y0.%&/
U%/,6'+)&/,3$(&'$)/,D+,&3",U%/,6'+)&/,3$(&'$)/,D+,&3",
(/,D"&.634)/%&,5'+),.00/),(/,5'(/),D.%(,0J/.+,*)y0.%&/(/,D"&.634)/%&,5'+),.00/),(/,5'(/),D.%(,0J/.+,*)y0.%&/0/,&3","&.$&,%"0/,&3","&.$&,%"
i/,&3"$/),.55.)&$/%&,=,0.,#.:$00/,D/(,]/)%(&)'/:$.6"/(i/,&3"$/),.55.)&$/%&,=,0.,#.:$00/,D/(,]/)%(&)'/:$.6"/(K]3".6"/(MK]3".6"/(Mf%,D$(&$%H+/,D/+7,?.)$"&"(,5)$%6$5.0/(,Ff%,D$(&$%H+/,D/+7,?.)$"&"(,5)$%6$5.0/(,F
Camellia sinensis sinensisCamellia sinensis sinensis K,83$%/@,�.5'%@,j+(($/@,[).%@]+)9+$/K,83$%/@,�.5'%@,j+(($/@,[).%@]+)9+$/Camellia sinensis assamicaCamellia sinensis assamica K,%')DK,%')D--/(&,D/,0J[%D/,M/(&,D/,0J[%D/,M
LE THEIER : Camellia sinensisLE THEIER : Camellia sinensis
8+0&$?",D.%(,0/(,5.2(,D+,8+0&$?",D.%(,0/(,5.2(,D+,(+D(+D--/(&,.($.&$9+/,/(&,.($.&$9+/,:.$(,.+(($,(+),0/,6'%&$%/%&,.#)$6.$%@,/%,:.$(,.+(($,(+),0/,6'%&$%/%&,.#)$6.$%@,/%,]+)9+$/,'+,/%6')/,/%,E)H/%&$%/]+)9+$/,'+,/%6')/,/%,E)H/%&$%/
>/&$&,.)*)/,).:/+7>/&$&,.)*)/,).:/+7@,=,#/+$00/(,5/)($(&.%&/(@@,=,#/+$00/(,5/)($(&.%&/(@:'00/(,/&,D+?/&/+(/(,0')(9+J/00/(,('%&,:'00/(,/&,D+?/&/+(/(,0')(9+J/00/(,('%&,P/+%/( 6')$.6/( /& 5)/(9+/ H0.*)/(P/+%/( 6')$.6/( /& 5)/(9+/ H0.*)/(P/+%/(@,6')$.6/(,/&,5)/(9+/,H0.*)/(,P/+%/(@,6')$.6/(,/&,5)/(9+/,H0.*)/(,0')(9+J/00/(,('%&,sH"/(,K(60")$&/(M0')(9+J/00/(,('%&,sH"/(,K(60")$&/(M
;%,6+0&+)/@,0/(,&3"$/)(,('%&,;%,6+0&+)/@,0/(,&3"$/)(,('%&,&.$00"(&.$00"( &)4(,&)4(,)"H+0$4)/:/%&,5'+),#.6$0$&/),0.,)"6'0&/)"H+0$4)/:/%&,5'+),#.6$0$&/),0.,)"6'0&/
n"6/(($&/,+%,n"6/(($&/,+%,/%('0/$00/:/%&/%('0/$00/:/%& D/,W,3/+)/(,D/,W,3/+)/(,:$%G,5.),P'+)@,3+:$D$&",D/,0J.$),KRO,:$%G,5.),P'+)@,3+:$D$&",D/,0J.$),KRO,-- bOXM,bOXM,/&,D/(,50+$/(,.*'%D.%&/(,K,/76/5&$'%,5'+),/&,D/(,50+$/(,.*'%D.%&/(,K,/76/5&$'%,5'+),0/(,&3"(,D_.0&$&+D/,M0/(,&3"(,D_.0&$&+D/,M
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LA RECOLTE DES FEUILLES DE THELA RECOLTE DES FEUILLES DE THE
k.*$&+/00/:/%&@,'%,%/,6+/$00/,9+/,0/,*'+)H/'% =,0_/7&)":$&",D/,0.,*).%63/,/&,0/(,D/+7,#/+$00/(,(+$?.%&/(,0/(,50+(,P/+%/(,)4H0/,D/(,` &o',0/.?/(,.%D,.,*+D a
;%,E#)$9+/@,'%,+&$0$(/,5.)#'$(,D/(,:.63$%/(@,$ B $ i c & [ D 0 &3" &:.$(,.+,B)$,i.%c.,/&,/%,[%D/@,0/,&3",/(&,
/%6')/,6+/$00$,=,0.,:.$%, :/$00/+)/,9+.0$&",6.),0/(,6+/$00/+)(,0.$((/%&,D/,6x&",0/(,5'+((/(,$%(+##$(.::/%&,:y)/(
E,*.((/,.0&$&+D/@,0/,&3",/(&,)"6'0&",P+(9+_=,ZO,#'$(,5.),.%@,D.%(,0/(,3.+&/+)(@,` (/+0/:/%& a,\W,#'$(@,6.),$0,5'+((/,50+(,0/%&/:/%&
LE THEIER : CAMELLIA SINENSISLE THEIER : CAMELLIA SINENSIS
8'::/)6$.0/:/%&@,'%,D$(&$%H+/,8'::/)6$.0/:/%&@,'%,D$(&$%H+/,(+)&'+&,,F(+)&'+&,,F
]3",*0.%6,]3",*0.%6,F,(&.*$0$(",=,0.,?.5/+),,/&,("63"F,(&.*$0$(",=,0.,?.5/+),,/&,("63"
]3",?/)&]3",?/)&@,#s%",5+$(,(&.*$0$(",5.),0.,63.0/+)@,#s%",5+$(,(&.*$0$(",5.),0.,63.0/+)(463/,'+,5.),0.,?.5/+)@,)'+0"@,("63",,(463/,'+,5.),0.,?.5/+)@,)'+0"@,("63",,5 5 @ @5 5 @ @).5$D/:/%&,/&,50+(,'+,:'$%(,&'))"#$"@,).5$D/:/%&,/&,50+(,'+,:'$%(,&'))"#$"@,K(+)&'+&,6'%('::",/%,83$%/,/&,.+,�.5'%@K(+)&'+&,6'%('::",/%,83$%/,/&,.+,�.5'%@:.$(,0_+(.H/,(/,D"?/0'55/,/%,;+)'5/M:.$(,0_+(.H/,(/,D"?/0'55/,/%,;+)'5/M
]3",%'$)]3",%'$)@,#s%",+%/,?$%H&.$%/,DJ3/+)/(@,@,#s%",+%/,?$%H&.$%/,DJ3/+)/(@,)'+0"@,#/):/%&",/%,.&:'(534)/,3+:$D/,)'+0"@,#/):/%&",/%,.&:'(534)/,3+:$D/,5+$(,("63",=,0J.$),63.+D@,5+$(,("63",=,0J.$),63.+D@,)/5)"(/%&.%&,)/5)"(/%&.%&,hO,X,D+,:.)63",:'%D$.0hO,X,D+,:.)63",:'%D$.0
]3",''0'%H,]3",''0'%H,F,0"H4)/:/%&,#/):/%&"F,0"H4)/:/%&,#/):/%&"
Thé vertThé vert
Thé noirThé noir
LE THEIER : CAMELLIA SINENSISLE THEIER : CAMELLIA SINENSIS
]3"(,6'::/)6$.+7]3"(,6'::/)6$.+7 FF~.)$"&"(,*'&.%$9+/(~.)$"&"(,*'&.%$9+/(?.)G,?.)G,sinensissinensis@,@,assamicaassamica GGGG
EH/,D/(,#/+$00/(,EH/,D/(,#/+$00/(,
~.)$"&" D/( &).$&/:/%&(F~.)$"&" D/( &).$&/:/%&(F~.)$"&",D/(,&).$&/:/%&(F~.)$"&",D/(,&).$&/:/%&(F?/)&@,(/:$?/)&@,(/:$--'72D"(@,'72D"(@,.)':.&$("(,GG'72D"(@,'72D"(@,.)':.&$("(,GG
f)$H$%/,H"'H).53$9+/f)$H$%/,H"'H).53$9+/8/20.%,KB)$,i.%c.M8/20.%,KB)$,i.%c.ME((.:@,!.)P//0$%H,/&,B$cc$:,K[%D/M,E((.:@,!.)P//0$%H,/&,B$cc$:,K[%D/M,E%3+$,Kr//:+%M,/&,Ä+%%.%,K83$%/ME%3+$,Kr//:+%M,/&,Ä+%%.%,K83$%/M]3"(,D_E#)$9+/,Kr"%2.@,jo.%D.M]3"(,D_E#)$9+/,Kr"%2.@,jo.%D.M]3"(,D+,<'2/%]3"(,D+,<'2/%--f)$/%&,K]+)9+$/@,[).%Mf)$/%&,K]+)9+$/@,[).%M]3"(,D_E:")$9+/,D+,(+D,KE)H/%&$%/M]3"(,D_E:")$9+/,D+,(+D,KE)H/%&$%/M
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VARIÉTÉS SELON LA TAILLE DES FEUILLES VARIÉTÉS SELON LA TAILLE DES FEUILLES
` V0'o/)2,f).%H/,>/c'/ a,KVf>M F0.,#$%/,#/+$00/,D+,*'+)H/'%,=,#/+$00/(
` f).%H/,>/c'/ a,Kf>M /(&,0.,5)/:$4)/,#/+$00/,&/%D)/,/%&$4)/:/%&,'+?/)&/ 9+$ (/ )/#'):/ = 63.9+/'+?/)&/,9+$,(/,)/#'):/,=,63.9+/,53.(/,D/,6)'$((.%6/,D+,&3"$/)G,B'%,H'y&,/(&,50+(,#')&,9+/,Vf>G,
` >/c'/ a,K>M,D"($H%/,0.,D/+7$4:/,#/+$00/,.5)4(,0/,*'+)H/'%,=,#/+$00/( F,/00/,D'%%/,+%,H'y&,:.)9+",/&,+%/,$%#+($'%,#')&/:/%&,6'0')"/
Dérivés flavaniques du thé vertDérivés flavaniques du thé vert
Flavanol
>)'&"$%/(@,.6$D/(,.:$%"(@,H0+6$D/(@,6.)'&4%/(>)'&"$%/(@,.6$D/(,.:$%"(@,H0+6$D/(@,6.)'&4%/(E6$D/,.(6')*$9+/,/&,?$&.:$%/(,D+,H)'+5/,1,E6$D/,.(6')*$9+/,/&,?$&.:$%/(,D+,H)'+5/,1,
1.(/(,7.%&3$9+/(,1.(/(,7.%&3$9+/(,5)$%6$5.0/:/%&,)/5)"(/%&"/(,5.),0.,5)$%6$5.0/:/%&,)/5)"(/%&"/(,5.),0.,6.#"$%/,KQ,6.#"$%/,KQ,-- N,X,(/0'%,?.)$"&"(,/&,#/+$00/(,6'%6/)%"/(M,d,N,X,(/0'%,?.)$"&"(,/&,#/+$00/(,6'%6/)%"/(M,d,#.$*0/(,9+.%&$&"(,D/,&3"'53200$%/,/&,&3"'*)':$%/#.$*0/(,9+.%&$&"(,D/,&3"'53200$%/,/&,&3"'*)':$%/k"&")'($D/( DJ.06''0( &/)5"%$9+/( D'%& 0J32D)'02(/ 0$*4)/k"&")'($D/( DJ.06''0( &/)5"%$9+/( D'%& 0J32D)'02(/ 0$*4)/
ASPECTS CHIMIQUES DU THE VERTASPECTS CHIMIQUES DU THE VERT
k"&")'($D/(,D .06''0(,&/)5"%$9+/(@,D'%&,0 32D)'02(/,0$*4)/,k"&")'($D/(,D .06''0(,&/)5"%$9+/(@,D'%&,0 32D)'02(/,0$*4)/,D/(,6'%(&$&+.%&(,9+$,6'%&)$*+/%&,=,0J.)x:/,D/,0J$%#+($'%D/(,6'%(&$&+.%&(,9+$,6'%&)$*+/%&,=,0J.)x:/,D/,0J$%#+($'%
8':5'("(,53"%'0$9+/(,8':5'("(,53"%'0$9+/(,KP+(9+J=,KP+(9+J=,ZO,ZO,X,X,D/,D/,0.,:.((/,(463/M,0.,:.((/,(463/M,:.$(,D'%&,0.,&/%/+),?.)$/,(/0'%,0.,?.)$"&"@,0JsH/,D/,0.,#/+$00/,:.$(,D'%&,0.,&/%/+),?.)$/,(/0'%,0.,?.)$"&"@,0JsH/,D/,0.,#/+$00/,K0/(,50+(,P/+%/(,('%&,0/(,50+(,)$63/(M,/&,0.,(.$('%,K0/(,50+(,P/+%/(,('%&,0/(,50+(,)$63/(M,/&,0.,(.$('%,KK "&"M,"&"M,FFD")$?"(,#0.?.%$9+/(,F,H.00.&/,D")$?"(,#0.?.%$9+/(,F,H.00.&/,D_"5$H.00'6.&"63'0,D_"5$H.00'6.&"63'0,K;Y8YMF,K;Y8YMF,WW--\Q,XM\Q,XM.6$D/(,53"%'0(,.6$D/(,53"%'0(,#0.?'%'CD/(,#0.?'%'CD/(,5)'.%&3'62.%$D'0(5)'.%&3'62.%$D'0(
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i.,9+.%&$&",D/,i.,9+.%&$&",D/,*.(/(,7.%&3$9+/(,*.(/(,7.%&3$9+/(,5)"(/%&/,"?'0+/,5/+5)"(/%&/,"?'0+/,5/+
!"?/0'55/:/%&,D/,0_.)x:/,5.),#'):.&$'%,D/,!"?/0'55/:/%&,D/,0_.)x:/,5.),#'):.&$'%,D/,5)'D+$&(,?'0.&$0(5)'D+$&(,?'0.&$0( FFD")$?"(,6"&'%$9+/(,5.),D"H).D.&$'%,D/(,6.)'&4%/(D")$?"(,6"&'%$9+/(,5.),D"H).D.&$'%,D/(,6.)'&4%/(3/7"%.0,5.),'72D.&$'%,D_.6$D/(,H).(,$%(.&+)"(3/7"%.0,5.),'72D.&$'%,D_.6$D/(,H).(,$%(.&+)"()".)).%H/:/%&,D/(,&/)54%/()".)).%H/:/%&,D/(,&/)54%/(
ASPECTS CHIMIQUES DU THE NOIRASPECTS CHIMIQUES DU THE NOIR
f72D.&$'%,D/(,f72D.&$'%,D/(,5'0253"%'0(5'0253"%'0( ?$($*0/,K63.%H/:/%&,D/,6'+0/+)M,,F?$($*0/,K63.%H/:/%&,D/,6'+0/+)M,,F
VV'):.&$'%,'):.&$'%,D/,&)'5'0'%/(,F,&3".#0.?$%/@,&3".#0.H.0$%/@,D/,&)'5'0'%/(,F,&3".#0.?$%/@,&3".#0.H.0$%/@,"5$&3".#0.H.0$%/"5$&3".#0.H.0$%/
V')&/,D$:$%+&$'%,D/,0.,&/%/+),/%,D")$?"(,#0.?.%$9+/(,K6.&"63$%/(MV')&/,D$:$%+&$'%,D/,0.,&/%/+),/%,D")$?"(,#0.?.%$9+/(,K6.&"63$%/(M
E6&$?$&"(,0$"/(,.+7,*.(/(,7.%&3$9+/(,K6.#"$%/M,.6&$?$&",(&$:+0.%&/,:'$%(,$%&/%(/,:.$(,50+(,
5)'0'%H"/,9+/,0/,6.#",K6.#"$%/,0$"/,.+7,5'0253"%'0(M,
>'0253"%'0( K%'% 5'02:")$("( D+ &3" ?/)&M F
ACTIVITES BIOLOGIQUES ACTIVITES BIOLOGIQUES DES CONSTITUANTS DU THEDES CONSTITUANTS DU THE
>'0253"%'0( K%'%,5'02:")$("(,D+,&3",?/)&M,F)"D+6&$'%,D/(,6.%6/)(,D$H/(&$#(,/&,5)"?/%&$'%,D+,,6.%6/),6'0')/6&.0,K,"&+D/(,"5$D":$'0'H$9+/(,M,.6&$?$&"(,.%&$'72D.%&/(.6&$?$&"(,.%&$*.6&")$/%%/(,K,6.)$/(@,(2(&4:/,D$H/(&$#,M
.6&$?$&",.%&$?$).0/
EVOLUTION DE LA PRODUCTION DE THÉ EVOLUTION DE LA PRODUCTION DE THÉ AU NIVEAU MONDIALAU NIVEAU MONDIAL
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EVOLUTION DE LA PRODUCTION DE THÉ EVOLUTION DE LA PRODUCTION DE THÉ AU NIVEAU MONDIALAU NIVEAU MONDIAL
Q,:'%'H).53$/(,=,0.,>3.):.6'5"/,#).%t.$(/,Q,:'%'H).53$/(,=,0.,>3.):.6'5"/,#).%t.$(/,THÉ VERT THÉ VERT KKCamelliae sinensis non fermentata foliaCamelliae sinensis non fermentata foliaMM
V/+$00/@,P/+%/@,%'%,#/):/%&"/@,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,V/+$00/@,P/+%/@,%'%,#/):/%&"/@,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,63.+D@,5+$(,("63"/@,D/,63.+D@,5+$(,("63"/@,D/,Camellia sinensisCamellia sinensis KiGM,r+%&e/,/&,D/,(/(,KiGM,r+%&e/,/&,D/,(/(,?.)$"&"(,6+0&$?"/(G,?.)$"&"(,6+0&$?"/(G,
DOMAINE PHARMACEUTIQUEDOMAINE PHARMACEUTIQUEMonographies analytiques du théMonographies analytiques du thé
i/,&3",?/)&,6'%&$/%&,i/,&3",?/)&,6'%&$/%&,.+,:$%$:+:,Q@O,X,D/,6.#"$%/,.+,:$%$:+:,Q@O,X,D/,6.#"$%/,6.06+0",5.),).55')&,6.06+0",5.),).55')&,=,0.,D)'H+/,D/(("63"/=,0.,D)'H+/,D/(("63"/
THÉ NOIR THÉ NOIR KKCamelliae sinensis fermentata foliaCamelliae sinensis fermentata foliaMM
V/+$00/,P/+%/@,#/):/%&"/@,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,V/+$00/,P/+%/@,#/):/%&"/@,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,63.+D@,5+$(,("63"/@,D/,63.+D@,5+$(,("63"/@,D/,Camellia sinensisCamellia sinensis KiGM,r+%&e/,/&,D/,(/(,KiGM,r+%&e/,/&,D/,(/(,?.)$"&"(,6+0&$?"/(G,?.)$"&"(,6+0&$?"/(G,
i/,&3",%'$),6'%&$/%&,i/,&3",%'$),6'%&$/%&,.+,:$%$:+:,Q@W,X,6/%&,D/,6.#"$%/,.+,:$%$:+:,Q@W,X,6/%&,D/,6.#"$%/,6.06+0",5.),6.06+0",5.),).55')&,=,0.,D)'H+/,D/(("63"/G,).55')&,=,0.,D)'H+/,D/(("63"/G,
;7.:/%,:$6)'(6'5$9+/,;7.:/%,:$6)'(6'5$9+/,FF
DOMAINE PHARMACEUTIQUEDOMAINE PHARMACEUTIQUEMonographies analytiques du théMonographies analytiques du thé
.G,,:.60/(,D_'7.0.&/,D/,8.,/&,5'$0(,&/6&/+)(,+%$6/00+0.$)/(,=,5.)'$(,"5.$((/,/&,/7&)":$&",6'%$9+/.G,,:.60/(,D_'7.0.&/,D/,8.,/&,5'$0(,&/6&/+)(,+%$6/00+0.$)/(,=,5.)'$(,"5.$((/,/&,/7&)":$&",6'%$9+/*G,,(60")$&/(*G,,(60")$&/(6G,,"5$D/):/,(+5")$/+),%'%,(&':.&$#4)/6G,,"5$D/):/,(+5")$/+),%'%,(&':.&$#4)/DG,,"5$D/):/,$%#")$/+),(&':.&$#4)/,.?/6,(&':.&/(,/%&'+)"(,5.),Z,'+,N,6/00+0/(,.%%/7/(DG,,"5$D/):/,$%#")$/+),(&':.&$#4)/,.?/6,(&':.&/(,/%&'+)"(,5.),Z,'+,N,6/00+0/(,.%%/7/(
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;7.:/%,/%,63)':.&'H).53$/,(+),6'+63/,,;7.:/%,/%,63)':.&'H).53$/,(+),6'+63/,,:$%6/,F:$%6/,F~$(+.0$(.&$'%,D/,0.,6.#"$%/,/&,D/,0.,&3"'*)':$%/,~$(+.0$(.&$'%,D/,0.,6.#"$%/,/&,D/,0.,&3"'*)':$%/,/%,U~/%,U~K,QWN,%:,M,/&,5.),5+0?")$(.&$'%,D/,K,QWN,%:,M,/&,5.),5+0?")$(.&$'%,D/,)".6&$#,$'D')".6&$#,$'D'--$'D+)",$'D+)",
DOMAINE PHARMACEUTIQUEDOMAINE PHARMACEUTIQUEMonographies analytiques du théMonographies analytiques du thé
K M 5 5K M 5 5/%,5)"(/%6/,D_+%,&":'$%,D/,6.#"$%//%,5)"(/%6/,D_+%,&":'$%,D/,6.#"$%/
>/)&/,=,0.,D/(($6.&$'%,F,>/)&/,=,0.,D/(($6.&$'%,F, h,Xh,X
8/%D)/(,&'&.0/(,F,8/%D)/(,&'&.0/(,F, b,Xb,X
!'(.H/,D/,0.,6.#"$%/,5.),8ik>!'(.H/,D/,0.,6.#"$%/,5.),8ik>
LE MATÉ : Ilex paraguariensisLE MATÉ : Ilex paraguariensis
LE MATÉ : Ilex paraguariensisLE MATÉ : Ilex paraguariensis
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FORMES COMMERCIALES DU MATÉFORMES COMMERCIALES DU MATÉ
CONSTITUANTS ACTIFS PRINCIPAUX DU MATECONSTITUANTS ACTIFS PRINCIPAUX DU MATE
MATÉ VERT MATÉ VERT KKIlex paraguarensisIlex paraguarensisM,,>3G,V).%t.$(/,\OM,,>3G,V).%t.$(/,\O4:/4:/ "D$&$'%"D$&$'%
i.,5.)&$/,+&$0$(",D+,:.&",?/)&,/(&,6'%(&$&+"/,5.),0.,#/+$00/,D/,i.,5.)&$/,+&$0$(",D+,:.&",?/)&,/(&,6'%(&$&+"/,5.),0.,#/+$00/,D/,Ilex Ilex paraguarensis paraguarensis B&G,k$0G,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,B&G,k$0G,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,63.+D@,5+$(,$%6$("/,G,i/,:.&",?/)&,6'%&$/%&,63.+D@,5+$(,$%6$("/,G,i/,:.&",?/)&,6'%&$/%&,.+,:$%$:+:,\@O,X,.+,:$%$:+:,\@O,X,D/,6.#"$%/D/,6.#"$%/ 6.06+0",5.),).55')&,=,0.,D)'H+/,D/(("63"/6.06+0",5.),).55')&,=,0.,D)'H+/,D/(("63"/i/ :.&" (/ 5)"(/%&/ /% :')6/.+7 $))"H+0$/)( .%H+0/+7i/ :.&" (/ 5)"(/%&/ /% :')6/.+7 $))"H+0$/)( .%H+0/+7
DOMAINE PHARMACEUTIQUEDOMAINE PHARMACEUTIQUEMonographie analytique du matéMonographie analytique du maté
i/,:.&",(/,5)"(/%&/,/%,:')6/.+7,$))"H+0$/)(@,.%H+0/+7@,i/,:.&",(/,5)"(/%&/,/%,:')6/.+7,$))"H+0$/)(@,.%H+0/+7@,H0.*)/(@,?/)&,P.+%s&)/@,/&,:/(+).%&,D.%(,0/+),50+(,H).%D/,H0.*)/(@,?/)&,P.+%s&)/@,/&,:/(+).%&,D.%(,0/+),50+(,H).%D/,D$:/%($'%,D/,Q::,=,N::GD$:/%($'%,D/,Q::,=,N::G;7.:/%,/%,63)':.&'H).53$/,(+),6'+63/,:$%6/,F;7.:/%,/%,63)':.&'H).53$/,(+),6'+63/,:$%6/,F-- ?$(+.0$(.&$'%?$(+.0$(.&$'% D/D/ 0.0. 6.#"$%/6.#"$%/ /&/& D/D/ 0.0. &3"'*)':$%/&3"'*)':$%/ /%/% U~U~ KK QWNQWN %:%: MM-- 5+0?")$(.&$'%5+0?")$(.&$'% D/D/ )".6&$#)".6&$# $'D'$'D'--$'D+)"$'D+)" /%/% 5)"(/%6/5)"(/%6/ D/D/ &":'$%&":'$% 6.#"$%/6.#"$%/
>/)&/,=,0.,D/(($6.&$'%,F,,h,X>/)&/,=,0.,D/(($6.&$'%,F,,h,X8/%D)/(,&'&.0/(,F,,h,X8/%D)/(,&'&.0/(,F,,h,X!'(.H/,D/,0.,6.#"$%/,5.),8ik>!'(.H/,D/,0.,6.#"$%/,5.),8ik>
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DOMAINE PHARMACEUTIQUEDOMAINE PHARMACEUTIQUEAnalyse microscopique du matéAnalyse microscopique du maté
LE GUARANA : Paullinia cupana LE GUARANA : Paullinia cupana KunthKunthvar. var. sorbilissorbilis
E)*+(&/ D/,0.,#.:$00/,D/(,,B.5$%D.6"/(,')$H$%.$)/,D/,0.,)"H$'%,.:.e'%$/%%/
i/(,#)+$&(,F,*.$/(,)'+H/,-').%H"/( 6'%&/%.%& Z H).$%/(').%H"/(,6'%&/%.%&,,Z,H).$%/(,
i.,D)'H+/,F,.:.%D/,D/,0.,H).$%/ '*&/%+/,.5)4(,5.((.H/,(+),+%/,('+)6/,D/,63.0/+)
U(.H/,.%6$/%,5.),0/(,6'::+%.+&"(,.:.e'%$/%%/(,6'::/,.%&$:.0.)$9+/@,(&$:+0.%&/&,` .%&$-#.$: a
1.(/(,7.%&3$9+/(,1.(/(,7.%&3$9+/(,5)$%6$5.0/:/%&,)/5)"(/%&"/(,5.)5)$%6$5.0/:/%&,)/5)"(/%&"/(,5.)0.,6.#"$%/,K,Z,0.,6.#"$%/,K,Z,-- S,X,M,S,X,M,D/,#.$*0/(,9+.%&$&"(,D/,&3"'53200$%/,/&,&3"'*)':$%/D/,#.$*0/(,9+.%&$&"(,D/,&3"'53200$%/,/&,&3"'*)':$%/
8':5'("(,53"%'0$9+/(,8':5'("(,53"%'0$9+/(, &.%$%(,6.&"63$9+/(,&.%$%(,6.&"63$9+/(, SXSX8.&"63'0,/&,D")$?"(,6.&"63$9+/(8.&"63'0,/&,D")$?"(,6.&"63$9+/(
COMPOSES ACTIFS DU GUARANACOMPOSES ACTIFS DU GUARANA
.6$D/,6.&"63+&.%%$9+/.6$D/,6.&"63+&.%%$9+/
>)"(/%6/,D/,(.5'%$%/(,K+(.H/,6'::/,5$(6$6$D/M>)"(/%6/,D/,(.5'%$%/(,K+(.H/,6'::/,5$(6$6$D/M]).6/(,D/,?.%$00$%/]).6/(,D/,?.%$00$%/
U(.H/(,5)$%6$5.+7,6'::/,FU(.H/(,5)$%6$5.+7,6'::/,FB&$:+0.%&,532($9+/,/&,$%&/00/6&+/0B&$:+0.%&,532($9+/,/&,$%&/00/6&+/08'+5/8'+5/--#.$:,`#.$:,` %.&+)/0%.&+)/0 a,K)$(9+/(,5'+),0.,(.%&"Ma,K)$(9+/(,5'+),0.,(.%&"M
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FORMES COMMERCIALES DU GUARANAFORMES COMMERCIALES DU GUARANA
Pharmacopée française : 2 monographies (graine et pâte) Pharmacopée française : 2 monographies (graine et pâte)
YjE[n;,YjE[n;,(Paulliniae sorbilis semen)(Paulliniae sorbilis semen)Y).$%/,('+:$(/,=,+%/,).5$D/,D/(($6.&$'%,=,63.+D,Y).$%/,('+:$(/,=,+%/,).5$D/,D/(($6.&$'%,=,63.+D,8 &$ & $ $ Z W X D #"$ 0 0" &8 &$ & $ $ Z W X D #"$ 0 0" &
DOMAINE PHARMACEUTIQUEDOMAINE PHARMACEUTIQUEMonographies analytiques du guaranaMonographies analytiques du guarana
8'%&$/%&,.+,:$%$:+:,Z@W,X,D/,6.#"$%/,6.06+0"/,5.),).55')&,8'%&$/%&,.+,:$%$:+:,Z@W,X,D/,6.#"$%/,6.06+0"/,5.),).55')&,=,0.,D)'H+/,D/(("63"/=,0.,D)'H+/,D/(("63"/
>E];,>E];,(Paulliniae sorbilis contriti siccatique nuclei)(Paulliniae sorbilis contriti siccatique nuclei)>s&/,("63"/,'*&/%+/,5.),"6).(/:/%&,D/,0_.:.%D/@,('+:$(/,>s&/,("63"/,'*&/%+/,5.),"6).(/:/%&,D/,0_.:.%D/@,('+:$(/,=,+%/,).5$D/,D/(($6.&$'%,=,63.+D,/&,3+:$D$#$"/=,+%/,).5$D/,D/(($6.&$'%,=,63.+D,/&,3+:$D$#$"/
i.,5s&/,D/,H+.).%.,6'%&$/%&,.+,:$%$:+:,Z@O,X,D/,6.#"$%/,6.06+0"/,i.,5s&/,D/,H+.).%.,6'%&$/%&,.+,:$%$:+:,Z@O,X,D/,6.#"$%/,6.06+0"/,5.),).55')&,=,0.,D)'H+/,D/(("63"/5.),).55')&,=,0.,D)'H+/,D/(("63"/
DOMAINE PHARMACEUTIQUEDOMAINE PHARMACEUTIQUEMonographies analytiques du guaranaMonographies analytiques du guarana
[D/%&$&",/%,88<,F,[D/%&$&",/%,88<,F,?$(+.0$(.&$'%,/%,U~,?$(+.0$(.&$'%,/%,U~,5+0?")$(.&$'%,D/,)".6&$#,$'D'5+0?")$(.&$'%,D/,)".6&$#,$'D'--$'D+)",/%,5)"(/%6/,$'D+)",/%,5)"(/%6/,D_+%,&":'$%,D/,6.#"$%/D_+%,&":'$%,D/,6.#"$%/
>/)&/,=,0.,D/(($6.&$'%,F,>/)&/,=,0.,D/(($6.&$'%,F,\O,X,KH).$%/,/&,5s&/M\O,X,KH).$%/,/&,5s&/M
8/%D)/(,&'&.0/(,F,,8/%D)/(,&'&.0/(,F,, N,X,5'+),0.,H).$%/N,X,5'+),0.,H).$%/S,X,5'+),0.,5s&/S,X,5'+),0.,5s&/
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LE CACAOTheobroma cacao L.
8.6.'2/),F,8.6.'2/),F,.)*)/,&)'5$6.0,.)*)/,&)'5$6.0,')$H$%.$)/,')$H$%.$)/,D+,</7$9+/,D/,0.,#.:$00/,D/(,D+,</7$9+/,D/,0.,#.:$00/,D/(,B&/)6+0$.6"/(B&/)6+0$.6"/(V)+$&,p,V)+$&,p,6.*'((/6.*'((/@,\W,@,\W,-- QO6:,D/,0'%H@,QO6:,D/,0'%H@,5'$D(,5'$D(, NOOHNOOH>'+((/%&,D$)/6&/:/%&,(+),0/(,>'+((/%&,D$)/6&/:/%&,(+),0/(,*).%63/(,:.g&)/((/(,'+,0/,&)'%6,*).%63/(,:.g&)/((/(,'+,0/,&)'%6,D/,0_.)*)/D/,0_.)*)/Ee&49+/(,Ee&49+/(, *)/+?.H/,.:/),/&,"5$6"@,*)/+?.H/,.:/),/&,"5$6"@,K,K,tchocolatl tchocolatl M@,)"(/)?",=,0_/:5/)/+)@,M@,)"(/)?",=,0_/:5/)/+)@,.+7,%'*0/(,/&,.+7,H+/))$/)(,.+7,%'*0/(,/&,.+7,H+/))$/)(,
LE CACAOTheobroma cacao L.
[%&)'D+6&$'%,/%,;+)'5/,5.),8')&"([%&)'D+6&$'%,/%,;+)'5/,5.),8')&"(;%H'+/:/%&,5'+),0.,*'$(('%,/%,;%H'+/:/%&,5'+),0.,*'$(('%,/%,;+)'5/,=,5.)&$),D+,}~[[;+)'5/,=,5.)&$),D+,}~[[4:/4:/ ($460/($460/
\hNb,F,%.$((.%6/,D+,63'6'0.&,`\hNb,F,%.$((.%6/,D+,63'6'0.&,` /%,/%,50.9+/50.9+/ a,=,5.)&$),D_+%,:"0.%H/,D/,a,=,5.)&$),D_+%,:"0.%H/,D/,
LE CACAOCultures dans le monde
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LE CACAOCulture et variété
A+.&)/,?.)$"&"(,5)$%6$5.0/,D/,6.6.'A+.&)/,?.)$"&"(,5)$%6$5.0/,D/,6.6.'i/,i/,#').(&/)'#').(&/)' KRW,X,D/,0.,5)'D+6&$'%,:'%D$.0/M,KRW,X,D/,0.,5)'D+6&$'%,:'%D$.0/M,')$H$%.$)/,DJE:.e'%$/,:.$(,5)$%6$5.0/:/%&,')$H$%.$)/,DJE:.e'%$/,:.$(,5)$%6$5.0/:/%&,6+0&$?",/%,E#)$9+/@,1)"($0,/&,Å9+.&/+),6+0&$?",/%,E#)$9+/@,1)"($0,/&,Å9+.&/+),)+(&$9+/,K)+(&$9+/,K22MMi/i/ 6)$'00'6)$'00' F 6+0&$?" /% E:")$9+/ 0.&$%/F 6+0&$?" /% E:")$9+/ 0.&$%/i/,i/,6)$'00'6)$'00' F,6+0&$?",/%,E:")$9+/,0.&$%/,F,6+0&$?",/%,E:")$9+/,0.&$%/,K8.).C*/(@,E%&$00/(@,</7$9+/@,~/%/e+/0.@,K8.).C*/(@,E%&$00/(@,</7$9+/@,~/%/e+/0.@,8'0':*$/M,8'0':*$/M, 6.6.',6.6.',#$%,/&,.)':.&$9+/#$%,/&,.)':.&$9+/i/,i/,&)$%$&.)$'&)$%$&.)$'@,$((+,D+,6)'$(/:/%&,D/(,D/+7,@,$((+,D+,6)'$(/:/%&,D/(,D/+7,5)"6"D/%&(,K\W,X,D/,0.,5)'D+6&$'%,:'%D$.0/M,5)"6"D/%&(,K\W,X,D/,0.,5)'D+6&$'%,:'%D$.0/M,/(546/,)"($(&.%&/,5)'D+$(.%&,+%,6.6.',#$%,/(546/,)"($(&.%&/,5)'D+$(.%&,+%,6.6.',#$%,
KK1 et 31 et 3MMi/,i/,%.6$'%.0%.6$'%.0 K6+0&+)/,.%D$%/M,K6+0&+)/,.%D$%/M, 6.6.',&)4(,#$%,6.6.',&)4(,#$%,:.$(,/(546/,#).H$0/,F,5)'D+6&$'%,&)4(,#.$*0/:.$(,/(546/,#).H$0/,F,5)'D+6&$'%,&)4(,#.$*0/
LE CACAOÉconomie du cacao
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LE CACAODu traitement post-récolte au cacao marchand
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;6.*'((.H/,F,'5").&$'%,:.%+/00/,;6.*'((.H/,F,'5").&$'%,:.%+/00/,%"6/(($&.%&,+%/,:.$%%"6/(($&.%&,+%/,:.$%--D_'/+?)/,D_'/+?)/,$:5')&.%&/$:5')&.%&/$:5')&.%&/$:5')&.%&/
i/(,i/(,ZOZO--WO,H).$%/(WO,H).$%/(@,/%&'+)"/(,D/,0/+),@,/%&'+)"/(,D/,0/+),5+05/,*0.%63/,:+6$0.H$%/+(/@,('%&,5+05/,*0.%63/,:+6$0.H$%/+(/@,('%&,/7&).$&/(,.?/6,0/(,D'$H&(/7&).$&/(,.?/6,0/(,D'$H&(
>+$(,H).$%/(,/&,5+05/,('%&,:$(,/%,&.(,>+$(,H).$%/(,/&,5+05/,('%&,:$(,/%,&.(,6'%$9+/,'+,/%,6.$((/,D/,\OO,=,\,OOO,6'%$9+/,'+,/%,6.$((/,D/,\OO,=,\,OOO,cH,5'+),0_"&.5/,D/,#/):/%&.&$'%cH,5'+),0_"&.5/,D/,#/):/%&.&$'%
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LE CACAODu traitement post-récolte au cacao marchand
i.,#/):/%&.&$'%,KW,P'+)(M,.*'+&$&,=,Fi.,#/):/%&.&$'%,KW,P'+)(M,.*'+&$&,=,FU%/,D/(&)+6&$'%,D+,5'+?'$),H/):$%.&$#,U%/,D/(&)+6&$'%,D+,5'+?'$),H/):$%.&$#,D/,0.,H).$%/,D/,0.,H).$%/,U%/,D$:$%+&$'%,D/,0_.:/)&+:/,5.),U%/,D$:$%+&$'%,D/,0_.:/)&+:/,5.),5/)&/ D/ &3"'*)':$%/5/)&/ D/ &3"'*)':$%/5/)&/,D/,&3"'*)':$%/5/)&/,D/,&3"'*)':$%/U%/,D$:$%+&$'%,D/,0_.(&)$%H/%6/,5.),U%/,D$:$%+&$'%,D/,0_.(&)$%H/%6/,5.),6'%D/%(.&$'%,D/(,5'0253"%'0(,.?/6,6'%D/%(.&$'%,D/(,5'0253"%'0(,.?/6,0/(,.6$D/(,.:$%"(,/&,0/(,5)'&"$%/(,0/(,.6$D/(,.:$%"(,/&,0/(,5)'&"$%/(,i_'*&/%&$'%,D_.6G,.:$%"(,/&,D/,(+6)/(,i_'*&/%&$'%,D_.6G,.:$%"(,/&,D/,(+6)/(,)"D+6&/+)(,`,5)"6+)(/+)(,D_.)x:/,a,)"D+6&/+)(,`,5)"6+)(/+)(,D_.)x:/,a,9+$,0')(,D/,0.,&'))"#.6&$'%,9+$,0')(,D/,0.,&'))"#.6&$'%, 6':5'("(,6':5'("(,.)':.&$9+/(,&25$9+/(.)':.&$9+/(,&25$9+/(
LE CACAODu traitement post-récolte au cacao marchand
i/,(463.H/,D/(,H).$%/(,Fi/,(463.H/,D/(,H).$%/(,F[%&")^&,F,).:/%/),0.,&/%/+),[%&")^&,F,).:/%/),0.,&/%/+),:.(($9+/,/%,/.+,D/(,H).$%/(,:.(($9+/,/%,/.+,D/(,H).$%/(,#/):/%&"/(,D_/%?$)'%,SO,X,=,#/):/%&"/(,D_/%?$)'%,SO,X,=,$ D h X$ D h X:'$%(,D/,h,X:'$%(,D/,h,X
B463.H/,%.&+)/0,'+,("63.H/,B463.H/,%.&+)/0,'+,("63.H/,.)&$#$6$/0,K.$),63.+D@,(463.H/,.)&$#$6$/0,K.$),63.+D@,(463.H/,:"6.%$9+/M:"6.%$9+/MU%/,#'$(,(463"/(,/&,%/&&'2"/(@,U%/,#'$(,(463"/(,/&,%/&&'2"/(@,0/(,H).$%/(,5)/%%/%&,0/,%':,D/,0/(,H).$%/(,5)/%%/%&,0/,%':,D/,`̀ #4?/(,D/,6.6.'#4?/(,D/,6.6.' a,a,
LE CACAODu traitement post-récolte au cacao marchand
8':5'($&$'%,D/(,#4?/(,(463"/(,F8':5'($&$'%,D/(,#4?/(,(463"/(,F>/)&/,/%,(.663.)'(/,/&,5+)$%/(,>/)&/,/%,(.663.)'(/,/&,5+)$%/(,E+H:/%&.&$'%,D/,0.,&/%/+),/%,E+H:/%&.&$'%,D/,0.,&/%/+),/%,(+6)/(,)"D+6&/+)((+6)/(,)"D+6&/+)(k2D)'02(/,D/(,5)'&"$%/(,k2D)'02(/,D/(,5)'&"$%/(,'0$H'5/5&$D/(,d,.6G,.:$%"(,0$*)/('0$H'5/5&$D/(,d,.6G,.:$%"(,0$*)/(V')&/,D$:$%+&$'%,D/(,6':5'("(,V')&/,D$:$%+&$'%,D/(,6':5'("(,53"%'0$9+/(@,%'&.::/%&,D/(53"%'0$9+/(@,%'&.::/%&,D/(#0.?.%#0.?.%--ZZ--'0(,K"5$6.&"63$%/,/&,'0(,K"5$6.&"63$%/,/&,5)'62.%$D$%/(M5)'62.%$D$%/(M
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LE CACAODu cacao marchand au produit semi-fini
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E06.0$%$(.&$'%E06.0$%$(.&$'% KrKrQQ8f8fZZM,M, :'D$#$6.&$'%,:'D$#$6.&$'%,6'+0/+),/&,#0.?/+)(,5.),.&&.9+/,D/(,6'+0/+),/&,#0.?/+)(,5.),.&&.9+/,D/(,&.%$%(&.%$%(
]'))"#.6&$'%]'))"#.6&$'% \OO = \WO\OO = \WO {{8 5/%D.%&8 5/%D.%&]'))"#.6&$'%]'))"#.6&$'% \OO,=,\WO,\OO,=,\WO, 8,5/%D.%&,8,5/%D.%&,QO,=,NO,:$%+&/(QO,=,NO,:$%+&/(
8':5'("(,?'0.&$0(,8':5'("(,?'0.&$0(,#'):"(,F,#'):"(,F,.0D"32D/(@,"&3/)(@,53"%'0(@,%$&)$0/(@,.0D"32D/(@,"&3/)(@,53"%'0(@,%$&)$0/(@,6':5'("(,('+#)"(@,52).e$%/(@,6':5'("(,('+#)"(@,52).e$%/(@,6"&'%/(@,.06''0(@,#+).%%/(,/&,/(&/)(6"&'%/(@,.06''0(@,#+).%%/(,/&,/(&/)(
V$0$4)/,5'+D)/,V$0$4)/,5'+D)/, &'+)&/.+7,5)/(("(,&'+)&/.+7,5)/(("(,Kz,QO,X,:.&G,H).((/M,5+0?")$("(Kz,QO,X,:.&G,H).((/M,5+0?")$("(
V$0$4)/,*/+))/,V$0$4)/,*/+))/, D"('D')$(.&$'%,('+(,D"('D')$(.&$'%,('+(,?$D/,5.),$%P/6&$'%,D/,?.5/+)?$D/,5.),$%P/6&$'%,D/,?.5/+)
LE CACAODu produit semi-fini au chocolat
[:5')&.%6/,D+,6'%63.H/,F[:5')&.%6/,D+,6'%63.H/,F
f5").&$'%,5)$:')D$.0/,/%,f5").&$'%,5)$:')D$.0/,/%,63'6'0.&/)$/63'6'0.&/)$/B_/##/6&+/,D.%(,D/,H).%D/(,B_/##/6&+/,D.%(,D/,H).%D/(,6+?/( K6'%63/(M 'Ç 0. 5s&/6+?/( K6'%63/(M 'Ç 0. 5s&/6+?/(,K6'%63/(M,'Ç,0.,5s&/,6+?/(,K6'%63/(M,'Ç,0.,5s&/,D/,63'6'0.&@,63.+##"/,/%&)/,D/,63'6'0.&@,63.+##"/,/%&)/,WO,=,hO,WO,=,hO,{{8,/(&,*).(("/,/&,8,/(&,*).(("/,/&,:.0.7"/,D/,%*,3/+)/(:.0.7"/,D/,%*,3/+)/(B&'6c.H/,=,NWB&'6c.H/,=,NW{{88]/:5").H/,]/:5").H/, '89'89::&&(;<=3>7(;<=3>7
CACAO ET CHOCOLATAspects nutritionnels
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CACAO ET CHOCOLATLe cacao contient-il de la caféine ?
>'+D)/,D/,6.6.'>'+D)/,D/,6.6.'B/0'%,0/,D/H)",D/,#/):/%&.&$'%,/&,0/,&25/,D/,#4?/(,D/,6.6.'@,0.,&/%/+),/%,B/0'%,0/,D/H)",D/,#/):/%&.&$'%,/&,0/,&25/,D/,#4?/(,D/,6.6.'@,0.,&/%/+),/%,6.#"$%/,?.)$/,/%&)/,OG\,/&,OGWXG,i/(,5'+D)/(,D/,6.6.',#.*)$9+"/(,=,5.)&$),D/,6.#"$%/,?.)$/,/%&)/,OG\,/&,OGWXG,i/(,5'+D)/(,D/,6.6.',#.*)$9+"/(,=,5.)&$),D/,#4?/(,D/,6.6.',#/):/%&"/(,/%,E#)$9+/,'%&,+%/,&)4(,#.$*0/,&/%/+),/%,6.#"$%/#4?/(,D/,6.6.',#/):/%&"/(,/%,E#)$9+/,'%&,+%/,&)4(,#.$*0/,&/%/+),/%,6.#"$%/ F,F,OG\X,'+,:'$%(GOG\X,'+,:'$%(G
83'6'0.&,83'6'0.&,i/,&.+7,D/,6.#"$%/,5'+),+%/,*.))/,D/,63'6'0.&,,60.(($9+/,KNO,HM,/&,5'+),+%/,i/,&.+7,D/,6.#"$%/,5'+),+%/,*.))/,D/,63'6'0.&,,60.(($9+/,KNO,HM,/&,5'+),+%/,&.((/,D/,63'6'0.&,.+,0.$&@,/(&,"9+$?.0/%&/,=,6/,9+J'%,&)'+?/,D.%(,+%/,&.((/,&.((/,D/,63'6'0.&,.+,0.$&@,/(&,"9+$?.0/%&/,=,6/,9+J'%,&)'+?/,D.%(,+%/,&.((/,D/,6.#",D"6.#"$%",F,\O,D/,6.#",D"6.#"$%",F,\O,ÉÉ \W,:HG,i.,&/%/+),/(&,0"H4)/:/%&,(+5")$/+)/,5'+),0/,\W,:HG,i.,&/%/+),/(&,0"H4)/:/%&,(+5")$/+)/,5'+),0/,63'6'0.&,%'$)G63'6'0.&,%'$)G
]/%/+),/%,&3"'*)':$%/,,]/%/+),/%,&3"'*)':$%/,,
i.,&3"'*)':$%/,/(&,+%,(&$:+0.%&,D'+7,D+,Bn8,/&,5)"(/%&/,"H.0/:/%&,i.,&3"'*)':$%/,/(&,+%,(&$:+0.%&,D'+7,D+,Bn8,/&,5)"(/%&/,"H.0/:/%&,D/(,,5)'5)$"&"(,D$+)"&$9+/@,?.('D$0.&.&)$6/,/&,6.)D$'(&$:+0.%&/GD/(,,5)'5)$"&"(,D$+)"&$9+/@,?.('D$0.&.&)$6/,/&,6.)D$'(&$:+0.%&/G
Fèves de cacao : 1,1 – 4,3 % Chocolat au lait : 0,1 – 0,2 %
Cacao en poudre : 0,5 – 2,6 % Chocolat noir : 0,4 – 1,6 %
CACAO ET CHOCOLATPolyphénols du cacao
CACAO ET CHOCOLATAspects règlementaires (décret n°76-692)
ChocolatChocolat F,5)'D+$&,'*&/%+,=,5.)&$),D/,6.6.',/%,H).$%(@,D/,6.6.',/%,5s&/@,D/,F,5)'D+$&,'*&/%+,=,5.)&$),D/,6.6.',/%,H).$%(@,D/,6.6.',/%,5s&/@,D/,6.6.',/%,5'+D)/,'+,D/,6.6.',:.$H)/,/%,5'+D)/,/&,D/,(.663.)'(/@,.?/6,'+,6.6.',/%,5'+D)/,'+,D/,6.6.',:.$H)/,/%,5'+D)/,/&,D/,(.663.)'(/@,.?/6,'+,(.%(,.DP'%6&$'%,D/,*/+))/,D/,6.6.'@,/&,6'%&/%.%&,.+,:'$%(,ZW,X,D/,:.&$4)/,(.%(,.DP'%6&$'%,D/,*/+))/,D/,6.6.'@,/&,6'%&/%.%&,.+,:'$%(,ZW,X,D/,:.&$4)/,(463/,&'&.0/,D/,6.6.'@,.+,:'$%(,\N,X,D/,6.6.',(/6,/&,D"H).$((",/&,.+,:'$%(,(463/,&'&.0/,D/,6.6.'@,.+,:'$%(,\N,X,D/,6.6.',(/6,/&,D"H).$((",/&,.+,:'$%(,\h,X,D/,*/+))/,D/,6.6.'G\h,X,D/,*/+))/,D/,6.6.'GChocolat au lait Chocolat au lait F,5)'D+$&,'*&/%+,=,5.)&$),D/,6.6.',/%,H).$%(@,D/,6.6.',/%,F,5)'D+$&,'*&/%+,=,5.)&$),D/,6.6.',/%,H).$%(@,D/,6.6.',/%,5s&/@,D/,6.6.',/%,5'+D)/,'+,D/,6.6.',:.$H)/,/%,5'+D)/,/&,D/,(.663.)'(/@,5s&/@,D/,6.6.',/%,5'+D)/,'+,D/,6.6.',:.$H)/,/%,5'+D)/,/&,D/,(.663.)'(/@,.?/6 '+ (.%( .DP'%6&$'% D/ */+))/ D/ 6.6.' .$%($ 9+_= 5.)&$) D/ 0.$& '+ D/.?/6 '+ (.%( .DP'%6&$'% D/ */+))/ D/ 6.6.' .$%($ 9+_= 5.)&$) D/ 0.$& '+ D/.?/6,'+,(.%(,.DP'%6&$'%,D/,*/+))/,D/,6.6.'@,.$%($,9+_=,5.)&$),D/,0.$&,'+,D/,.?/6,'+,(.%(,.DP'%6&$'%,D/,*/+))/,D/,6.6.'@,.$%($,9+_=,5.)&$),D/,0.$&,'+,D/,:.&$4)/(,5)'?/%.%&,D/,0.,D"(32D).&.&$'%,5.)&$/00/,'+,/%&$4)/,D+,0.$&,/%&$/),'+,D+,:.&$4)/(,5)'?/%.%&,D/,0.,D"(32D).&.&$'%,5.)&$/00/,'+,/%&$4)/,D+,0.$&,/%&$/),'+,D+,0.$&,5.)&$/00/:/%&,'+,/%&$4)/:/%&,"6)":",/&,"?/%&+/00/:/%&,D/,6)4:/@,D/,6)4:/,0.$&,5.)&$/00/:/%&,'+,/%&$4)/:/%&,"6)":",/&,"?/%&+/00/:/%&,D/,6)4:/@,D/,6)4:/,5.)&$/00/:/%&,'+,/%&$4)/:/%&,D"(32D).&"/@,D/,*/+))/,'+,D/,H).$((/,*+&2)$9+/G5.)&$/00/:/%&,'+,/%&$4)/:/%&,D"(32D).&"/@,D/,*/+))/,'+,D/,H).$((/,*+&2)$9+/GChocolat blanc Chocolat blanc F,5)'D+$&,/7/:5&,D/,:.&$4)/(,6'0').%&/(,@'*&/%+,=,5.)&$),D/,F,5)'D+$&,/7/:5&,D/,:.&$4)/(,6'0').%&/(,@'*&/%+,=,5.)&$),D/,*/+))/,D/,6.6.',/&,D/,(.663.)'(/@,.$%($,9+_=,5.)&$),D/,0.$&,'+,D/,:.&$4)/(,*/+))/,D/,6.6.',/&,D/,(.663.)'(/@,.$%($,9+_=,5.)&$),D/,0.$&,'+,D/,:.&$4)/(,5)'?/%.%&,D/,0.,D"(32D).&.&$',%5.)&$/00/,'+,/%&$4)/,D+,0.$&,/%&$/),'+,D+,0.$&,5)'?/%.%&,D/,0.,D"(32D).&.&$',%5.)&$/00/,'+,/%&$4)/,D+,0.$&,/%&$/),'+,D+,0.$&,5.)&$/00/:/%&,'+,/%&$4)/:/%&,"6)":",/&,"?/%&+/00/:/%&,D/,6)4:/@,D/,6)4:/,5.)&$/00/:/%&,'+,/%&$4)/:/%&,"6)":",/&,"?/%&+/00/:/%&,D/,6)4:/@,D/,6)4:/,5.)&$/00/:/%&,'+,/%&$4)/:/%&,D"(32D).&"/@,D/,*/+))/,'+,D/,H).$((/,*+&2)$9+/G5.)&$/00/:/%&,'+,/%&$4)/:/%&,D"(32D).&"/@,D/,*/+))/,'+,D/,H).$((/,*+&2)$9+/G
n1,F,!/5+$(,QOOZ,KD$)/6&$?/,/+)'5"/%%/,QOOO|ZS|;8M@,5'(($*$0$&",n1,F,!/5+$(,QOOZ,KD$)/6&$?/,/+)'5"/%%/,QOOO|ZS|;8M@,5'(($*$0$&",D_.DP'%6&$'%,D/,,D_.DP'%6&$'%,D/,,H).$((/(,?"H"&.0/H).$((/(,?"H"&.0/ KW,X,:.7GM,.?/6,'*0$H.&$'%,D_"&$9+/&.H/GKW,X,:.7GM,.?/6,'*0$H.&$'%,D_"&$9+/&.H/G
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CACAO ET CHOCOLATContrôle de la qualité finale
;:*.00.H/,F,;:*.00.H/,F,.(5/6&@,"&.%63"$&",.(5/6&@,"&.%63"$&",
E(5/6&,/7&/)%/,F,E(5/6&,/7&/)%/,F,*)$00.%6/@,6'+0/+)@,.*(/%6/,D/,*+00/(,D_.$)@,D/,*)$00.%6/@,6'+0/+)@,.*(/%6/,D/,*+00/(,D_.$)@,D/,6)$(&.+7GGG6)$(&.+7GGG
]/7&+)/,F,]/7&+)/,F,%'%,H).%+0/+(/%'%,H).%+0/+(/
V0.?/+),F,V0.?/+),F,5.%/0,D/,D"H+(&.&/+)(,5.%/0,D/,D"H+(&.&/+)(,
]/(&(,532($6']/(&(,532($6'--63$:$9+/(,F,63$:$9+/(,F,)3"'0'H$/@,#$%/((/@,:.&$4)/,H).((/,)3"'0'H$/@,#$%/((/@,:.&$4)/,H).((/,
]/(&(,:$6)'*$'0'H$9+/(,F,]/(&(,:$6)'*$'0'H$9+/(,F,j/63/)63/,D/,*.6&")$/(,5.&3'H4%/(,F,j/63/)63/,D/,*.6&")$/(,5.&3'H4%/(,F,Salmonella sp., Escherichia Salmonella sp., Escherichia Coli, Staphylococcus sp. Coli, Staphylococcus sp. /&,/&,Listeria monocytogenesesListeria monocytogeneses
j/63/)63/,D/(,0/?+)/(,/&,:'$($((+)/(,j/63/)63/,D/(,0/?+)/(,/&,:'$($((+)/(,
8'%#'):$&",D/,0_"&$9+/&.H/,8'%#'):$&",D/,0_"&$9+/&.H/,E%.02(/,D/(,(+6)/(,5.),k>i8E%.02(/,D/(,(+6)/(,5.),k>i8
COMPARAISON DANS LA TENEUR EN CAFEINE COMPARAISON DANS LA TENEUR EN CAFEINE DE DIVERSES BOISSONSDE DIVERSES BOISSONS
nG1G,F,8'6.,6'0.,nG1G,F,8'6.,6'0., Zh,:H,D/,6.#"$%/,5'+),S,'%6/(,K\hh,:0MZh,:H,D/,6.#"$%/,5'+),S,'%6/(,K\hh,:0M
PAVOT, OPIUM ET MORPHINEPAVOT, OPIUM ET MORPHINE
\G\G [%&)'D+6&$'%[%&)'D+6&$'%
QGQG f)$H$%/@,D$(&)$*+&$'%@,0'6.0$(.&$'%f)$H$%/@,D$(&)$*+&$'%@,0'6.0$(.&$'%
ZGZG f5$+:f5$+:
NGNG >.$00/,D_'5$+:>.$00/,D_'5$+:
WGWG ;7&).6&$'%,D/,0.,:')53$%/;7&).6&$'%,D/,0.,:')53$%/
SGSG E(5/6&(,(&)+6&+).+7E(5/6&(,(&)+6&+).+7
RGRG >)'5)$"&"(,53.):.6'0'H$9+/(>)'5)$"&"(,53.):.6'0'H$9+/(
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INTRODUCTIONINTRODUCTION[('9+$%'0"$%/(,#)"9+/%&/(,[('9+$%'0"$%/(,#)"9+/%&/(, >.5.?").6"/(,>.5.?").6"/(,<')53$%.%/(,(5"6$#$9+/(,<')53$%.%/(,(5"6$#$9+/(, PapaverPapaver (55G(55G<')53$%/,<')53$%/, Papaver somniferumPapaver somniferum /&,/&,P. setigerumP. setigerum +%$9+/:/%&+%$9+/:/%&
!")$?"(,D/,!")$?"(,D/,Papaver somniferumPapaver somniferum D.%(,0.,0$(&/,D/(,D.%(,0.,0$(&/,D/(,(+*(&.%6/(,60.(("/(,6'::/,(&+5"#$.%&,/%,V).%6/,F(+*(&.%6/(,60.(("/(,6'::/,(&+5"#$.%&,/%,V).%6/,F
-- f5$+:@,5.$00/,D/,5.?'&@,:')53$%/,K.%%/7/,\Mf5$+:@,5.$00/,D/,5.?'&@,:')53$%/,K.%%/7/,\M-- 8'D"$%/,K.%%/7/,QM8'D"$%/,K.%%/7/,QM
PLANTES D’ORIGINEPLANTES D’ORIGINE
P. somniferumP. somniferum /&,/&,P. setigerum P. setigerum K'+,((5G,K'+,((5G,setigerumsetigerumMM
>0.%&/,.%%+/00/@,\:,=,\@WO:,@,>0.%&/,.%%+/00/@,\:,=,\@WO:,@,#/+$00/(,.0&/)%/(,#/+$00/(,.0&/)%/(,H0.*)/(H0.*)/(
VV)+$&,)+$&,F,F,6.5(+0/,'?'CD/,=,60'$('%(,6.5(+0/,'?'CD/,=,60'$('%(,).D$.0/(,).D$.0/(,KK :+0&$&+D/,H).$%/(,M:+0&$&+D/,H).$%/(,M
E5)4(,$%6$($'%,E5)4(,$%6$($'%, 0.&/7,*0.%6,0.&/7,*0.%6,*)+%$((/:/%&,=,0_.$)*)+%$((/:/%&,=,0_.$)
PLANTES D’ORIGINEPLANTES D’ORIGINE
].7$%':$/,6':50/7/@,?.)$.*$0$&",:')53'0'H$9+/,D+,H/%)/,Papaver
~.)G,'+,((5,Papaver somniferum
5.?'&,=,#0/+)(,/&,H).$%/(,*0.%63/(,K[%D/M
5.?'&,%'$),K5.?'&,'/$00/&&/M,6+0&$?",/%,;+)'5/,K#0/+)(,?$'0.6"/(M
5.?'&,DJE($/,:$%/+)/,K#0/+)(,5'+)5)/(M
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L’OPIUM>.2(,D/,5)'D+6&$'%,0$6$&/,F,[%D/@,83$%/,>.2(,D/,5)'D+6&$'%,0$6$&/,F,[%D/@,83$%/,
i.&/7,("63",=,0J.$),'*&/%+,.5)4(i.&/7,("63",=,0J.$),'*&/%+,.5)4($%6$($'%,6.5(+0/(,/%6')/,?/)&/($%6$($'%,6.5(+0/(,/%6')/,?/)&/(
8'00/6&/,D+,0.&/7,5.),).60.H/@,8'00/6&/,D+,0.&/7,5.),).60.H/@,5+$(,("63.H/,=,0J.$)5+$(,("63.H/,=,0J.$)5 H5 H
<.((/,<.((/,:'00/,:'00/,=,D+)/=,D+)/@,(.?/+)@,(.?/+) 5$9+.%&/,5$9+.%&/,/&,.:4)/@,'D/+),6.).6&")$(&$9+//&,.:4)/@,'D/+),6.).6&")$(&$9+/
8'%&/%+,63$:$9+/,F8'%&/%+,63$:$9+/,F\O,=,\Q,X,:')53$%/\O,=,\Q,X,:')53$%/Q,=,W,X,6'D"$%/,K,:"6'%.&/@,#+:.).&/,MQ,=,W,X,6'D"$%/,K,:"6'%.&/@,#+:.).&/,M#.$*0/(,9+.%&$&"(,F,%'(6.5$%/@,#.$*0/(,9+.%&$&"(,F,%'(6.5$%/@,&3"*.C%/@,5.5.?")$%/,GG,K,E]F,QO,X,M&3"*.C%/@,5.5.?")$%/,GG,K,E]F,QO,X,M
<'%'H).53$/,D/,0_'5$+:,*)+&,>3.):.6'5"/,/+)'5"/%%/,S4:/ "D$&$'%K,%'%,D"0$?).*0/,/%,0_"&.&,M
[D/%&$&" F
OPIUM
[D/%&$&",F,:$6)'H).53$/,KrfkM,F,
H).%+0.&$'%(,*)+%/(@,#$0.:/%&(@,5'00/%
)".6&$'%(,63$:$9+/(,F,'5$+:,d,kQf, #$0&).&,,,,,,,,,d,80ZV/ )'+H/,K,.6$D/,:"6'%$9+/,M,d,80k, D$(5.)$&$'%
88<,K,.06.0'CD/(,&":'$%(,M,F,)"?"0.&$'%,.+,$'D'*$(:+&3.&/,r,K!).H/%D')##M
MATIÈRES PREMIÈRES ISSUES DE L’OPIUM : MATIÈRES PREMIÈRES ISSUES DE L’OPIUM : PAILLE DE PAVOTPAILLE DE PAVOT
8+0&+)/,.%6$/%%/,/%,;+)'5/,8+0&+)/,.%6$/%%/,/%,;+)'5/, H).$%/(,K5.?'&,,H).$%/(,K5.?'&,,'/$00/&&/M'/$00/&&/M
E:"0$').&$'%,?.)$"&"(,/&,5).&$9+/(,6+0&+).0/,E:"0$').&$'%,?.)$"&"(,/&,5).&$9+/(,6+0&+).0/,5)'D+6&$'% D$)/6&/ D/(5)'D+6&$'% D$)/6&/ D/( .06.0'CD/(.06.0'CD/( K5.( D/ 5)'D+6&$'%K5.( D/ 5)'D+6&$'%5)'D+6&$'%,D$)/6&/,D/(,5)'D+6&$'%,D$)/6&/,D/(,.06.0'CD/(,.06.0'CD/(,K5.(,D/,5)'D+6&$'%K5.(,D/,5)'D+6&$'%D_'5$+:MD_'5$+:M
!/+7,5'(($*$0$&"(,F!/+7,5'(($*$0$&"(,F
B+5/)#$6$/,K,V).%6/,M,F,ROOO,3.,B+5/)#$6$/,K,V).%6/,M,F,ROOO,3., RORO &'%%/(,&'%%/(,:')53$%/:')53$%/
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EXTRACTION DE LA MORPHINEEXTRACTION DE LA MORPHINE
E,5.)&$),D/,0_'5$+:,Z,X,'5$+:, +(.H/,D$)/6&,/%,H.0"%$9+/,bR,X,K0$6$&/M, (/)&,=,0_/7&).6&$'%,D/,0.,:')53$%/,>)'6"D" &).D$&$'%%/0 F>)'6"D",&).D$&$'%%/0,F<"&3'D/,:'D$#$"/,D/,Y)/H')2,Ñ,j'*/)&('%@,\b4:/ ($460/G,!"50.6/:/%&,=,5.)&$),D/,0.,#'):/,%.&+)/00/, :"6'%.&/,D/:')53$%/,F
Morphine
EXTRACTION DE LA MORPHINEEXTRACTION DE LA MORPHINE
+ eau ( 25 °C ) + Ca(OH)2
Opium
Concentration
Morphinate de Ca en solution
Méconate de Ca
Ebullition + NH4Cl
Morphine en refroidissant
EXTRACTION DE LA MORPHINEEXTRACTION DE LA MORPHINE
A partir de la paille de pavot A partir de la paille de pavot ;7&).6&$'%,;7&).6&$'%,('0$D/('0$D/--0$9+$D/,0$9+$D/, 6'%6/%&)",D/,5.$00/,D/,5.?'&,KH).%+0"(M,6'%6/%&)",D/,5.$00/,D/,5.?'&,KH).%+0"(M,d,/.+,.6$D/,d,/.+,.6$D/, .06.0'CD/(,(/0(,.06.0'CD/(,(/0(, d,*.(/,#.$*0/,d,*.(/,#.$*0/, :')53$%/,:')53$%/,("0/6&$?/:/%&,("0/6&$?/:/%&,
>+)$#$6.&$'%,5.),)"($%/(,"63.%H/+(/(,DJ$'%(,'+,5)"6$5$&.&$'%(,>+)$#$6.&$'%,5.),)"($%/(,"63.%H/+(/(,DJ$'%(,'+,5)"6$5$&.&$'%(,("0/6&$?/(("0/6&$?/(
;((/%&$/0,5)'D+6&$'%,:')53$%/,;((/%&$/0,5)'D+6&$'%,:')53$%/, 5)"5.).&$'%,D/,0.,5)"5.).&$'%,D/,0.,6'D"$%/,/&,D/,0.,6'D"&320$%/6'D"$%/,/&,D/,0.,6'D"&320$%/
QOOO,F,6'%('::.&$'%,:'%D$.0/,:')53$%/, ,QQ,&'%%/(,QOOO,F,6'%('::.&$'%,:'%D$.0/,:')53$%/, ,QQ,&'%%/(,K6'D"$%/, ,QOO,&'%%/(,p,RWX,D/,&'+(,0/(,'5$.6"/(MK6'D"$%/, ,QOO,&'%%/(,p,RWX,D/,&'+(,0/(,'5$.6"/(M
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ASPECTS STRUCTURAUXASPECTS STRUCTURAUX
Morphine : Morphine : .06.0'CD/,:.P')$&.$)/,D/,0J'5$+:,F.06.0'CD/,:.P')$&.$)/,D/,0J'5$+:,FK\O,=,\Q,XMK\O,=,\Q,XMW,6/%&)/(,.((2:"&)$9+/(,F,W,6/%&)/(,.((2:"&)$9+/(,F,(2%&34(/,&'&.0/,6':50/7/(2%&34(/,&'&.0/,6':50/7/
;%.%&$':4)/,0"?'H$)/,%.&+)/0,.6&$#,;%.%&$':4)/,0"?'H$)/,%.&+)/0,.6&$#,>3"%'0,/%,Z,F,('0+*$0$&",D.%(,('0G,>3"%'0,/%,Z,F,('0+*$0$&",D.%(,('0G,.06.0$%/(,K:')53$%.&/M,/&,5)'5)$"&"(,.06.0$%/(,K:')53$%.&/M,/&,5)'5)$"&"(,)"D+6&)$6/()"D+6&)$6/(830')32D).&/,F,6)$(&.00$(/,.?/6,Z,k830')32D).&/,F,6)$(&.00$(/,.?/6,Z,kQQff
Codéine : Codéine : f8kf8kZZ /%,5'($&$'%,Z,/%,5'($&$'%,Z,5.(,D/,#'%6&$'%,53"%'05.(,D/,#'%6&$'%,53"%'0
PROPRIETES PHARMACOLOGIQUESPROPRIETES PHARMACOLOGIQUES
;##/&(,D/,0.,:')53$%/,(+),0/,Bn8,F;##/&(,D/,0.,:')53$%/,(+),0/,Bn8,FV$7.&$'%,(&")"'(5"6$#$9+/,/&,)"?/)($*0/,(+),)"6/5&/+)(,(5"6$#$9+/(V$7.&$'%,(&")"'(5"6$#$9+/,/&,)"?/)($*0/,(+),)"6/5&/+)(,(5"6$#$9+/(;##/&,.%.0H"($9+/,F;##/&,.%.0H"($9+/,FÖ,,Ö,, (/+$0,5/)6/5&$'%,D'+0/+)@,(/+$0,5/)6/5&$'%,D'+0/+)@, 5/)6/5&$'%,%'6$6/5&$?/5/)6/5&$'%,%'6$6/5&$?/Ö,,Ö,, (+P/&,('+##).%&,/&,(+P/&,%'):.0(+P/&,('+##).%&,/&,(+P/&,%'):.0;##/&,)/(5$).&'$)/,F;##/&,)/(5$).&'$)/,F55Ö,,Ö,, 6/%&)/(,*+0*.$)/(@,*).D25%"/@,$))"H+0.)$&",)2&3:/6/%&)/(,*+0*.$)/(@,*).D25%"/@,$))"H+0.)$&",)2&3:/E+&)/(,/##/&(,6/%&).+7,FE+&)/(,/##/&(,6/%&).+7,FÖ,,Ö,, 6/%&)/,&'+7@,6/%&)/,&'+7@, 325'532(/@,:2'($(325'532(/@,:2'($(!"5/%D.%6/,F!"5/%D.%6/,FÖ,,;##/&,5(263'D2(0/5&$9+/,F,/+53')$/,/&,*$/%Ö,,;##/&,5(263'D2(0/5&$9+/,F,/+53')$/,/&,*$/%--^&)/^&)/Ö,,E))^&,*)+&.0,Ö,,E))^&,*)+&.0, (2%D)':/,D/,:.%9+/,F,)3$%')3"/@,(+/+)(@,.H$&.&$'%@,(2%D)':/,D/,:.%9+/,F,)3$%')3"/@,(+/+)(@,.H$&.&$'%@,
:2D)$.(/@,.0H$/(,:2D)$.(/@,.0H$/(, D"5/%D.%6/,532($9+/D"5/%D.%6/,532($9+/
;##/&(,5")$53")$9+/(;##/&(,5")$53")$9+/( :: 6'%(&$5.&$'%@,)"&/%&$'%,+)$%.$)/6'%(&$5.&$'%@,)"&/%&$'%,+)$%.$)/
QUINQUINA ET QUININEQUINQUINA ET QUININE
\G [%&)'D+6&$'%,/&,.(5/6&(,3$(&')$9+/(QG !"#$%$&$'%ZG i/(,D$##")/%&/(,/(546/(,D/,9+$%9+$%.NG >.)&$/(,+&$0$("/(
B'+)6/(8':5'($&$'%,63$:$9+/
WG <'%'H).53$/,9+$%9+$%.,)'+H/8.).6&4)/(,')H.%'0/5&$9+/(,/&,:$6)'(6'5$9+/([D/%&$#$6.&$'%,/&,/((.$(!'(.H/
SG, ;:50'$(
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INTRODUCTION ET DEFINITIONINTRODUCTION ET DEFINITIONU&$0$(.&$'%,&).D$&$'%/00/,.%6$/%%/,6'::/,#"*)$#+H/,.+,>")'+U&$0$(.&$'%,&).D$&$'%/00/,.%6$/%%/,6'::/,#"*)$#+H/,.+,>")'+
[%&)'D+$&/,/%,;+)'5/,K,P"(+$&/(,M,.+,}~[[[%&)'D+$&/,/%,;+)'5/,K,P"(+$&/(,M,.+,}~[[4:/4:/ ($460/,($460/,H).%D,(+664(,6'::/,#"*)$#+H/@,.%&$:.0.)$9+/H).%D,(+664(,6'::/,#"*)$#+H/@,.%&$:.0.)$9+/
Y/%)/,Y/%)/,CinchonaCinchona K,j+*$.6"/(,M,6)"/,5.),i$%%",/%,\RNQ,K,j+*$.6"/(,M,6)"/,5.),i$%%",/%,\RNQ,=,=,5.)&$),5.)&$),D_"63.%&$00'%(,D_"63.%&$00'%(,5)'?/%.%&,D+,>")'+5)'?/%.%&,D+,>")'+55 55
[('0/:/%&,D/,0.,[('0/:/%&,D/,0.,9+$%$%/9+$%$%/ F,>/00/&$/),/&,8.?/%&'+,K\hQOMF,>/00/&$/),/&,8.?/%&'+,K\hQOM
!"#$%$&$'%,D/,0.,>3.):.6'5"/,/+)'5"/%%/,!"#$%$&$'%,D/,0.,>3.):.6'5"/,/+)'5"/%%/,FFA+$%9+$%.,)'+H/,F,"6')6/,D/(("63"/,D/,A+$%9+$%.,)'+H/,F,"6')6/,D/(("63"/,D/,C. pubescensC. pubescens ~.30,~.30,KKC. succirubraC. succirubra >.?'%M,'+,D/,(/(,?.)$"&"(,'+,32*)$D/(>.?'%M,'+,D/,(/(,?.)$"&"(,'+,32*)$D/(
B/+0/,(5G,B/+0/,(5G, :'%'H).53$/,53.):.6/+&$9+/:'%'H).53$/,53.):.6/+&$9+/
E+&)/(,(55G,,E+&)/(,(55G,, (5(5G,/7&).6&$'%,9+$%$%/,F,G,/7&).6&$'%,9+$%$%/,F,C. ledgerianaC. ledgeriana(5(5G,0$9+')$(&/)$/,F,G,0$9+')$(&/)$/,F,C. officinalisC. officinalis
LES ESPECESLES ESPECESY/%)/,Cinchona F,9+.).%&.$%/,DJ/(546/(,D_.)*)/(
f)$H$%/,F,,8')D$004)/,.%D$%/,K8'0':*$/, >")'+M\WOO,- ZOOO:@,#')&/,50+?$'($&"#/+$00/(,'55'("/(@,#0/+)(,*0.%63/(,'+,)'("/(
;7$(&/%6/,32*)$D/( F .%6$/%%/&",D/(,6+0&+)/(,/&,("0/6&$'%2
!$(&$%6&$'%(,/%&)/,FAG,)'+H/,,KC. pubescens ~.30@,(2%G,C. succirubra >.?'%M,F,
/(546/,'##$6$%.0/,K')$H$%/,(5G,(.+?.H/,p,;9+.&/+)M
AG,H)$(,,KC. officinalis iGM,F,D$(&)$*+"/,8'0':*$/ .+,>")'+/(546/,.)':.&$9+/,F,+(.H/,/%,0$9+')$(&/)$/
AG,P.+%/,,KC. calisaya q/DD/00MF,D$(&)$*+"/,8'0':*$/ =,0.,1'0$?$/
Cinchona ledgeriana F,,/7&).6&$'%,D/,0.,9+$%$%/
A+$%9+$%.,)'+H/A+$%9+$%.,)'+H/
Cinchona Cinchona succirubrasuccirubra
A+$%9+$%.,H)$(A+$%9+$%.,H)$(
Cinchona Cinchona officinaofficina A+$%9+$%.,P.+%/A+$%9+$%.,P.+%/
Cinchona Cinchona calisayacalisaya A+$%9+$%.,0/DH/)$.%.A+$%9+$%.,0/DH/)$.%.
Cinchona Cinchona ledgerianaledgeriana
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LA DROGUE : ÉCORCELA DROGUE : ÉCORCE
B'+)6/(,F,,B'+)6/(,F,,A+$%9+$%.(,D/,6+0&+)/,A+$%9+$%.(,D/,6+0&+)/,
E#)$9+/,'66$D/%&.0/,/&,')$/%&.0/E#)$9+/,'66$D/%&.0/,/&,')$/%&.0/
E:")$9+/,0.&$%/,E:")$9+/,0.&$%/, Å6')6/ D/ 9+$%9+$%. )'+H/Å6')6/ D/ 9+$%9+$%. )'+H/" 9+/ . /" 9+/ . /K,>")'+@,1'0$?$/@,;9+.&/+),MK,>")'+@,1'0$?$/@,;9+.&/+),M
f*&/%&$'%,F,f*&/%&$'%,F,1.&&.H/,/&,"6')t.H/,D/(,&)'%6(,1.&&.H/,/&,"6')t.H/,D/(,&)'%6(,/&,D/(,*).%63/(/&,D/(,*).%63/(
Å6')6/,D/,9+$%9+$%.,)'+H/Å6')6/,D/,9+$%9+$%.,)'+H/
Å6')6/,D/,Å6')6/,D/,Cinchona ledgerianaCinchona ledgeriana
COMPOSITION CHIMIQUECOMPOSITION CHIMIQUE>'0253"%'0(>'0253"%'0( F,#0.?.%F,#0.?.%--ZZ--'0(,(+*(&$&+"(,5.),.6$D/,6.#"$9+/'0(,(+*(&$&+"(,5.),.6$D/,6.#"$9+/
5)'.%&3'62.%$D'0(,D$:4)/(,/&,&)$:4)/(5)'.%&3'62.%$D'0(,D$:4)/(,/&,&)$:4)/(
E6$D/(,')H.%$9+/(,5.)&$6+0$/)(,E6$D/(,')H.%$9+/(,5.)&$6+0$/)(,F,.6$D/,9+$%$9+/,F,.6$D/,9+$%$9+/,
B.5'%'($D/(B.5'%'($D/( =,H"%$%/,&)$&/)5"%$9+/,D$6.)*'720$9+/=,H"%$%/,&)$&/)5"%$9+/,D$6.)*'720$9+/
]).6/(,DJ3+$0/,/((/%&$/00/]).6/(,DJ3+$0/,/((/%&$/00/
i.,&/%/+),D/(,i.,&/%/+),D/(,.06.0'CD/(.06.0'CD/( ?.)$/,(/0'%,0_/(546/,F?.)$/,(/0'%,0_/(546/,F
E06.0'CD/(,&'&.+7,E06.0'CD/(,&'&.+7,XX
A+$%$%/,XA+$%$%/,X
A+$%9+$%.,)'+H/A+$%9+$%.,)'+H/ N@W,N@W,ÉÉ h@Wh@W \,\,ÉÉ ZZ
A+$%9+$%.,H)$(A+$%9+$%.,H)$( W,W,ÉÉ hh Q,Q,ÉÉ R@WR@W
A+$%9+$%.,P.+%/A+$%9+$%.,P.+%/ Z,Z,ÉÉ RR O,O,ÉÉ NN
A+$%9+$%.,0/DH/)$.%.A+$%9+$%.,0/DH/)$.%. S,S,ÉÉ \N\N Z,Z,ÉÉ \Z\Z
STRUCTURE DES ALCALOIDESSTRUCTURE DES ALCALOIDES
E06.0'CD/(,:.P')$&.$)/(,D.%(,0_"6')6/,F,E06.0'CD/(,:.P')$&.$)/(,D.%(,0_"6')6/,F,
9+$%$%/,/&,9+$%$D$%/,9+$%$%/,/&,9+$%$D$%/,K,(&")"'K,(&")"'--$(':4)/(M,F,$(':4)/(M,F,9+$%'0"$%/,)/0$"/,=,%'2.+,*$6260$9+/,9+$%+60$D$9+/9+$%'0"$%/,)/0$"/,=,%'2.+,*$6260$9+/,9+$%+60$D$9+/
6$%63'%$D$%/,/&,6$%63'%$%/,6$%63'%$D$%/,/&,6$%63'%$%/,F,3':'0'H+/(,F,3':'0'H+/(,D":"&3'720"(,/%,8D":"&3'720"(,/%,8--SSll
E06.0'CD/(,:$%')$&.$)/(,D/,%.&+)/,$%D'0$9+/,K,6$%63'%.:$%/,M,:.P')$&.$)/(,D.%(,0/(,#/+$00/(
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MONOGRAPHIE QUINQUINA ROUGEMONOGRAPHIE QUINQUINA ROUGE
8.).6&4)/(,')H.%'0/5&$9+/(,FV).H:/%&(,D_"6')6/,D/,*).%63/,/&,&)'%6,- B+)#.6/,/7&/)%/,H)$(-*)+%@,#$((+)"/,&).%(?G@,($00'%"/,0'%H$&+D$%.0/:/%&
- B+)#.6/,$%&/)%/,F,*)+%-)'+H/,#'%6"- B.?/+),&)4(,.:4)/
8.).6&4)/(,:.6)'(6'5$9+/(,F- V$*)/(,P.+%/(,=,5.)'$(,"5.$((/(@,(&)$"/(,/&,6.%.0$6+0"/(
- [D$'*0.(&/(,=,:$6)'6)$(&.+7,D_'7.0.&/
- >)"(/%6/,D/,(+*/)
MONOGRAPHIE QUINQUINA ROUGEMONOGRAPHIE QUINQUINA ROUGE
88<88< K,8k80K,8k80ZZ-- D$"&320.:$%/,bF\,MD$"&320.:$%/,bF\,M
;7&).$&,630')'#'):$9+/,;7&).$&,630')'#'):$9+/,FF]":'$%(,F,,9+$%$%/@,9+$%$D$%/@,6$%63'%$%/@,]":'$%(,F,,9+$%$%/@,9+$%$D$%/@,6$%63'%$%/@,6$%63'%$D$%/6$%63'%$D$%/6$%63'%$D$%/6$%63'%$D$%/
~$(+.0$(.&$'%~$(+.0$(.&$'% U~,U~,5+$(,5+0?")$(.&$'%,5+$(,5+0?")$(.&$'%,D_.6$D/,D_.6$D/,#'):$9+/#'):$9+/
>+0?")$(.&$'%,>+0?")$(.&$'%,)".6&$#,$'D'50.&$%.&/)".6&$#,$'D'50.&$%.&/&.63/(,?$'0/&&/(,F,,9+$%$%/,j#,0/,50+(,*.(,F,&.63/(,?$'0/&&/(,F,,9+$%$%/,j#,0/,50+(,*.(,F,
/%&)/,O@\O,/%&)/,O@\O,-- O@QWO@QW
j".6&$'%,/%,&+*/,j".6&$'%,/%,&+*/,F,63.+##.H/,D/,0.,5'+D)/,F,63.+##.H/,D/,0.,5'+D)/, H'+&/00/&&/(,)'+H/,H'+&/00/&&/(,)'+H/,(+),0/(,(+),0/(,5.)'$(,F,5.)'$(,F,530'*.534%/(530'*.534%/( #0+')/(6/%6/,*0/+,/%,U~,#0+')/(6/%6/,*0/+,/%,U~,
9+$%$%/
9+$%$D$%/6$%63'%$%/
6$%63'%$D$%/
EMPLOIS DES QUINQUINASEMPLOIS DES QUINQUINAS
A+$%9+$%.,)'+H/,A+$%9+$%.,)'+H/,F,/:50'$,:"D$6$%.0,)"D+$&,D.%(,F,/:50'$,:"D$6$%.0,)"D+$&,D.%(,0/(,"&.&(,#"*)$0/(,/&,H)$55.+7,/&,/%,3':"'5.&3$/0/(,"&.&(,#"*)$0/(,/&,H)$55.+7,/&,/%,3':"'5.&3$/
5'+),(&$:+0/),.55"&$&,/&,5)$(/,D/,5'$D(,K~fM5'+),(&$:+0/),.55"&$&,/&,5)$(/,D/,5'$D(,K~fM
D":.%H/.$('%( /& "&.&( 5/00$6+0.$)/( K+(.H/ /7&/)%/MD":.%H/.$('%( /& "&.&( 5/00$6+0.$)/( K+(.H/ /7&/)%/MD":.%H/.$('%(,/&,"&.&(,5/00$6+0.$)/(,K+(.H/,/7&/)%/MD":.%H/.$('%(,/&,"&.&(,5/00$6+0.$)/(,K+(.H/,/7&/)%/M
A+$%9+$%.,/%,H"%").0,A+$%9+$%.,/%,H"%").0,K\O,OOO,&'%%/(|.%M,F,K\O,OOO,&'%%/(|.%M,F,
WO,X,$%D+(&)$/,.H)'WO,X,$%D+(&)$/,.H)'--.0$:/%&.$)/,K.5")$&$#(@,I&'%$6(IM,,,,.0$:/%&.$)/,K.5")$&$#(@,I&'%$6(IM,,,,
/7&).6&$'%,D/,0.,9+$%$%/,/7&).6&$'%,D/,0.,9+$%$%/,
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>.0+D$(:/,F>.0+D$(:/,F.6&$?/,(+),#'):/(,$%&)..6&$?/,(+),#'):/(,$%&).--")2&3)'62&.$)/(,K(.+#,(63$e'%&/(,.H"(M")2&3)'62&.$)/(,K(.+#,(63$e'%&/(,.H"(M
.6&$?/,(+),0/(,N,>0.(:'D$+:,.6&$?/,(+),0/(,N,>0.(:'D$+:, 3'::/3'::/
$%.6&$?/,(+),#'):/(,/7'$%.6&$?/,(+),#'):/(,/7'--")2&3)'62&.$)/(,F,(5')'e'C&/(@,&)'53'e'C&/(,,")2&3)'62&.$)/(,F,(5')'e'C&/(@,&)'53'e'C&/(,,/&,H.:"&'62&/(/&,H.:"&'62&/(
PROPRIETES PHARMACOLOGIQUES PROPRIETES PHARMACOLOGIQUES DE LA QUININEDE LA QUININE
<"6.%$(:/,F,<"6.%$(:/,F,$%3$*$&$'%,D/,0.,(2%&34(/,5)'&"$9+/,D+,5.).($&/,5.),*0'6.H/,D/,0.,$%3$*$&$'%,D/,0.,(2%&34(/,5)'&"$9+/,D+,5.).($&/,5.),*0'6.H/,D/,0.,D"H).D.&$'%,D/(,.:$%'.6$D/(,D/,0J3":'H0'*$%/,D/,0J")2&3)'62&/D"H).D.&$'%,D/(,.:$%'.6$D/(,D/,0J3":'H0'*$%/,D/,0J")2&3)'62&/$%3$*$&$'%,5'02:")$(.&$'%,34:/,/%,3":'e'C%/,%'%,&'7$9+/$%3$*$&$'%,5'02:")$(.&$'%,34:/,/%,3":'e'C%/,%'%,&'7$9+/&'7$6$&",5'+),0/,5.).($&/&'7$6$&",5'+),0/,5.).($&/
<2'6.)D/,<2'6.)D/,F,F, /76$&.*$0$&"@,6'%D+6&$*$0$&"@,6'%&).6&$*$0$&"/76$&.*$0$&"@,6'%D+6&$*$0$&"@,6'%&).6&$*$0$&"
<'D/(&/:/%&,F,<'D/(&/:/%&,F,.%&$52)"&$9+/@,.%.0H"($9+/@,6+).)$(.%&.%&$52)"&$9+/@,.%.0H"($9+/@,6+).)$(.%&
;:50'$,D/,0.,9+$%$%/,.+P'+)DJ3+$,F;:50'$,D/,0.,9+$%$%/,.+P'+)DJ3+$,Fj"(/)?",.+7,6.(,("?4)/(,D/,:.0.)$.,=,j"(/)?",.+7,6.(,("?4)/(,D/,:.0.)$.,=,P. falciparumP. falciparum
]).$&/:/%&,.664(,5.0+(&)/,K/%,5.)&$6+0$/),($,)"($(&.%6/M,]).$&/:/%&,.664(,5.0+(&)/,K/%,5.)&$6+0$/),($,)"($(&.%6/M,.D+0&/,.D+0&/,per osper os F,\@W,=,Q,H,|,P,,/%,Z,5)$(/(,5/%D.%&,R,P'+)(F,\@W,=,Q,H,|,P,,/%,Z,5)$(/(,5/%D.%&,R,P'+)(E664(,5/)%$6$/+7,F,D'(/,D/,63.)H/,5+$(,D'(/,DJ/%&)/&$/%@E664(,5/)%$6$/+7,F,D'(/,D/,63.)H/,5+$(,D'(/,DJ/%&)/&$/%@/%,5/)#+($'%,$%&).?/$%/+(/,0/%&/,5/%D.%&,R,P'+)(/%,5/)#+($'%,$%&).?/$%/+(/,0/%&/,5/%D.%&,R,P'+)(
EMPLOI DE LA QUININEEMPLOI DE LA QUININE
5 5 P5 5 PE+&)/(,/:50'$(,K/%,.(('6$.&$'%M,FE+&)/(,/:50'$(,K/%,.(('6$.&$'%M,F.##/6&$'%(,#"*)$0/(@,6).:5/(,:+(6+0.$)/(.##/6&$'%(,#"*)$0/(@,6).:5/(,:+(6+0.$)/(
8'%&)/8'%&)/--$%D$6.&$'%(,F$%D$6.&$'%(,F])'+*0/(,D/,0.,6'%D+6&$?$&",.+)$6+0'?/%&)$6+0.$)/])'+*0/(,D/,0.,6'%D+6&$?$&",.+)$6+0'?/%&)$6+0.$)/U(.H/,5)'0'%H",K(+)&'+&,($,D'(/(,"0/?"/(M,FU(.H/,5)'0'%H",K(+)&'+&,($,D'(/(,"0/?"/(M,Fuu ])'+*0/(,%/+)'(/%(')$/0(,K325'.6'+($/@,&)'+*0/(,'6+0.$)/(M])'+*0/(,%/+)'(/%(')$/0(,K325'.6'+($/@,&)'+*0/(,'6+0.$)/(Muu ])'+*0/(,D$H/(&$#(])'+*0/(,D$H/(&$#(uu B+)?/$00.%6/,H026":$/,%"6/((.$)/B+)?/$00.%6/,H026":$/,%"6/((.$)/
SOLANACÉES À ALCALOÏDES SOLANACÉES À ALCALOÏDES TROPANIQUESTROPANIQUES
>)$%6$5.0/(,/(546/(,D_$%&")^&,53.):.6/+&$9+/>)$%6$5.0/(,/(546/(,D_$%&")^&,53.):.6/+&$9+/1/00.D'%/,F,1/00.D'%/,F,Atropa belladonna Atropa belladonna ii. . K0$(&/,\MK0$(&/,\M
!.&+).,K'+,(&).:'$%/M,F,!.&+).,K'+,(&).:'$%/M,F,Datura stramonium Datura stramonium iG,K0$(&/,\MiG,K0$(&/,\M
�+(9+$.:/,%'$)/,F,�+(9+$.:/,%'$)/,F,Hyoscyamus niger Hyoscyamus niger iG,K0$(&/,\MiG,K0$(&/,\M
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SOLANACÉES À ALCALOÏDES SOLANACÉES À ALCALOÏDES TROPANIQUESTROPANIQUES
ALCALOIDES ANTITUMORAUX NATURELSALCALOIDES ANTITUMORAUX NATURELS
\G,,E%&$&+:').+7,$%&/).H$((.%&,.?/6,0.,\G,,E%&$&+:').+7,$%&/).H$((.%&,.?/6,0.,&+*+0$%/&+*+0$%/ FF!")$?"(,D/,0.,5/)?/%63/,D/,<.D.H.(6.)!")$?"(,D/,0.,5/)?/%63/,D/,<.D.H.(6.)
].7'CD/(].7'CD/(
QG,,E%&$&+:').+7,.6&$#(,(+),0/(,QG,,E%&$&+:').+7,.6&$#(,(+),0/(,&'5'$(':").(/(&'5'$(':").(/( FF!")$?"(,D/,0.,6.:5&'&3"6$%/!")$?"(,D/,0.,6.:5&'&3"6$%/
!")$?"(,D/,0_/00$5&$6$%/!")$?"(,D/,0_/00$5&$6$%/
ANTITUMORAUX NATURELS INTERAGISSANT ANTITUMORAUX NATURELS INTERAGISSANT AVEC LA TUBULINEAVEC LA TUBULINE
\G\G [%&)'D+6&$'%[%&)'D+6&$'%QGQG !")$?"(,%.&+)/0(,D/,0.,5/)?/%63/!")$?"(,%.&+)/0(,D/,0.,5/)?/%63/
i.,50.%&/i.,50.%&/8':5'($&$'%,63$:$9+/8':5'($&$'%,63$:$9+/E6&$?$&",53.):.6'0'H$9+/,D/(,.06.0'CD/(E6&$?$&",53.):.6'0'H$9+/,D/(,.06.0'CD/(]'7$6$&"]'7$6$&"]'7$6$&"]'7$6$&"8.).6&")$(&$9+/(,/&,/:50'$(8.).6&")$(&$9+/(,/&,/:50'$(
ZGZG !")$?"(,3":$(2%&3"&$9+/(,D/,0.,5/)?/%63/!")$?"(,3":$(2%&3"&$9+/(,D/,0.,5/)?/%63/~$%D"($%/~$%D"($%/~$%')/0*$%/~$%')/0*$%/
NGNG ].7'CD/(].7'CD/([#([#(>.60$&.7/0,/&,!'6/&.7/0>.60$&.7/0,/&,!'6/&.7/0E6&$'%,53.):.6'0'H$9+/E6&$'%,53.):.6'0'H$9+/8.).6&")$(&$9+/(,/&,/:50'$(8.).6&")$(&$9+/(,/&,/:50'$(
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82&'(9+/0/&&/ F,/%(/:*0/,D/(,#$0.:/%&(,5)'&"$9+/(,9+$,(J/%&)/6)'$(/%&,D.%(,0/(,6/00+0/(,.%$:.0/(,/&,9+$,('%&,D/,Z,&25/(F,0/(,#$0.:/%&(,DJ.6&$%/@,0/(,:$6)'&+*+0/(,/&,0/(,#$0.:/%&(,$%&/):"D$.$)/(,
<$6)'&+*+0/( 620$%D)/( 6)/+7 D/ QN
INTRODUCTIONINTRODUCTION
<$6)'&+*+0/( 620$%D)/(,6)/+7,D/,QN,%:,D/,D$.:4&)/,/7&/)%/@,#'):"(,D/,#$0.:/%&(,D/,5'02:4)/(,D_ -&+*+0$%/,/&,D/, -&+*+0$%/@,63.6+%/,('+(,#'):/,D/,D$:4)/,
B&)+6&+)/(,/%,"9+$0$*)/,D2%.:$9+/@,(/,#.$(.%&,/&,(/,D"#.$(.%&,/%,5/):.%/%6/,K:$6)'&+*+0/(,/%&'+)"(,D/,&+*+0$%/(,0$*)/(M
]+*+0$%/(,/&,:$6)'&+*+0/(,]+*+0$%/(,/&,:$6)'&+*+0/(,$%&/)?$/%%/%&,D.%(,0/,$%&/)?$/%%/%&,D.%(,0/,&).%(5')&@,0.,&).%(5')&@,0.,:')53'0'H$/,/&,0.,D$?$($'%,6/00+0.$)/:')53'0'H$/,/&,0.,D$?$($'%,6/00+0.$)/
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INTRODUCTION
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6/+7,9+$,6/+7,9+$,$%3$*/%&,0.,5'02:")$(.&$'%,D/,0.,&+*+0$%/,$%3$*/%&,0.,5'02:")$(.&$'%,D/,0.,&+*+0$%/,/%,/%,:$6)'&+*+0/(@,6'::/,0/(,.06.0'CD/(,D/,0.,5/)?/%63/,/&,:$6)'&+*+0/(@,6'::/,0/(,.06.0'CD/(,D/,0.,5/)?/%63/,/&,D")$?"(,D")$?"(,
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DÉRIVÉS NATURELS DE LA PERVENCHEDÉRIVÉS NATURELS DE LA PERVENCHE
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DÉRIVÉS NATURELS DE LA PERVENCHEDÉRIVÉS NATURELS DE LA PERVENCHE
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ACTION PHARMACOLOGIQUEACTION PHARMACOLOGIQUE
;:5^63/%&,.$%($,0.,;:5^63/%&,.$%($,0.,#'):.&$'%,D+,#+(/.+,#'):.&$'%,D+,#+(/.+,5/):/&&.%&5/):/&&.%&0.,:$H).&$'%,D/(,63)':'(':/(,/&,*0'9+/%&,0.,0.,:$H).&$'%,D/(,63)':'(':/(,/&,*0'9+/%&,0.,D$?$($'%,6/00+0.$)/,=,0J"&.&,D/,D$?$($'%,6/00+0.$)/,=,0J"&.&,D/,:"&.53.(/:"&.53.(/
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8'::/)6$.0$("(,('+(,#'):/,02'53$0$(.&,'+,('0+&$'%,D/,(/08'::/)6$.0$("(,('+(,#'):/,02'53$0$(.&,'+,('0+&$'%,D/,(/0K(+0#.&/(M@,+&$0$(.&$'%,5.),K(+0#.&/(M@,+&$0$(.&$'%,5.),?'$/,$%&).?/$%/+(/,+%$9+/:/%&?'$/,$%&).?/$%/+(/,+%$9+/:/%&
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CARACTÉRISTIQUES, EMPLOI ET TOXICITÉCARACTÉRISTIQUES, EMPLOI ET TOXICITÉ
VincristineVincristine F,0/+6":$/(,.$H+Ü(@,:.0.D$/,D k'DHc$%(@,02:53':/@,F,0/+6":$/(,.$H+Ü(@,:.0.D$/,D k'DHc$%(@,02:53':/@,6.%6/),D+,(/$%@,6'0,D/,0_+&")+(6.%6/),D+,(/$%@,6'0,D/,0_+&")+(
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]'7$6$&","0/?"/,]'7$6$&","0/?"/,F,/##/&(,%/+)'0'H$9+/(,K,6"53.0"/(@,,F,/##/&(,%/+)'0'H$9+/(,K,6"53.0"/(@,,%"?)$&/(@,6'%?+0($'%(,M@,D$H/(&$#(@,)/(5$).&'$)/(@,.0'5"6$/GG%"?)$&/(@,6'%?+0($'%(,M@,D$H/(&$#(@,)/(5$).&'$)/(@,.0'5"6$/GG
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!")$?/%&,D/,D$##")/%&/(,/(546/(,!")$?/%&,D/,D$##")/%&/(,/(546/(,D+,H/%)/,D+,H/%)/,TaxusTaxus K,].7.6"/(,MK,].7.6"/(,M
TAXOÏDESTAXOÏDES
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COMPOSITION CHIMIQUECOMPOSITION CHIMIQUE
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8'::/)6$.0$(",D/5+$(,\bbN8'::/)6$.0$(",D/5+$(,\bbN[('0",$%$&$.0/:/%&,D/,0_"6')6/,D/,[('0",$%$&$.0/:/%&,D/,0_"6')6/,D/,Taxus brevifoliaTaxus brevifoliaKO@O\,XMKO@O\,XMR,&'%%/(,D_"6')6/,R,&'%%/(,D_"6')6/, \,cH,D/,&.7'0\,cH,D/,&.7'0
PACLITAXEL = TAXOLPACLITAXEL = TAXOL®®
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HÉMISYNTHÈSE DU TAXOL®
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DOCETAXEL = TAXOTERE DOCETAXEL = TAXOTERE ®®
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ANTITUMORAUX NATURELS ACTIFS SUR ANTITUMORAUX NATURELS ACTIFS SUR LES TOPOISOMÉRASESLES TOPOISOMÉRASES
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8.:5&'&3"6$%/8.:5&'&3"6$%/$('0"/,D/,$('0"/,D/,Campthoteca acuminataCampthoteca acuminata Kn2((.6/./M@,83$%/Kn2((.6/./M@,83$%/
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