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![Page 1: PowerPoint プレゼンテーション(induction phase) HTI HTI heterozygous Mafa HTI homozygous iPS Sorting CD45- CD34- CD11b- CD14- HLA-DR- IDO+ TGF-b+ HI-A-G+ PGE2+ CD105+ CD44+](https://reader036.vdocuments.pub/reader036/viewer/2022063016/5fd6a711223cb21cc932f0a6/html5/thumbnails/1.jpg)
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DNAタイピングによるHT1ホモ接合体個体の選抜�
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(京都大学iPS細胞研究所・資料より改変)
再生医療用iPS細胞ストック計画
(京都大学 CiRA)
HLAハプロタイプホモ接合体を有する個人から樹立・評価したiPS
細胞を同一HLAハプロタイプヘテロ接合体を有する個人に用いる
ことにより、拒絶反応を軽減できると予想される。150種類程度の
HLAハプロタイプホモ接合体を有するiPS細胞をストックする。
→ 免疫学的有効性を検証を含む前臨床試験が必要
HLA(赤)ホモ ドナー由来
iPS細胞
赤のHLAを有する ヒトへの移植では、 免疫拒絶反応が 生じにくい
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ご清聴ありがとうございます