RADIOSS
1Kim H. Parker
2 1
1
2 Physiological Flow Studies Group, Department of Bioengineering, Imperial College London
1
[1 2]3
[3 4]
2
2-1
ri
10_mm h 2_mm L
L_=_1000_mm =_100ri Es
0.5_MPa 1000_kg/m3
0.45 μ 4.0_ _10-3
_Pa s
Z-X Y Fig._1
Ls 100_mm AR AR_=_70% 1
476 224 5_mm
147987 141400
Figure_1_Schematic view of the stenosed artery model.
2-2
RADIOSS_ver._4.6 RADIOSS
ALE
f u jf( )
t+
f uif u j
f( )xi
=p
x j
+ μ2u j
f
xi xi (1)
f
t+
f u i
f( )xi
= 0 (2)
fuif
p μ fp c
f= 0
f+
p
c2 (3)
0f
1000_kg/m3
ij
x jV
dV =s ui
s
tVdV (4)
ij =Cijkl kl (5)
ij Cauchy Cijkl kl
2-3
(6) (7)
(8)
ui
f= ui
s (6)
p
t= f c
un
f
t+ c
p p( )2lc
(7)
u
i
s= 0 (8)
f s n
c p
1.0_ _10-3
_~_1.0_ _10-2
_mm
0.1%_~_1% Re 1000
10_ms
Re 4000 Fig._2
Figure_2_Boundary condition at the inlet.
2-4
= μ
u f s
r (9)
uf-s
3
x_=_0 uy Dc Dl
Us
Fig._3 t_=_0_ms
5% 1.0_Pa
0.5_Pa 2.0_Pa
0.5_Pa
Us
2 Dc 1 Us
uy Us
uy
2
0.1_m/s t_=_35_ms y_=_200_mm
t_=_55_ms uy
Us
t_=_80_ms Us
t_=_125 175_ms
(t_=_0_ms) (t_=_20_ms)
(t_=_125_ms) (t_=_175_ms)
Figure_3_Wave propagation and WSS distribution in the stenosed artery model.
4
Us
Us
3.0_Pa
1.0_Pa Us
3.5_Pa t_=_125_ms
1.5_Pa t_=_175_ms
Somer[5]
Evans blue
Newman[6]
trypan blue Somer
Newman
Somer
Newman
Newman
IT
(768)
(A)(2) No.16200031
RADIOSS_ver._4.6
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Evans blue uptake in vivo,” Atherosclerosis, vol. 16, pp. 127-133, 1972.
[6] D. L. Newman, J. R. Batten, and N. L. Bowden, “Influence of experimental stnosis on uptake of albumin by the
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