B

AR&D MAB 0983 SC AB N18 SC AB F18

R&D MAB 0983, preabsorbed SC AB N18, preabsorbed SC AB F18, preabsorbed

*

*

*

*

*

0

1

2

3

tum

or

vess

el

muc

osa

R&D MAB 0983

Ang

-2 s

tain

ing

inte

nsity

0 = no staining1 = weak staining2 = moderate staining3 = strong staining

n = 10

tum

or

vess

el

muc

osa

tum

or

vess

el

muc

osa

SC AB N18 SC AB F18

primary Ang-2 AB onlypreabsorbed primary Ang-2 AB

100 m

A

B

y

SW

948

DLD

1

HT

29

LS17

4T

HU

VE

C0

0.5

1.0

> 3.0

Ang

-2 [

ng/m

l]

normoxiahypoxia

RP

MI

DM

EM

EG

M

cont

rol

cont

rol

-actin

Ang-2

130100

70

55

40

35

HT

29

DLD

1

LS17

4T

SW

948

HU

VE

C

colon carcinoma