Download - SnRNP (snRNA) nello spliceosoma. Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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snRNP (snRNA) nello spliceosoma
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Intermedi di splicing: complessi E, A
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Intermedi di splicing: complessi B
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Intermedi di splicing: complessi C
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Watson et al., BIOLOGIA MOLECOLARE DEL GENE, Zanichelli editore S.p.A. Copyright © 2005
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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…CUGCUGAGGCGAGGUAGAUACA........CUCCUCCAUAGGUGGUGCUGGC...
...UACUGCUGAGGCGAGGUGGUGCUGGGCAUC..
introneesone esone
esone esone
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•Splicing nucleare
•Splicing di introni di tipo II
•Splicing di introni di tipo I
•Splicing di tRNA di lievito
spliceosoma
nucleasi e ligasi
autosplicing
trans-esterificazio
ni
meccanismosimile
Tipi di splicing
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RNA catalitico
•RNAsi P
•Viroidi e virusoidi
•Introni di gruppo I e II
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GG C
G
N
NNN
A
NN
N
N
N
A
A
UGC
A U
NGN
NNG
C N
CA
loop 1
loop 2
loop 3
GGC
CU
A
G
U
G AU
GC CAGC G
5'ppp3'OH
ribozima
La “testa di martello” (hammerhead)
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Ribozima “hammerhead”
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Struttura dell’intronedell’rRNA di Tetrahymena
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Trans-splicing in C. elegans
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Splicing alternativo
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Regolazione dello splicing
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Editing
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Editing dell’mRNA per la Apolipoproteina B umana
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Editing dell’mRNA per la subunità B di GluR
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Editing inserzionale in Tripanosoma
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Editing inserzionale mediante RNA guida
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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