220 Journal of Young Pharmacists Vol 4 / No 4
p m
antiemetic, antispasmodic, and local anesthetic effects in
INTRODUCTION
Access this article online
Quick Response Code:Website: www.jyoungpharm.in
DOI: 10.4103/0975-1483.104365
Studies on the Preparation, Characterization, and Solubility of
George SJ, Vasudevan DT
Department of Pharmaceutics, Amrita School of Pharmacy, AIMS Health Care Campus, Kochi, Kerala, India
Address for correspondence: Dr. Deepa T Vasudevan; E-mail: [email protected]
ABSTRACT
An in vitro study showed that the
From the results of dissolution study, it was found that the prepared formulation was showing better release, which P < t
Key words:
Pharmaceutics
Journal of Young Pharmacists Vol 4 / No 4 221
other antihistamines of its class and also has longer duration
particular
and dissolution properties.
but toroidal or cone shaped. Based on this architecture, the
and their derivatives have been of considerable interest in
inclusion complexes formulation.
of the formulation is to attain faster dissolution rates, the
drug.
forms.
in vitro
MATERIALS AND METHODS
Chemicals
Phase solubility studies
222 Journal of Young Pharmacists Vol 4 / No 4
Kc
K S0 (1
Preparation of solid inclusion complexes
Physical mixture
Kneading method
Co-precipitation method
at ambient temperature until complete evaporation of
Differential scanning calorimetrydifferential scanning calorimetry
Fourier transform infrared spectroscopy
.
In vitro dissolution studies
Formulation of tablets by direct compression method
Evaluation of precompression parameters of powder blend
evaluated.
Evaluation of postcompression parameters of tablets
Journal of Young Pharmacists Vol 4 / No 4 223
RESULTS
Phase solubility study
Kc, obtained from the slope of
studies.
Differential scanning calorimetry
Fourier transform infrared spectroscopy
2 2
Table 1: Formulae of fast dissolving tablets of binary
Ingredients F1 (mg)Eq. blend of Meclizine HCl
97.63
Pearlitol SD200 58.57MCC (Avicel pH 102) 30Sodium starch glycolate 4Aspartame 1.5
1.5Aerosil (0.4%) 0.8Talc (3%) 6Total 200 mg
Figure 1: Phase solubility diagram of Meclizine HCl with -CD and HP- -CD
224 Journal of Young Pharmacists Vol 4 / No 4
to the restriction of bending and stretching vibration of
due
indicating noncovalent interaction in inclusion complex.
Drug content
In vitro dissolution studies
release on the y x
Figure 2: DSC thermogram of Meclizine HClFigure 3: DSC thermogram of HP- -CD
Figure 4: DSC thermogram of physical mixtures
Figure 5: DSC thermogram of the co-precipitation complex
Journal of Young Pharmacists Vol 4 / No 4 225
Evaluation of precompression parameters of powder blend
,
Evaluation of postcompression parameters of tablets
2
in vitro
in
DISCUSSION
Figure 6: DSC thermogram of the kneading complex
Figure 7: FT-IR spectra of Meclizine HCl
Figure 8: FT-IR spectra of HP- -CD
581.
81756.
22851.
71
942.
85
1032
.28
1157
.93
1245
.86
1335
.75
1373
.21
1413
.39
1645
.73
2929
.13
-10 0
10 20 30 40 50 60 70 80 90
%T
5001000150020002500300035004000Wavenumbers (cm-1)
Figure 9: FT-IR spectra of physical mixture
Time (min) % Release from prepared tableta
% Release from marketed tableta
5 44.44 ± 0.61 3.49 ± 0.3210 68.28 ± 0.46 9.87 ± 0.2315 72.34 ± 0.64 22.43 ± 0.9320 78.31 ± 0.48 28.98 ± 0.3425 84.12 ± 0.46 34.93 ± 0.9430 95.16 ± 0.64 53.39 ± 0.4545 - 70.39 ± 0.5060 - 81.39 ± 0.49aMean ± SD, n = 3
226 Journal of Young Pharmacists Vol 4 / No 4
indicates the formation of true complex and conversion of
could be diagnosed as a superimposition of the bands of
formation of inclusion complex in the solid state. All the
inclusion complex. In vitro drug release from prepared tablets
technique and inclusion complex based fast dissolving tablets
ACKNOWLEDGMENTS
REFERENCES
Figure 10: FT-IR spectra of the kneading method
-10 0
10 20 30 40 50 60 70 80 90
%T
4000 3500 300026
36.0
5
2927
.63
2500
2202
.04
2450
.67
2513
.84
2000Wavenumbers (cm-1)
1430
.51
1644
.21
1155
.9612
41.7
7
1373
.27
1500
700.
3675
7.25
850.
39
941.
54
1000
581.
15
500
Figure 11: FT-IR spectra of co-precipitation
Figure 12: -CD systems
Figure 13:tablet and marketed tablet
Journal of Young Pharmacists Vol 4 / No 4 227
How to cite this article: George SJ, Vasudevan DT. Studies on the
Source of Support: Nil, None declared.
“QUICK RESPONSE CODE” LINK FOR FULL TEXT ARTICLES
