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Page 1: Supplemental Figure 1

Supplemental Figure 1.

Codon L576P CTT →　 CCT

Wild type Mutation

Page 2: Supplemental Figure 1

DM440 DM366

Srcp-Src

FAKp-FAKP130p-P130Actin

0 10 100 1000 0 10 100 1000nM

Srcp-SrcFAKp-FAKP130p-P130

Actin

DM6 DM738 0 10 100 1000 0 10 100 1000 0 10 100 1000nM

WM3211

Supplemental Figure 2.

Page 3: Supplemental Figure 1

Src-predicted dysregulation

% in

hibi

tion

of

cell

pro

life

rati

on

wit

h 10

00nM

das

atin

ib a

lone

Supplemental Figure 3.

0.1 0.2 0.3 0.4 0.5 0.6 0.7

-10

0

10

20

30

40

50

f(x) = 77.0862545040333 x − 18.8516123329777R² = 0.501655589597122

DM6

DM443

DM366

DM738

PRMel

DM440

Page 4: Supplemental Figure 1

Model1(Control)

0 4hr 8hr 16hr 24hr

Model 2

Model 3

Model 4

Model 5

Model 6

Model 7

Model 8

Harvest

Dasatinib Harvest

Dasatinib

Dasatinib

Dasatinib

Dasatinib

Dasatinib

Dasatinib

Harvest

Harvest

Harvest

Dasatinib

Dasatinib

Dasatinib Dasatinib

Harvest

Harvest

Harvest

Supplemental Figure 4.

Src

p-Src

FAKp-FAK

P130

p-P130

Actin

Model number1 2 3 4 5 6 7 8

A

B


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